Therapeutic vaccination and immunomodulation in the treatment of chronic hepatitis B: preclinical studies in the woodchuck

Nucleoside analogues alone or combined with vaccination prevent hepadnavirus viremia and induce protective immunity: Alternative strategy for hepatitis B virus post-exposure prophylaxis

(2014) Baoju Wang et al.   ANTIVIRAL RESEARCH

PD-1 Blockade in Rhesus Macaques: Impact on Chronic Infection and Prophylactic Vaccination

(2014) A. C. Finnefrock et al.   JOURNAL OF IMMUNOLOGY

Comment on "Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA"

(2014) F. V. Chisari et al.   SCIENCE

Response to Comment on "Specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA"

(2014) Y. Xia et al.   SCIENCE

Specific and Nonhepatotoxic Degradation of Nuclear Hepatitis B Virus cccDNA

(2014) J. Lucifora et al.   SCIENCE

Enhancing Virus-Specific Immunity In Vivo by Combining Therapeutic Vaccination and PD-L1 Blockade in Chronic Hepadnaviral Infection

(2014) Jia Liu et al.   PLoS Pathogens

Results of a phase III clinical trial with an HBsAg-HBIG immunogenic complex therapeutic vaccine for chronic hepatitis B patients: Experiences and findings

(2013) Dao-Zhen Xu et al.   JOURNAL OF HEPATOLOGY

Interferon-Induced Proteins with Tetratricopeptide Repeats 1 and 2 Are Cellular Factors That Limit Hepatitis B Virus Replication

(2013) Rongjuan Pei et al.   Journal of Innate Immunity

Immunological and Antiviral Responses After Therapeutic DNA Immunization in Chronic Hepatitis B Patients Efficiently Treated by Analogues

(2013) O Godon et al.   MOLECULAR THERAPY

A Randomized, Double-Blind, Placebo-Controlled Assessment of BMS-936558, a Fully Human Monoclonal Antibody to Programmed Death-1 (PD-1), in Patients with Chronic Hepatitis C Virus Infection

(2013) David Gardiner et al.   PLoS One

RNAi Induces Innate Immunity through Multiple Cellular Signaling Pathways

(2013) Zhongji Meng et al.   PLoS One

Immunotherapy of chronic hepatitis C virus infection with antibodies against programmed cell death-1 (PD-1)

(2013) M. J. Fuller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Combination of DNA Prime – Adenovirus Boost Immunization with Entecavir Elicits Sustained Control of Chronic Hepatitis B in the Woodchuck Model

(2013) Anna D. Kosinska et al.   PLoS Pathogens

Regulation of hepatitis B virus replication by epigenetic mechanisms and microRNAs

(2013) Xiaoyong Zhang et al.   Frontiers in Genetics

Molecular characterization of woodchuck interleukin-10 receptor and enhanced function of specific T cells from chronically infected woodchucks following its blockade

(2012) Min Jiang et al.   COMPARATIVE IMMUNOLOGY MICROBIOLOGY AND INFECTIOUS DISEASES

Molecular characterization of the type I IFN receptor in two woodchuck species and detection of its expression in liver samples from woodchucks infected with woodchuck hepatitis virus (WHV)

(2012) Hebin Fan et al.   CYTOKINE

Transcriptomic analysis of the woodchuck model of chronic hepatitis B

(2012) Simon P. Fletcher et al.   HEPATOLOGY

Role of Toll-like receptor 2 in the immune response against hepadnaviral infection

(2012) Xiaoyong Zhang et al.   JOURNAL OF HEPATOLOGY

DNA Prime-Adenovirus Boost Immunization Induces a Vigorous and Multifunctional T-Cell Response against Hepadnaviral Proteins in the Mouse and Woodchuck Model

(2012) A. D. Kosinska et al.   JOURNAL OF VIROLOGY

Global epidemiology of hepatitis B virus infection: New estimates of age-specific HBsAg seroprevalence and endemicity

(2012) J.J. Ott et al.   VACCINE

The Expression of PD-1 Ligands and Their Involvement in Regulation of T Cell Functions in Acute and Chronic Woodchuck Hepatitis Virus Infection

(2011) Ejuan Zhang et al.   PLoS One

Establishing a new animal model for hepadnaviral infection: susceptibility of Chinese Marmota-species to woodchuck hepatitis virus infection

(2010) B.-J. Wang et al.   JOURNAL OF GENERAL VIROLOGY

Serum HBeAg sero-conversion correlated with decrease of HBsAg and HBV DNA in chronic hepatitis B patients treated with a therapeutic vaccine

(2010) Xuan-Yi Wang et al.   VACCINE

Randomized Controlled Study Investigating Viral Suppression and Serological Response following Pre-S1/Pre-S2/S Vaccine Therapy Combined with Lamivudine Treatment in HBeAg-Positive Patients with Chronic Hepatitis B

(2009) P. T. L. Hoa et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Lipopolysaccharide-induced innate immune responses in primary hepatocytes downregulates woodchuck hepatitis virus replication via interferon-independent pathways

(2009) Xiaoyong Zhang et al.   CELLULAR MICROBIOLOGY

Characterization of interleukin 8 in woodchucks with chronic hepatitis B and hepatocellular carcinoma

(2008) C-J Liu et al.   GENES AND IMMUNITY

Enhancing SIV-specific immunity in vivo by PD-1 blockade

(2008) Vijayakumar Velu et al.   NATURE

A Randomized Controlled Phase IIb Trial of Antigen-Antibody Immunogenic Complex Therapeutic Vaccine in Chronic Hepatitis B Patients

(2008) Dao-Zhen Xu et al.   PLoS One

Inhibition of woodchuck hepatitis virus gene expression in primary hepatocytes by siRNA enhances the cellular gene expression

(2008) Zhongji Meng et al.   VIROLOGY

Molecular characterization of woodchuck type I interferons and their expression by woodchuck peripheral blood lymphocytes

(2007) Yinping Lu et al.   CYTOKINE