Therapeutic vaccines in treating chronic hepatitis B: the end of the beginning or the beginning of the end?

EASL Clinical Practice Guidelines: Management of chronic hepatitis B virus infection

(2015)   JOURNAL OF HEPATOLOGY

Anti-HBV DNA vaccination does not prevent relapse after discontinuation of analogues in the treatment of chronic hepatitis B: a randomised trial—ANRS HB02 VAC-ADN

(2014) H Fontaine et al.   GUT

A Whole Recombinant Yeast-Based Therapeutic Vaccine Elicits HBV X, S and Core Specific T Cells in Mice and Activates Human T Cells Recognizing Epitopes Linked to Viral Clearance

(2014) Thomas H. King et al.   PLoS One

Safety, tolerability and immunogenicity of GS-4774, a hepatitis B virus-specific therapeutic vaccine, in healthy subjects: A randomized study

(2014) Anuj Gaggar et al.   VACCINE

Enhancing Virus-Specific Immunity In Vivo by Combining Therapeutic Vaccination and PD-L1 Blockade in Chronic Hepadnaviral Infection

(2014) Jia Liu et al.   PLoS Pathogens

Safety, pharmacokinetics and pharmacodynamics of GS-9620, an oral Toll-like receptor 7 agonist

(2013) Uri Lopatin et al.   ANTIVIRAL THERAPY

Therapeutic potential of a combined hepatitis B virus surface and core antigen vaccine in patients with chronic hepatitis B

(2013) Mamun Al-Mahtab et al.   Hepatology International

776 ESTABLISHMENT OF A POTENT ANTI-HBsAg RESPONSE AND DURABLE IMMUNOLOGICAL CONTROL OF VIREMIA WITH SHORT TERM IMMUNOTHERAPY AFTER REP 9AC-INDUCED HBsAg SEROCLEARANCE IN CHRONIC HBV INFECTION

(2013) M. Al-Mahtab et al.   JOURNAL OF HEPATOLOGY

Results of a phase III clinical trial with an HBsAg-HBIG immunogenic complex therapeutic vaccine for chronic hepatitis B patients: Experiences and findings

(2013) Dao-Zhen Xu et al.   JOURNAL OF HEPATOLOGY

Immunological and Antiviral Responses After Therapeutic DNA Immunization in Chronic Hepatitis B Patients Efficiently Treated by Analogues

(2013) O Godon et al.   MOLECULAR THERAPY

Synthetic DNA Vaccines: Improved Vaccine Potency by Electroporation and Co-Delivered Genetic Adjuvants

(2013) Seleeke Flingai et al.   Frontiers in Immunology

Long-term entecavir treatment reduces hepatocellular carcinoma incidence in patients with hepatitis B virus infection

(2012) Tetsuya Hosaka et al.   HEPATOLOGY

Responses to multiple injections with alum alone compared to injections with alum adsorbed to proteins in mice

(2012) Xuan-Yi Wang et al.   IMMUNOLOGY LETTERS

A pilot randomized controlled trial of dual-plasmid HBV DNA vaccine mediated by in vivo electroporation in chronic hepatitis B patients under lamivudine chemotherapy

(2012) F.-Q. Yang et al.   JOURNAL OF VIRAL HEPATITIS

First-line treatment of chronic hepatitis B with entecavir or tenofovir in ‘real-life’ settings: from clinical trials to clinical practice

(2012) S. Pol et al.   JOURNAL OF VIRAL HEPATITIS

Safety, Activity, and Immune Correlates of Anti–PD-1 Antibody in Cancer

(2012) Suzanne L. Topalian et al.   NEW ENGLAND JOURNAL OF MEDICINE

Optimization of immune responses induced by therapeutic vaccination with cross-reactive antigens in a humanized hepatitis B surface antigen transgenic mouse model

(2012) Maryline Bourgine et al.   VIROLOGY

Randomised clinical trial: anti-viral activity of ANA773, an oral inducer of endogenous interferons acting via TLR7, in chronic HCV

(2011) J. F. Bergmann et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Innate and adaptive immune responses in chronic hepatitis B virus infections: towards restoration of immune control of viral infection

(2011) Antonio Bertoletti et al.   GUT

Elimination of hepatocellular carcinoma and acute hepatitis B in children 25 years after a hepatitis B newborn and catch-up immunization program

(2011) Brian J. McMahon et al.   HEPATOLOGY

Therapeutic vaccines and immune-based therapies for the treatment of chronic hepatitis B: Perspectives and challenges

(2011) Marie-Louise Michel et al.   JOURNAL OF HEPATOLOGY

Partially Randomized, Non-Blinded Trial of DNA and MVA Therapeutic Vaccines Based on Hepatitis B Virus Surface Protein for Chronic HBV Infection

(2011) James S. Cavenaugh et al.   PLoS One

The molecular basis of the failed immune response in chronic HBV: Therapeutic implications

(2010) Mala K. Maini et al.   JOURNAL OF HEPATOLOGY

Changes to the Natural Killer Cell Repertoire after Therapeutic Hepatitis B DNA Vaccination

(2010) Daniel Scott-Algara et al.   PLoS One

Randomized Controlled Study Investigating Viral Suppression and Serological Response following Pre-S1/Pre-S2/S Vaccine Therapy Combined with Lamivudine Treatment in HBeAg-Positive Patients with Chronic Hepatitis B

(2009) P. T. L. Hoa et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Increased in vivo immunological potency of HB-110, a novel therapeutic HBV DNA vaccine, by electroporation

(2009) Chae Young Kim et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Antigen–antibody immunogenic complex: promising novel vaccines for microbial persistent infections

(2009) Yu-mei Wen   EXPERT OPINION ON BIOLOGICAL THERAPY

Chronic hepatitis B: Update 2009

(2009) Anna S. F. Lok et al.   HEPATOLOGY

Hepatitis B vaccination: The key towards elimination and eradication of hepatitis B

(2009) Ding-Shinn Chen   JOURNAL OF HEPATOLOGY

High antigen levels are the cause of T cell exhaustion during chronic viral infection

(2009) S. N. Mueller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Increase of Plasma IL-12/p40 Ratio Induced by the Combined Therapy of DNA Vaccine and Lamivudine Correlates with Sustained Viremia Control in CHB Carriers

(2009) Se Jin Im et al.   Immune Network

Hepatitis B Virus Infection

(2008) Jules L. Dienstag   NEW ENGLAND JOURNAL OF MEDICINE

A Randomized Controlled Phase IIb Trial of Antigen-Antibody Immunogenic Complex Therapeutic Vaccine in Chronic Hepatitis B Patients

(2008) Dao-Zhen Xu et al.   PLoS One