Overexpression of p62/SQSTM1 promotes the degradations of abnormally accumulated PrP mutants in cytoplasm and relieves the associated cytotoxicities via autophagy–lysosome-dependent way

4-hydroxytamoxifen leads to PrPSc clearance by conveying both PrPC and PrPSc to lysosomes independently of autophagy

(2013) L. Marzo et al.   JOURNAL OF CELL SCIENCE

PrP octarepeats region determined the interaction with caveolin-1 and phosphorylation of caveolin-1 and Fyn

(2013) Qi Shi et al.   MEDICAL MICROBIOLOGY AND IMMUNOLOGY

p62/SQSTM1-Dependent Autophagy of Lewy Body-Like α-Synuclein Inclusions

(2013) Yoshihisa Watanabe et al.   PLoS One

Activation of the macroautophagic system in scrapie-infected experimental animals and human genetic prion diseases

(2012) Yin Xu et al.   Autophagy

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Stimulation of autophagy reduces neurodegeneration in a mouse model of human tauopathy

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Lysosomal storage disorders: The cellular impact of lysosomal dysfunction

(2012) Frances M. Platt et al.   JOURNAL OF CELL BIOLOGY

Protein Disulfide Isomerase Regulates Endoplasmic Reticulum Stress and the Apoptotic Process during Prion Infection and PrP Mutant-Induced Cytotoxicity

(2012) Shao-Bin Wang et al.   PLoS One

Heat shock protein 70 selectively mediates the degradation of cytosolic PrPs and restores the cytosolic PrP-induced cytotoxicity via a molecular interaction

(2012) Jin Zhang et al.   Virology Journal

Reticulon 3 attenuates the clearance of cytosolic prion aggregates via inhibiting autophagy

(2011) Rui Chen et al.   Autophagy

Stimulation of GSH synthesis to prevent oxidative stress-induced apoptosis by hydroxytyrosol in human retinal pigment epithelial cells: activation of Nrf2 and JNK-p62/SQSTM1 pathways

(2011) Xuan Zou et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Prion propagation and toxicity in vivo occur in two distinct mechanistic phases

(2011) Malin K. Sandberg et al.   NATURE

Heat Shock Proteins: Cell Protection through Protein Triage

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A reporter cell system to monitor autophagy based on p62/SQSTM1

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Lysosomal Proteolysis and Autophagy Require Presenilin 1 and Are Disrupted by Alzheimer-Related PS1 Mutations

(2010) Ju-Hyun Lee et al.   CELL

Convergence of Presenilin- and Tau-Mediated Pathways on Axonal Trafficking and Neuronal Function

(2010) E. Peethumnongsin et al.   JOURNAL OF NEUROSCIENCE

Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity

(2010) Ying Zhao et al.   NATURE CELL BIOLOGY

Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease

(2010) Marta Martinez-Vicente et al.   NATURE NEUROSCIENCE

Generating a Prion with Bacterially Expressed Recombinant Prion Protein

(2010) F. Wang et al.   SCIENCE

Autophagy induction by trehalose counter-acts cellular prion-infection

(2009) Yasmine Aguib et al.   Autophagy

p62 at the Crossroads of Autophagy, Apoptosis, and Cancer

(2009) Jorge Moscat et al.   CELL

Delivery of single-chain antibodies (scFvs) directed against the 37/67 kDa laminin receptor into mice via recombinant adeno-associated viral vectors for prion disease gene therapy

(2008) C. Zuber et al.   JOURNAL OF GENERAL VIROLOGY

p62 protects SH-SY5Y neuroblastoma cells against H2O2-induced injury through the PDK1/Akt pathway

(2008) Seong Ryong Heo et al.   NEUROSCIENCE LETTERS