Review
Critical Care Medicine
Etienne-Marie Jutant, Ly Tu, Marc Humbert, Christophe Guignabert, Alice Huertas
Summary: Leptin, a pleotropic hormone, regulates a wide range of systemic functions and is expressed not only in adipose tissue, but also in various organs, including the lungs. It plays important physiological roles in the respiratory system, independent of body weight, and dysregulation of its signaling pathway may lead to lung diseases.
Review
Immunology
Martin Regensburger, Shafqat Rasul Chaudhry, Hammad Yasin, Yining Zhao, Andreas Stadlbauer, Michael Buchfelder, Thomas Kinfe
Summary: An increasing body of experimental evidence suggests a link between immunometabolic deterioration and the progression of Parkinson's disease. In particular, the dysregulation of central and peripheral neuroinflammatory networks mediated by circulating adipokines, such as leptin, may play a role. This article summarizes the existing evidence on the role of adipokines in Parkinson's disease and discusses their potential as therapeutic targets.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Biochemistry & Molecular Biology
Marilia L. Cirqueira, Leandro O. Bortot, Mayte Bolean, Mariana A. A. Aleixo, Pedro H. Luccas, Antonio J. Costa-Filho, Ana Paula Ramos, Pietro Ciancaglini, M. Cristina Nonato
Summary: Due to its severe burden and geographic distribution, Chagas disease has a significant social and economic impact on low-income countries. This study aims to understand the role of TcNTR in the basic parasite biology, investigate its potential as a drug target, and contribute to the fight against neglected tropical diseases. The results showed that TcNTR interacts with membranes, with a preference for those containing cardiolipin, and a 23-residue long insertion is involved in enzyme specificity and protein-membrane interaction.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Biochemistry & Molecular Biology
Roberto Docampo, Anibal Eugenio Vercesi
Summary: This review discusses the mechanisms of mitochondrial oxidant generation and removal, and the involvement of Ca2+ in trypanosome cell death, highlighting the need for further studies on ROS generation, defense mechanisms, and mitochondrial permeability transition pore in trypanosomatids.
ANTIOXIDANTS & REDOX SIGNALING
(2022)
Article
Biochemistry & Molecular Biology
Naiara Dutra Barroso Gomes, Emanuel Paula Magalhaes, Lyanna Rodrigues Ribeiro, John Washington Cavalcante, Marcelo Morais Gomes Maia, Felipe Ramon Cunha da Silva, Arif Ali, Marcia Machado Marinho, Emmanuel Silva Marinho, Helcio Silva dos Santos, Alice Maria Costa Martins, Ramon Roseo Paula Pessoa Bezerra de Menezes
Summary: This study evaluated the activity of synthetic p-aminochalcones against T. cruzi and found that they have a trypanocidal effect by causing membrane damage and oxidative stress. Their mechanism of action may be related to inhibition of cruzain and TR.
BIOORGANIC CHEMISTRY
(2023)
Article
Immunology
Carezza Botto-Mahan, Juana P. Correa, Raul Araya-Donoso, Francisca Farias, Esteban San Juan, Nicol Quiroga, Ricardo Campos-Soto, Claudio Reyes-Olivares, Daniel Gonzalez-Acuna
Summary: In this study, we assessed 4 lizard species in Chile for Trypanosoma cruzi and found that all species were infected. We also discovered that one species had the ability to transmit the protozoan, highlighting their role as reservoirs for T. cruzi.
EMERGING INFECTIOUS DISEASES
(2022)
Article
Immunology
Jose L. Saenz-Garcia, Beatriz S. Borges, Normanda Souza-Melo, Luiz V. Machado, Juliana S. Miranda, Lisandro Alfonso Pacheco-Lugo, Nilmar S. Moretti, Richard Wheleer, Lia C. Soares Medeiros, Wanderson D. DaRocha
Summary: The flagellum of Trypanosomatids contributes to multiple functions, and this study explores the role of Trypanin in T. cruzi. The deletion of Trypanin affects the growth and motility of T. cruzi epimastigotes, as well as their infection capacity.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Immunology
Lucia Lopez, Maria Laura Chiribao, Magali C. Girard, Karina A. Gomez, Paula Carasi, Marisa Fernandez, Yolanda Hernandez, Carlos Robello, Teresa Freire, Maria Dolores Pineyro
Summary: The study showed that c-TXNPx induces the recruitment of IL-12/23p40-producing innate antigen-presenting cells and promotes a strong specific Th1 immune response, while c-TXNPxC52S does not. The presence of peroxidatic cysteine is essential for the peroxidase activity and quaternary structure of the protein.
Article
Multidisciplinary Sciences
Wendell Girard-Dias, Ingrid Augusto, Tacio V. A. Fernandes, Pedro G. Pascutti, Wanderley de Souza, Kildare Miranda
Summary: In this study, the three-dimensional distribution of diffusible elements within acidocalcisomes in Trypanosoma cruzi was mapped using advanced electron microscopy techniques. The existence of nanodomains with specific element distribution patterns was discovered. These findings have significant implications for understanding nanophysiology of organelles.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Agriculture, Dairy & Animal Science
Derek J. Matthews, Ryan C. Fries, Nicholas D. Jeffery, Sarah A. Hamer, Ashley B. Saunders
Summary: Trypanosoma cruzi infection causes cardiac damage in dogs, and cardiac magnetic resonance imaging (CMR) can detect the damage. This study aimed to describe CMR in naturally infected dogs with chronic Chagas disease and evaluate the frequency of abnormalities in CMR and other diagnostic tests. The results suggest that CMR can provide useful information and support the use of naturally infected dogs as an animal model for Chagas disease.
Review
Biology
Oscar Hernan Rodriguez-Bejarano, Catalina Avendano, Manuel Alfonso Patarroyo
Summary: Chagas disease, caused by Trypanosoma cruzi parasite, is mainly transmitted by insect bites. The parasite's lifecycle includes an intracellular phase and infective forms, involving various signaling cascades and intracellular associations for recognition and internalization in host cells.
Article
Immunology
Nadjania Saraiva de Lira Silva, Cristina Mary Orikaza, Fabiana Rodrigues de Santana, Luana Aguiar dos Santos, Bruno Ramos Salu, Maria Luiza Vilela Oliva, Rita de Cassia Sinigaglia, Renato Arruda Mortara
Summary: IL-9 plays a role in controlling T. cruzi infection by reducing invasion and multiplication in vitro, and acts as a protective factor during the chronic phase of experimental infection in BALB/c mice, controlling cardiac fibrosis and proinflammatory cytokine production.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Microbiology
Sergio Castaneda, Marina Munoz, Peter J. Hotez, Maria Elena Bottazzi, Alberto E. Paniz-Mondolfi, Kathryn M. Jones, Rojelio Mejia, Cristina Poveda, Juan David Ramirez
Summary: Chagas disease is caused by Trypanosoma cruzi and has a profound impact on the gastrointestinal tract. Alterations in the gut microbiome caused by the parasite may play a crucial role in host-parasite interactions and immune responses. Understanding this interaction could provide valuable insights into the pathophysiology of the disease and the development of new treatments.
MICROBIOLOGY SPECTRUM
(2023)
Review
Biochemistry & Molecular Biology
Alfonso Cordero-Barreal, Maria Gonzalez-Rodriguez, Clara Ruiz-Fernandez, Djedjiga Ait Eldjoudi, Yousof Ramadan Farrag AbdElHafez, Francisca Lago, Javier Conde, Rodolfo Gomez, Miguel Angel Gonzalez-Gay, Ali Mobasheri, Jesus Pino, Oreste Gualillo
Summary: Leptin, a adipokine, has significant impact on cartilage metabolism and pathology by inducing the expression of pro-inflammatory molecules and cartilage degenerative enzymes through its signaling pathway involving the long isoform of the leptin receptor (LEPRb). It has been shown that inhibition of leptin signaling can have protective effects in degenerative cartilage diseases such as osteoarthritis, rheumatoid arthritis, and systemic lupus erythematosus. Leptin also plays a key role in increasing the proliferation and activation of immune cells, exacerbating the severity of immune degenerative cartilage diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Plant Sciences
Barbara Verena Dias Galvao, Carlos Fernando Araujo-Lima, Monica Cristine Pereira dos Santos, Mariana Pulmar Seljan, Eduardo Kennedy Carrao-Dantas, Claudia Alessandra Fortes Aiub, Luiz Claudio Cameron, Mariana Simoes Larraz Ferreira, Edira Castello Branco de Andrade Goncalves, Israel Felzenszwalb
Summary: The study identified 14 phenolic compounds in Plinia cauliflora leaf extract, showing certain anti-Trypanosoma cruzi activity but also cytotoxic effects on liver cell lines.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Immunology
Eduardo Roggero, Ana Rosa Perez, Natalia Pollachini, Silvina Raquel Villar, Johannes Wildmann, Hugo Besedovsky, Adriana del Rey
BRAIN BEHAVIOR AND IMMUNITY
(2016)
Article
Infectious Diseases
Florencia Belen Gonzalez, Flavia Calmon-Hamaty, Synara No Seara Cordeiro, Rodrigo Fernandez Bussy, Silvana Virginia Spinelli, Luciano D'Attilio, Oscar Bottasso, Wilson Savino, Vinicius Cotta-de-Almeida, Silvina Raquel Villar, Ana Rosa Perez
PLOS NEGLECTED TROPICAL DISEASES
(2016)
Article
Microbiology
Ana F. F. R. Nardy, Celio G. Freire-de-Lima, Ana R. Perez, Alexandre Morrot
FRONTIERS IN MICROBIOLOGY
(2016)
Review
Endocrinology & Metabolism
Ana Rosa Perez, Alexandre Morrot, Vinicius Frias Carvalho, Juliana de Meis, Wilson Savino
FRONTIERS IN ENDOCRINOLOGY
(2018)
Article
Endocrinology & Metabolism
Florencia Gonzalez, Silvina Villar, Luciano D'Attilio, Rodolfo Leiva, Julia Marquez, Susana Lioi, Juan Beloscar, Oscar Bottasso, Ana Rosa Perez
NEUROIMMUNOMODULATION
(2018)
Article
Microbiology
Ingrid Quintana, Martin Espariz, Silvina R. Villar, Florencia B. Gonzalez, Maria F. Pacini, Gabriel Cabrera, Ivan Bontempi, Estefania Prochetto, Joerg Stuelke, Anaa R. Perez, Ivan Marcipar, Victor Blancato, Christian Magni
FRONTIERS IN MICROBIOLOGY
(2018)
Article
Immunology
Florencia B. Gonzalez, Silvina R. Villar, Judith Toneatto, Maria F. Pacini, Julia Marquez, Luciano DAttilio, Oscar A. Bottasso, Graciela Piwien-Pilipuk, Ana R. Perez
MEDICAL MICROBIOLOGY AND IMMUNOLOGY
(2019)
Review
Pharmacology & Pharmacy
Adriana Ribeiro Silva, Cassiano Felippe Goncalves-de-Albuquerque, Ana Rosa Perez, Vinicius de Frias Carvalho
EUROPEAN JOURNAL OF PHARMACOLOGY
(2019)
Article
Immunology
Ana R. Perez, Flavia Lambertucci, Florencia B. Gonzalez, Eduardo A. Roggero, Oscar A. Bottasso, Juliana de Meis, Maria T. Ronco, Silvina R. Villar
BRAIN BEHAVIOR AND IMMUNITY
(2017)
Review
Microbiology
Alexandre Morrot, Silvina R. Villar, Florencia B. Gonzalez, Ana R. Perez
FRONTIERS IN MICROBIOLOGY
(2016)