Article
Infectious Diseases
Ioana Miriana Cismaru, Maria Adelina Radu, Ani Ioana Cotar, Florin Oancea, Violeta Melinte, Cristina Vacaroiu, Isabela Ghemulet, Valeriu Gheorghita
Summary: Global travel has been increasing every year, leading to an increase in travel-imported cases of tropical diseases such as dengue. The clinical presentation of dengue is often atypical and misdiagnosis is common even among experienced doctors. This article presents two cases of dengue diagnosed in Romania, highlighting the challenges clinicians face in recognizing travel-related imported dengue virus disease.
TROPICAL MEDICINE AND INFECTIOUS DISEASE
(2023)
Review
Ophthalmology
Amy Xie Cen, Aaron Wei Wen Ng, William Rojas-Carabali, Carlos Cifuentes-Gonzalez, Alejandra de-la-Torre, Padmamalini Mahendradas, Rupesh Agrawal
Summary: Dengue fever is a major global public health concern, with increasing incidence over the past two decades. Symptoms range from mild to severe, including fever, headache, rash, and joint pain. Ocular complications, such as hemorrhage and inflammation, are common among hospitalized patients and can be diagnosed and treated using modern tools like OCT and FFA.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2023)
Article
Multidisciplinary Sciences
Jeth WeiQuan Chng, Tamilsalvan Parvathi, Junxiong Pang
Summary: This study compared the knowledge, attitudes, and practices scores between dengue sustained hotspots (SHS) and non-sustained hotspots (NSHS), and identified factors associated with dengue prevention among SHS residents in Singapore. The findings showed that there were no significant differences in the mean scores for knowledge, attitudes, and practices between SHS and NSHS. However, certain factors such as age, ethnicity, education level, housing type, and healthcare-seeking behavior were associated with SHS and may influence the risk of dengue transmission in residential areas.
SCIENTIFIC REPORTS
(2022)
Article
Emergency Medicine
Ana-Isabel Lopez-Amoros, Diego Torrus-Tendero, Esperanza Merino de Lucas, Sergio Reus Banuls, Vicente Boix Martinez, Pere Llorens Soriano, Isabel Escribano Canadas, Jose-Manuel Ramos-Rincon
Summary: This study aimed to identify predictors of malaria and arboviral disease in patients with febrile syndrome who seek care after traveling from tropical or subtropical locations. The results showed that patients from sub-Saharan Africa, immigrants who returned to visit friends and relatives, or those with platelet concentrations <150 000/mm(3) and headache were most likely to have malaria. Patients from Central or South America with exanthems or joint pain were more likely to have arboviral disease.
Review
Microbiology
Awadalkareem Adam, Christian Jassoy
Summary: Arbovirus infections are prevalent in Africa due to the lack of established epidemiological surveillance systems and accurate differential diagnosis. Studies indicate these infections are endemic in most African countries, highlighting the need for improved monitoring to enhance diagnostic accuracy. Healthcare providers should be informed about prevalent arboviral diseases to better identify and manage possible cases.
Article
Chemistry, Analytical
Pei-Shan Tsai, Pin-Xian Du, Batuhan Birol Keskin, Nan-Yao Lee, Shu-Wen Wan, Ya-Lan Lin, Wen-Yu Su, Pei-Chun Lin, Wei-Hsun Lin, Hsi-Chang Shih, Tzong-Shiann Ho, Guan-Da Syu
Summary: This study aims to analyze the humoral immunity and cross-reactivity in dengue patients using a multiplexed protein microarray. The results show that patients with severe dengue have higher levels of IgG antibodies against multiple Flavivirus antigens. Logistic regression analysis identifies groups of markers that can effectively distinguish dengue patients from healthy controls and hospitalized patients from mild cases.
ANALYTICAL CHEMISTRY
(2023)
Article
Multidisciplinary Sciences
Aloisio S. Nascimento Filho, Thiago B. Murari, Paulo Ferreira, Hugo Saba, Marcelo A. Moret
Summary: The study investigated the spread of dengue in the Brazilian dry climate region of Bahia from 2000 to 2009 through a multiscale statistical analysis. Results showed significant and persistent cross-correlation between most economic regions, suggesting that economic regions or climatic conditions are not statistically significant in the spread of dengue in Bahia. The study's main contribution lies in revealing multiple aspects related to the propagation of dengue in dry climate regions through cross-correlation analysis.
SCIENTIFIC REPORTS
(2021)
Article
Infectious Diseases
Jaime E. Castellanos, Nayeli Jaimes, Carolina Coronel-Ruiza, Juan Pablo Rojas, Luis F. Mejia, Victor H. Villarreal, Luz E. Maya, Luz M. Claros, Cielo Orjuela, Eliana Calvo, Maria Victoria Munoz, Myriam L. Velandia-Romero
Summary: A study conducted in a pediatric clinic in Cali, Colombia, identified CHIKV as the arbovirus causing febrile cases in children, potentially leading to double infections. The results emphasize the importance of clinical tests to determine the arbovirus involved in infectious diseases for better treatment and surveillance.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Medicine, Research & Experimental
Ruixue Hou, Lewis E. Tomalin, Jessica Pintado Silva, Seunghee Kim-Schulze, Stephen S. Whitehead, Ana Fernandez-Sesma, Anna P. Durbin, Mayte Suarez-Farinas
Summary: Understanding the immune response to dengue virus is crucial for dengue vaccine development. This study showed that the tetravalent vaccine has better protective effects against DENV compared to the trivalent admixture. Additionally, differences in immune responses between Black and White participants were observed.
Article
Pharmacology & Pharmacy
Yihong Wan, Wenyu Wu, Jiawen Zhang, Liren Li, Yuanda Wan, Xiaodong Tang, Xiaoguang Chen, Shuwen Liu, Xingang Yao
Summary: The new drug tenovin-1 shows promising potential in treating dengue virus infection by significantly inhibiting viral replication and inflammatory response. By targeting SIRT2, tenovin-1 exerts its antiviral effects with specificity.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Review
Public, Environmental & Occupational Health
Muhammad Bilal Khan, Zih-Syuan Yang, Chih-Yen Lin, Ming-Cheng Hsu, Aspiro Nayim Urbina, Wanchai Assavalapsakul, Wen-Hung Wang, Yen-Hsu Chen, Sheng-Fan Wang
Summary: Dengue is a disease caused by dengue virus infection, and its clinical manifestations vary. Currently, there is a lack of effective antiviral drugs and vaccines, so it is necessary to study the virus characteristics, epidemiology, and develop treatment and control strategies.
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2023)
Article
Immunology
Andrew G. Letizia, Catherine B. Pratt, Michael R. Wiley, Anne T. Fox, Mba Mosore, Bright Agbodzi, Clara Yeboah, Selassie Kumordjie, Nicholas Di Paola, Kone Cisse Assana, David Coulidiaty, Casimir Ouedraogo, Joseph H. Kofi Bonney, William Ampofo, Zekiba Tarnagda, Lassana Sangare
Summary: Through next-generation sequencing of samples from the 2017 DENV outbreak in Burkina Faso, 29 DENV genomes were isolated, showing the endemic nature of DENV-2 in the region. Discordant diagnostic results were observed, likely due to genetic divergence between these genomes.
EMERGING INFECTIOUS DISEASES
(2022)
Article
Multidisciplinary Sciences
Chathurani Sigera, Chaturaka Rodrigo, Nipun L. de Silva, Praveen Weeratunga, Deepika Fernando, Senaka Rajapakse
Summary: This study aimed to characterize the direct costs of managing hospitalized patients with suspected dengue infection in Sri Lanka. The findings suggest that confirming dengue diagnosis using subsidized tests for patients presenting in the first three days of fever may be cost-efficient, as non-dengue patients incur a similar cost per day as dengue patients.
Review
Biochemistry & Molecular Biology
Delia Yubero, Daniel Natera-de Benito, Jordi Pijuan, Judith Armstrong, Loreto Martorell, Guerau Fernandez, Joan Maynou, Cristina Jou, Monica Roldan, Carlos Ortez, Andres Nascimento, Janet Hoenicka, Francesc Palau
Summary: The diagnosis of neuromuscular diseases has evolved from clinical symptoms to molecular definitions, utilizing various clinical, biochemical, electrophysiological, and histopathological characteristics. Genetic approaches include gene-targeted and genomic analyses, but some patients still have unidentified genetic variants. Integrating omics and experimental biology methods can help improve molecular diagnosis and provide a more accurate approach to addressing health issues for patients and their families.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Infectious Diseases
Olivier Maillard, Jeanne Belot, Thibault Adenis, Olivier Rollot, Antoine Adenis, Bertrand Guihard, Patrick Gerardin, Antoine Bertolotti
Summary: This study aimed to evaluate the performance of the SD Bioline Dengue Duo rapid diagnostic test in adults consulting at an emergency department during the 2019 epidemic. The results showed that the test had a sensitivity of 42% and a specificity of 15%, indicating that it did not achieve sufficient performance levels for early dengue diagnosis in this setting.
PLOS NEGLECTED TROPICAL DISEASES
(2023)