Journal
MEDICAL MICROBIOLOGY AND IMMUNOLOGY
Volume 199, Issue 3, Pages 173-183Publisher
SPRINGER
DOI: 10.1007/s00430-010-0149-y
Keywords
Neisseria meningitidis; BioWlms; DNA; Extracellular matrix; Anti-bacterial agents; Autolysis; Pili
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Funding
- Boehringer Ingelheim Fonds
- Deutsche Forschungsgemeinschaft [Sonderforschungsbereich 479]
- graduate college Immunomodulation at the University of Wurzburg
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The past decade has seen an increasing interest in biofilm formation by Neisseria meningitidis, a human facultative pathogen causing life-threatening childhood disease commencing from asymptomatic nasopharyngeal colonization. Studying the biology of in vitro biofilm formation improves the understanding of inter-bacterial processes in asymptomatic carriage, of bacterial aggregate formation on host cells, and of meningococcal population biology. This paper reviews publications referring to meningococcal biofilm formation with an emphasis on the role of motility and of extracellular DNA. The theory of sub-dividing the meningococcal population in settler and spreader lineages is discussed, which provides a mechanistic framework for the assumed balance of colonization efficacy and transmission frequency.
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