Article
Neurosciences
Kevin S. O'Connell, Oleksandr Frei, Shahram Bahrami, Olav B. Smeland, Francesco Bettella, Weiqiu Cheng, Yunhan Chu, Guy Hindley, Aihua Lin, Alexey Shadrin, Elizabeth Ann Barrett, Trine Vik Lagerberg, Nils Eiel Steen, Anders M. Dale, Srdjan Djurovic, Ole A. Andreassen
Summary: The study reveals extensive genetic overlap between psychiatric disorders and sleep-related phenotypes, with moderate levels of congruence. Specific shared loci have been identified and mapped to 70 credible genes. These findings offer new opportunities for future research.
BIOLOGICAL PSYCHIATRY
(2021)
Article
Health Care Sciences & Services
Ioanna Grigoriou, Paschalia Skalisti, Ioanna Papagiouvanni, Anastasia Michailidou, Konstantinos Charalampidis, Serafeim-Chrysovalantis Kotoulas, Konstantinos Porpodis, Dionysios Spyratos, Athanasia Pataka
Summary: The relationship between smoking and sleep disorders, especially non-obstructive sleep apnea-related disorders, needs further investigation. This study compared sleep-related characteristics between smokers and non-smokers and found that smokers had higher body mass index, neck and waist circumference, and a higher frequency of metabolic and cardiovascular co-morbidities. They also had a higher apnea-hypopnea index and were more likely to be diagnosed with severe and moderate sleep apnea. Smokers also experienced more frequent episodes of sleep talking, abnormal movements, restless sleep, and leg movements during sleep.
Article
Immunology
Sinead King, Laurena Holleran, David Mothersill, Saahithh Patlola, Karolina Rokita, Ross McManus, Marcus Kenyon, Colm McDonald, Brian Hallahan, Aiden Corvin, Derek Morris, John Kelly, Declan McKernan, Gary Donohoe
Summary: The study found that IL-6 may mediate the association between childhood trauma and social cognition by altering default mode network connectivity. Higher IL-6 levels were correlated with higher childhood trauma scores and lower cognitive and social cognitive function.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Clinical Neurology
Daniel J. Oakes, Holly A. Pearce, Cerian Roberts, Phillip G. Gehrman, Catrin Lewis, Ian Jones, Katie J. S. Lewis
Summary: This study investigated the association between comorbid anxiety disorder and sleep disturbance in individuals with bipolar disorder. The results showed that comorbid anxiety was associated with subjective sleep disturbance, but not with objective sleep metrics.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Clinical Neurology
Nelson B. Rodrigues, Roger S. McIntyre, Orly Lipsitz, Yena Lee, Danielle S. Cha, Margarita Shekotikhina, Maj Vinberg, Hartej Gill, Mehala Subramaniapillai, Kevin Kratiuk, Kangguang Lin, Roger Ho, Rodrigo B. Mansur, Joshua D. Rosenblat
Summary: This study developed a brief version of the CADSS, CADSS-6, with 6 items sensitive to dissociation symptoms in patients receiving IV ketamine. The CADSS-6 demonstrated a strong correlation with the full-length CADSS at each infusion. Validation of the CADSS-6 in a TRD sample is recommended for future studies.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Clinical Neurology
Yuki Kageyama, Yasuhiko Deguchi, Takaoki Kasahara, Munehide Tani, Kenji Kuroda, Koki Inoue, Tadafumi Kato
Summary: Patients with bipolar disorder have elevated plasma IL-6 levels, higher in depressed patients than in remitted patients. However, the study did not find a significant difference in plasma circulating cell-free mitochondrial DNA levels between depressed and remitted BD patients.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Behavioral Sciences
Frederike T. Fellendorf, Eva Z. Reininghaus, Michaela Ratzenhofer, Melanie Lenger, Alexander Maget, Martina Platzer, Susanne A. Bengesser, Armin Birner, Robert Queissner, Carlo Hamm, Rene Pilz, Nina Dalkner
Summary: This study found that during the COVID-19 pandemic, individuals with bipolar disorder experienced poorer sleep quality compared to controls. Higher frequency of pandemic-related information seeking and greater COVID-19 fears were associated with worse sleep quality in bipolar disorder patients.
BRAIN AND BEHAVIOR
(2021)
Article
Clinical Neurology
Margo W. Menkes, Carolyn M. Andrews, Helen J. Burgess, Isabel Carley, David F. Marshall, Scott A. Langenecker, Melvin G. McInnis, Patricia J. Deldin, Kelly A. Ryan
Summary: Individuals with bipolar I disorder (BD-I) have poorer sleep quality and neuropsychological functioning compared to healthy controls, and poor sleep quality is associated with learning, memory, and executive functioning impairments, with similar effects across groups.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Pharmacology & Pharmacy
Qiuhua Cao, Yanting Lin, Chongxiu Yue, Yue Wang, Fei Quan, Xinmeng Cui, Ran Bi, Xinying Tang, Yong Yang, Chen Wang, Xianjing Li, Xinghua Gao
Summary: Deficiency of IL-6 can promote the development of ulcerative colitis and cause adverse immune reactions, mainly by regulating chemokines, cell migration, and inflammatory responses to affect disease progression.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Immunology
Laure Ricard, Deborah Eshagh, Lama Siblany, Frederic de Vassoigne, Florent Malard, Charlotte Laurent, Pauline Beurier, Vincent Jachiet, Sebastien Riviere, Olivier Fain, Mohamad Mohty, Beatrice Gaugler, Arsene Mekinian
Summary: The study evaluated the application of PCR testing method in the early diagnosis of COVID-19 and found that it has high sensitivity and specificity.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Anais Mariscal, Carlos Zamora, Cesar Diaz-Torne, Ma Angels Ortiz, Juan Jose de Agustin, Delia Reina, Paula Estrada, Patricia Moya, Hector Corominas, Silvia Vidal
Summary: The binding of platelets to monocytes is increased in rheumatoid arthritis, and this interaction is modulated by IL-6 blockage. After treatment, the percentage of CD14+PLT+ increases in patients who achieve remission.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Rhiannon McNeill, Christopher Kehrwald, Murielle Brum, Katrin Knopf, Nathalie Brunkhorst-Kanaan, Semra Etyemez, Carolin Koreny, Robert A. Bittner, Florian Freudenberg, Sabine Herterich, Andreas Reif, Sarah Kittel-Schneider
Summary: Nitric oxide (NO) signaling has been studied in relation to mental illnesses, but its specific contribution remains unclear. This study investigated the association between peripheral NO concentration, specific diagnoses, and genetic variation in NO synthase (NOS) genes. The results showed that patients with schizophrenia had significantly higher peripheral NO metabolite concentrations compared to other groups. Additionally, carriers of the NOS1 VNTR1 short allele had increased NO concentrations, which remained significant even at discharge. The data also suggested that patients with unresolved depressive symptoms had higher NO concentrations, with a positive correlation between symptom severity and NO concentration.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Clinical Neurology
Tsung-Han Tsai, Tsung-Hua Lu, Huai-Hsuan Tseng, Wei Hung Chang, Tzu-Yun Wang, Yen Kuang Yang, Hui Hua Chang, Po See Chen
Summary: The present study examined the association between peripheral insulin resistance (IR) and emotion-related social-cognitive abilities in bipolar disorder (BD) patients. The results showed that BD patients with IR experience additional impairments in specific domains of social cognition.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Immunology
James A. A. DeVoti, Mohd Israr, Fung Lam, Christopher Papayannakos, Douglas K. K. Frank, Dev P. P. Kamdar, Lucio M. M. Pereira, Allan Abramson, Bettie M. M. Steinberg, Vincent R. R. Bonagura
Summary: This study found that elevated plasma levels of PGE(2) are expressed in half of patients with OPC secondary to overexpression of COX-2 by peripheral blood monocytes, and this expression is driven by IL-1 alpha secreted by the tumors. Monocytes from patients are much more sensitive to the stimulation than monocytes from controls, suggesting the possibility of enhanced immune-modulating feed-back loops. Furthermore, control monocytes pre-exposed to PGE(2) overexpress COX-2 in response to IL-1 alpha, simulating responses made by monocytes from some OPC patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Psychiatry
Igor Soares Vieira, Nathalia Tessele Barreto, Fernanda Pedrotti Moreira, Thaise Campos Mondin, Mario Simjanoski, Taiane de Azevedo Cardoso, Flavio Kapczinski, Karen Jansen, Luciano Dias de Mattos Souza, Ricardo Azevedo da Silva
Summary: The study revealed differences in sleep efficiency and disturbances between euthymic BD and MDD, highlighting the importance of regular sleep assessments for individuals recently diagnosed with BD. These differences can provide valuable insights for prognosis, treatment, and the presence of subsyndromal symptoms in the absence of a mood episode.
PSYCHIATRY RESEARCH
(2021)
Review
Pharmacology & Pharmacy
Philipp Ritter, Hannelore Findeis, Michael Bauer
PHARMACOPSYCHIATRY
(2020)
Review
Health Care Sciences & Services
Pablo Nicaise, Domenico Giacco, Bettina Soltmann, Andrea Pfennig, Elisabetta Miglietta, Antonio Lasalvia, Marta Welbel, Jacek Wciorka, Victoria Jane Bird, Stefan Priebe, Vincent Lorant
Article
Clinical Neurology
Karolina Leopold, Michael Bauer, Andreas Bechdolf, Christoph U. Correll, Martin Holtmann, Georg Juckel, Martin Lambert, Thomas D. Meyer, Steffi Pfeiffer, Sarah Kittel-Schneider, Andreas Reif, Thomas J. Stamm, Maren Rottmann-Wolf, Josephine Mathiebe, Eva L. Kellmann, Philipp Ritter, Seza Kruger-Ozgurdal, Anne Karow, Lene-Marie Sondergeld, Veit Roessner, Cathrin Sauer, Andrea Pfennig
Article
Neurosciences
Philipp Ritter, Falk Wieland, Debra J. Skene, Andrea Pfennig, Maria Weiss, Michael Bauer, Emanuel Severus, Henry Gueldner, Cathrin Sauer, Bettina Soltmann, Stefanie Neumann
JOURNAL OF PSYCHIATRY & NEUROSCIENCE
(2020)
Article
Clinical Neurology
A. Pfennig, B. Soltmann, P. Ritter, T. Bschor, M. Hautzinger, T. D. Meyer, F. Padberg, P. Brieger, M. Schaefer, C. U. Correll, M. Bauer
Review
Clinical Neurology
Greg Murray, John Gottlieb, Maria Paz Hidalgo, Bruno Etain, Philipp Ritter, Debra J. Skene, Corrado Garbazza, Ben Bullock, Kathleen Merikangas, Vadim Zipunnikov, Haochang Shou, Robert Gonzalez, Jan Scott, Pierre A. Geoffroy, Benicio N. Frey
Article
Clinical Neurology
Mirko Manchia, Eduard Vieta, Olav B. Smeland, Cara Altimus, Andreas Bechdolf, Frank Bellivier, Veerle Bergink, Andrea Fagiolini, John R. Geddes, Tomas Hajek, Chantal Henry, Ralph Kupka, Trine Lagerberg, Rasmus W. Licht, Monica Martinez-Cengotitabengoa, Gunnar Morken, Rene E. Nielsen, Ana Gonzalez Pinto, Andreas Reif, Marcella Rietschel, Phillip Ritter, Thomas G. Schulze, Jan Scott, Emanuel Severus, Aysegul Yildiz, Lars Vedel Kessing, Michael Bauer, Guy M. Goodwin, Ole A. Andreassen
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2020)
Article
Clinical Neurology
Edgar Arrua Vares, Sarah Lehmann, Cathrin Sauer, Carmine Pariante, Falk Wieland, Bettina Soltmann, Michael Bauer, Philipp Ritter
JOURNAL OF AFFECTIVE DISORDERS
(2020)
Article
Neurosciences
Hannelore Findeis, Cathrin Sauer, Anthony Cleare, Michael Bauer, Philipp Ritter
PSYCHOPHARMACOLOGY
(2020)
Article
Psychiatry
Kurt Buhagiar, Stefan Priebe, Justyna Klingemann, Antonio Lasalvia, Pablo Nicaise, Bettina Soltmann, Domenico Giacco
Summary: Objective and subjective social relationship indicators were weakly correlated concepts among patients with severe mental illness. While patients with psychotic disorders initially reported less social contact with friends, this difference disappeared when confounders were taken into account, suggesting that interventions targeting social relationships do not necessitate diagnosis-specific adaptations.
SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY
(2021)
Article
Clinical Neurology
Vera M. Ludwig, Cathrin Sauer, Allan H. Young, James Rucker, Michael Bauer, Hannelore Findeis, Philipp Ritter
Summary: The study evaluated changes in blood pressure and heart rate during esketamine administration in patients with and without concomitant tranylcypromine treatment. Results showed that while there were statistically significant increases in blood pressure for patients receiving tranylcypromine, these changes were clinically insignificant. The study suggests that combining esketamine and tranylcypromine at standard doses is safe, but caution should be taken with higher doses of tranylcypromine.
Article
Psychiatry
Bettina Soltmann, Anne Neumann, Stefanie March, Ines Weinhold, Dennis Haeckl, Roman Kliemt, Fabian Baum, Marcel Romanos, Julian Schwarz, Sebastian von Peter, Yuriy Ignatyev, Katrin Arnold, Enno Swart, Martin Heinze, Jochen Schmitt, Andrea Pfennig
Summary: Germany has initiated new cross-sectoral mental health care models, including FIT64b projects, to improve the quality of hospital-based mental health care. The PsychCare study combines quantitative and qualitative data to evaluate and develop quality indicators for modern, flexible, and integrated care.
FRONTIERS IN PSYCHIATRY
(2021)
Article
Clinical Neurology
H. Findeis, V Ludwig, P. Mikolas, J. Graff, M. Bauer, Philipp Ritter
Summary: Ketamine appears to be a safe and effective option for the treatment of unipolar and bipolar depression, with a dose of 0.5 mg/kg of S-ketamine three times per week showing effectiveness. Treatment appears to be safe regarding urotoxic side effects, combination treatment with tranylcypromine, and comorbid posttraumatic stress disorder.
Article
Neurosciences
Fabian Huth, Leonardo Tozzi, Michael Marxen, Philipp Riedel, Kyra Broeckel, Julia Martini, Christina Berndt, Cathrin Sauer, Christoph Vogelbacher, Andreas Jansen, Tilo Kircher, Irina Falkenberg, Florian Thomas-Odenthal, Martin Lambert, Vivien Kraft, Gregor Leicht, Christoph Mulert, Andreas J. Fallgatter, Thomas Ethofer, Anne Rau, Karolina Leopold, Andreas Bechdolf, Andreas Reif, Silke Matura, Silvia Biere, Felix Bermpohl, Jana Fiebig, Thomas Stamm, Christoph U. Correll, Georg Juckel, Vera Flasbeck, Philipp Ritter, Michael Bauer, Andrea Pfennig, Pavol Mikolas
Summary: The pathophysiology of bipolar disorder (BD) is unclear, but a valid biomarker is needed for early detection. This study used structural MRI to compare volumes of hippocampus, amygdala, and their subfields/nuclei in individuals at risk for BD. Although there were no volume differences between risk groups, machine learning could still predict the risk for BD based on certain criteria. This suggests that neural changes may have prognostic value in BD.
Article
Neurosciences
Philipp Ritter, Bettina Soltmann, Cathrin Sauer, Abdulbaki Yakac, Lynn Boekstaegers, Mirjam Reichard, Konstanze Koenitz, Michael Bauer, Henry Gueldner, Stefanie Neumann, Falk Wieland, Debra J. Skene
Summary: This study found that patients with bipolar I disorder are more prone to experiencing phase delays following exposure to blue light in the evening compared to healthy control subjects. The enhanced phase delay in bipolar disorder patients may contribute to their observed phase instability and vulnerability to forced phase shifts.
BIOLOGICAL PSYCHIATRY: GLOBAL OPEN SCIENCE
(2022)
Article
Medicine, Research & Experimental
Tong Cheng, Zhusheng Chen, Yibin Qin, Xiang Zhu, Hongsheng Chen, Zhongling Xu, Xiaqing Ma
Summary: Morphine is commonly used and effective for pain relief, but its side effect of itching limits its clinical use. This paper discusses the potential of using esketamine to treat morphine-induced itching.
MEDICAL HYPOTHESES
(2024)
Article
Medicine, Research & Experimental
Sung Eun Lee, Eunjung Park, Ji-yun Kim, HyukHoon Kim
Summary: Hyperbaric oxygen therapy (HBOT) is a potential therapeutic modality that has been recognized for its favorable mechanisms in various diseases, including sepsis-associated encephalopathy (SAE). HBOT has neuroprotective effects through its anti-inflammatory and antiapoptotic effects as well as increased tissue oxygenation capacity. However, there are caveats and limitations in applying HBOT in sepsis.
MEDICAL HYPOTHESES
(2024)
