Article
Oncology
Emily Smart, Svetlana E. Semina, Luis H. Alejo, Nidhi S. Kansara, Jonna Frasor
Summary: This study identifies two specific gene signatures in estrogen receptor (ER)-positive breast cancer that are associated with invasion and poor patient outcome. The findings reveal the complex role of ER in promoting invasion and metastasis and provide insights into potential targeted therapies.
Article
Biochemistry & Molecular Biology
Ngoc Bao To, Nguyen-Phuong Truong, Meran Keshawa Ediriweera, Somi Kim Cho
Summary: The combination therapy of pentadecanoic acid and tamoxifen can synergistically suppress the growth of tamoxifen-resistant breast cancer cells with low expression of estrogen receptor alpha (ER-alpha). This treatment not only induces apoptosis and inhibits epithelial-to-mesenchymal transition, but also reverses tamoxifen resistance by re-expressing ER-alpha and suppressing critical survival signal pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Genetics & Heredity
Ajay Kumar, Arun Dhillon, Mohan Chowdenahalli Manjegowda, Neha Singh, Dixcy Jaba Sheeba John Mary, Sachin Kumar, Deepak Modi, Anil Mukund Limaye
Summary: This study reveals that estrogen suppresses HOXB2 expression, with ERα playing a role in this suppression. Future investigations should explore the implications of estrogen-mediated suppression on the proposed tumor suppressor function of HOXB2.
Article
Cell Biology
Yu-Chen S. H. Yang, Zi-Lin Li, Tung-Yung Huang, Kuan-Wei Su, Chi-Yu Lin, Chi-Hung Huang, Han-Yu Chen, Mei-Chin Lu, Haw-Ming Huang, Sheng-Yang Lee, Jaqueline Whang-Peng, Hung-Yun Lin, Paul J. Davis, Kuan Wang
Summary: Heteronemin can suppress proliferation of both ER-positive and ER-negative breast cancer cells by inhibiting the activation of ERK1/2 and STAT3. It can also counteract E-2-induced proliferation in breast cancer cells and affect mitochondrial reactive oxygen species, leading to G(0)/G(1) phase arrest.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Igor L. Bado, Weijie Zhang, Jingyuan Hu, Zhan Xu, Hai Wang, Poonam Sarkar, Lucian Li, Ying-Wooi Wan, Jun Liu, William Wu, Hin Ching Lo, Ik Sun Kim, Swarnima Singh, Mahnaz Janghorban, Aaron M. Muscarella, Amit Goldstein, Purba Singh, Hyun-Hwan Jeong, Chaozhong Liu, Rachel Schiff, Shixia Huang, Matthew J. Ellis, M. Waleed Gaber, Zbigniew Gugala, Zhandong Liu, Xiang H-F Zhang
Summary: Estrogen receptor-positive (ER+) breast cancer shows strong bone tropism in metastasis, with the bone microenvironment impacting ER signaling and endocrine therapy. The osteogenic niche transiently reduces ER expression and activities specifically in bone micrometastases, leading to endocrine resistance. EZH2-mediated epigenomic reprogramming drives ER+ BMMs towards a basal and stem-like state, and EZH2 inhibition reverses endocrine resistance.
DEVELOPMENTAL CELL
(2021)
Article
Biochemistry & Molecular Biology
Shaimaa Hamza, Ekaterina E. E. Garanina, Mohammad Alsaadi, Svetlana F. F. Khaiboullina, Gulcin Tezcan
Summary: NLRP3 may contribute to the growth and propagation of breast cancer, and the effects of ER-alpha, PR, and HER2 on NLRP3 activation in breast cancer are still unknown.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Yunfeng Ding, Yonghong Liu, Dong-Kee Lee, Zhangwei Tong, Xiaobin Yu, Yi Li, Yong Xu, Rainer B. Lanz, Bert W. O'Malley, Jianming Xu
Summary: This study reveals that ERα*RFP*Erbb2* cells progressively lose ERα during tumorigenesis to become highly metastatic, and these ERα*origin breast cancers are more aggressive.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Oncology
Seungyeon Ryu, So-Hyun Yoon, Junhyuk Song, Yoonjung Choi, Sangeun Lee, Moonjou Baek, Han-Byoel Lee, Sook Young Jeon, Sangyong Jon, Daeyoup Lee, Hoe Suk Kim, Wonshik Han
Summary: The study investigated the effects of different media components and culture methods on BCSC-associated immunophenotypes and gene expression in ER+ PDBCCs. Results showed significant changes in phenotype and gene expression in different culture conditions, highlighting the importance of defining culture conditions for in vitro studies of PDBCCs.
Article
Medicine, General & Internal
Ioannis A. Voutsadakis
Summary: This study investigates ER-positive/HER2-negative or luminal breast cancers with high mutation numbers and compares them with cancers of the same subtype and low mutation numbers. The results show that breast cancers with high mutation numbers have a higher prevalence of certain genetic mutations and DNA damage response genes. However, the prognosis of these breast cancers is not significantly different compared to those with lower mutation counts. These findings provide information on the suitability of these cancers for immunotherapy and potential combination therapies.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Jiaqi Yao, Yiran Tao, Zelin Hu, Junjie Li, Ziyi Xue, Ya Zhang, Yi Lei
Summary: This paper provides a comprehensive review of ER's structural functions and highlights the recent advancements in novel drugs targeting ER, namely SERD and SERCA, focusing on their structural optimization strategies and future directions. It also discusses the therapeutic potential and challenges of these drugs in breast cancer and other ER-related diseases.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Lea Clusan, Francois Ferriere, Gilles Flouriot, Farzad Pakdel
Summary: Breast cancer, the most common and deadliest cancer among women worldwide, is closely associated with estrogen signaling. Hormone therapy using antiestrogens is the standard treatment, but resistance inevitably occurs through various biological mechanisms. Understanding the estrogen pathway is crucial for the development of new therapies for hormone-dependent breast cancer. This mini-review summarizes the current literature on estrogen receptors in breast cancer, including their signalization, mechanisms of action, and clinical implications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Dahae Lee, Young-Mi Kim, Young-Won Chin, Ki Sung Kang
Summary: This study demonstrated that schisandrol A has estrogen-like effects by inducing the expression of ER alpha through the PI3K/AKT and ERK signaling pathways, promoting the proliferation of MCF-7 cells. The effects of schisandrol A were more significant compared to E2 and could be mitigated by the ER antagonist ICI.
Review
Pathology
Shi Wei
Summary: Breast cancer is the most common cancer affecting women, and estrogen receptor (ER) signaling plays a crucial role in its development. ER expression levels are strongly correlated with the therapeutic effects of endocrine therapies targeting ER. Controversies exist regarding the biology and prognostic power of progesterone receptor (PR) status, especially in uncommon subtypes of breast cancer.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Multidisciplinary Sciences
Nastaran Mohammadi Ghahhari, Magdalena K. Sznurkowska, Nicolas Hulo, Lilia Bernasconi, Nicola Aceto, Didier Picard
Summary: This study demonstrates that the transcription factor ZEB1 can modulate ER alpha-mediated transcription during the early stages of EMT, potentially facilitating the migration of breast cancer cells to the bone.
NATURE COMMUNICATIONS
(2022)
Review
Chemistry, Medicinal
Teesha Downton, Fiona Zhou, Davendra Segara, Rinath Jeselsohn, Elgene Lim
Summary: The translated article discusses the limitations of current endocrine therapies for ER-positive breast cancer and the mechanisms of drug resistance, focusing on ESR1 mutations. It also provides an overview of the development and research progress of oral SERDs in improving treatment outcomes.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2022)
Article
Medicine, Research & Experimental
Tong Cheng, Zhusheng Chen, Yibin Qin, Xiang Zhu, Hongsheng Chen, Zhongling Xu, Xiaqing Ma
Summary: Morphine is commonly used and effective for pain relief, but its side effect of itching limits its clinical use. This paper discusses the potential of using esketamine to treat morphine-induced itching.
MEDICAL HYPOTHESES
(2024)
Article
Medicine, Research & Experimental
Sung Eun Lee, Eunjung Park, Ji-yun Kim, HyukHoon Kim
Summary: Hyperbaric oxygen therapy (HBOT) is a potential therapeutic modality that has been recognized for its favorable mechanisms in various diseases, including sepsis-associated encephalopathy (SAE). HBOT has neuroprotective effects through its anti-inflammatory and antiapoptotic effects as well as increased tissue oxygenation capacity. However, there are caveats and limitations in applying HBOT in sepsis.
MEDICAL HYPOTHESES
(2024)
