Article
Immunology
Carmen Picon, Amalia Tejeda-Velarde, Jose Ignacio Fernandez-Velasco, Manuel Comabella, Roberto Alvarez-Lafuente, Ester Quintana, Susana Sainz de la Maza, Enric Monreal, Noelia Villarrubia, Jose Carlos Alvarez-Cermeno, Maria Inmaculada Dominguez-Mozo, Lluis Ramio-Torrenta, Eulalia Rodriguez-Martin, Ernesto Roldan, Yolanda Aladro, Silvia Medina, Mercedes Espino, Jaime Masjuan, Clara Matute-Blanch, Marta Munoz-San Martin, Carmen Espejo, Carmen Guaza, Alfonso Muriel, Lucienne Costa-Frossard, Luisa Maria Villar
Summary: Patients with multiple sclerosis (MS) undergo an early immunosenescence process with age, impacting treatment response and infection risks. Lipid-specific oligoclonal IgM bands (LS-OCMB) in MS patients may modify the immunological profile influenced by age. Additionally, age leads to changes in CSF levels of various molecules and cellular subsets, affecting disability in MS patients.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Boyi Zong, Fengzhi Yu, Xiaoyou Zhang, Wenrui Zhao, Shichang Li, Lin Li
Summary: This article provides an overview of the etiology of multiple sclerosis (MS) and the relationship between MS pathology and immune cells. It is found that physical exercise can reduce autoimmune responses triggered by immune cells, thus potentially preventing and treating MS.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Clinical Neurology
Calogero Edoardo Cicero, Francesca Elsa Allibrio, Loretta Giuliano, Jaime Luna, Pierre-Marie Preux, Alessandra Nicoletti
Summary: The study found through a systematic review and meta-analysis that there is an association between T. gondii infection and multiple sclerosis (MS), suggesting that T. gondii infection may have a protective effect against the development of MS.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Nutrition & Dietetics
Noah Joseph Murr, Tyler B. Olender, Margaret R. Smith, Amari S. Smith, Jennifer Pilotos, Lyndsay B. Richard, Chishimba Nathan Mowa, Michael Makokha Opata
Summary: The study revealed that moderately malnourished mice infected with malaria had lower parasite burden at the peak of infection, but showed damaged mucosal epithelial cells, increased intestinal permeability, shortened small intestine, and decreased number of innate immune cells in the large intestine. Despite lower numbers, macrophages in the moderately malnourished mice were highly activated in the small intestine, indicating exacerbation of some abnormalities in the gut induced by the moderate malnutrition.
Article
Multidisciplinary Sciences
Camila Marques-da-Silva, Barun Poudel, Rodrigo P. Baptista, Kristen Peissig, Lisa S. Hancox, Justine C. Shiau, Lecia L. Pewe, Melanie J. Shears, Thirumala-Devi Kanneganti, Photini Sinnis, Dennis E. Kyle, Prajwal Gurung, John T. Harty, Samarchith P. Kurup
Summary: Malaria, caused by Plasmodium parasites, is a severe disease affecting millions of people worldwide. The researchers have discovered a pathway of natural immunity critical for the control of malaria in the liver, which involves the sensing of Plasmodium DNA by cytosolic AIM2 receptors in infected hepatocytes, leading to Caspase-1 activation.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Biochemistry & Molecular Biology
John-Mark Fitzpatrick, Becky Hackett, Lisa Costelloe, William Hind, Eric J. Downer
Summary: The plant-derived cannabinoids THC and CBD can regulate TLR3 and TLR4 signaling pathways, with significant impact on multiple sclerosis.
Article
Clinical Neurology
Qi Wu, Qin Wang, Jennifer Yang, Elizabeth A. Mills, Pavani Chilukuri, Aiya Saad, Catherine A. Dowling, Caitlyn Fisher, Brittany Kirch, Yang Mao-Draayer
Summary: The study found that Teriflunomide (TER) can shift the balance of immune cell subsets, promoting a tolerogenic immune response and suppressing the pathogenic immune response in patients with relapsing-remitting multiple sclerosis (RRMS). TER affects regulatory T cells (Tregs) and CD4+ T helper cells, increasing the expression of the immunosuppressive marker CD39 and reducing the expression of the activation marker CXCR3. Additionally, TER has an impact on B cell and NK cell subsets. Therefore, TER plays an important role in immune regulation in RRMS patients.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2023)
Article
Cell Biology
Leyre Mestre, Graciela Alonso, Ana Feliu, Miriam Mecha, Carolina Martin, Luisa M. Villar, Carmen Guaza
Summary: Aging has been shown to have an impact on immune cells and neuroinflammatory processes in the CNS of both healthy and infected mice. Microglia and macrophages in old mice showed opposite response to CNS viral infection, with increased programmed death-ligand 1 expression in microglia. The study suggests the need for new or adapted pharmacological strategies for elderly MS patients.
Article
Oncology
Louise M. E. Muller, Gemma Migneco, Gina B. Scott, Jenny Down, Sancha King, Basem Askar, Victoria Jennings, Babatunde Oyajobi, Karen Scott, Emma West, Christy Ralph, Adel Samson, Elizabeth J. Ilett, Munitta Muthana, Matt Coffey, Alan Melcher, Christopher Parrish, Gordon Cook, Michelle Lawson, Fiona Errington-Mais
Summary: The study demonstrates that reovirus can reduce MM tumor burden and myeloma-induced bone disease, increase NK cell and CD8(+) T cell numbers, activate these cells, and upregulate effector-memory CD8(+) T cells. Reovirus is able to kill MM cells by activating NK cells and MM-specific CD8(+) T cells, suggesting that reovirus-induced immunotherapy should be combined with agents that enhance antitumor immune responses.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Review
Immunology
Jiajie Li, Lin Liu, Dianhui Chen, Weiguo Yin, Jun Huang
Summary: The immune system of vertebrates consists of innate immunity and adaptive immunity. Recent studies have found that immune memory exists in innate immunity, supporting efficient responses against reinfection or restimulation. In the case of Plasmodium infection, the innate immune system is the first line of defense and can develop memory to play a role in subsequent infections. This review discusses the role of trained immunity in malaria and other diseases, providing insights for therapeutic strategies.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2023)
Article
Medicine, Research & Experimental
Jibeom Choi
Summary: Immunity is essential for survival, but can sometimes cause allergic responses to benign stimuli. This study used Bayes' theorem to explain the hygiene hypothesis of allergies and found that infrequent exposure to virulent pathogens in childhood may increase allergic responses.
MEDICAL HYPOTHESES
(2023)
Review
Clinical Neurology
Navid Manouchehri, Victor H. Salinas, Negar Rabi Yeganeh, David Pitt, Rehana Z. Hussain, Olaf Stuve
Summary: The effectiveness of disease modifying therapies (DMT) differs between different phenotypes of multiple sclerosis (MS), with progressive MS showing resistance. Immune senescence may explain this resistance.
FRONTIERS IN NEUROLOGY
(2022)
Review
Immunology
Huanhuan Cai, Wei Xiong, Haoyan Zhu, Qiongxin Wang, Shi Liu, Zhibing Lu
Summary: O-GlcNAcylation is a protein post-translational modification that adds O-GlcNAc to serine or threonine residues of nuclear or cytoplasmic proteins, catalyzed by O-GlcNAc transferase (OGT). This modification plays a critical role in regulating immune cell function and is involved in various physiological and pathophysiological processes. However, the exact role of O-GlcNAcylation in the immune system requires further elucidation. This review provides a comprehensive overview of the current research on protein O-GlcNAcylation, emphasizing the molecular mechanisms that control immune cell growth, maturation, and performance through this post-translational modification.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, Research & Experimental
Wenxia Wang, Swarna Bale, Bharath Yalavarthi, Priyanka Verma, Pei-Suen Tsou, Ken M. Calderone, Dibyendu Bhattacharyya, Gary J. Fisher, John Varga, Swati Bhattacharyya
Summary: RP105 has been identified as a novel cell-intrinsic negative regulator of TLR4-MD2-driven sustained fibroblast activation, and its impaired function may contribute to the progression of systemic sclerosis.
Article
Multidisciplinary Sciences
B. Brett Finlay, Katherine R. Amato, Meghan Azad, Martin J. Blaser, Thomas C. G. Bosch, Hiutung Chu, Maria Gloria Dominguez-Bello, Stanislav Dusko Ehrlich, Eran Elinav, Naama Geva-Zatorsky, Philippe Gros, Karen Guillemin, Frederic Keck, Tal Korem, Margaret J. McFall-Ngai, Melissa K. Melby, Mark Nichter, Sven Pettersson, Hendrik Poinar, Tobias Rees, Carolina Tropini, Liping Zhao, Tamara Giles-Vernick
Summary: The COVID-19 pandemic has the potential to impact the human microbiome in infected and uninfected individuals, especially high-risk groups. Current pandemic control measures may have opaque and long-term effects on the global microbiome.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Genetics & Heredity
Andrea Angius, Paolo Uva, Manuela Oppo, Insa Buers, Ivana Persico, Stefano Onano, Gianmauro Cuccuru, Margot I. Van Allen, Gurdip Hulait, Gudrun Aubertin, Francesco Muntoni, Andrew E. Fry, Goeran Anneren, Eva-Lena Stattin, Maria Palomares-Bralo, Fernando Santos-Simarro, Francesco Cucca, Giangiorgio Crisponi, Frank Rutsch, Laura Crisponi
Article
Biochemistry & Molecular Biology
Andrea Angius, Paolo Uva, Giovanna Pira, Maria Rosaria Muroni, Giovanni Sotgiu, Laura Saderi, Elena Uleri, Maurizio Caocci, Gabriele Ibba, Maria Rosaria Cesaraccio, Caterina Serra, Ciriaco Carru, Alessandra Manca, Francesca Sanges, Alberto Porcu, Antonia Dolei, Antonio Mario Scanu, Paolo Cossu Rocca, Maria Rosaria De Miglio
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Multidisciplinary Sciences
Giovanna Pira, Paolo Uva, Antonio Mario Scanu, Paolo Cossu Rocca, Luciano Murgia, Elena Uleri, Claudia Piu, Alberto Porcu, Ciriaco Carru, Alessandra Manca, Ivana Persico, Maria Rosaria Muroni, Francesca Sanges, Caterina Serra, Antonia Dolei, Andrea Angius, Maria Rosaria De Miglio
SCIENTIFIC REPORTS
(2020)
Article
Nutrition & Dietetics
Andrea Baragetti, Marco Severgnini, Elena Olmastroni, Carola Conca Dioguardi, Elisa Mattavelli, Andrea Angius, Luca Rotta, Javier Cibella, Giada Caredda, Clarissa Consolandi, Liliana Grigore, Fabio Pellegatta, Flavio Giavarini, Donatella Caruso, Giuseppe Danilo Norata, Alberico Luigi Catapano, Clelia Peano
Summary: The study found that subjects without clinically manifest ACVD tended to consume more cereals, starchy vegetables, and dairy products, while those with SCA consumed more meats. The diversity of dietary sources significantly overlapped with separations in GM composition, providing insights for potential personalized dietary intervention strategies.
Review
Biochemistry & Molecular Biology
Andrea Angius, Antonio Mario Scanu, Caterina Arru, Maria Rosaria Muroni, Vincenzo Rallo, Giulia Deiana, Maria Chiara Ninniri, Ciriaco Carru, Alberto Porcu, Giovanna Pira, Paolo Uva, Paolo Cossu-Rocca, Maria Rosaria De Miglio
Summary: Colorectal cancer stem cells (CCSCs) with stemness behaviors play a crucial role in tumor progression and therapy resistance, associated with genetic changes in signaling pathways. Dysregulated CCSC-related miRNAs modulate stemness features and functions, involving cell cycle gene expression, epithelial-mesenchymal transition, and drug-resistance mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Maria Rosaria Muroni, Silvia Ribback, Giovanni Sotgiu, Nils Kroeger, Laura Saderi, Andrea Angius, Paolo Cossu-Rocca, Maria Rosaria De Miglio
Summary: EGFR is commonly overexpressed in CCRCC, but its association with responsiveness to EGFR-targeted therapy and prognostic significance remain controversial. The study suggests that membranous-cytoplasmic EGFR expression correlates with grade, pT stage, SSIGN score, while nuclear EGFR expression does not show significant correlations with clinic-pathological features. Positive expression of nuclear EGFR and SGLT1 is associated with increased survival rate in CCRCC patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Ophthalmology
R. Serra, F. Coscas, A. Angius, A. Pinna
JOURNAL FRANCAIS D OPHTALMOLOGIE
(2022)
Article
Ophthalmology
Rita Serra, Vincenzo Rallo, Antonio Pinna, Maristella Steri, Maria Grazia Piras, Michele Marongiu, Florence Coscas, Myriam Gorospe, David Schlessinger, Edoardo Fiorillo, Francesco Cucca, Andrea Angius
Summary: This study investigated the prevalence and clinical and genetic features of age-related macular degeneration (AMD) in a population living in the Lanusei valley, Central Sardinia, Italy. The results showed that most subjects did not show any signs of AMD, and late AMD was rare. The study supports the hypothesis that the Sardinian population may have a protective background against AMD development.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Article
Oncology
Andrea Angius, Giovanna Pira, Paolo Cossu-Rocca, Giovanni Sotgiu, Laura Saderi, Maria Rosaria Muroni, Patrizia Virdis, Daniela Piras, Rallo Vincenzo, Ciriaco Carru, Donatella Coradduzza, Maria Gabriela Uras, Pierina Cottu, Alessandro Fancellu, Sandra Orru, Paolo Uva, Maria Rosaria De Miglio
Summary: This study found that BCL11A is significantly overexpressed in TNBC at both transcriptional and translational levels. BCL11A protein expression predicts poor LIV and downregulation of AR, as well as a higher proliferative index in TNBC cells. BCL11A-L expression is associated with more aggressive histological types of TNBC.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Donatella Coradduzza, Caterina Arru, Nicola Culeddu, Antonella Congiargiu, Emanuela Gigliola Azara, Antonio Mario Scanu, Angelo Zinellu, Maria Rosaria Muroni, Vincenzo Rallo, Serenella Medici, Ciriaco Carru, Andrea Angius, Maria Rosaria De Miglio
Summary: Colorectal cancer (CRC) is a major public health and socio-economic problem that requires non-invasive screening tests. By using ultra-high-resolution liquid chromatography and mass spectrometry, we profiled eleven polyamines, including spermine and spermidine with their acetylated forms, and evaluated their potential as biomarkers for identifying CRC patients. The statistical models showed good discrimination in distinguishing CRC patients and healthy subjects. Plasma assessment of ornithine and acetylspermine, as well as lymphocyte/platelet ratio, provided helpful information on the progression of CRC. The combined profiles of circulating polyamines and inflammatory indexes, along with innovative technology, could be a valuable tool for discriminating patients from different clinical groups.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, General & Internal
Xiaofen Wen, Donatella Coradduzza, Jiaxin Shen, Antonio Mario Scanu, Maria Rosaria Muroni, Matteo Massidda, Vincenzo Rallo, Ciriaco Carru, Andrea Angius, Maria Rosaria De Miglio
Summary: Minimal residual disease (MRD) detection offers an effective method for predicting recurrence in colorectal cancer (CRC) and has the potential to revolutionize management for CRC patients. The use of circulating tumor DNA (ctDNA) in MRD detection has shown promising applications in risk stratification, treatment guidance, and early relapse monitoring.
MEDICINA-LITHUANIA
(2023)
Review
Medicine, General & Internal
Andrea Angius, Antonio Mario Scanu, Caterina Arru, Maria Rosaria Muroni, Ciriaco Carru, Alberto Porcu, Paolo Cossu-Rocca, Maria Rosaria De Miglio
Summary: Omics technologies are driving the shift towards precision medicine in cancer research, with the study of intra-tumoral heterogeneity playing a key role in advancing CRC diagnosis and treatment. Single-cell technologies offer a promising approach to identifying cell subpopulations and uncovering new drug targets.
MEDICINA-LITHUANIA
(2021)
Review
Oncology
Andrea Angius, Paolo Cossu-Rocca, Caterina Arru, Maria Rosaria Muroni, Vincenzo Rallo, Ciriaco Carru, Paolo Uva, Giovanna Pira, Sandra Orru, Maria Rosaria De Miglio
Article
Biochemistry & Molecular Biology
Rita Serra, Matteo Floris, Antonio Pinna, Francesco Boscia, Francesco Cucca, Andrea Angius
Article
Medicine, General & Internal
Andrea Angius, Giovanna Pira, Antonio Mario Scanu, Paolo Uva, Giovanni Sotgiu, Laura Saderi, Alessandra Manca, Caterina Serra, Elena Uleri, Claudia Piu, Maurizio Caocci, Gabriele Ibba, Angelo Zinellu, Maria Rosaria Cesaraccio, Francesca Sanges, Maria Rosaria Muroni, Antonina Dolei, Paolo Cossu-Rocca, Maria Rosaria De Miglio
INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
(2019)
Article
Medicine, Research & Experimental
Tong Cheng, Zhusheng Chen, Yibin Qin, Xiang Zhu, Hongsheng Chen, Zhongling Xu, Xiaqing Ma
Summary: Morphine is commonly used and effective for pain relief, but its side effect of itching limits its clinical use. This paper discusses the potential of using esketamine to treat morphine-induced itching.
MEDICAL HYPOTHESES
(2024)
Article
Medicine, Research & Experimental
Sung Eun Lee, Eunjung Park, Ji-yun Kim, HyukHoon Kim
Summary: Hyperbaric oxygen therapy (HBOT) is a potential therapeutic modality that has been recognized for its favorable mechanisms in various diseases, including sepsis-associated encephalopathy (SAE). HBOT has neuroprotective effects through its anti-inflammatory and antiapoptotic effects as well as increased tissue oxygenation capacity. However, there are caveats and limitations in applying HBOT in sepsis.
MEDICAL HYPOTHESES
(2024)