Journal
MEDICAL ENGINEERING & PHYSICS
Volume 35, Issue 9, Pages 1290-1297Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.medengphy.2013.02.002
Keywords
Fractional flow reserve; Hemodynamics; Red blood cells; Atherosclerosis
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Funding
- PRACE supercomputing time
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We present the results of a computational study of the entire left coronary system simulated both at Newtonian level and at red blood cell resolution for a sizeable number of physiological conditions. We analyze the cardiovascular implications of stenotic plaques and show that the standard clinical criterion for surgical or percutaneous intervention, based on the fractional flow reserve (FFR), is significantly affected by system-dependent, local hemodynamic factors. A refined version, based on the new notion of local FFR response to stenotic growth, and accounting for statistical uncertainties due to flow heterogeneity, is suggested and illustrated. (C) 2013 IPEM. Published by Elsevier Ltd. All rights reserved.
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