Journal
MEDICAL ENGINEERING & PHYSICS
Volume 33, Issue 9, Pages 1072-1078Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.medengphy.2011.04.008
Keywords
Pressure ulcer; Deep tissue injury; Cell model; Diffusion; Deformation
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Funding
- Ministry of Science & Technology, Israel
- Ministry of Research, Taiwan
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In this study we integrated between confocal-based cell-specific finite element (FE) modeling and Virtual Cell (VC) transport simulations in order to determine trends of relationship between externally applied compressive deformations and build-up rates of oxygen in myoblast cells, and to further test how mild culture temperature drops (similar to 3 degrees C) might affect such trends. Geometries of two different cells were used, and each FE cell model was computationally subjected to large compressive deformations. Build-up of oxygen concentrations within the deformed cell shapes over time were calculated using the VC software. We found that the build-up of oxygen in the cells was slightly but consistently hindered when compressive cell deformations were applied. Temperature drops characteristic to ischemic conditions further hinder the oxygen built-up in cells. In a real-world condition, a combination of the deformation and temperature factors should be anticipated, and their combined effect might substantially impair cell respiration functions. (C) 2011 IPEM. Published by Elsevier Ltd. All rights reserved.
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