Article
Multidisciplinary Sciences
Manya Wu, Jinhui Jin, Zhenghuan Li, Fantu Kong, Yadi He, Lijiang Liu, Wei Yang, Xiangying Xu
Summary: The study found that beamlet width has a significant impact on dose distribution to targets and organs at risk in dynamic intensity-modulated radiation therapy for nasopharyngeal carcinoma, with 4 mm beamlet width considered as the optimal choice.
Article
Oncology
Wenzhao Sun, Jun Zhang, Yixuan Wang, Meining Chen, Jianli Wang, Li Chen, Lixia Lu, Xiaowu Deng
Summary: This study compared the effects of helical tomotherapy (HT) and RapidArc (RA) in total dura mater irradiation (TDMI) and found that HT provided a more homogenous dose distribution and lower dose to the central region of the brain. This may contribute to reducing long-term cognitive decline in young patients.
TECHNOLOGY IN CANCER RESEARCH & TREATMENT
(2022)
Article
Oncology
Shan Lu, Huiqi Fan, Xueyuan Hu, Xin Li, Yingying Kuang, Deyang Yu, Shanshan Yang
Summary: This study compared different radiotherapy plans for locally advanced nasopharyngeal carcinoma (NPC) and found that helical tomotherapy (HT) and volume-modulated arc therapy (VMAT) had better target homogeneity and conformity. HT also showed the best reduction in doses delivered to organs at risk. VMAT, on the other hand, had the shortest treatment time and improved radiation delivery efficiency.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Sheng-Dean Luo, Hsin-Ting Tsai, Tai-Jan Chiu, Shau-Hsuan Li, Ya-Ling Hsu, Li-Jen Su, Meng-Hsiu Tsai, Ching-Yi Lee, Chang-Chun Hsiao, Chang-Han Chen
Summary: Leptin plays an important role in regulating lipid metabolism in nasopharyngeal carcinoma cells and could be a potential therapeutic target.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Richard She, Tyler Fair, Nathan K. Schaefer, Reuben A. Saunders, Bryan J. Pavlovic, Jonathan S. Weissman, Alex A. Pollen
Summary: By comparing human and chimpanzee pluripotent stem cells, researchers identified 75 genes that have species-specific effects on cellular proliferation in humans. These genes are associated with coherent processes, including cell-cycle progression and lysosomal signaling, and are confirmed to be unique to humans by comparing them with orangutan cells. This study supports the hypothesis that an extended G1 phase may be an evolutionary mechanism in human brain expansion.
Article
Oncology
Sheng-Dean Luo, Hsin-Ting Tsai, Chung-Feng Hwang, Tai-Jan Chiu, Shau-Hsuan Li, Ya-Ling Hsu, Chang-Chun Hsiao, Chang-Han Chen
Summary: Leptin is highly expressed in patients with nasopharyngeal carcinoma, promoting cell growth and invasion by regulating cell cycle, glycolysis, and EGFR signaling. miR-874-3p influences the progression of NPC by modulating Leptin expression, affecting cell growth, motility, and metabolism.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2022)
Article
Health Care Sciences & Services
Wei Chen, Fangfang Wang, Zhendong Yang, Tingting Zhang, Mingjun Shen, Rensheng Wang, Min Kang
Summary: The study aimed to compare the long-term efficacy and late adverse reactions of intensity-modulated radiation therapy (IMRT) combined with recombinant human endostatin (Endostar) versus IMRT combined with concurrent chemotherapy (CCT) in patients with locoregionally advanced nasopharyngeal carcinoma (NPC). Results showed no significant difference in overall survival rates between the two groups, but the IMRT + Endostar group displayed better efficacy and less severe late side effects. More research with a larger sample size and longer follow-up period is needed.
ANNALS OF PALLIATIVE MEDICINE
(2021)
Article
Multidisciplinary Sciences
Deo R. Singh, Scott E. Nelson, Abigail S. Pawelski, Alisha S. Kansra, Stuart A. Fogarty, Jillian A. Bristol, Makoto Ohashi, Eric C. Johannsen, Shannon C. Kenney
Summary: Latent Epstein-Barr virus (EBV) infection promotes undifferentiated nasopharyngeal carcinomas (NPCs) by inducing cellular proliferation and inhibiting spontaneous differentiation through the activation of YAP and TAZ. LMP1 enhances YAP and TAZ activity by reducing serine phosphorylation and increasing Src kinase-mediated phosphorylation of YAP. Knockdown of YAP and TAZ reduces proliferation and promotes differentiation in EBV-infected cells. Ibrutinib restores spontaneous differentiation and inhibits proliferation of EBV-infected cells, suggesting a potential therapeutic approach for treating NPCs.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Public, Environmental & Occupational Health
Dan Li, Hai-Ke Lei, Xiao-Lei Shu, Xin Zhang, Hong-Lei Tu, Feng Wang, Yu-Wei Wang, Ying Wang, Jiang-Dong Sui
Summary: Health insurance programs are effective in preventing financial hardship in cancer patients. However, little is known about how health insurance policies influence the prognosis of patients with nasopharyngeal carcinoma in Southwest China. This study investigated the association of insurance types and self-paying rates with NPC-specific mortality.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Oncology
Chunmei Fan, Hongke Qu, Fang Xiong, Yanyan Tang, Ting Tang, Lishen Zhang, Yongzhen Mo, Xiayu Li, Can Guo, Shanshan Zhang, Zhaojian Gong, Zheng Li, Bo Xiang, Hao Deng, Ming Zhou, Qianjin Liao, Yujuan Zhou, Xiaoling Li, Yong Li, Guiyuan Li, Fuyan Wang, Zhaoyang Zeng
Summary: This study identified a novel circRNA circARHGAP12 that was significantly upregulated in NPC, promoting cell migration and invasion by regulating cytoskeletal remodeling related proteins. CircARHGAP12 was found to directly bind to EZR mRNA and promote its stability, leading to enhanced invasion and metastasis of NPC cells.
Review
Biochemistry & Molecular Biology
Huidan Luo, Bin Yi
Summary: Exosomes, as nanoscale membrane vesicles, are important for cell communication and can serve as non-invasive liquid biopsy biomarkers in nasopharyngeal carcinoma. They play a role in regulating physiological processes of the tumor and have implications in cell growth, angiogenesis, metastasis, immunosuppression, radiation resistance, and chemotherapy resistance in NPC.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Jianbin Zhang, Yan Jiang, Ye Yu, Jiangping Li
Summary: This study evaluated the combination of TORC1/2 inhibitor sapanisertib and chemotherapy drug cisplatin for nasopharyngeal carcinoma (NPC) treatment. The results showed that sapanisertib effectively decreased NPC cell viability and proliferation, and acted synergistically with cisplatin to induce cell arrest and apoptosis. Sapanisertib had minimal effects on normal cells and also reduced NPC cell migration. These findings were evident in both in vitro and in vivo models.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Oncology
Ju-Pi Li, Chiao-Wen Lin, Cheng-Chen Huang, Yen-Ting Lu, Yu-Ting Ho, Shun-Fa Yang, Chung-Han Hsin
Summary: Lipocalin-2 (LCN2) inhibits cell migration of human nasopharyngeal carcinoma by reducing MET levels through the MEK/ERK signaling pathway.
Article
Oncology
Lingzhi Wang, Yanling Lin, Xiaohan Zhou, Yuting Chen, Xueying Li, Wenxiao Luo, Yingtong Zhou, Longmei Cai
Summary: CYLD inhibits glycolysis in nasopharyngeal carcinoma by regulating p53 and FZR1, delaying tumor growth and progression, and serving as a biomarker for poor prognosis.
Article
Biochemistry & Molecular Biology
Deepika Raman, Patricia Tay, Jayshree L. Hirpara, Dan Liu, Shazib Pervaiz
Summary: The study shows that TRAIL can induce apoptosis in nasopharyngeal cancer cell lines by activating caspase-3, with the membrane protein TMTC2 playing a crucial role in this process. Patients with high TMTC2 expression have significantly improved disease-free survival, suggesting TMTC2 may serve as a biomarker for TRAIL sensitivity.