☆ 4.1 Article

PROTON RADIOTHERAPY FOR LIVER TUMORS: DOSIMETRIC ADVANTAGES OVER PHOTON PLANS

MEDICAL DOSIMETRY (2008)

Journal

MEDICAL DOSIMETRY

Volume 33, Issue 4, Pages 259-267

Publisher

ELSEVIER SCIENCE INC

DOI: 10.1016/j.meddos.2007.04.008

Keywords

Liver; Dosimetry; Proton; Photon

Categories

Oncology Radiology, Nuclear Medicine & Medical Imaging

Funding

National Cancer Institute [CA74043]
NATIONAL CANCER INSTITUTE [R01CA074043] Funding Source: NIH RePORTER

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Abstract

The purpose of the study is to dosimetrically investigate the advantages of proton radiotherapy over photon radiotherapy for liver tumors. The proton plan and the photon plan were designed using commercial treatment planning systems. The treatment target dose conformity and heterogeneity and dose-volume analyses of normal structures were compared between proton and photon radiotherapy for 9 patients with liver tumors. Proton radiotherapy delivered a more conformal target dose with slightly less homogeneity when compared with photon radiotherapy. Protons significantly reduced the fractional volume of liver receiving dose greater or equal to 30 Gy (V-30) and the mean liver dose. The stomach and duodenal V-45 were significantly lower with the use of proton radiotherapy. The V-40 and V-50 of the heart and the maximum spinal cord dose were also significantly lower with the use of proton radiotherapy. Protons were better able to spare one kidney completely and deliver less dose to one (generally the left) kidney than photons. The mean dose to the total body and most critical structures was significantly decreased using protons when compared to corresponding photon plans. In conclusion, our study suggests the dosimetric benefits of proton radiotherapy over photon radiotherapy. These dosimetric advantages of proton plans may permit further dose escalation with lower risk of complications. (C) 2008 American Association of Medical Dosimetrists.

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Khalil, J. King, G. Krintiras, A. Kropivnitskaya, C. Lindsey, N. Minafra, M. Murray, C. Rogan, C. Royon, S. Sanders, E. Schmitz, J. D. Tapia Takaki, Q. Wang, J. Williams, G. Wilson, S. Duric, A. Ivanov, K. Kaadze, D. Kim, Y. Maravin, T. Mitchell, A. Modak, A. Mohammadi, F. Rebassoo, D. Wright, E. Adams, A. Baden, O. Baron, A. Belloni, S. C. Eno, Y. Feng, N. J. Hadley, S. Jabeen, G. Y. Jeng, R. G. Kellogg, T. Koeth, A. C. Mignerey, S. Nabili, M. Seidel, A. Skuja, S. C. Tonwar, L. Wang, K. Wong, D. Abercrombie, B. Allen, R. Bi, S. Brandt, W. Busza, I. A. Cali, Y. Chen, M. D'Alfonso, G. Gomez-Ceballos, M. Goncharov, P. Harris, D. Hsu, M. Hu, M. Klute, D. Kovalskyi, J. Krupa, Y. -J. Lee, P. D. Luckey, B. Maier, A. C. Marini, C. Mironov, S. Narayanan, X. Niu, C. Paus, D. Rankin, C. Roland, G. Roland, Z. Shi, G. S. F. Stephans, K. Tatar, D. Velicanu, J. Wang, T. W. Wang, Z. Wang, B. Wyslouch, R. M. Chatterjee, A. Evans, P. Hansen, J. Hiltbrand, Sh. Jain, M. Krohn, Y. Kubota, Z. Lesko, J. Mans, M. Revering, R. Rusack, R. Saradhy, N. Schroeder, N. Strobbe, M. A. Wadud, J. G. Acosta, S. Oliveros, K. Bloom, M. Bryson, S. Chauhan, D. R. Claes, C. Fangmeier, L. Finco, F. Golf, J. R. Gonzalez Fernandez, C. Joo, I. Kravchenko, J. E. Siado, G. R. Snow, W. Tabb, F. Yan, G. Agarwal, H. Bandyopadhyay, L. Hay, I. Iashvili, A. Kharchilava, C. McLean, D. Nguyen, J. Pekkanen, S. Rappoccio, G. Alverson, E. Barberis, C. Freer, Y. Haddad, A. Hortiangtham, J. Li, G. Madigan, B. Marzocchi, D. M. Morse, V. Nguyen, T. Orimoto, A. Parker, L. Skinnari, A. Tishelman-Charny, T. Wamorkar, B. Wang, A. Wisecarver, D. Wood, S. Bhattacharya, J. Bueghly, Z. Chen, A. Gilbert, T. Gunter, K. A. Hahn, N. Odell, M. H. Schmitt, K. Sung, M. Velasco, R. Bucci, N. Dev, R. Goldouzian, M. Hildreth, K. Hurtado Anampa, C. Jessop, K. Lannon, N. Loukas, N. Marinelli, I. Mcalister, F. Meng, K. Mohrman, Y. Musienko, R. Ruchti, P. Siddireddy, M. Wayne, A. Wightman, M. Wolf, L. Zygala, J. Alimena, B. Bylsma, B. Cardwell, L. S. Durkin, B. Francis, C. Hill, A. Lefeld, B. L. Winer, B. R. Yates, F. M. Addesa, B. Bonham, P. Das, G. Dezoort, P. Elmer, B. Greenberg, N. Haubrich, S. Higginbotham, A. Kalogeropoulos, G. Kopp, S. Kwan, D. Lange, M. T. Lucchini, D. Marlow, K. Mei, I. Ojalvo, J. Olsen, C. Palmer, P. Piroue, D. Stickland, C. Tully, S. Malik, S. Norberg, A. S. Bakshi, V. E. Barnes, R. Chawla, S. Das, L. Gutay, M. Jones, A. W. Jung, S. Karmarkar, M. Liu, G. Negro, N. Neumeister, C. C. Peng, S. Piperov, A. Purohit, J. F. Schulte, M. Stojanovic, N. Trevisani, F. Wang, A. Wildridge, R. Xiao, W. Xie, J. Dolen, N. Parashar, A. Baty, S. Dildick, K. M. Ecklund, S. Freed, F. J. M. Geurts, A. Kumar, W. Li, B. P. Padley, R. Redjimi, J. Roberts, J. Rorie, W. Shi, A. G. Stahl Leiton, A. Bodek, P. de Barbaro, R. Demina, J. L. Dulemba, C. Fallon, T. Ferbel, M. Galanti, A. Garcia-Bellido, O. Hindrichs, A. Khukhunaishvili, E. Ranken, R. Taus, B. Chiarito, J. P. Chou, A. Gandrakota, Y. Gershtein, E. Halkiadakis, A. Hart, M. Heindl, E. Hughes, S. Kaplan, O. Karacheban, I. Laflotte, A. Lath, R. Montalvo, K. Nash, M. Osherson, S. Salur, S. Schnetzer, S. Somalwar, R. Stone, S. A. Thayil, S. Thomas, H. Wang, H. Acharya, A. G. Delannoy, S. Spanier, O. Bouhali, M. Dalchenko, A. Delgado, R. Eusebi, J. Gilmore, T. Huang, T. Kamon, H. Kim, S. Luo, S. Malhotra, R. Mueller, D. Overton, L. Pernie, D. Rathjens, A. Safonov, N. Akchurin, J. Damgov, V. Hegde, S. Kunori, K. Lamichhane, S. W. Lee, T. Mengke, S. Muthumuni, T. Peltola, S. Undleeb, I. Volobouev, Z. Wang, A. Whitbeck, E. Appelt, S. Greene, A. Gurrola, R. Janjam, W. Johns, C. Maguire, A. Melo, H. Ni, K. Padeken, F. Romeo, P. Sheldon, S. Tuo, J. Velkovska, M. W. Arenton, B. Cox, G. Cummings, J. Hakala, R. Hirosky, M. Joyce, A. Ledovskoy, A. Li, C. Neu, B. Tannenwald, E. Wolfe, P. E. Karchin, N. Poudyal, P. Thapa, K. Black, T. Bose, J. Buchanan, C. Caillol, S. Dasu, I. De Bruyn, P. Everaerts, C. Galloni, H. He, M. Herndon, A. Herve, U. Hussain, A. Lanaro, A. Loeliger, R. Loveless, J. Madhusudanan Sreekala, A. Mallampalli, D. Pinna, A. Savin, V. Shang, V. Sharma, W. H. Smith, D. Teague, S. Trembath-Reichert, W. Vetens, S. Afanasiev, V. Andreev, Yu. Andreev, T. Aushev, M. Azarkin, A. Babaev, A. Belyaev, V. Blinov, E. Boos, V. Borchsh, P. Bunin, O. Bychkova, M. Chadeeva, V. Chekhovsky, A. Dermenev, T. Dimova, I. Dremin, V. Epshteyn, A. Ershov, M. Gavrilenko, G. Gavrilov, V. Gavrilov, S. Gninenko, V. Golovtcov, N. Golubev, I. Golutvin, I. Gorbunov, A. Iuzhakov, V. Ivanchenko, Y. Ivanov, V. Kachanov, A. Kalinin, A. Kamenev, L. Kardapoltsev, V. Karjavine, A. Karneyeu, L. Khein, V. Kim, M. Kirakosyan, M. Kirsanov, O. Kodolova, D. Konstantinov, V. Korotkikh, N. Krasnikov, E. Kuznetsova, A. Lanev, A. Litomin, O. Lukina, N. Lychkovskaya, V. Makarenko, A. Malakhov, V. Matveev, V. Murzin, A. Nikitenko, S. Obraztsov, V. Okhotnikov, V. Oreshkin, I. Ovtin, V. Palichik, A. Pashenkov, V. Perelygin, S. Petrushanko, D. Philippov, G. Pivovarov, V. Popov, E. Popova, V. Rusinov, G. Safronov, M. Savina, V. Savrin, D. Seitova, V. Shalaev, S. Shmatov, S. Shulha, Y. Skovpen, I. Smirnov, V. Smirnov, A. Snigirev, D. Sosnov, A. Spiridonov, A. Stepennov, J. Suarez Gonzalez, L. Sukhikh, V. Sulimov, E. Tcherniaev, A. Terkulov, O. Teryaev, D. Tlisov, M. Toms, A. Toropin, L. Uvarov, A. Uzunian, I. Vardanyan, E. Vlasov, S. Volkov, A. Vorobyev, N. Voytishin, A. Zarubin, I. Zhizhin, A. Zhokin

Summary: The first measurements of Fourier coefficients for the azimuthal distributions of charged hadrons emitted from gamma-p interactions are presented. The results show that the mean transverse momentum of charged particles is smaller in gamma-p collisions compared to pPb collisions, and the V-1 Delta coefficient is negative while V-2 Delta is positive. The data are consistent with model predictions that do not include collective effects.

PHYSICS LETTERS B (2023)

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Article Radiology, Nuclear Medicine & Medical Imaging

Combined proton-photon therapy for non-small cell lung cancer

Florian Amstutz, Silvia Fabiano, Louise Marc, Damien Charles Weber, Antony John Lomax, Jan Unkelbach, Ye Zhang

Summary: Optimally combined proton-photon plans have been shown to improve treatment plan quality compared to IMRT alone, potentially reducing the risk of toxicity while also allowing for increased accessibility to proton therapy for NSCLC patients.

MEDICAL PHYSICS (2022)

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Article Multidisciplinary Sciences

Development of a time-resolved mirrorless scintillation detector

Wonjoong Cheon, Hyunuk Jung, Moonhee Lee, Jinhyeop Lee, Sung Jin Kim, Sungkoo Cho, Youngyih Han

Summary: A compact and lightweight time-resolved mirrorless scintillation detector (TRMLSD) was developed for high-resolution two-dimensional dosimetry using image processing techniques and a convolutional neural network (CNN). The dosimeter showed excellent dose linearity, reproducibility, and dose rate dependency, making it suitable for quality assurance of clinical intensity-modulated radiation therapy (IMRT) plans.

PLOS ONE (2021)

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Article Engineering, Biomedical

Roadmap: proton therapy physics and biology

Harald Paganetti, Chris Beltran, Stefan Both, Lei Dong, Jacob Flanz, Keith Furutani, Clemens Grassberger, David R. Grosshans, Antje-Christin Knopf, Johannes A. Langendijk, Hakan Nystrom, Katia Parodi, Bas W. Raaymakers, Christian Richter, Gabriel O. Sawakuchi, Marco Schippers, Simona F. Shaitelman, B. K. Kevin Teo, Jan Unkelbach, Patrick Wohlfahrt, Tony Lomax

Summary: Proton radiation therapy has become a mainstream treatment option for cancer, with almost 200 000 patients treated worldwide. Despite its advanced dose shaping capabilities, there are still challenges to address, including uncertainties, room for improvement in dose delivery, and biological effect differences compared to photon radiation. Additionally, the economic aspect of proton therapy, with its higher costs compared to conventional treatments, is also an area of active research.

PHYSICS IN MEDICINE AND BIOLOGY (2021)

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Article Engineering, Biomedical

A portable primary-standard level graphite calorimeter for absolute dosimetry in clinical pencil beam scanning proton beams

A. Lourenco, N. Lee, F. Charlwood, J. Lambert, J. A. Vera-Sanchez, M. Hussein, D. Shipley, F. Romano, M. Lowe, M. Clarke, S. Lorentini, A. Mazal, J. Pettingell, H. Palmans, R. Thomas

Summary: A portable primary standard level graphite calorimeter was used to directly measure the dose in clinical pencil beam scanning proton beams. The study was conducted at four clinical proton therapy facilities and correction factors were applied to account for impurities and vacuum gaps. The absorbed dose to water determined with the calorimeter was compared to ionisation chambers calibrated in Co-60, and the overall uncertainty was reduced to 0.9% (k = 1).

PHYSICS IN MEDICINE AND BIOLOGY (2023)

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Article Engineering, Biomedical

Dose perturbations in proton pencil beam delivery investigated by dynamically deforming silicone-based radiochromic dosimeters

Simon Jensen, Ludvig P. Muren, Peter Balling, Jorgen B. B. Petersen, Lia B. Valdetaro, Per R. Poulsen

Summary: This study investigated the dose perturbation caused by dynamic motion and deformation during proton pencil beam deliveries using deformable 3D dosimeters. Results showed that dose delivery was accurate and efficient when gating was employed during motion experiments, while unstable delivery was observed without gating.

PHYSICS IN MEDICINE AND BIOLOGY (2022)

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Article Oncology

Treatment planning comparison for head and neck cancer between photon, proton, and combined proton-photon therapy - From a fixed beam line to an arc

Florian Amstutz, Reinhardt Krcek, Barbara Bachtiary, Damien C. Weber, Antony J. Lomax, Jan Unkelbach, Ye Zhang

Summary: This study investigates whether combined proton-photon therapy (CPPT) improves treatment plan quality compared to single-modality intensity-modulated radiation therapy (IMRT) or intensity-modulated proton therapy (IMPT) for head and neck cancer (HNC) patients. The findings suggest that CPPT needs adaptive treatments and increasing proton beam flexibility can improve treatment plan quality.

RADIOTHERAPY AND ONCOLOGY (2024)

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Article Chemistry, Multidisciplinary

The Performance of LiF:Mg-Ti for Proton Dosimetry within the Framework of the MoVe IT Project

Vittoria D'Avino, Francesco Tommasino, Stefano Lorentini, Giuseppe La Verde, Mariagabriella Pugliese

Summary: This study evaluated the performance of TLDs-100 for dose verification in proton beam line. The results showed the good performance of TLDs-100, proving their reliability for dose recordings in future radiobiological experiments.

APPLIED SCIENCES-BASEL (2021)

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Article Radiology, Nuclear Medicine & Medical Imaging

Technical Note: First report on an in vivo range probing quality control procedure for scanned proton beam therapy in head and neck cancer patients

Arturs Meijers, Carmen Seller Oria, Jeffrey Free, Johannes A. Langendijk, Antje C. Knopf, Stefan Both

Summary: The study aimed to evaluate range accuracy in head and neck cancer patients using range probing (RP) based on proton radiography. Results showed that performing RP calculations based on day-specific patient anatomy rather than planning CT led to smaller discrepancies between measured and calculated ranges. Patient-specific range evaluation demonstrated agreement within 3% for spots in anatomically consistent areas.

MEDICAL PHYSICS (2021)

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Article Physics, Multidisciplinary

Small accelerators and their applications in the CANAM research infrastructure at the NPI CAS

A. Mackova, P. Malinsky, M. Cutroneo, V Havranek, J. Flaks, V Semian, L. Vonka, V Zach, P. Bem, J. Mrazek, P. Krist, D. Poklop, M. Stefanik, J. Stursa, V Olsansky, D. Chvatil, J. Kamenik, J. Tecl, R. Behal, M. Ciltak, J. Kueera, M. Nemec, I Svetlik

Summary: The Nuclear Physics Institute of the Czech Academy of Sciences operates various facilities including accelerators, cyclotrons, and a microtron for conducting fundamental nuclear physics experiments and applications. Each facility offers unique capabilities such as ion-beam analytical methods, material synthesis, and cultural heritage preservation. The recently acquired AMS instrument provides highly sensitive isotopic ratio measurements for long-lived radionuclides.

EUROPEAN PHYSICAL JOURNAL PLUS (2021)

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Article Chemistry, Analytical

General Purpose Transistor Characterized as Dosimetry Sensor of Proton Beams

J. A. Moreno-Perez, I. Ruiz-Garcia, P. Martin-Holgado, A. Romero-Maestre, M. Anguiano, R. Vila, M. A. Carvajal

Summary: A commercial pMOS transistor from Vishay (USA) was characterized as a low-energy proton beam dosimeter. The transistor was biased and the silicon temperature was monitored during irradiations. Bias voltages of 0, 1, 5, and 10 V were applied, showing a linearly dependent sensitivity on voltage. The device presented promising characteristics as a dosimeter sensor for proton beams.

SENSORS (2023)

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Article Engineering, Biomedical

Implementing dispersion measurement as part of scanning proton therapy commissioning and quality assurance

Hong Qi Tan, Kah Seng Lew, Calvin Wei Yang Koh, Andrew Wibawa, Ping Lin Yeap, Zubin Master, James Cheow Lei Lee, Chris J. Beltran, Sung Yong Park, Keith M. Furutani

Summary: This article presents a safe method for measuring dispersion in the clinic and finds that dispersion is the cause of dose fluctuation in absolute dosimetry measurement.

PHYSICS IN MEDICINE AND BIOLOGY (2023)

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Article Radiology, Nuclear Medicine & Medical Imaging

Optimization of a multipoint plastic scintillator dosimeter for high dose rate brachytherapy

Haydee M. Linares Rosales, Patricia Duguay-Drouin, Louis Archambault, Sam Beddar, Luc Beaulieu

MEDICAL PHYSICS (2019)

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Article Oncology

Proton beam therapy outcomes for localized unresectable hepatocellular carcinoma

Awalpreet S. Chadha, Jillian R. Gunther, Cheng-En Hsieh, Maureen Aliru, Lakshmi S. Mahadevan, Bhanu P. Venkatesulu, Christopher H. Crane, Prajnan Das, Joseph M. Herman, Eugene J. Koay, Cullen Taniguchi, Emma B. Holliday, Bruce D. Minsky, Yelin Suh, Peter Park, Gabriel Sawakuchi, Sam Beddar, Bruno C. Odisio, Sanjay Gupta, Evelyne Loyer, Harmeet Kaur, Kanwal Raghav, Milind M. Javle, Ahmed O. Kaseb, Sunil Krishnan

RADIOTHERAPY AND ONCOLOGY (2019)

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Article Multidisciplinary Sciences

A Super-Learner Model for Tumor Motion Prediction and Management in Radiation Therapy: Development and Feasibility Evaluation

Hui Lin, Wei Zou, Taoran Li, Steven J. Feigenberg, Boon-Keng K. Teo, Lei Dong

SCIENTIFIC REPORTS (2019)

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Article Engineering, Biomedical

Ionization quenching correction for a 3D scintillator detector exposed to scanning proton beams

Fahed Alsanea, Chinmay Darne, Daniel Robertson, Sam Beddar

PHYSICS IN MEDICINE AND BIOLOGY (2020)

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Article Engineering, Biomedical

Computational model for detector timing effects in Compton-camera based prompt-gamma imaging for proton radiotherapy

Paul Maggi, Steve Peterson, Rajesh Panthi, Dennis Mackin, Hao Yang, Zhong He, Sam Beddar, Jerimy Polf

PHYSICS IN MEDICINE AND BIOLOGY (2020)

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Article Engineering, Biomedical

Image quality evaluation of projection- and depth dose-based approaches to integrating proton radiography using a monolithic scintillator detector

Irwin Tendler, Daniel Robertson, Chinmay Darne, Rajesh Panthi, Fahed Alsanea, Charles-Antoine Collins-Fekete, Sam Beddar

Summary: The study compared the image quality of an integrating proton radiography system using different reconstruction techniques, finding that single-event reconstruction had the highest spatial resolution and particle tracking method had the best contrast levels. The results indicate that the image quality of the integrating proton radiography system is promising for potential clinical applications.

PHYSICS IN MEDICINE AND BIOLOGY (2021)

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Article Radiology, Nuclear Medicine & Medical Imaging

Development of Ultra-High Dose-Rate (FLASH) Particle Therapy

Michele M. Kim, Arash Darafsheh, Jan Schuemann, Ivana Dokic, Olle Lundh, Tianyu Zhao, Jose Ramos-Mendez, Lei Dong, Kristoffer Petersson

Summary: Research on FLASH radiotherapy (FLASH-RT) has been progressing rapidly recently, with a focus on different modalities, physical aspects, treatment planning, and unresolved questions regarding safe clinical implementation. Studies have shown that FLASH-RT can reduce toxicity to normal tissue while maintaining tumor response, but challenges remain in translating these findings into clinical practice.

IEEE TRANSACTIONS ON RADIATION AND PLASMA MEDICAL SCIENCES (2022)

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Article Radiology, Nuclear Medicine & Medical Imaging

Advanced Topics in Particle Radiotherapy

Kyung-Wook Jee, Thomas Bortfeld, Issam El Naqa, Lei Dong

Summary: This special issue collects and presents research and developmental works in the forefront of particle radiotherapy (pRT) investigations. It focuses on seven subfields that represent recent advances in medical physics communities, including ultrahigh dose rate (FLASH) particle therapy, online adaptive particle therapy, MR-particle RT systems, compact, affordable, and accessible particle RT systems, range uncertainty reduction, range verification, and artificial intelligence in particle therapy. The editorial provides visionary perspectives on each subfield's present activities and future research directions, along with a synopsis of the published articles pertaining to each subfield.

IEEE TRANSACTIONS ON RADIATION AND PLASMA MEDICAL SCIENCES (2022)

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Article Radiology, Nuclear Medicine & Medical Imaging

The Effects of Compton Camera Data Acquisition and Readout Timing on PG Imaging for Proton Range Verification

Jerimy C. Polf, Paul Maggi, Rajesh Panthi, Stephen Peterson, Dennis Mackin, Sam Beddar

Summary: The purpose of this study was to investigate how the characteristics of the data acquisition electronics of a Compton camera affect the quality of the recorded prompt gamma interaction data and reconstructed images during clinical proton beam delivery. The study used a simulation model to analyze the changes in recorded data as the number of data readout channels and the readout/reset timing were altered. The findings showed that increasing the number of readout channels and reducing the readout/reset timing resulted in a decrease in the number of recorded events and an improvement in data quality, allowing for higher quality image reconstruction even at high clinical dose rates.

IEEE TRANSACTIONS ON RADIATION AND PLASMA MEDICAL SCIENCES (2022)

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Article Radiology, Nuclear Medicine & Medical Imaging

Evaluation of Two-Voltage and Three-Voltage Linear Methods for Deriving Ion Recombination Correction Factors in Proton FLASH Irradiation

Lingshu Yin, Wei Zou, Michele M. Kim, Stephen M. Avery, Rodney D. Wiersma, Boon-Keng K. Teo, Lei Dong, Eric S. Diffenderfer

Summary: This study investigates the response of ion chambers to proton beams at ultrahigh dose rates and finds that some ion chambers demonstrate adequate ion collection efficiency, while others exhibit significant ion recombination correction.

IEEE TRANSACTIONS ON RADIATION AND PLASMA MEDICAL SCIENCES (2022)

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Article Chemistry, Analytical

Characterization of the Plastic Scintillator Detector System Exradin W2 in a High Dose Rate Flattening-Filter-Free Photon Beam

Sara Thrower, Surendra Prajapati, Shannon Holmes, Emil Schuler, Sam Beddar

Summary: This study investigates the performance of the W2 scintillator compared to ion chambers for small field dosimetry. The results show excellent agreement between the two detectors in terms of beam profiles and percent depth dose curves. It is also demonstrated that the ion recombination effect of ion chambers can be adequately corrected using the two-voltage method.

SENSORS (2022)

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Article Radiology, Nuclear Medicine & Medical Imaging

Secondary Particle Interactions in a Compton Camera Designed for in vivo Range Verification of Proton Therapy

Rajesh Panthi, Paul Maggi, Stephen Peterson, Dennis Mackin, Jerimy Polf, Sam Beddar

Summary: This study used Geant4 software to simulate the interactions of secondary particles in a Compton camera during the delivery of clinical proton beams. The results showed that for a 150-MeV proton beam, the majority of secondary particles reaching the camera modules were gamma rays, neutrons, and electrons, with a high percentage interacting with the modules. Strategies for reducing neutron backgrounds and non-PG radiation are needed for proton range verification using CCs.

IEEE TRANSACTIONS ON RADIATION AND PLASMA MEDICAL SCIENCES (2021)

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Article Oncology

Initial Clinical Experience Treating Patients With Gynecologic Cancers on a 6MV Flattening Filter Free O-Ring Linear Accelerator

Andrew R. Barsky, Michele M. Kim, Alexandra Dreyfuss, Lei Dong, James M. Metz, Shibu Anamalayil, Taoran Li, Neil K. Taunk

ADVANCES IN RADIATION ONCOLOGY (2020)

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Article Oncology

Increase in Superficial Dose in Whole-Breast Irradiation With Halcyon Straight-Through Linac Compared With Traditional C-arm Linac With Flattening Filter: In vivo Dosimetry and Planning Study

Fionnbarr O'Grady, Andrew R. Barsky, Shibu Anamalayil, Gary M. Freedman, Christopher Kennedy, Bin Cai, Eric Laugeman, Lei Dong, Geoffrey D. Hugo, James M. Metz, Sasa Mutic, Neil K. Taunk, Taoran Li

ADVANCES IN RADIATION ONCOLOGY (2020)

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Proceedings Paper Engineering, Biomedical

Novel direct conversion imaging detector without selenium or semiconductor conversion layer

Denny L. Lee, Andrew Maidment, Ali Kassaee, Lei Dong, Taoran Li, Trevor Vent, Heather Petroccia, Peyton Irmen, Irina Malajovich, Kang Heo, Dooho Kim, Hyunsuk Jang

MEDICAL IMAGING 2019: PHYSICS OF MEDICAL IMAGING (2019)

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