Article
Clinical Neurology
Elia Sechi, Marina Buciuc, Sean J. Pittock, John J. Chen, James P. Fryer, Sarah M. Jenkins, Adrian Budhram, Brian G. Weinshenker, A. Sebastian Lopez-Chiriboga, Jan-Mendelt Tillema, Andrew McKeon, John R. Mills, W. Oliver Tobin, Eoin P. Flanagan
Summary: This study investigated the positive predictive value of myelin oligodendrocyte glycoprotein (MOG)-IgG1 testing in a single tertiary referral center, revealing a PPV of 72% with variations depending on antibody titer and clinical phenotypes at testing.
Article
Gastroenterology & Hepatology
Jordan K. Voss, Derek W. Ebner, Keli N. Burger, Douglas W. Mahoney, Mary E. Devens, Kari L. Lowrie, John B. Kisiel
Summary: Multitarget stool DNA (mt-sDNA) testing is an effective screening method for colorectal cancer. The positive rate and positive predictive value (PPV) of mt-sDNA were examined in a second round of testing and found to be similar to those in the first round. These findings confirm the usefulness of mt-sDNA for CRC screening.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Nan Guo, Meiying Cai, Min Lin, Huili Xue, Hailong Huang, Liangpu Xu
Summary: Early and intermediate serological screening cannot detect sex chromosome abnormalities. Noninvasive prenatal testing (NIPT) is the only available procedure for screening such disorders. This study found that karyotype analysis and SNP array can improve the diagnostic accuracy for pregnant women with a positive NIPT result indicating sex chromosome abnormalities. The study also identified age-related differences in the positive predictive value.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Ecology
Kim I. Drager, Michael D. Rivera, Joshua C. Gibson, Selina A. Ruzi, Priscila E. Hanisch, Rafael Achury, Andrew V. Suarez
Summary: Associating morphological features with ecological traits is crucial for understanding the relationship between organisms and their environmental roles. However, functional trait data without natural history information provide an incomplete understanding of an organism's ecological role. In this study, we found that body size, relative eye position, and scape length were informative for predicting diet/trophic position in ant communities, albeit with relatively weak predictive values.
ECOLOGY AND EVOLUTION
(2023)
Article
Cardiac & Cardiovascular Systems
Anuradha Lala, Keyur B. Shah, David E. Lanfear, Jennifer T. Thibodeau, Maryse Palardy, Amrut Ambardekar, Dennis M. McNamara, Wendy C. Taddei-Peters, J. Timothy Baldwin, Neal Jeffries, Shokoufeh Khalatbari, Cathie Spino, Blair Richards, Douglas L. Mann, Garrick C. Stewart, Keith D. Aaronson, Donna M. Mancini
Summary: This study aimed to determine CPX predictors of outcomes at 1 year for patients with ambulatory advanced HF, finding that CP and VE/VCO2 were the strongest predictors of MCS implantation, transplantation, or death.
JACC-HEART FAILURE
(2021)
Review
Chemistry, Medicinal
Sheng Han, Yiming Lu
Summary: Human immunodeficiency virus (HIV) is the cause of acquired immunodeficiency syndrome (AIDS). The FDA has approved over thirty antiretroviral drugs, one-third of which contain fluorine atoms. The addition of fluorine to drug compounds is a well-known strategy in medicinal chemistry. This review summarizes 11 fluorine-containing anti-HIV drugs, focusing on their efficacy, resistance, safety, and the role of fluorine in their development. These examples may aid in the discovery of new drug candidates with fluorine-containing structures.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Cardiac & Cardiovascular Systems
Edoardo Bertero, Giulia Fracasso, Virginia Eustachi, Domenico Coviello, Massimiliano Cecconi, Stefano Giovinazzo, Matteo Toma, Marco Merlo, Gianfranco Sinagra, Italo Porto, Pietro Ameri, Marco Canepa
Summary: This study aims to assess the diagnostic yield of genetic testing and the relationship between left ventricular reverse remodelling (LVRR) and DNA pathogenic or likely pathogenic variants in patients with dilated cardiomyopathy (DCM). The results showed a diagnostic yield of 24% for genetic testing, and patients without genetic variants had a better LVRR response to guideline-directed medical therapy.
Article
Infectious Diseases
Jordan P. Skittrall, Michael Wilson, Anna A. Smielewska, Surendra Parmar, Mary D. Fortune, Dominic Sparkes, Martin D. Curran, Hongyi Zhang, Hamid Jalal
Summary: Confirmatory testing is crucial for reducing false positive results and improving specificity and positive predictive value of SARS-CoV-2 testing. Results of the study suggest that in low prevalence settings, confirmatory testing significantly reduces the detection of false positives.
CLINICAL MICROBIOLOGY AND INFECTION
(2021)
Review
Pharmacology & Pharmacy
Daniel L. Hertz, D. Max Smith, Stuart A. Scott, Jai N. Patel, J. Kevin Hicks
Summary: FP chemotherapy has severe toxicities for patients with DPYD gene variants. DPYD testing is standard in Europe but not recommended in the US. The FDA updated the capecitabine package insert to inform patients about the toxicity risk and test availability, but without specific recommendations for testing or dose adjustment. It is important for the FDA to follow European recommendations and promote DPYD testing and genotype-based dose adjustment.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Health Care Sciences & Services
Rachael Muinde, Kevin Owuor, Jones Mutiso, Jonathan Mwangi, Paul Wekesa
Summary: This study analyzed data from six health facilities in central Kenya and identified non-clinical and clinical characteristics that influence HIV testing, such as age, marital status, test entry point, first-time and repeat testing, and tuberculosis status. These findings can be used to develop screening tools for targeted HIV testing in low prevalence settings.
BMC HEALTH SERVICES RESEARCH
(2023)
Review
Anesthesiology
Ana Cristina Paredes, Joana Milhazes Pinto, Armando Almeida, Patricia R. Pinto
Summary: Quantitative sensory testing (QST) can be useful in identifying high-risk patients for chronic postsurgical pain, but the association between presurgical QST and acute and chronic postsurgical pain after total joint arthroplasty remains unclear.
Article
Biochemistry & Molecular Biology
Christopher Heng Xuan Ha, Nung Kion Lee, Taufiq Rahman, Siaw San Hwang, Wai Keat Yam, Xavier Wezen Chee
Summary: This study demonstrates the use of regression QSAR modeling to predict the activity of INSTIs and applies the models to drug repositioning. The top-ranked compounds are further evaluated for their target engagement activity using molecular docking and accelerated Molecular Dynamics simulation, and their potential as INSTIs is assessed through literature search.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Infectious Diseases
Paul Little, Robert C. Read, Taeko Becque, Nick A. Francis, Alastair D. Hay, Beth Stuart, Gilly O'Reilly, Natalie Thompson, Kerenza Hood, Saul Faust, Kay Wang, Michael Moore, Theo Verheij
Summary: The study found that the presence of bacteria or viruses in the upper airway of children with lower respiratory tract infection did not predict the benefit of antibiotic treatment. Regardless of the presence of potentially antibiotic-susceptible bacteria, antibiotics did not show a significant improvement in the duration of symptoms. More validating trials are needed before using microbiologic point-of-care tests for children with uncomplicated lower respiratory tract infection in primary care.
CLINICAL MICROBIOLOGY AND INFECTION
(2022)
Review
Obstetrics & Gynecology
Melissa L. Acreman, Sofia Bussolaro, Yvette C. Raymond, Ilaria Fantasia, Daniel L. Rolnik, Fabricio Da Silva Costa
Summary: This study conducted a systematic review and meta-analysis to determine the predictive value of cell-free DNA in screening for rare autosomal trisomies, finding that the positive predictive value is approximately 11%.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Nicholas R. Hess, Laura M. Seese, Gavin W. Hickey, Mary E. Keebler, Yisi Wang, Floyd Thoma, Arman Kilic
Summary: The presence of abnormal preoperative PFTs in LVAD patients is associated with increased risk of respiratory adverse events and mortality, especially when the FEV1/FVC ratio is less than 0.5. However, abnormal PFTs are not a contraindication for LVAD implantation and can be used for risk stratification. Careful patient selection is crucial in higher-risk subsets of patients.
JOURNAL OF CARDIAC SURGERY
(2021)
Article
Immunology
Eric L. Ross, Milton C. Weinstein, Bruce R. Schackman, Paul E. Sax, A. David Paltiel, Rochelle P. Walensky, Kenneth A. Freedberg, Elena Losina
CLINICAL INFECTIOUS DISEASES
(2015)
Article
Immunology
Michael P. Girouard, Paul E. Sax, Robert A. Parker, Babafemi Taiwo, Kenneth A. Freedberg, Roy M. Gulick, Milton C. Weinstein, A. David Paltiel, Rochelle P. Walensky
CLINICAL INFECTIOUS DISEASES
(2016)
Article
Immunology
Rochelle P. Walensky, Tim H. Horn, A. David Paltiel
CLINICAL INFECTIOUS DISEASES
(2016)
Article
Infectious Diseases
Pamela P. Pei, Milton C. Weinstein, X. Cynthia Li, Michael D. Hughes, A. David Paltiel, Taige Hou, Robert A. Parker, Melanie R. Gaynes, Paul E. Sax, Kenneth A. Freedberg, Bruce R. Schackman, Rochelle P. Walensky
HIV CLINICAL TRIALS
(2015)
Article
Immunology
Rochelle P. Walensky, Margo M. Jacobsen, Linda-Gail Bekker, Robert A. Parker, Robin Wood, Stephen C. Resch, N. Kaye Horstman, Kenneth A. Freedberg, A. David Paltiel
JOURNAL OF INFECTIOUS DISEASES
(2016)
Article
Medicine, General & Internal
Rochelle P. Walensky, Ethan D. Borre, Linda-Gail Bekker, Stephen C. Resch, Emily P. Hyle, Robin Wood, Milton C. Weinstein, Andrea L. Ciaranello, Kenneth A. Freedberg, A. David Paltiel
ANNALS OF INTERNAL MEDICINE
(2016)
Article
Immunology
Eric N. Ouattara, Marion Robine, Serge P. Eholie, Rachel L. MacLean, Raoul Moh, Elena Losina, Delphine Gabillard, A. David Paltiel, Christine Danel, Rochelle P. Walensky, Xavier Anglaret, Kenneth A. Freedberg
CLINICAL INFECTIOUS DISEASES
(2016)
Article
Immunology
Krishna P. Reddy, Robert A. Parker, Elena Losina, Travis P. Baggett, A. David Paltiel, Nancy A. Rigotti, Milton C. Weinstein, Kenneth A. Freedberg, Rochelle P. Walensky
JOURNAL OF INFECTIOUS DISEASES
(2016)
Article
Orthopedics
J. N. Katz, S. R. Smith, J. E. Collins, D. H. Solomon, J. M. Jordan, D. J. Hunter, L. G. Suter, E. Yelin, A. D. Paltiel, E. Losina
OSTEOARTHRITIS AND CARTILAGE
(2016)
Article
Orthopedics
E. Losina, G. Michl, J. E. Collins, D. J. Hunter, J. M. Jordan, E. Yelin, A. D. Paltiel, J. N. Katz
OSTEOARTHRITIS AND CARTILAGE
(2016)
Article
Biology
Alyssa M. Bilinski, Meagan C. Fitzpatrick, Charles E. Rupprecht, A. David Paltiel, Alison P. Galvani
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2016)
Article
Immunology
Paula M. Luz, Michael P. Girouard, Beatriz Grinsztejn, Kenneth A. Freedberg, Valdilea G. Veloso, Elena Losina, Claudio J. Struchiner, Rachel L. MacLean, Robert A. Parker, A. David Paltiel, Rochelle P. Walensky
JOURNAL OF THE INTERNATIONAL AIDS SOCIETY
(2016)
Article
Immunology
Gregg S. Gonsalves, A. David Paltiel, Paul D. Cleary, Michael J. Gill, Mari M. Kitahata, Peter F. Rebeiro, Michael J. Silverberg, Michael Horberg, Alison G. Abraham, Keri N. Althoff, Richard Moore, Ronald J. Bosch, Tian Tang, H. Irene Hall, Edward H. Kaplan
JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES
(2017)
Article
Immunology
Marina Antillon, Joke Bilcke, A. David Paltiel, Virginia E. Pitzer
Article
Multidisciplinary Sciences
Jennifer A. Gilbert, Sheela V. Shenoi, Anthony P. Moll, Gerald H. Friedland, A. David Paltiel, Alison P. Galvani