Letter
Clinical Neurology
Harriet Demnitz-King, Natalie L. Marchant
Summary: This study responds to Dr. Daly's query on the social determinants of brain health and finds that the association between self-reflection and AD-sensitive markers remains even after adjusting for education.
Letter
Clinical Neurology
Aravind Ganesh, Steven Galetta
Summary: The study found an association between self-reflection and better cognitive ability and glucose metabolism in older adults. However, further longitudinal and experimental studies are needed to clarify the specific impact of self-reflection on cognition and glucose metabolism.
Review
Nutrition & Dietetics
Mickeal N. Key, Amanda N. Szabo-Reed
Summary: Preserving cognitive function and protecting brain structure during aging and neurodegenerative diseases is the goal of non-pharmacologic interventions, such as diet and exercise. This review examines the current trends of diet and exercise interventions and their impact on cognition and brain health. Various diets, including the Mediterranean diet, DASH, MIND, ketogenic diet, intermittent fasting, and weight loss management, as well as exercise approaches such as endurance, resistance, combined programs, yoga, tai chi, and high-intensity interval training, are discussed. While evidence is accumulating regarding the influence of diet and exercise on cognitive performance and brain structure, more research is needed to understand the underlying mechanisms.
Article
Geriatrics & Gerontology
Alba Castells-Sanchez, Francesca Roig-Coll, Rosalia Dacosta-Aguayo, Noemi Lamonja-Vicente, Angelika K. Sawicka, Pere Toran-Monserrat, Guillem Pera, Pilar Montero-Alia, Antonio Heras-Tebar, Sira Domenech, Marc Via, Kirk Erickson, Maria Mataro
Summary: This study examined the relationship between physical activity and cognitive health in adults aged 50-70. Results showed that women who engaged in more exercise had lower TNF-alpha levels and greater brain volumes, while men had greater brain volumes with increased exercise levels. Higher cardiorespiratory fitness in men was associated with lower inflammation levels and greater brain volumes, highlighting the potential benefits of exercise on brain health.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Review
Geriatrics & Gerontology
Junxin Li, Miranda McPhillips, Zhongyue Deng, Fangfang Fan, Adam Spira
Summary: This systematic review explores the association between daytime napping and cognitive function in older adults. Observational studies suggest a U-shaped relationship between napping duration and cognitive function, with moderate napping benefiting cognitive health compared to no napping or long napping. Intervention studies indicate that a single session of afternoon napping may improve psychomotor function and working memory, but more research is needed on the effects of multiple napping sessions.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Goretti Espana-Irla, Joyce Gomes-Osman, Gabriele Cattaneo, Sergiu Albu, Maria Cabello-Toscano, Javier Solana-Sanchez, Maria Redondo-Camos, Selma Delgado-Gallen, Vanessa Alviarez-Schulze, Catherine Pachon-Garcia, Josep M. Tormos, David Bartres-Faz, Timothy P. Morris, Alvaro Pascual-Leone
Summary: The study found differential associations among cardiorespiratory fitness, cardiovascular risk, cognition, and cortical thickness in middle-aged adults. Higher cardiorespiratory fitness was associated with better cognitive functions, while cardiovascular risk was negatively associated with cognitive abilities. The relationships between modifiable cardiovascular factors and cognition were mediated by brain structure, highlighting the importance of maintaining cardiovascular health for cognitive function in midlife.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Review
Nutrition & Dietetics
Jacob M. M. Eubank, Douglas J. J. Oberlin, Andrew Alto, Nadine R. R. Sahyoun, Elmira Asongwed, Lillie Monroe-Lord, Elgloria A. A. Harrison
Summary: The onset of dementia and Alzheimer's disease is expected to increase in the United States as the population ages, with Hispanics and African Americans being at higher risk. Lifestyle factors such as social engagement, physical activity, dietary intake, sleep, and stress are related to cognitive decline, but research in minority populations is limited.
FRONTIERS IN NUTRITION
(2022)
Review
Physiology
Michelle W. Voss, Shivangi Jain
Summary: Physical activity has great potential for combating cognitive aging, but the cognitive benefits vary greatly. This article discusses the evidence of how exercise affects cognitive and brain aging, and whether cardiorespiratory fitness is a crucial factor. The brain network framework is highlighted as a valuable paradigm for understanding the mechanisms behind cognitive benefits and tailoring physical activity accordingly.
Article
Hospitality, Leisure, Sport & Tourism
Tatsuya T. Shigeta, Angus A. Leahy, Jordan J. Smith, Narelle Eather, David R. Lubans, Charles H. Hillman
Summary: The study indicated that cardiorespiratory fitness (CRF) is more closely related to cognitive control in older adolescents, contributing to better performance in tasks requiring more inhibition and working memory.
JOURNAL OF SPORT AND HEALTH SCIENCE
(2021)
Article
Geriatrics & Gerontology
Min Fang, Keri Strand, Juan Zhang, Matthew Totillo, Joseph F. Signorile, James E. Galvin, Jianhua Wang, Hong Jiang
Summary: The study revealed a correlation between retinal vessel density and MoCA cognitive scores in healthy older adults with no reported cognitive decline, while no correlation was found between MMSE cognitive scores and retinal vessel densities or physical fitness.
EXPERIMENTAL GERONTOLOGY
(2021)
Article
Geriatrics & Gerontology
Beatriz Fernandez-Gamez, P. Solis-Urra, M. Olvera-Rojas, C. Molina-Hidalgo, J. Fernandez-Ortega, C. P. Lara, A. Coca-Pulido, D. Bellon, A. Sclafani, J. Mora-Gonzalez, A. Toval, I. Martin-Fuentes, E. A. Bakker, R. M. Lozano, S. Navarrete, D. Jimenez-Pavon, T. Liu-Ambrose, K. I. Erickson, F. B. Ortega, Irene Esteban-Cornejo
Summary: This study provides a comprehensive description of the resistance exercise program implemented in the AGUEDA study. The exercise program consisted of a combination of upper and lower limb exercises using elastic bands and the participant's own body weight as resistance. The feasibility of the program was evaluated and it was found to be feasible with high retention and attendance rates, low adverse events, and low economic cost. It is predicted that a 24-week resistance exercise program will have positive effects on brain health in cognitively normal older adults.
JOURNAL OF NUTRITION HEALTH & AGING
(2023)
Article
Psychology, Multidisciplinary
David Predovan, Nicolas Berryman, Maxime Lussier, Francis Comte, Thien Tuong Minh Vu, Juan Manuel Villalpando, Louis Bherer
Summary: The study found that cardiorespiratory fitness estimates are associated with executive function performance in healthy older adults, particularly in terms of global switch costs, while associations with local switch costs or updating costs are not significant.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Neurosciences
Galit Yogev-Seligmann, Tamir Eisenstein, Elissa Ash, Nir Giladi, Haggai Sharon, Shikma Nachman, Noa Bregman, Einat Kodesh, Talma Hendler, Yulia Lerner
Summary: This study explored the effects of aerobic exercise intervention and cardiorespiratory fitness improvement on brain and cognitive functions in older adults with amnestic mild cognitive impairment. The results showed increased brain activity and neural synchronization in the aerobic group, while the control group demonstrated decreased brain activity during memory encoding. Increases in cardiorespiratory fitness were associated with improvements in brain activation and performance on neuropsychological tests.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Geriatrics & Gerontology
Pei-Lun Kuo, Yang An, Alden L. Gross, Qu Tian, Vadim Zipunnikov, Adam P. Spira, Amal A. Wanigatunga, Eleanor M. Simonsick, Luigi Ferrucci, Susan M. Resnick, Jennifer A. Schrack
Summary: This study found a link between energy utilisation and cognitive performance, with higher energy utilisation associated with poorer cognitive functioning. These findings highlight an intriguing connection between brain function and the energy needed for walking.
Article
Neurosciences
Spencer Loong, Samuel Barnes, Nicole M. Gatto, Shilpy Chowdhury, Grace J. Lee
Summary: The elderly population is growing rapidly, and the nutrients associated with omega-3 FAs in healthy foods and diets are significantly related to cognition and brain health. This study found that increased levels of omega-3 FAs are associated with improved memory, processing speed, and brain structure in healthy older adults.
Meeting Abstract
Geriatrics & Gerontology
Mercedes M. Rodriguez-Suarez, Abhilash Desai, George T. Grossberg
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
(2013)
Article
Geriatrics & Gerontology
Raman K. Malhotra, Abhilash K. Desai
CLINICS IN GERIATRIC MEDICINE
(2010)
Article
Geriatrics & Gerontology
Abhilash K. Desai, George T. Grossberg, John T. Chibnall
CLINICS IN GERIATRIC MEDICINE
(2010)
Letter
Geriatrics & Gerontology
Abhilash K. Desai, Susan H. McFadden
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2013)
Article
Psychiatry
Abhilash K. Desai, Lori Schwartz, George T. Grossberg
CURRENT PSYCHIATRY REPORTS
(2012)
Article
Geriatrics & Gerontology
Abhilash K. Desai, Faith Galliano Desai
CURRENT GERIATRICS REPORTS
(2014)
Review
Geriatrics & Gerontology
AK Desai
CLINICS IN GERIATRIC MEDICINE
(2003)
Article
Geriatrics & Gerontology
AK Desai, GT Grossberg
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
(2003)
Article
Medicine, General & Internal
Jeanne E. Conner, Joshua A. Steinberg
Summary: Diagnosis of anaphylaxis should involve comprehensive consideration, including detailed history and objective findings. Using diagnostic criteria and considering rare triggers, as well as evaluating for mast cell disorders, can aid in the diagnosis. Referral to specialists may be necessary.
MEDICAL CLINICS OF NORTH AMERICA
(2024)
Article
Medicine, General & Internal
Alejandra Escobar Vasco, Julie -Ann Talano, Larisa Broglie
Summary: HLH is a rare but fatal disease, and maintaining a high level of suspicion is crucial for patients with evidence of hyperinflammation. Adolescents with HLH should undergo genetic evaluation for familial HLH, and primary immune deficiencies and dysregulation disorders should also be considered. Early diagnosis and treatment are necessary to prevent morbidity and mortality related to HLH's hyperinflammation.
MEDICAL CLINICS OF NORTH AMERICA
(2024)
Article
Medicine, General & Internal
Kathleen Ryan
Summary: Fevers of unknown origin (FUO) present a diagnostic challenge, with a wide range of potential causes including infectious, autoimmune, and malignant. Some adolescents with FUO may never have an identifiable etiology, but the prognosis is generally favorable in the absence of red flag symptoms.
MEDICAL CLINICS OF NORTH AMERICA
(2024)
Article
Medicine, General & Internal
Brett J. Bordini, Ryan D. Walsh, Donald Basel, Tejaswini Deshmukh
MEDICAL CLINICS OF NORTH AMERICA
(2024)
Article
Medicine, General & Internal
Hsi Yen, Leah Lalor
Summary: The article emphasizes the importance of increased awareness among healthcare providers when faced with severe adolescent acne that may not be typical teenage acne. It provides a summary of uncommon causes of severe adolescent acne and a simplified diagnostic approach. Additionally, it discusses rare autoinflammatory syndromic causes of acne and acne associated with excess androgen states.
MEDICAL CLINICS OF NORTH AMERICA
(2024)
Article
Medicine, General & Internal
Bethany Auble, Justin Dey
MEDICAL CLINICS OF NORTH AMERICA
(2024)
Article
Medicine, General & Internal
Kaitlin V. Kirkpatrick, James J. Nocton
MEDICAL CLINICS OF NORTH AMERICA
(2024)
Article
Medicine, General & Internal
Louella Amos
MEDICAL CLINICS OF NORTH AMERICA
(2024)
Article
Medicine, General & Internal
Tracey Thompson, Ashley Phimister, Alexander Raskin
Summary: Heart failure occurs as a result of pressure or volume overload in congenital and acquired heart diseases, and its treatment varies depending on the underlying cause.
MEDICAL CLINICS OF NORTH AMERICA
(2024)
Article
Medicine, General & Internal
Allison Remiker, Kristina Bolling, James Verbsky
Summary: CVID is a heterogeneous group of disorders characterized by abnormal B-cell differentiation and impaired production of specific immunoglobulin. Clinical manifestations vary and include recurrent bacterial infections, lymphoproliferation, autoimmunity, pulmonary disease, gastrointestinal disease, granulomas, and increased cancer risk. The diagnosis of CVID is complex, requiring exclusion of other causes of immunoglobulin deficiency and assessment based on clinical criteria models. Treatment involves regular immunoglobulin replacement therapy, infection prevention, and surveillance for complications.
MEDICAL CLINICS OF NORTH AMERICA
(2024)
Article
Medicine, General & Internal
Bridget A. Rafferty, Pooja Thakrar
Summary: CNO/CRMO is an underrecognized autoinflammatory disorder of the skeletal system resulting from immune dysregulation. Diagnosis is often delayed due to vague symptoms and the lack of accepted diagnostic criteria or specific biomarkers. Untreated CRMO can lead to chronic skeletal deformities, arthritis, and chronic pain. Diagnosis requires MRI and WB-MRI. Treatment primarily involves antiinflammatory medications.
MEDICAL CLINICS OF NORTH AMERICA
(2024)
Article
Medicine, General & Internal
Vaishali Singh, Scott K. Van Why
Summary: Hypertension in adolescents is rare, and evaluation for identifiable causes beyond primary hypertension is necessary. Common causes of hypertension in this age group are usually acquired or congenital renal or vascular diseases. If these etiologies are not found, exploration for rare causes, including monogenic hypertension, should be pursued.
MEDICAL CLINICS OF NORTH AMERICA
(2024)
Article
Medicine, General & Internal
Dominic O. Co
Summary: Acquired demyelinating syndromes (ADS) are a group of inflammatory demyelinating conditions that include optic neuritis, transverse myelitis, and acute demyelinating encephalomyelitis. Differentiating between subtypes of ADS is important for optimal patient management, and this can be achieved by considering clinical features, laboratory tests (especially autoantibodies), and MRI findings.
MEDICAL CLINICS OF NORTH AMERICA
(2024)
Article
Medicine, General & Internal
Meghan K. Konda, Matthew Harmelink
Summary: Pediatric adolescent muscle weakness can have various causes. A methodical diagnostic evaluation is necessary to determine the specific disease category, which may require specialized care or extensive testing. The ultimate diagnosis is crucial for prognostication.
MEDICAL CLINICS OF NORTH AMERICA
(2024)
