Journal
MEDICAL CARE
Volume 47, Issue 7, Pages S115-S119Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/MLR.0b013e31819bc08a
Keywords
identifiability; induced dependent censoring; lifetime medical cost; statistical method; time-restricted medical cost
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Funding
- NCI NIH HHS [HHSN261200700148M] Funding Source: Medline
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Economic evaluation of medical interventions has become an accepted, and often required, adjunct to the standard effectiveness and safety assessment in clinical research. However, the statistical analysis can be challenging due to censored cost data, as commonly obtained in medical studies. Over the past decade, important statistical issues that arise from censored cost data have been identified and a number of advances made to tackle them. In this article, we will describe these issues, including induced dependent censoring and limited identifiability with the cost distribution, and review recent statistical developments. Available methods address either time-restricted medical cost or lifetime medical cost jointly with Survival time. Their applicability and limitation in various practical situations will be discussed.
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