Article
Clinical Neurology
Charles F. Yates, Kate Riney, Stephen Malone, Ubaid Shah, Liam G. Coulthard, Robert Campbell, Geoff Wallace, Martin Wood
Summary: A study evaluated the outcomes and complications of VNS therapy in a large pediatric cohort in Queensland over a 20-year period, finding that a majority of patients benefited significantly from VNS therapy over extended treatment periods. Most patients retained VNS therapy long-term, with cessation mainly related to minimal benefit, and patient demographics did not influence outcomes.
ACTA NEUROCHIRURGICA
(2022)
Review
Veterinary Sciences
Marta Nowakowska, Muammer uecal, Marios Charalambous, Sofie F. M. Bhatti, Timothy Denison, Sebastian Meller, Gregory A. Worrell, Heidrun Potschka, Holger A. Volk
Summary: Neurostimulation methods have shown promising results in controlling seizures and improving the quality of life for patients with drug-resistant epilepsy. This comprehensive review focuses on the available neurostimulation methods for managing seizures in dogs, with highlights on recent progress in non-invasive modalities.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Clinical Neurology
Yasushi Iimura, Hiroharu Suzuki, Takumi Mitsuhashi, Tetsuya Ueda, Kazuki Nishioka, Kou Horikoshi, Kazuki Nomura, Hidenori Sugano, Akihide Kondo
Summary: This study retrospectively reviewed 136 patients with drug-resistant epilepsy who underwent VNS implantation, and found that approximately 56% of patients showed at least a 50% reduction in seizure frequency after VNS implantation. The study results suggest that generalized seizure is the most responsive to VNS, and that VNS may reduce the risk of recurrence of status epilepticus.
FRONTIERS IN NEUROLOGY
(2023)
Article
Neurosciences
Jiayi Ma, Zhiyan Wang, Tungyang Cheng, Yingbing Hu, Xiaoya Qin, Wen Wang, Guojing Yu, Qingzhu Liu, Taoyun Ji, Han Xie, Daqi Zha, Shuang Wang, Zhixian Yang, Xiaoyan Liu, Lixin Cai, Yuwu Jiang, Hongwei Hao, Jing Wang, Luming Li, Ye Wu
Summary: This study established the first prediction model integrating clinical and baseline synchronization features for preoperative VNS responder screening among children with DRE. The findings of this research are important for predicting VNS efficacy in pediatric epilepsy patients.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Medicine, General & Internal
Ming Shan, Hongliang Mao, Hutao Xie, Yifei Gan, Delong Wu, Jian Song, Yutong Bai, Jianguo Zhang
Summary: This study retrospectively evaluated the efficacy and safety of VNS in 45 patients with drug resistant epilepsy and explored potential prognostic factors. The results showed a significant decrease in seizure frequency after VNS treatment. No significant prognostic factors were identified in this study.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Clinical Neurology
Yaroslav Winter, Katharina Sandner, Martin Glaser, Dumitru Ciolac, Viktoria Sauer, Andreas Ziebart, Ali Karakoyun, Vitalie Chiosa, Assel Saryyeva, Joachim Krauss, Florian Ringel, Sergiu Groppa
Summary: This study aimed to identify the synergistic effects between VNS and different ASMs. The results showed that the combination of VNS with SV2A modulators or slow sodium channel inhibitors was associated with a better seizure reduction compared to other mechanisms of action. These preliminary data require further validation under controlled conditions.
JOURNAL OF NEUROLOGY
(2023)
Article
Neurosciences
Yulin Sun, Jian Chen, Tie Fang, Lin Wan, Xiuyu Shi, Jing Wang, Zhichao Li, Jiaxin Wang, Zhiqiang Cui, Xin Xu, Zhipei Ling, Liping Zou, Guang Yang
Summary: VNS has shown to be effective in reducing seizure frequency and severity in patients with refractory PEE. The effective rates at 3, 6, and 12 months post-operation were 30%, 45%, and 70% respectively, demonstrating promising outcomes for VNS in patients with refractory PEE.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Clinical Neurology
Alexandre Berger, Evelina Carapancea, Simone Vespa, Venethia Danthine, Pascal Doguet, Jean Delbeke, Antoine Nonclercq, Riem El Tahry
Summary: The objective of this study was to record Laryngeal Motor Evoked Potentials (LMEPs) in Vagus Nerve Stimulation (VNS)-implanted patients with Drug-Resistant Epilepsy (DRE). The characteristics of LMEPs were evaluated and compared between responders (R) and non-responders (NR). A Support Vector Machine (SVM) model was built to discriminate between R and NR based on LMEPs and dose-response curves features. The study suggests a possible link between vagus nerve recruitment characteristics and treatment effectiveness.
CLINICAL NEUROPHYSIOLOGY
(2023)
Article
Clinical Neurology
Mengyi Guo, Jing Wang, Chongyang Tang, Jiahui Deng, Jing Zhang, Zhonghua Xiong, Siqi Liu, Yuguang Guan, Jian Zhou, Feng Zhai, Guoming Luan, Tianfu Li
Summary: VNS therapy is effective and well-tolerated in patients with refractory HIE-induced epilepsy, with better effectiveness observed in patients without neonatal seizures or with a predominant seizure type of generalized onset.
THERAPEUTIC ADVANCES IN NEUROLOGICAL DISORDERS
(2022)
Article
Neurosciences
Henrique Jannuzzelli Pires do Prado, Lecio Figueira Pinto, Daniela Fontes Bezerra, Luciano de Paola, Francisco Arruda, Andrea Juliao de Oliveira, Tayla Taynan Romao, Vanessa Cristina Colares Lessa, Jonadab dos Santos Silva, Isabella D'Andrea-Meira
Summary: This retrospective study evaluated the use of vagus nerve stimulation (VNS) as an adjuvant therapy for drug-resistant epilepsy. The study found that 65.6% of patients experienced a seizure reduction of at least 50% after VNS implantation, with most patients achieving a reduction of 50-90% and 9 patients becoming seizure-free. Factors associated with a better response to VNS included no history of neurosurgery, focal interictal epileptiform activity, and a focal seizure pattern. Tumors were predictive of a better response, while vascular malformations and Lennox-Gastaut Syndrome were associated with a worse response.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Behavioral Sciences
Anna A. Feygina, Yana N. Koshelyaevskaya, Maxine Dibue, Kira V. Voronkova, Mikhail N. Klochkov, Nadezhda Y. Koroleva, Stanislav S. Ivanov, Ekaterina S. Bolshakova, Elza F. Fatykhova
Summary: This study conducted in Russia is the first multicenter evaluation of Vagus Nerve Stimulation Therapy for pediatric patients with drug-resistant epilepsy. The results demonstrate the safety and efficacy of VNS Therapy in decreasing seizure frequency and severity in the majority of patients.
BRAIN AND BEHAVIOR
(2023)
Article
Medicine, General & Internal
Dongyeop Kim, Taekyung Kim, Yoonha Hwang, Chae Young Lee, Eun Yeon Joo, Dae-Won Seo, Seung Bong Hong, Young-Min Shon
Summary: This study compares the directed transfer function (DTF) derived from scalp EEGs between responder and nonresponder groups with vagus-nerve stimulation (VNS) for drug-resistant epilepsy. The findings show that responders have similar DTF profiles to control group, while nonresponders exhibit increased connectivity measures. Furthermore, presurgical normal DTF profiles may predict good responsiveness to VNS.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Ahmet Sevki Taskiran, Mustafa Ergul
Summary: Thiamine has a preventative effect on PTZ-induced seizures in rats and PTZ-induced neurotoxicity in SH-SY5Y neuroblastoma cells, reducing oxidative stress and apoptosis.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Clinical Neurology
Hrishikesh Suresh, Karim Mithani, Karanbir Brar, Han Yan, Samuel Strantzas, Mike Vandenberk, Roy Sharma, Ivanna Yau, Christina Go, Elizabeth Pang, Elizabeth Kerr, Ayako Ochi, Hiroshi Otsubo, Puneet Jain, Elizabeth Donner, O. Carter Snead, George M. Ibrahim
Summary: This study retrospectively analyzed the intraoperative data of 7 children who received vagus nerve stimulation (VNS) treatment and found a strong negative correlation between SSEP amplitude and seizure reduction, revealing the mechanism of VNS and the importance of brainstem afferent circuitry within the Vagus Afferent Network (VagAN) for seizure responsiveness following VNS.
FRONTIERS IN NEUROLOGY
(2022)
Review
Clinical Neurology
Nathan A. Shlobin, Katherine Hofmann, Nathan T. Cohen, Mohamad Z. Koubeissi, William D. Gaillard, Chima O. Oluigbo
Summary: This study conducted a systematic review and individual patient data analysis to investigate the outcomes of deep brain stimulation (DBS) of the centromedian nucleus of the thalamus in patients with Lennox-Gastaut syndrome (LGS). The results showed that DBS can significantly reduce seizure frequency and improve functional ability in LGS patients. It is considered to be an effective and safe treatment option for LGS.
Article
Acoustics
Martin Andersen, Cooper Moore, Peter Sogaard, Daniel Friedman, Brett D. Atwater, Kristine Arges, Melissa LeFevre, Johannes J. Struijk, Joseph Kisslo, Samuel E. Schmidt, Olaf T. von Ramm
ULTRASOUND IN MEDICINE AND BIOLOGY
(2019)
Article
Cardiac & Cardiovascular Systems
S. E. Schmidt, S. Winther, B. S. Larsen, M. H. Groenhoej, L. Nissen, J. Westra, L. Frost, N. R. Holm, H. Mickley, F. H. Steffensen, J. Lambrechtsen, M. S. Norskov, J. J. Struijk, A. C. P. Diederichsen, M. Boettcher
INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING
(2019)
Article
Physiology
Parastoo Dehkordi, Farzad Khosrow-Khavar, Marco Di Rienzo, Omer T. Inan, Samuel E. Schmidt, Andrew P. Blaber, Kasper Sorensen, Johannes J. Struijk, Vahid Zakeri, Prospero Lombardi, Md Mobashir H. Shandhi, Mojtaba Borairi, John M. Zanetti, Kouhyar Tavakolian
FRONTIERS IN PHYSIOLOGY
(2019)
Article
Medicine, General & Internal
Christoffer Polcwiartek, Kristian Kragholm, Daniel J. Friedman, Brett D. Atwater, Claus Graff, Jonas B. Nielsen, Anders G. Holst, Johannes J. Struijk, Adrian Pietersen, Jesper H. Svendsen, Lars Kober, Peter Sogaard, Svend E. Jensen, Christian Torp-Pedersen, Steen M. Hansen
AMERICAN JOURNAL OF MEDICINE
(2020)
Article
Cardiac & Cardiovascular Systems
Jacob Melgaard, Johannes J. Struijk, Jurgen K. Kanters, Peter L. Sorensen, Claus Graff
JOURNAL OF ELECTROCARDIOLOGY
(2019)
Article
Sport Sciences
Kasper Sorensen, Mathias Krogh Poulsen, Dan Stieper Karbing, Peter Sogaard, Johannes Jan Struijk, Samuel Emil Schmidt
INTERNATIONAL JOURNAL OF SPORTS MEDICINE
(2020)
Article
Biophysics
Kim Munck, Kasper Sorensen, Johannes J. Struijk, Samuel E. Schmidt
PHYSIOLOGICAL MEASUREMENT
(2020)
Article
Acoustics
Martin S. Andersen, Cooper Moore, Melissa Lefevre, Kristine Arges, Daniel J. Friedman, Brett D. Atwater, Joseph Kisslo, Peter Sogaard, Johannes J. Struijk, Olaf T. von Ramm, Samuel E. Schmidt
ULTRASOUND IN MEDICINE AND BIOLOGY
(2020)
Correction
Multidisciplinary Sciences
Kasper Sorensen, Samuel E. Schmidt, Ask S. Jensen, Peter Sogaard, Johannes J. Struijk
SCIENTIFIC REPORTS
(2020)
Article
Biophysics
Bjarke Skogstad Larsen, Simon Winther, Louise Nissen, Axel Diederichsen, Morten Bottcher, Johannes Jan Struijk, Mads Graesboll Christensen, Samuel Emil Schmidt
Summary: This study aimed to find spectral differences in heart sound recordings between patients with coronary artery disease (CAD) and healthy subjects. Analysis revealed increased energy at certain frequencies in the diastole and systole segments of CAD patients, as well as differences in the mid-S1 and mid-S2 segments. The time-frequency spectra of S1 and S2 segments indicated potential for untapped information for risk assessment of CAD using phonocardiography.
PHYSIOLOGICAL MEASUREMENT
(2021)
Article
Cardiac & Cardiovascular Systems
Samuel Emil Schmidt, Lene Helleskov Madsen, John Hansen, Henrik Zimmermann, Henning Kelbaek, Simon Winter, Dorte Hammershoi, Egon Toft, Johannes Jan Struijk, Peter Clemmensen
Summary: This study developed a computerized acoustic CAD-score based on heart sounds for the non-invasive detection of coronary artery disease (CAD). The CAD-score showed significant differences between CAD and non-CAD patients, and had a moderate diagnostic performance in the validation group.
CARDIOVASCULAR ENGINEERING AND TECHNOLOGY
(2022)
Article
Biophysics
Kasper Sorensen, Peter Sogaard, Kasper Emerek, Ask Schou Jensen, Johannes Jan Struijk, Samuel Emil Schmidt
Summary: Conduction-induced heart failure patients with left bundle branch block can benefit from cardiac resynchronization therapy. Pacing-induced changes in the seismocardiogram (SCG) can be used to detect cardio-mechanic changes, but interpreting the SCG in patients remains challenging.
PHYSIOLOGICAL MEASUREMENT
(2022)
Article
Cardiac & Cardiovascular Systems
Marc Meller Sondergaard, Jonas Bille Nielsen, Rikke Normark Mortensen, Gunnar Gislason, Lars Kober, Freddy Lippert, Claus Graff, Stig Haunso, Jesper Hastrup Svendsen, Kristian Hay Kragholm, Adrian Holger Pietersen, Bent Struer Lind, Soren Pihlkjaer Hjortshoj, Anders Gaarsdal Holst, Johannes Jan Struijk, Christian Torp-Pedersen, Steen Moller Hansen
Proceedings Paper
Computer Science, Interdisciplinary Applications
Johannes J. Struijk, Dagbjort H. Eiriksdottir, Asgerdur A. Palsdottir, Samuel E. Schmidt
2018 COMPUTING IN CARDIOLOGY CONFERENCE (CINC)
(2018)
Article
Pharmacology & Pharmacy
Tanveer A. Bhuiyan, Claus Graff, Jorgen K. Kanters, Jacob Melgaard, Egon Toft, Stefan Kaeaeb, Johannes J. Struijk
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2018)
