Article
Chemistry, Multidisciplinary
Qi-xiang Mei, Jun-hui Hu, Ze-hua Huang, Jun-jie Fan, Chun-lan Huang, Ying-ying Lu, Xing-peng Wang, Yue Zeng
Summary: Severe acute pancreatitis (SAP) is a severe acute abdominal disease, and recent evidence suggests that maintaining intestinal homeostasis is crucial for managing this condition. Chitosan oligosaccharides (COS) with antioxidant properties have shown promising therapeutic effects in treating inflammatory diseases. This study demonstrated that COS administration alleviated the severity of SAP by reducing inflammation, oxidative stress, and restoring intestinal homeostasis, indicating its potential as a prebiotic agent for SAP treatment.
ACTA PHARMACOLOGICA SINICA
(2021)
Review
Pharmacology & Pharmacy
Sean Teabagy, Emma Wood, Evan Bilsbury, Sean Doherty, Priya Janardhana, Darren J. Lee
Summary: Ocular immune privilege refers to the ability of foreign tissue grafts placed in the eye to survive indefinitely. This privilege is maintained by various mechanisms, including the blood-ocular barrier, lack of lymphatics in the eye, production of immune-suppressing molecules in the ocular microenvironment, and induction of systemic regulatory immunity. Failure of ocular immune privilege can lead to uveitis, which is a group of inflammatory disorders that can cause vision loss. Current treatments for uveitis involve immunosuppressive and anti-inflammatory medications. Research on ocular immune privilege mechanisms and the development of novel uveitis treatments is ongoing.
ADVANCED DRUG DELIVERY REVIEWS
(2023)
Article
Biochemistry & Molecular Biology
Avik Shome, Odunayo O. Mugisho, Rachael L. Niederer, Ilva D. Rupenthal
Summary: This study aimed to develop a comprehensive grading system to objectively evaluate the progression of experimental autoimmune uveitis (EAU) in mice. Weekly fundus and optical coherence tomography (OCT) images were acquired over 12 weeks, and each mouse was graded based on changes seen on both types of images. The analysis of the clinical scores showed a gradual increase in inflammatory signs in EAU mice, with most signs reaching a plateau towards the end of the study period. The development of this grading system enhances the preclinical evaluation of novel uveitis treatments.
Article
Biochemistry & Molecular Biology
Yasuhiko Sato, Shoko Saito, Makiko Nakayama, Sunao Sugita, Akihiko Kudo, Hiroshi Keino
Summary: This study investigates the role of Nrf2 in the development of autoimmune uveoretinitis and suggests that Nrf2 deficiency exacerbates retinal inflammation, while activation of Nrf2 has a suppressive effect on the development of uveoretinitis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Avik Shome, Odunayo O. Mugisho, Rachael L. Niederer, Ilva D. Rupenthal
Summary: Uveitis is a complex ocular inflammatory disease that can be caused by infections or autoimmune factors. While infectious uveitis can often be resolved with anti-infective therapy and corticosteroids, non-infectious uveitis requires a better understanding of inflammatory pathways to develop more effective treatments.
DRUG DISCOVERY TODAY
(2021)
Article
Cell Biology
Su Pan, Handan Tan, Rui Chang, Qingfeng Wang, Ying Zhu, Lin Chen, Hongxi Li, Guannan Su, Chunjiang Zhou, Qingfeng Cao, Aize Kijlstra, Peizeng Yang
Summary: The study demonstrates that high ambient temperature exacerbates the severity of experimental autoimmune uveitis in mice, leading to an increase in Th1 and Th17 cell frequency, as well as elevated generation of neutrophil extracellular traps (NETs). These effects may be mediated by the NADPH oxidase-dependent pathway.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Immunology
Yoko Okunuki, Steven J. Tabor, May Y. Lee, Kip M. Connor
Summary: CD47 plays a significant role in the development of autoimmune uveitis by regulating SIRP alpha(+) DCs, which is essential for the induction of the disease.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Lydia J. Bradley, Amy Ward, Madeleine C. Y. Hsue, Jian Liu, David A. Copland, Andrew D. Dick, Lindsay B. Nicholson
Summary: Ocular inflammation imposes significant burden on patients and healthcare systems, with classification of uveitis severity remaining a challenge. Experimental autoimmune uveitis models can replicate clinical features and provide insights into tissue changes, offering potential for new approaches to monitoring tissue health with modern image processing techniques.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Nu Chen, Shuang Chen, Zhihui Zhang, Xuexue Cui, Lingzi Wu, Kailei Guo, Hui Shao, Jian-Xing Ma, Xiaomin Zhang
Summary: Kallistatin plays a role in promoting Th17 cell differentiation in autoimmune diseases, potentially being a key factor in exacerbating autoinflammation. Targeting Kallistatin could be a potential therapeutic strategy for treating autoimmune diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Azza Dammak, Cristina Pastrana, Alba Martin-Gil, Carlos Carpena-Torres, Assumpta Peral Cerda, Mirjam Simovart, Pilar Alarma, Fernando Huete-Toral, Gonzalo Carracedo
Summary: The eye is constantly exposed to solar radiations and vulnerable to reactive oxygen species, leading to biomolecular modifications in ocular diseases. Anterior eye segment injury originates from the imbalance of pro-oxidant/antioxidant levels, resulting in increased oxidative damage. Oxidative stress is related to various ocular diseases, such as dry eye, keratoconus, uveitis, and cataract, through mechanisms like inflammation and mitochondrial dysfunction. Biomarkers offer potential for predictive diagnostics of eye diseases. This review analyzes oxidative stress, inflammation, and the importance of biomarkers in anterior ocular diseases.
Article
Biology
Maren Kasper, Michael Heming, David Schafflick, Xiaolin Li, Tobias Lautwein, Melissa Meyer zu Horste, Dirk Bauer, Karoline Walscheid, Heinz Wiendl, Karin Loser, Arnd Heiligenhaus, Gerd Meyer zu Hoerste
Summary: Uveitis is a group of inflammatory eye diseases characterized by infiltration of leukocytes into the uveal tissues. HLA-B27-positive uveitis displays a unique pattern of ocular leukocyte infiltration with a prominent presence of plasmacytoid and classical dendritic cells. These cells play a central role in predicted local cell-cell communication within the eye, suggesting their importance in HLA-B27-associated inflammation.
Article
Chemistry, Applied
Xiaoyu Zhang, Huabing Yang, Junping Zheng, Nan Jiang, Guangjun Sun, Xinkun Bao, Aizhen Lin, Hongtao Liu
Summary: Chitosan oligosaccharides (COS) can effectively alleviate constipation by modulating gut microbiota, enhancing intestinal motility, inhibiting inflammatory responses, improving water-electrolyte metabolism, and preventing gut barrier damage. The balance of intestinal bacteria and metabolites plays a key role in this process, as shown in a study on loperamide-induced constipated mice.
CARBOHYDRATE POLYMERS
(2021)
Article
Medicine, Research & Experimental
Yuna Choi, Kyungsook Jung, Hyo Jin Kim, Jiyoon Chun, Meejung Ahn, Youngheun Jee, Hyun Ju Ko, Changjong Moon, Hiroshi Matsuda, Akane Tanaka, Jeongtae Kim, Taekyun Shin
Summary: The study demonstrated that betaine has anti-inflammatory effects in experimental autoimmune uveitis (EAU) rats by increasing serum superoxide dismutase levels, downregulating pro-inflammation molecules, and suppressing inflammation in the retina and ciliary bodies. This suggests that betaine plays a role in mitigating EAU through its anti-oxidation and anti-inflammatory activities.
EXPERIMENTAL NEUROBIOLOGY
(2021)
Review
Pharmacology & Pharmacy
Christopher D. Conrady, Steven Yeh
Summary: Uveitis is a group of inflammatory disorders of the eye that require medical and surgical management, with challenges in drug delivery due to absorption barriers. New drugs and drug delivery platforms are being developed to reduce intraocular inflammation and its complications.
Article
Medicine, General & Internal
Yosuke Harada, Tomona Hiyama, Yoshiaki Kiuchi
Summary: This single-center retrospective study found that MTX is effective in controlling ocular inflammation for Japanese patients with non-infectious uveitis, but the relatively high incidence of MTX-related adverse effects in the Japanese population emphasizes the need for careful monitoring and dose adjustments for long-term use of this therapy.
FRONTIERS IN MEDICINE
(2021)
Article
Ophthalmology
Cherng-Ru Hsu, Yi-Ting Hsieh, Chung-May Yang, Chang-Ping Lin
Summary: This study aims to investigate the effectiveness of single-dose intravitreal dexamethasone (DEX) implants for patients with post-vitrectomy macular edema (ME) under silicone oil (SO) tamponade. The results suggest that the single-dose DEX implant treatment may benefit patients with recalcitrant post-vitrectomy ME under SO tamponade, with maximum central macular thickness (CMT) improvement observed at 1 month.
OCULAR IMMUNOLOGY AND INFLAMMATION
(2023)
Article
Ophthalmology
Yun Hsia, Cheng-Yung Lee, Tzyy-Chang Ho, Chang-Hao Yang, Chung-May Yang
Summary: This study aimed to investigate the development, evolution, outcomes, and prognostic factors of lamellar macular hole (LMH) in highly myopic patients. The study identified four different traction-related LMH developmental processes with varying evolution and outcomes. LMHs caused by foveal thinning induced by epiretinal membranes were associated with the worst visual outcomes.
Article
Multidisciplinary Sciences
Cherng-Ru Hsu, Tso-Ting Lai, Yi-Ting Hsieh, Tzyy-Chang Ho, Chung-May Yang, Chang-Hao Yang
Summary: This study investigated biomarkers of OCT and OCTA for good visual outcomes in eyes with mCNV treated with anti-VEGF therapy. The study found that visual improvement was associated with thicker subfoveal choroid thickness and ellipsoid zone integrity at baseline, while OCTA biomarkers played a less important role in predicting visual outcomes of mCNV.
SCIENTIFIC REPORTS
(2022)
Article
Ophthalmology
Yun Hsia, Chung-May Yang, Yi-Ting Hsieh, Lu-Chun Wang
Summary: The purpose of this study is to describe the clinical characteristics and surgical treatment of secondary full-thickness macular hole (MH) after diabetic vitrectomy (DV) in patients with proliferative diabetic retinopathy (PDR). The study found that the formation of MH was related to unreleased tractional force and weakened foveal structure. The development of anterior proliferative vitreoretinopathy and epiretinal membrane (ERM) may also lead to MH. Various surgical techniques can be used for MH closure.
JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Ophthalmology
Jia-Horung Hung, Chung-May Yang, Chang-Hao Yang, Tzyy-Chang Ho, Tzo-Ting Lai, Yi-Ting Hsieh
Summary: In exudative pachychoroid neovasculopathy (PNV), eyes with dilated choroidal vascular channels (DCVC) have a higher vascular density of macular neovascularization and poorer corrected distance visual acuity (CDVA) at baseline, and they also exhibit poorer visual and anatomical outcomes despite receiving more anti-VEGF injections.
CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Tso-Ting Lai, Chung-May Yang, Yi-Ting Hsieh, Po-Ting Yeh, Ching-Wen Huang, Chia-Ying Tsai
Summary: The purpose of this study was to evaluate the rate and time to complete vascularization in premature infants and explore associated factors. The findings showed that lower birth weight, presence of retinopathy of prematurity (ROP), and antivascular endothelial growth factor therapy may delay complete vascularization. These results can contribute to a better understanding and management of persistent avascular retina in preterm infants.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2023)
Article
Ophthalmology
Yu-Ting Su, Yi-Jun Chen, Chang-Ping Lin, Yi-Ting Hsieh, Chung-May Yang, Angelique Chiu-Ang, Po-Ting Yeh
Summary: This retrospective cohort study aimed to explore the clinical features and outcomes of cytomegalovirus retinitis (CMVR) in patients with HIV and non-HIV. The study found that CMVR patients without HIV had higher mortality and recurrence rates, and risk factors for poor visual outcome included poor initial visual acuity, retinal detachment, and a high plasma cytomegalovirus titer.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2023)
Article
Ophthalmology
Tso-Ting Lai, Ching-Wen Huang, Chung-May Yang
Summary: Distinct structural changes were observed following surgery for MTM, including large intraretinal cavities and schisis associated with paravascular inner breaks. The condition can progress after a stable period, highlighting the importance of continuous follow-up.
JAPANESE JOURNAL OF OPHTHALMOLOGY
(2023)
Letter
Ophthalmology
Ta-Ching Chen, Pei-Lung Chen, Yi-Chieh Chen, Chang-Hao Yang, Chung-May Yang
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2023)
Review
Ophthalmology
San-Ni Chen, Shih-Jen Chen, Tsung-Tien Wu, Wei-Chi Wu, Chang-Hao Yang, Chung-May Yang
Summary: Pars plana vitrectomy (PPV) has been widely used in the treatment of severe diabetic retinopathy, and new technologies have expanded its applications. This article reviews the applications of new technologies for PPV in eyes with diabetic retinopathy, based on the experiences with Asian patients, and highlights important procedures and entities not commonly mentioned in the literature.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2023)
Letter
Ophthalmology
Yi-Ting Hsieh, Jih-Pin Lin, Chung-May Yang
Article
Ophthalmology
Mei-Chi Tsui, Yi-Ting Hsieh, Tso-Ting Lai, Yun Hsia, Shih-Wen Wang, I-Hsin Ma, Kuo-Chi Hung, Chang-Pin Lin, Chang-Hao Yang, Chung-May Yang, Tzyy-Chang Ho
Summary: The study investigated changes in the vitreoretinal interface after anti-vascular endothelial growth factor (anti-VEGF) treatment in highly myopic eyes. The prevalence of myopic macular retinoschisis (MRS) was 25.4%, with rates of progression and onset of 75.9% and 16.2% respectively. Outer retinal schisis and lamellar macular hole (LMH) were identified as risk factors for MRS progression and onset, while male sex and outer retinal schisis were risk factors for MRS progression. The study concluded that changes in the vitreoretinal interface, including progression, onset, and improvement of MRS, were observed after anti-VEGF treatment.
OPHTHALMOLOGY AND THERAPY
(2023)
Article
Ophthalmology
Mei-Chi Tsui, Chung-May Yang, Lu-Chun Wang
Summary: This study investigated the clinical features, management, and prognosis of full-thickness macular holes (FTMHs) created during vitrectomy for eyes with proliferative diabetic retinopathy (PDR) and fibrovascular proliferation (FVP). The study group achieved anatomical success and MH closure through ILM peeling or the inverted ILM flap technique, and had a higher proportion of condensed prefoveal tissue and a higher ratio of silicone oil tamponade compared to the control group.
INTERNATIONAL OPHTHALMOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Chao-Wen Lin, Yi-Chun Cheng, Chang-Hao Yang, Hsien-Sung Huang
Summary: This study found that extended exposure to white or blue light can promote the expression of the Angelman syndrome-related gene UBE3A in the retina but not in the visual cortex. Additionally, it was observed that this light exposure caused changes in the chromatin structure of the Ube3a promoter, which further impacted gene expression.
JOURNAL OF NEUROCHEMISTRY
(2023)
