4-1BB/4-1BBL Interaction Promotes Obesity-Induced Adipose Inflammation by Triggering Bidirectional Inflammatory Signaling in Adipocytes/Macrophages

CD40L Deficiency Ameliorates Adipose Tissue Inflammation and Metabolic Manifestations of Obesity in Mice

(2011) Marjorie Poggi et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Deficiency for Costimulatory Receptor 4-1BB Protects Against Obesity-Induced Inflammation and Metabolic Disorders

(2011) C.-S. Kim et al.   DIABETES

HVEM-deficient mice fed a high-fat diet are protected from adipose tissue inflammation and glucose intolerance

(2011) Ha-Jung Kim et al.   FEBS LETTERS

LIGHT/TNFSF14 enhances adipose tissue inflammatory responses through its interaction with HVEM

(2011) Hong-Min Kim et al.   FEBS LETTERS

Reverse signaling through the costimulatory ligand CD137L in epithelial cells is essential for natural killer cell-mediated acute tissue inflammation

(2011) H. J. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CD137 (4–1BB) Deficiency Reduces Atherosclerosis in Hyperlipidemic Mice

(2010) Hyung Jun Jeon et al.   CIRCULATION

Interactive Changes between Macrophages and Adipocytes

(2010) L. Xie et al.   Clinical and Vaccine Immunology

CD137 ligand, a member of the tumor necrosis factor family, regulates immune responses via reverse signal transduction

(2010) Zhe Shao et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The inflammatory receptor CD40 is expressed on human adipocytes: contribution to crosstalk between lymphocytes and adipocytes

(2009) M. Poggi et al.   DIABETOLOGIA

CD137 ligand-mediated reverse signals increase cell viability and cytokine expression in murine myeloid cells: Involvement of mTOR/p70S6 kinase and Akt

(2009) Dong-Ku Kim et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Attenuation of experimental autoimmune myocarditis by blocking T cell activation through 4-1BB pathway

(2009) Takaaki Haga et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity

(2009) Satoshi Nishimura et al.   NATURE MEDICINE

CD137-CD137 Ligand Interactions in Inflammation

(2009) Byungsuk Kwon   Immune Network

CD137 Is Expressed in Human Atherosclerosis and Promotes Development of Plaque Inflammation in Hypercholesterolemic Mice

(2008) Peder S. Olofsson et al.   CIRCULATION

Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes

(2008) Adilson Guilherme et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Multi-layered action mechanisms of CD137 (4-1BB)-targeted immunotherapies

(2008) Ignacio Melero et al.   TRENDS IN PHARMACOLOGICAL SCIENCES