Role of Prostaglandins in Neuroinflammatory and Neurodegenerative Diseases

Pharmacological inhibition of Akt and downstream pathways modulates the expression of COX-2 and mPGES-1 in activated microglia

(2012) Antonio CP de Oliveira et al.   Journal of Neuroinflammation

The role of neuroinflammation on the pathogenesis of Parkinson's disease

(2011) Young-Cheul Chung et al.   BMB Reports

Role of LOX/COX pathways in 3-nitropropionic acid-induced Huntington's Disease-like symptoms in rats: protective effect of licofelone

(2011) Puneet Kumar et al.   BRITISH JOURNAL OF PHARMACOLOGY

Experimental models of multiple sclerosis

(2011) Andrew R Pachner   CURRENT OPINION IN NEUROLOGY

Minocycline reduces prostaglandin E synthase expression and 8-isoprostane formation in LPS-activated primary rat microglia

(2011) Leandro Francisco Silva Bastos et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Cyclooxygenase expression and prostaglandin levels in central nervous system tissues during the course of chronic relapsing experimental autoimmune encephalomyelitis (EAE)

(2011) Samir S. Ayoub et al.   INFLAMMATION RESEARCH

Cytosolic Phospholipase A2  Blockade Abrogates Disease during the Tissue-Damage Effector Phase of Experimental Autoimmune Encephalomyelitis by Its Action on APCs

(2011) P. Thakker et al.   JOURNAL OF IMMUNOLOGY

Suppressing inflammatory cascade by cyclo-oxygenase inhibitors attenuates quinolinic acid induced Huntington's disease-like alterations in rats

(2011) Harikesh Kalonia et al.   LIFE SCIENCES

Increased expression and activation of cytosolic phospholipase A2 in the spinal cord of patients with sporadic amyotrophic lateral sclerosis

(2010) Noriyuki Shibata et al.   ACTA NEUROPATHOLOGICA

Anti-inflammatory Role of Microsomal Prostaglandin E Synthase-1 in a Model of Neuroinflammation

(2010) Christian Brenneis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Prostaglandin E2 E-Prostanoid 4 Receptor Exerts Anti-Inflammatory Effects in Brain Innate Immunity

(2010) J. Shi et al.   JOURNAL OF IMMUNOLOGY

Neuroinflammation in Huntington’s disease

(2010) Thomas Möller   JOURNAL OF NEURAL TRANSMISSION

Neuroinflammation is a key player in Parkinson’s disease and a prime target for therapy

(2010) Li Qian et al.   JOURNAL OF NEURAL TRANSMISSION

Targeting Glial Cells to Elucidate the Pathogenesis of Huntington’s Disease

(2010) Han-Yun Hsiao et al.   MOLECULAR NEUROBIOLOGY

Microglia in the aging brain: relevance to neurodegeneration

(2010) Xiao-Guang Luo et al.   Molecular Neurodegeneration

Protective effect of rofecoxib and nimesulide against intra-striatal quinolinic acid-induced behavioral, oxidative stress and mitochondrial dysfunctions in rats

(2010) Harikesh Kalonia et al.   NEUROTOXICOLOGY

Cyclopentenone prostaglandin-induced unfolding and aggregation of the Parkinson disease-associated UCH-L1

(2010) L. M. I. Koharudin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dual roles of PGE2-EP4 signaling in mouse experimental autoimmune encephalomyelitis

(2010) Y. Esaki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Striatal 6-OHDA lesion in mice: Investigating early neurochemical changes underlying Parkinson's disease

(2009) Igor Branchi et al.   BEHAVIOURAL BRAIN RESEARCH

Differing roles for members of the phospholipase A2 superfamily in experimental autoimmune encephalomyelitis

(2009) Athena Kalyvas et al.   BRAIN

NSAID Use and the Risk of Parkinsonʼs Disease

(2009) Ali Samii et al.   DRUGS & AGING

Anti-inflammatory and analgesic activity of a novel inhibitor of microsomal prostaglandin E synthase-1 expression

(2009) María Dolores Guerrero et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Impaired cognition, sensorimotor gating, and hippocampal long-term depression in mice lacking the prostaglandin E2 EP2 receptor

(2009) A. Savonenko et al.   EXPERIMENTAL NEUROLOGY

Microsomal prostaglandin E synthase-2: Cellular distribution and expression in Alzheimer's disease

(2009) Uzma Chaudhry et al.   EXPERIMENTAL NEUROLOGY

Prostaglandin E2Stimulates the Production of Amyloid-β Peptides through Internalization of the EP4Receptor

(2009) Tatsuya Hoshino et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Does neuroinflammation fan the flame in neurodegenerative diseases?

(2009) Tamy C Frank-Cannon et al.   Molecular Neurodegeneration

PGF2α FP Receptor Contributes to Brain Damage Following Transient Focal Brain Ischemia

(2009) Sofiyan Saleem et al.   NEUROTOXICITY RESEARCH

Targeted lipidomics reveals mPGES-1-PGE2 as a therapeutic target for multiple sclerosis

(2009) Y. Kihara et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effects of caffeic acid, rofecoxib, and their combination against quinolinic acid-induced behavioral alterations and disruption in glutathione redox status

(2009) Harikesh Kalonia et al.   Neuroscience Bulletin

The prostaglandin E2EP2 receptor accelerates disease progression and inflammation in a model of amyotrophic lateral sclerosis

(2008) Xibin Liang et al.   ANNALS OF NEUROLOGY

Cyclooxygenase-2 inhibition improves amyloid-β-mediated suppression of memory and synaptic plasticity

(2008) Linda A. Kotilinek et al.   BRAIN

Regulation of prostaglandin E2 synthase expression in activated primary rat microglia: Evidence for uncoupled regulation of mPGES-1 and COX-2

(2008) Antonio Carlos Pinheiro de Oliveira et al.   GLIA

Blockade of cytosolic phospholipase A2α prevents experimental autoimmune encephalomyelitis and diminishes development of Th1 and Th17 responses

(2008) S MARUSIC et al.   JOURNAL OF NEUROIMMUNOLOGY

Microglial Dysfunction and Defective  -Amyloid Clearance Pathways in Aging Alzheimer's Disease Mice

(2008) S. E. Hickman et al.   JOURNAL OF NEUROSCIENCE

Prostaglandin receptor EP2 protects dopaminergic neurons against 6-OHDA-mediated low oxidative stress

(2008) Emilce Carrasco et al.   NEUROSCIENCE LETTERS

Why neurodegenerative diseases are progressive: uncontrolled inflammation drives disease progression

(2008) Hui-Ming Gao et al.   TRENDS IN IMMUNOLOGY

Elevated microsomal prostaglandin-E synthase–1 in Alzheimer’s disease

(2007) Uzma A. Chaudhry et al.   Alzheimers & Dementia

The role of inflammation in CNS injury and disease

(2006) Sian-Marie Lucas et al.   BRITISH JOURNAL OF PHARMACOLOGY