Targeting Toll-Like Receptors for Treatment of SLE

Up-regulated expression of Toll-like receptors mRNAs in peripheral blood mononuclear cells from patients with systemic lupus erythematosus

(2010) A. Komatsuda et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Toll-like Receptor and RIG-1-like Receptor Signaling

(2009) Taro Kawai et al.   Annals of the New York Academy of Sciences

Toll-like receptor 7 (TLR7) modulates anti-nucleosomal autoantibody isotype and renal complement deposition in mice exposed to syngeneic late apoptotic cells

(2009) Z.-j. Pan et al.   ANNALS OF THE RHEUMATIC DISEASES

Regression of systemic lupus erythematosus after development of an acquired Toll-like receptor signaling defect and antibody deficiency

(2009) Marcella Visentini et al.   ARTHRITIS AND RHEUMATISM

Targeting protein kinases for the development of anti-inflammatory drugs

(2009) Philip Cohen   CURRENT OPINION IN CELL BIOLOGY

Meta-analysis and imputation identifies a 109 kb risk haplotype spanning TNFAIP3 associated with lupus nephritis and hematologic manifestations

(2009) J S Bates et al.   GENES AND IMMUNITY

Recent insights into the genetic basis of systemic lupus erythematosus

(2009) K L Moser et al.   GENES AND IMMUNITY

Plasma cell toll-like receptor (TLR) expression differs from that of B cells, and plasma cell TLR triggering enhances immunoglobulin production

(2009) Marcus Dorner et al.   IMMUNOLOGY

Critical Role of TLR2 and TLR4 in Autoantibody Production and Glomerulonephritis in lpr Mutation-Induced Mouse Lupus

(2009) A. Lartigue et al.   JOURNAL OF IMMUNOLOGY

Innate immunity, epigenetics and autoimmunity in rheumatoid arthritis

(2009) Hanna Maciejewska Rodrigues et al.   MOLECULAR IMMUNOLOGY

Endosomal TLR signaling is required for anti-nucleic acid and rheumatoid factor autoantibodies in lupus

(2009) D. H. Kono et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Type I interferons might form the link between Toll-like receptor (TLR) 3/7 and TLR4-mediated synovial inflammation in rheumatoid arthritis (RA)

(2008) M F Roelofs et al.   ANNALS OF THE RHEUMATIC DISEASES

Requirement of toll-like receptor 7 for pristane-induced production of autoantibodies and development of murine lupus nephritis

(2008) Emina Savarese et al.   ARTHRITIS AND RHEUMATISM

Dynamics of the RING Domain from Human TRAF6 by15N NMR Spectroscopy: Implications for Biological Function†

(2008) Craig J. Markin et al.   BIOCHEMISTRY

IRAK-4 inhibitors. Part III: A series of imidazo[1,2-a]pyridines

(2008) George M. Buckley et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Signalling pathways leading to IFN-α production in human plasmacytoid dendritic cell and the possible use of agonists or antagonists of TLR7 and TLR9 in clinical indications

(2008) C. Guiducci et al.   JOURNAL OF INTERNAL MEDICINE

The innate immune system in SLE: type I interferons and dendritic cells

(2008) L Rönnblom et al.   LUPUS

Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus

(2008) Robert R Graham et al.   NATURE GENETICS

Multiple polymorphisms in the TNFAIP3 region are independently associated with systemic lupus erythematosus

(2008) Stacy L Musone et al.   NATURE GENETICS

Phosphatase SHP-1 promotes TLR- and RIG-I-activated production of type I interferon by inhibiting the kinase IRAK1

(2008) Huazhang An et al.   NATURE IMMUNOLOGY

Engagement of TLR signaling as adjuvant: Towards smarter vaccine and beyond

(2008) Amit Lahiri et al.   VACCINE

Increased Toll-Like Receptor (TLR) 2 and TLR4 Expression in Monocytes from Patients with Type 1 Diabetes: Further Evidence of a Proinflammatory State

(2007) Sridevi Devaraj et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM