Journal
MECHANISMS OF DEVELOPMENT
Volume 127, Issue 1-2, Pages 28-35Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.mod.2009.11.003
Keywords
Epithelial morphogenesis; Anoikis
Categories
Funding
- Deutsche Forschungsgemeinschaft
- Kantons Basel-Stadt and Basel-Land
- Swiss National Science Foundation
- NRW Graduate School for Genetics and Functional Genomics, E.C
- European community
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The tubular network of the tracheal system in the Drosophila embryo is created from a set of epithelial placodes by cell migration, rearrangements, fusions and shape changes. A designated number of cells is initially allocated to each branch of the system. We show here that the final cell number in the dorsal branches is not only determined by early patterning events and subsequent cell rearrangements but also by elimination of cells from the developing branch. Extruded cells die and are engulfed by macrophages. Our results suggest that the pattern of cell extrusion and death is not hard-wired, but is deter-mined by environmental cues. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
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