A model for mechanical adaptation of trabecular bone incorporating cellular accommodation and effects of microdamage and disuse

The purpose of this research is to improve a semi-mechanistic bone remodeling theory. In addition to entering the cellular accommodation effect into the model, a novel unifying formulation to include the effects of both microdamage and disuse on activation of resorption as the first phase of remodeling was introduced. Using the modified model, trabecular-like structures for different loading conditions and directionalities similar to actual human trabecular bone have been resulted. This research also shows that including cellular accommodation and simultaneous effects of microdamage and disuse will help to predict more realistic morphologies in time-dependent simulations. (C) 2008 Elsevier Ltd. All rights reserved.