Article
Critical Care Medicine
Bradley A. Maron, Steven H. Abman, C. Greg Elliott, Robert P. Frantz, Rachel K. Hopper, Evelyn M. Horn, Mark R. Nicolls, Oksana A. Shlobin, Sanjiv J. Shah, Gabor Kovacs, Horst Olschewski, Erika B. Rosenzweig
Summary: The diagnosis and management of pulmonary arterial hypertension have seen advances in early diagnosis, multiple pharmacotherapeutics, and new risk factors becoming focal points. Developmental biology may be useful in predicting incident PAH.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2021)
Review
Cardiac & Cardiovascular Systems
Felicity Lee, Lisa M. Mielniczuk
Summary: Pulmonary hypertension due to left heart disease is a common complication of heart failure, with significant changes in classification and treatment after the Sixth World Symposium on Pulmonary Hypertension in 2018. Categorization into isolated postcapillary PH and combined precapillary and postcapillary PH is important, as the latter is associated with worse outcomes similar to pulmonary arterial hypertension. Despite limited benefits from medical therapy for pulmonary arterial hypertension, expert centres in Canada offer ongoing care for complex patient subgroups with PH-LHD.
CANADIAN JOURNAL OF CARDIOLOGY
(2021)
Article
Multidisciplinary Sciences
Ali T. Kahraman, Tomas Froding, Dimitrios Toumpanakis, Natasa Sladoje, Tobias Sjoblom
Summary: An automated algorithm was developed to accurately detect, segment, and measure mediastinal structures in routine CTPA examinations. The system showed good accuracy in multiple tasks and the automatic measurements correlated well with those of radiologists.
SCIENTIFIC REPORTS
(2023)
Editorial Material
Medicine, General & Internal
Masahiro Nemoto, Chi Wan Koo, Jay H. Ryu
Summary: This article discusses the diagnosis, prognosis, and treatment of combined pulmonary fibrosis and emphysema, highlighting that this condition is likely underestimated and underreported.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2022)
Article
Cardiac & Cardiovascular Systems
Atakan Erkilinc, Nezih Onur Ermerak, Ahmet Zengin, Sehnaz Olgun Yildizeli, Bulent Mutlu, Ayse Zehra Karakoc, Mehmed Yanartas, Serpil Tas, Emine Bozkurtlar, Hasan Sunar, Bedrettin Yildizeli
Summary: This study reviewed the experience of surgical treatment for pulmonary arterial hydatidosis. Pulmonary endarterectomy can be used to diagnose and treat patients who do not respond to medical therapy, and pulmonary arterial hydatidosis can mimic chronic thromboembolic pulmonary hypertension.
ANNALS OF THORACIC SURGERY
(2022)
Article
Medicine, General & Internal
Olga Dzikowska-Diduch, Katarzyna Kurnicka, Barbara Lichodziejewska, Olga Zdonczyk, Dominika Dabrowska, Marek Roik, Szymon Pacho, Maksymilian Bielecki, Piotr Pruszczyk
Summary: This study suggests that a Doppler index, TRPG/AcT, improves the assessment of symptomatic pulmonary embolism (PE) survivors. TRPG/AcT > 0.6 indicates a high probability of chronic thromboembolic pulmonary hypertension (CTEPH) or chronic thromboembolic pulmonary disease (CTED), while TRPG/AcT < 0.6 allows for the safe exclusion of CTEPH + CTED in patients with a low echocardiographic probability of pulmonary hypertension (PH).
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Medicine, General & Internal
Mi-Hyang Jung, Hae Ok Jung, Soo Jin Kwon, Suyon Chang
Summary: Chronic thromboembolic pulmonary hypertension (CTEPH) is a rare but life-threatening pulmonary vascular disease caused by a prolonged thrombus in the pulmonary artery. It is classified as a distinct entity of pulmonary hypertension group 4 according to the World Symposium on Pulmonary Hypertension. Timely diagnosis and treatment are often hindered by nonspecific symptoms and a lack of awareness among physicians. Thus, understanding the clinical features and diagnostic processes of CTEPH is crucial.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Junhua Xu, John Linneman, Yanfeng Zhong, Haoyang Yin, Qinyi Xia, Kang Kang, Deming Gou
Summary: This article introduces the role of microRNAs in pulmonary hypertension (PH) and the challenges they face. MicroRNAs participate in regulating gene expression and influencing biological processes, and play a critical role in the pathogenesis of PH. Some microRNAs have been identified as diagnostic biomarkers for PH, but challenges such as normalization, specificity, and large sample-sized studies remain. Furthermore, finding clinically safe and effective microRNA drugs is also a major challenge.
Review
Cell Biology
Zachary A. Haynes, Abhimanyu Chandel, Christopher S. King
Summary: The article provides a comprehensive review of pulmonary hypertension in interstitial lung disease, including its pathophysiology, updated diagnostic approaches, and recent clinical trials, offering an effective approach for medical management.
Review
Medicine, General & Internal
Mario Naranjo, Paul M. Hassoun
Summary: Systemic sclerosis-associated pulmonary arterial hypertension (SSc-PAH) is a catastrophic complication of autoimmune diseases, causing high mortality rates among patients. Despite advancements in screening methods and therapies, improved outcomes are still needed, urging the search for innovative treatment options.
Review
Cardiac & Cardiovascular Systems
Zhang Xiao, Huangfu Zhao
Summary: This review discusses the risks associated with pregnant individuals with PAH and emphasizes the importance of contraception and reducing hemodynamic fluctuations in minimizing maternal mortality and improving pregnancy outcomes.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Biology
Rigmor Hojland Jensen, Vlasta Vukovic-Cvetkovic, Johanne Juhl Korsbaek, Marianne Wegener, Steffen Hamann, Dagmar Beier
Summary: This review proposes a referral pathway and organization scheme for the diagnosis and management of IIH, emphasizing the necessity of an educational campaign involving medical care providers and patients with chronic headaches.
Review
Medicine, General & Internal
Nicole F. Ruopp, Barbara A. Cockrill
Summary: Pulmonary arterial hypertension, a subtype of pulmonary hypertension characterized by pulmonary arterial remodeling, can progress to right heart failure and death if left untreated. Approved therapies targeting multiple biological pathways have significantly improved survival rates.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2022)
Review
Medicine, General & Internal
Beatrice Pezzuto, Piergiuseppe Agostoni
Summary: Pulmonary arterial hypertension (PAH) is a progressive disease that has a poor prognosis if not treated. Despite advances in understanding the disease and its treatment, a definitive cure is still lacking. Early diagnosis and treatment have been emphasized to improve the prognosis. Cardiopulmonary exercise testing (CPET) is the standard method for assessing functional capacity and the underlying mechanisms of exercise limitation. It has been shown to be valuable in early detection, differential diagnosis, and prognostic stratification of PAH patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, Research & Experimental
Wen Zhang, Xinchun Duan, Zhenrong Zhang, Zhenrong Yang, Changyun Zhao, Chunzi Liang, Zhidong Liu, Shujun Cheng, Kaitai Zhang
Summary: The TBCD based CTC detection can serve as an independent biomarker for diagnosing pulmonary nodules with high sensitivity and specificity. The combination of CTCs with CT significantly improves the differentiation ability of benign and malignant nodules in lung nodules.