Review
Medicine, General & Internal
Jane Fisher, Adam Linder, Maria Grazia Calevo, Peter Bentzer
Summary: The study assessed non-corticosteroid adjuvant pharmacological therapies for acute bacterial meningitis. Only a few adjuvant therapies have been tested in randomized controlled trials, with paracetamol showing little impact on mortality and high uncertainty in the absolute effects on neurological sequelae.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2021)
Article
Clinical Neurology
Carolin Beuker, Nils Werring, Nadine Bonberg, Jan-Kolja Strecker, Antje Schmidt-Pogoda, Wolfram Schwindt, Paul Stracke, Andreas Schulte-Mecklenbeck, Catharina Gross, Heinz Wiendl, Heike Minnerup, Jens Minnerup
Summary: This study characterized patients with ischemic stroke due to bacterial meningitis and found a strong association between stroke and mortality. It also discovered that ischemic stroke is caused by cerebral vasculopathy near the infection focus and has specific time courses.
ANNALS OF NEUROLOGY
(2023)
Review
Clinical Neurology
Emma C. Wall, Jia Mun Chan, Eliza Gil, Robert S. Heyderman
Summary: Community-acquired bacterial meningitis is a dynamic disease with evolving epidemiology and pathogenesis data. Early antibiotic administration is crucial for improving survival, while unnecessary cranial imaging causes diagnostic delays. New treatments such as C5 inhibitors and daptomycin are currently in clinical trials.
CURRENT OPINION IN NEUROLOGY
(2021)
Review
Infectious Diseases
Rami H. Jaber, Nathan P. Beahm
Summary: This review evaluated the clinical evidence for the use of daptomycin in acute bacterial meningitis in both pediatric and adult patients. The results suggest that daptomycin could be a safe and effective alternative for the treatment of meningitis caused by Gram-positive bacteria. However, further research is needed to establish the optimal dosing regimen, duration of therapy, and place in therapy for the management of meningitis.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2023)
Article
Medicine, General & Internal
Virginia Pomar, Natividad Benito, Pol Duch, Marc Colome, Alba Rivera, Pere Domingo
Summary: A long-term observational study of adult BM patients in Barcelona has found that in recent years, patients without underlying conditions who develop BM are older and more likely to have pneumococcal or listerial infections and systemic complications, although the in-hospital mortality has decreased compared to the first period.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Y. Kalchev, P. Argirova, I. Boev, A. Yaneva, N. Vatev, M. Stoycheva, M. Murdjeva
Summary: The levels of interleukin (IL)-6, IL-8, IL-10, IL-12(p40), and tumor necrosis factor (TNF)-α are correlated with disease severity, complications, and outcome in patients with acute bacterial meningitis. The levels of IL-6, IL-8, IL-10, and TNF-α in cerebrospinal fluid (CSF) are significantly higher than in serum. Elevated serum IL-8 levels may indicate increased risk of neurological complications, severe clinical course, and fatal outcome.
Review
Pharmacology & Pharmacy
Chao Tian, Siyao Jin, Zinan Zhao, Xiaohui Liu, Haixin Cheng, Xiaoling Wang, Libo Zhao
Summary: The use of corticosteroids for the treatment of pediatric bacterial meningitis has been controversial. A systematic review and meta-analysis were conducted to assess the benefits and risks of corticosteroids in this context. The findings showed that corticosteroid treatment reduced the risk of hearing loss but had no significant benefit in preventing neurologic sequelae. Low-dose corticosteroids were found to be more effective than high-dose corticosteroids. However, the use of corticosteroids was associated with an increased risk of secondary fever. Additionally, corticosteroids significantly shortened the duration of fever. There was no significant difference in mortality rate and reactive arthritis between the corticosteroid and control groups.
CLINICAL THERAPEUTICS
(2022)
Article
Clinical Neurology
Johannes Weller, Jonas Simon Enkirch, Felix Lehmann, Alexander Radbruch, Thomas Klockgether, Julian Zimmermann
Summary: This study retrospectively analyzed patients with community-acquired bacterial meningitis treated at a tertiary academic center between 2009 and 2019, evaluating the impact of early intracranial hemorrhage on clinical outcomes. The presence of intracranial micro- or macrohemorrhages was found to be significantly associated with poor clinical outcomes, suggesting that early cerebral hemorrhage can serve as a potential prognostic marker for clinicians managing critically ill patients with community-acquired bacterial meningitis.
FRONTIERS IN NEUROLOGY
(2022)
Review
Medicine, General & Internal
Heeyeon Kim, Yun-Ho Roh, Seo-Hee Yoon
Summary: Blood procalcitonin exhibits high diagnostic accuracy in detecting bacterial meningitis in children, surpassing other conventional biomarkers.
Article
Psychology, Multidisciplinary
Jun Li, Guangming Ran, Qi Zhang, Xiaoyan He
Summary: Many scholars have studied the prevalence of cyber dating abuse (CDA) and acknowledge that it is widespread among adolescents and emerging adults. However, there is no consensus on the extent of CDA perpetration and victimization. This study conducted separate meta-analyses for adolescents and emerging adults and aimed to estimate the pooled prevalence and explain discrepancies in the literature.
COMPUTERS IN HUMAN BEHAVIOR
(2023)
Article
Immunology
Celine Aerts, Shannon Leahy, Humberto Mucasse, Sanjay Lala, Justina Bramugy, Cally J. Tann, Shabir A. Madhi, Azucena Bardaji, Quique Bassat, Ziyaad Dangor, Joy E. Lawn, Mark Jit, Simon R. Procter
Summary: This study investigated the acute costs of neonatal sepsis and meningitis in sub-Saharan Africa and found significant expenses associated with these conditions. The findings will contribute to the economic evaluations of interventions aiming to prevent neonatal invasive bacterial infections.
CLINICAL INFECTIOUS DISEASES
(2022)
Review
Pharmacology & Pharmacy
Bin Cheng, Jinxiu Ma, Yani Yang, Tingting Shao, Binghao Zhao, Linxiang Zeng
Summary: The study found that corticosteroid use in COVID-19 patients can reduce the risk of mechanical ventilation and mortality in critically ill/severe patients, but may lead to prolonged hospital stays and virus clearance time.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Medicine, General & Internal
Juliana H. VanderPluym, Rashmi B. Halker Singh, Meritxell Urtecho, Allison S. Morrow, Tarek Nayfeh, Victor D. Torres Roldan, Magdoleen H. Farah, Bashar Hasan, Samer Saadi, Sahrish Shah, Rami Abd-Rabu, Lubna Daraz, Larry J. Prokop, Mohammad Hassan Murad, Zhen Wang
Summary: This study found that multiple acute treatments for migraine were associated with improvements in short-term pain outcomes, but evidence for interventions such as opioids was limited.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2021)
Article
Clinical Neurology
Yudy Fonseca, Taty Tshimanga, Stephen Ray, Helen Malhotra, Jean Pongo, Joseph Bodi Mabiala, Montfort Bernard Gushu, Tusekile Phiri, Bertha Mekiseni Chikaonda, Davin Ambitapio Musungufu, Mananu Uchama, Nicole Fortier O'Brien
Summary: This study found that abnormal TCD flow patterns were common in children with bacterial meningitis, and identified those at high risk of poor neurological outcome. The study suggests that transcranial Doppler ultrasound may be helpful in predicting neurological prognosis in children with BM.
FRONTIERS IN NEUROLOGY
(2021)
Review
Clinical Neurology
Eduardo Villa, Teresita Sarquis, Jose de Grazia, Rene Nunez, Pablo Alarcon, Rodrigo Villegas, Carlos Guevara
Summary: Rheumatoid meningitis predominantly affects older adults with manifestations of transient neurological signs, systemic symptoms, episodic headache, and neuropsychiatric alterations. Maintenance therapy with high-dose corticosteroids is key for a better outcome in RM patients.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
