Review
Obstetrics & Gynecology
Stefano Lello, Anna Capozzi, Giovanni Scambia, Gianluca Franceschini
Summary: The safety profile of hormone replacement therapy (HRT) on breast is still being debated. Tibolone, as a treatment option for climacteric syndrome, has its risk profile on breast under discussion. This narrative review presents updated data from preclinical and clinical studies regarding the impact of tibolone on breast tissue and breast density, as well as its potential association with breast cancer risk. It aims to enhance the awareness and expertise of clinicians in managing menopausal symptoms with this drug. According to the available literature, tibolone appears to have an interesting safety profile on breast tissue.
REPRODUCTIVE SCIENCES
(2023)
Article
Oncology
Mollie E. Barnard, Natalie C. Dupre, John J. Heine, Erin E. Fowler, Divya J. Murthy, Rebecca L. Nelleke, Ariane Chan, Erica T. Warner, Rulla M. Tamimi
Summary: There are differences in the distributions of breast cancer incidence and risk factors by race and ethnicity. Reproductive history factors show variation in their associations with breast density across different racial and ethnic groups.
BREAST CANCER RESEARCH AND TREATMENT
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Leah H. Portnow, Lina Choridah, Kardinah Kardinah, Triwulan Handarini, Ruud Pijnappel, Adriana M. J. Bluekens, Lucien E. M. Duijm, Peter K. Schoub, Pamela S. Smilg, Liat Malek, Jessica W. T. Leung, Sughra Raza
Summary: The purpose of this study was to determine variability in visually assessed mammographic breast density categorization among radiologists practicing in different countries. The results showed that although the interreader agreement was almost perfect, there were still significant differences in density distribution across the four categories.
JOURNAL OF THE AMERICAN COLLEGE OF RADIOLOGY
(2023)
Article
Multidisciplinary Sciences
Camila Engler, Lucas Paixao, Luiza Freire de Souza, Margarita Chevalier, Maria do Socorro Nogueira
Summary: The study aimed to evaluate variations in breast density among Brazilian women in different regions, revealing that women in the Southeast region had the highest breast density. The results support existing data showing a correlation between breast density and breast cancer incidence, with the most urbanized region of Brazil (Southeast) having the highest breast density.
Article
Computer Science, Interdisciplinary Applications
Angie Hernandez, David A. Miranda, Said Pertuz
Summary: The study reviews the algorithms and methods for computerized analysis of mammography images for breast cancer risk assessment, pointing out the challenges faced by these methods. Deep learning algorithms show promising performance in parenchymal analysis, while a wider variety of performance indicators is reported for breast density estimation methods.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2021)
Article
Medicine, General & Internal
Gisella Gennaro, Melissa L. Hill, Elisabetta Bezzon, Francesca Caumo
Summary: Contrast-enhanced mammography may play an important role in personalized breast cancer screening models, especially for women at high risk or with dense breasts. Volumetric breast density measured from low-energy contrast-enhanced spectral mammography showed no significant difference compared to density measurements from standard digital mammography or tomosynthesis. The differences in volumetric breast density were associated with various independent variables, primarily related to breast positioning.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Kristin Johnson, Kristina Lang, Debra M. Ikeda, Anna Akesson, Ingvar Andersson, Sophia Zackrisson
Summary: Interval cancer rates were lower in DBT screening compared to DM screening, potentially indicating screening benefits. Interval cancers in the trial generally exhibited nonfavorable characteristics.
Article
Radiology, Nuclear Medicine & Medical Imaging
Lucy B. Spalluto, Kemberlee Bonnet, Chiamaka Sonubi, Sonya A. Reid, Jennifer A. Lewis, Laura L. Ernst, Katie M. Davis, Rifat Wahab, Pooja Agrawal, Chloe D'Agostino, Kris Gregory, Elizabeth Berardi, Crissy Hartsfield, Maureen Sanderson, Rebecca Selove, David Schlundt, Carolyn M. Audet
Summary: The purpose of this study was to gather the perspectives of Black women on breast cancer risk assessment through one-on-one interviews. The study conducted qualitative interviews with Black women in Tennessee and developed a framework of influences on a woman's decision to engage in breast cancer risk assessment. The decision context was based on risk appraisal, emotions, and perceived risks and benefits, and further influenced by communication, the risk assessment protocol, access to health care, knowledge, and health status.
JOURNAL OF THE AMERICAN COLLEGE OF RADIOLOGY
(2023)
Article
Oncology
Rowan T. Chlebowski, Aaron K. Aragaki
Summary: This study graphically displays the relationship between mammography, obesity, hormone therapy, and breast cancer incidence over 50 years. It analyzes the contributions of these factors to breast cancer incidence.
BREAST CANCER RESEARCH AND TREATMENT
(2023)
Article
Computer Science, Artificial Intelligence
Omid Haji Maghsoudi, Aimilia Gastounioti, Christopher Scott, Lauren Pantalone, Fang-Fang Wu, Eric A. Cohen, Stacey Winham, Emily F. Conant, Celine Vachon, Despina Kontos
Summary: Breast density is a crucial risk factor for breast cancer and affects the accuracy of screening mammography. An AI method has been introduced to estimate breast density, showing strong agreement with expert assessment and improved performance in breast cancer risk assessment compared to other methods.
MEDICAL IMAGE ANALYSIS
(2021)
Article
Endocrinology & Metabolism
Jiming Chen, Huihui Wang, Zhiyong Dong, Junling Liu, Zhenyue Qin, Mingyue Bao, Hongxia Yu, Shoufeng Zhang, Wendi Zhang, Chunjian Qi, Jie Wu
Summary: This study successfully established a rat model of perimenopausal symptoms induced by GnRH-a injection. Black cohosh preparations were found to effectively relieve perimenopausal symptoms in rats, with no obvious impact on serum sex hormone levels.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Medicine, General & Internal
Amy H. Farkas, Ann B. Nattinger
Summary: Breast cancer is the most common cancer among U.S. women, with its incidence increasing with age. Various factors like endogenous estrogen exposure, benign breast disease, breast density, and family history can indicate increased risk for breast cancer. Early detection through screening mammography helps reduce breast cancer mortality, but the benefits vary depending on age. Evaluating a patient's individual risk can guide decisions on breast cancer screening. All women benefit from healthy behaviors that can lower the risk. Women at higher risk may benefit from risk-reducing medications. The use of screening measures, especially among uninsured women, remains suboptimal.
ANNALS OF INTERNAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Adam Yala, Peter G. Mikhael, Constance Lehman, Gigin G. Lin, Fredrik Strand, Yung-Liang Wan, Kevin Hughes, Siddharth Satuluru, Thomas Kim, Imon Banerjee, Judy Gichoya, Hari Trivedi, Regina Barzilay
Summary: A reinforcement learning model, Tempo, was introduced to predict risk-based follow-up recommendations in breast cancer screening. The model was trained and validated using large datasets from multiple hospitals. The results showed that Tempo combined with an image-based AI risk model outperformed current clinical practice in terms of simulated early detection. The study demonstrated the potential of AI-based risk models and agile AI-designed screening policies in improving screening programs.
Review
Oncology
Sara P. Lester, Aparna S. Kaur, Suneela Vegunta
Summary: This review examines emerging evidence for the association of modifiable factors on mammographic breast density (MBD) and the influence of MBD on breast cancer risk, recommending that patients be counseled on modifiable risk factors to tailor breast cancer prevention strategies.
Article
Health Care Sciences & Services
Daniele Ugo Tari, Rosalinda Santonastaso, Davide Raffaele De Lucia, Marika Santarsiere, Fabio Pinto
Summary: This study aimed to compare the concordance of automatic breast density classification with visual assessment. The results showed that the categorization proposed by the Quantra software had good agreement with radiological evaluations, although it did not completely reflect the visual assessment. Therefore, clinical decisions regarding supplemental screening should be based on the radiologist's subjective judgement of masking effect rather than solely relying on the data produced by the Quantra software.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Endocrinology & Metabolism
Kerstin Ekbom, Anna Strandqvist, Svetlana Lajic, Angelica Hirschberg, Henrik Falhammar, Anna Nordenstrom
Summary: The study found that a good adherence rate to therapy regimens and a younger age were key factors for a better quality of life in patients with CAH. Patients with classic CAH reported higher QoL than those with nonclassic CAH. Compared to the general population, patients with CAH, especially nonclassic, more frequently reported limitations related to body pain, vitality, and mental health.
CLINICAL ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Henrik Falhammar, Louise Frisen, Angelica Linden Hirschberg, Agneta Nordenskjold, Catarina Almqvist, Anna Nordenstrom
Summary: Patients with congenital adrenal hyperplasia (CAH) have an increased prevalence of fractures, especially those associated with osteoporosis. This highlights the need for regular assessment of fracture risk and optimization of treatment.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Obstetrics & Gynecology
Angelica Linden Hirschberg
Summary: Essential hyperandrogenism is prevalent among female elite athletes, possibly due to the beneficial effects of androgens on muscle mass, bone mass, and erythropoiesis. In addition to rare sex development differences, menstrual disorders in female athletes are often caused by acquired hypothalamic disturbances resulting from excessive energy expenditure in relation to energy intake, leading to low bone density and increased injury risk.
SEMINARS IN REPRODUCTIVE MEDICINE
(2022)
Editorial Material
Sport Sciences
Angelica Linden Hirschberg
Correction
Multidisciplinary Sciences
A. Kasielska-Trojan, J. T. Manning, M. Jablkowski, J. Bialkowska-Warzecha, A. L. Hirschberg, B. Antoszewski
SCIENTIFIC REPORTS
(2022)
Article
Physiology
Lena Ekstroem, Jona Elings Knutsson, Christina Stephanou, Angelica Linden Hirschberg
Summary: Administration of testosterone (T) is associated with increased serum T concentrations and improved physical performance in women. Genetic variations may contribute to the inter-individual variation in T concentrations after T treatment. Polymorphisms in androgen metabolic enzyme genes and klotho gene were investigated in this study. The results suggest that individuals with a polymorphism in klotho may be more prone to detection using serum T and A as biomarkers.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Biochemical Research Methods
Jona Elings Knutsson, Lena Ekstrom, Angelica Linden Hirschberg
Summary: Analyzing doping control samples from female athletes requires understanding non-doping factors like exercise, alcohol consumption, hormonal changes during menstrual cycle, and the effect of approved drugs. Serum samples are proposed as a complement to urine samples for doping testing. This study investigated the effect of combined oral contraceptives on serum steroid levels in 340 healthy females, finding that the glucuronide metabolites were unaffected while testosterone levels increased during the ovulation phase, suggesting the ratio of testosterone and androstenedione as a potential marker for doping with endogenous anabolic androgenic steroids in women.
DRUG TESTING AND ANALYSIS
(2023)
Article
Geriatrics & Gerontology
Irene Lambrinoudaki, Eleni Armeni, Dimitrios Goulis, Silvia Bretz, Iuliana Ceausu, Fatih Durmusoglu, Risto Erkkola, Ivan Fistonic, Marco Gambacciani, Marije Geukes, Haitham Hamoda, Caiomhe Hartley, Angelica Linden Hirschberg, Blazej Meczekalski, Nicolas Mendoza, Alfred Mueck, Antonina Smetnik, Petra Stute, Mick van Trotsenburg, Margaret Rees
Summary: This care pathway provides an updated approach for monitoring and guiding middle-aged women, offering individualized treatment based on their needs, symptoms, and reproductive stage. It also includes details on screening for chronic diseases related to menopause and aging. Treatment options range from hormone therapy to lifestyle modifications, tailored to personal needs and wishes.
Article
Environmental Sciences
Philip von Rosen, Linda Ekenros, Guro Strom Solli, Oyvind Sandbakk, Hans-Christer Holmberg, Angelica Linden Hirschberg, Cecilia Friden
Summary: Many female athletes believe that symptoms related to the menstrual cycle negatively affect their training and well-being. However, there is a lack of knowledge and communication about female athlete health in the athletic community. The study highlights the need for a multi-professional medical team and enhanced educational efforts focused on female athlete health.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Biochemical Research Methods
Alexander Andersson, Thomas Piper, Lena Ekstrom, Angelica Linden Hirschberg, Mario Thevis
Summary: Monitoring the urinary steroid profile in the athlete biological passport helps detect testosterone intake, but current research has mainly focused on male subjects, neglecting steroid concentration and variation in females. This study evaluates the usefulness of carbon isotope ratio (CIR) analysis in serum samples from female subjects. Results show significant depletion of CIR in two targeted steroid sulphates after 10 weeks of transdermal testosterone administration. Although the urinary athlete biological passport lacks sensitivity, CIR analysis of androsterone and epiandrosterone in serum can be used as a complementary method to confirm exogenous testosterone in women.
DRUG TESTING AND ANALYSIS
(2023)
Article
Endocrinology & Metabolism
Lea Tschaidse, Nicole Reisch, Wiebke Arlt, Aude Brac de la Perriere, Angelica Linden Hirschberg, Anders Juul, Ashwini Mallappa, Deborah P. Merke, John D. C. Newell-Price, Colin G. Perry, Alessandro Prete, D. Aled Rees, Nike M. M. L. Stikkelbroeck, Philippe A. Touraine, Helen Coope, John Porter, Richard John M. Ross, Marcus Quinkler
Summary: This study compared the renin-angiotensin-aldosterone system in patients with salt-wasting congenital adrenal hyperplasia (SW-CAH) receiving modified-release hydrocortisone (MR-HC) or standard glucocorticoid (GC) therapy. It was found that MR-HC therapy decreased 17-hydroxyprogesterone levels, reduced plasma renin activity, and increased serum sodium concentrations, while standard GC therapy did not have these effects.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Review
Endocrinology & Metabolism
Angelica Linden Hirschberg
Summary: Postmenopausal hyperandrogenism is commonly caused by polycystic ovary syndrome, leading to symptoms such as hirsutism and androgenic alopecia, as well as metabolic disorders like abdominal obesity, insulin resistance, and type 2 diabetes. Patients with serum testosterone levels exceeding 5 nmol/L should undergo further investigation to rule out tumors producing androgens from the ovaries or adrenal glands.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Letter
Sport Sciences
Angelica Linden Hirschberg
Article
Geriatrics & Gerontology
Panagiotis Anagnostis, Sarantis Livadas, Dimitrios G. Goulis, Silvia Bretz, Iuliana Ceausu, Fatih Durmusoglu, Risto Erkkola, Ivan Fistonic, Marco Gambacciani, Marije Geukes, Haitham Hamoda, Caoimhe Hartley, Angelica Linden Hirschberg, Blazej Meczekalski, Nicolas Mendoza, Alfred Mueck, Antonina Smetnik, Petra Stute, Mick van Trotsenburg, Margaret Rees, Irene Lambrinoudaki
Summary: Vitamin D deficiency is associated with various negative health outcomes such as osteoporosis, cardiovascular disease, cancer, infections, and neurodegenerative disease. However, the impact of vitamin D supplementation on non-skeletal outcomes needs further clarification, especially in postmenopausal women.
Review
Endocrinology & Metabolism
Angelica Linden Hirschberg
Summary: Hyperandrogenism in women is associated with increased prevalence of cardiovascular risk factors and risk of cardiovascular disease. The relationship is independent of body mass index in premenopausal women, but dependent on obesity in postmenopausal women. The overall risk of cardiovascular disease in hyperandrogenic postmenopausal women is similar to controls. The reason for reduced cardiometabolic risk after menopause in hyperandrogenic women is not clear.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Geriatrics & Gerontology
Lum Kastrati, Dion Groothof, Hugo G. Quezada-Pinedo, Hamidreza Raeisi-Dehkordi, Lia Bally, Martin H. De Borst, Stephan J. L. Bakker, Pedro-Marques Vidal, Michele F. Eisenga, Taulant Muka
Summary: The study aimed to examine the association between iron biomarkers and menopausal status and assess whether these biomarkers can help differentiate menopausal status beyond age. The results showed that iron biomarkers were significantly associated with menopausal status in both cohorts and modestly improved a model with age alone for differentiating menopause status.
Article
Geriatrics & Gerontology
Osvaldo P. Almeida, Christopher Etherton-Beer, Frank Sanfilippo, David B. Preen, Amy Page
Summary: The use of antineoplastic medications has been found to be associated with a decreased risk of dementia, which may contribute to the development of novel approaches for dementia prevention.
Article
Geriatrics & Gerontology
Bamini Gopinath, Diana Tang, George Burlutsky, Paul Mitchell
Summary: This study used a cohort of community-dwelling adults to establish the 10-year incidence and predictors of dizziness/vertigo, and its impacts on health-related quality of life. The results showed that age and presence of migraine were significant predictors of incident dizziness/vertigo, and dizziness/vertigo was associated with a significant decrease in quality of life.
Article
Geriatrics & Gerontology
Yuto Kiuchi, Kota Tsutsumimoto, Takehiko Doi, Satoshi Kurita, Kazuhei Nishimoto, Hyuma Makizako, Hiroyuki Shimada
Summary: This study found that high dietary diversity is associated with a lower risk of incident disability among sarcopenic Japanese older adults.
Article
Geriatrics & Gerontology
C. . Tamer Erel, Ipek Betul Ozcivit Erkan, Neslihan Gokmen Inan, Kubra Hamzaoglu Canbolat, Sena Alkan, Dildar Konukoglu, Yalim Dikmen
Summary: This study aimed to compare the clinical course and outcomes of Covid-19 between premenopausal and postmenopausal women, and investigate the factors that influence disease severity. The results showed that premenopausal women had a more favorable prognosis, and age, postmenopausal status, and serum levels of dehydroepiandrosterone sulfate were important predictors of the severity of Covid-19 in women.
Article
Geriatrics & Gerontology
Kazuhei Nishimoto, Kota Tsutsumimoto, Takehiko Doi, Satoshi Kurita, Yuto Kiuchi, Hiroyuki Shimada
Summary: The combination of urinary incontinence and low life-space activity/mobility is associated with an increased risk of incident disability among older adults, while having urinary incontinence but high life-space activity/mobility is not associated with an increased risk of incident disability.
Review
Geriatrics & Gerontology
Nikolaos Evangelinakis, Eleni V. Geladari, Charalampia V. Geladari, Adamantia Kontogeorgi, Georgios-Konstantinos Papaioannou, Melpomeni Peppa, Sophia Kalantaridou
Summary: Premature ovarian insufficiency and ovarian aging are complex conditions that affect women's reproductive health and overall well-being. This review explores the influence of environmental factors, including endocrine-disrupting chemicals and lifestyle choices, on the development and progression of these conditions. Understanding the impact of environmental factors is important for public and clinical health contexts.
Article
Geriatrics & Gerontology
Adela Castello, Miguel Rodriguez-Barranco, Virginia Lope, Marcela Guevara, Sandra Colorado-Yohar, Ane Dorronsoro, Jose Ramon Quiros, Carlota Castro-Espin, Carmen Sayon-Orea, Carmen Santiuste, Pilar Amiano, Cristina Lasheras, Maria-Jose Sanchez, Marina Pollan
Summary: The study found that the intake of foods such as high-fat dairy products, red and processed meats, refined grains, sweets, caloric drinks, convenience food and sauces might be associated with a higher risk of breast cancer.