Article
Clinical Neurology
Zhi-Bo Wang, Lan Tan, Hui-Fu Wang, Shi-Dong Chen, Yan Fu, Pei-Yang Gao, Ya-Hui Ma, Yu Guo, Jia-Hui Hou, Dan-Dan Zhang, Jin-Tai Yu
Summary: This study aimed to assess the accuracy of biomarkers related to amyloid, tau, and neurodegeneration in predicting Alzheimer's disease (AD) neuropathology at different clinical stages. The results showed that amyloid positron emission tomography (PET) and cerebrospinal fluid (CSF) amyloid beta (Aβ)42/phosphorylated tau (p-tau)181 performed well in differentiating AD and predicting neuropathological changes in early and late clinical stages. However, CSF Aβ42 performed better in early clinical stage, while CSF p-tau181, CSF t-tau, and plasma p-tau181 performed better in late clinical stage.
ALZHEIMERS & DEMENTIA
(2023)
Review
Immunology
Jie Huang
Summary: This review discusses the current status and applications of molecule-based positron emission tomography (PET) imaging in neuroinflammation. Despite certain limitations, neuroinflammation PET imaging is considered a promising approach to understanding the pathophysiological process of Alzheimer's disease (AD) and mild cognitive impairment (MCI).
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Yuuki Sasaki, Noriyuki Kimura, Yasuhiro Aso, Kenichi Yabuuchi, Miki Aikawa, Etsuro Matsubara
Summary: The study found that CSF levels of MMP-2 were negatively correlated with brain amyloid deposition, especially in the parietotemporal lobe and posterior cingulate gyrus, and that CSF levels of MMP-7 were positively correlated with the severity of WMLs. These findings provide insights into the role of MMPs in amyloid beta catabolism and blood-brain barrier integration at the MCI stage.
Article
Cell Biology
Eun-Hye Lee, Myung-Hoon Han, Jungsoon Ha, Hyun-Hee Park, Seong-Ho Koh, Seong Hye Choi, Jae-Hong Lee
Summary: The study indicated a negative association between age and telomere length, with individuals with Alzheimer's disease showing a greater rate of telomere shortening per year compared to healthy individuals and those with mild cognitive impairment. Additionally, women experienced more significant telomere shortening per year than men.
Article
Clinical Neurology
Alexis Moscoso, Michel J. Grothe, Nicholas J. Ashton, Thomas K. Karikari, Juan Lantero Rodriguez, Anniina Snellman, Marc Suarez-Calvet, Henrik Zetterberg, Kaj Blennow, Michael Scholl
Summary: Measurement of tau phosphorylated at threonine 181 (p-tau181) in blood plasma is proposed as a specific biomarker for Alzheimer's disease. Longitudinal study reveals that plasma p-tau181 increases before amyloid-beta markers reach abnormal levels, correlating with amyloid-beta pathology. Plasma p-tau181 also shows associations with widespread cortical tau aggregation and may be a useful diagnostic and screening tool for Alzheimer's disease.
Article
Neurosciences
Charles D. Chen, Maria Rosana Ponisio, Jordan A. Lang, Shaney Flores, Suzanne E. Schindler, Anne M. Fagan, John C. Morris, Tammie L. S. Benzinger
Summary: F-18-flortaucipir PET was approved by FDA for visualizing neurofibrillary tangles in the brains of patients with cognitive impairment. Visual interpretation was found to be consistent with SUVR and moderately consistent with CSF biomarkers. However, it could not predict the clinical assessment in some cases.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Neurosciences
Bingyu Li, Kening Shi, Chao Ren, Min Kong, Maowen Ba
Summary: This study aimed to find a simple and effective method to predict the tau-PET status in individuals with mild cognitive impairment (MCI). The study found that by combining multiple clinical markers, including Alzheimer's Disease Assessment Scale-Cognitive Subscale 13, Mini-Mental State Examination, and ADNI-Memory summary score, the tau-PET status can be accurately predicted. This finding has non-invasive and cost-effective clinical application value for predicting tau pathology among MCI individuals.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Clinical Neurology
Laura Nisenbaum, Robert Martone, Tianle Chen, Rajasimhan Rajagovindan, Gersham Dent, John Beaver, Carrie Rubel, Annie Racine, Ping He, Katie Harrison, Robert Dean, Manu Vandijck, Samantha Budd Haeberlein
Summary: This study assessed the use of cerebrospinal fluid (CSF) biomarkers as an alternative to positron emission tomography (PET) for confirming brain amyloid beta (A beta) pathology. The results showed a robust concordance between CSF biomarkers and amyloid PET, and the ratios of CSF biomarkers exhibited higher diagnostic accuracy for A beta pathology confirmation.
ALZHEIMERS & DEMENTIA
(2023)
Article
Medicine, General & Internal
Min Young Chun, Geon Ha Kim, Hee Kyung Park, Dong Won Yang, SangYun Kim, Seong Hye Choi, Jee Hyang Jeong
Summary: This study aimed to develop a new predictive scale for amyloid positron emission tomography (PET) positivity using easily accessible tools. The results showed that verbal and visual memory tests, medial temporal lobe atrophy, apolipoprotein E (APOE) genotype, and age were significant predictors of A beta deposition. The new predictive scale performed well in the validation cohort.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Neurosciences
Gwenn S. Smith, Hiroto Kuwabara, Haijuan Yan, Najlla Nassery, Mark Yoon, Vidya Kamath, Michael Kraut, Neda F. Gould, Alena Savonenko, Jennifer M. Coughlin, Martin Lodge, Martin G. Pomper, Ayon Nandi, Daniel Holt, Robert F. Dannals, Jeannie M. Leoutsakos
Summary: This study found degeneration of the serotonin system and increased cortical levels of A beta in individuals with MCI, which are associated with deficits in memory and semantic fluency.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Medicine, General & Internal
Nicholas J. Ashton, Andrea L. Benedet, Tharick A. Pascoal, Thomas K. Karikari, Juan Lantero-Rodriguez, Wagner S. Brum, Sulantha Mathotaarachchi, Joseph Therriault, Melissa Savard, Mira Chamoun, Erik Stoops, Cindy Francois, Eugeen Vanmechelen, Serge Gauthier, Eduardo R. Zimmer, Henrik Zetterberg, Kaj Blennow, Pedro Rosa-Neto
Summary: CSF p-tau epitopes increase early in the development of AD pathology and are a primary candidate for detecting incipient Aβ pathology.
Article
Neurosciences
Tyler Saunders, Ciaran Gunn, Kaj Blennow, Hlin Kvartsberg, Henrik Zetterberg, Susan D. Shenkin, Simon R. Cox, Ian J. Deary, Colin Smith, Declan King, Tara Spires-Jones
Summary: Neurogranin (Ng), a post-synaptic protein, has been investigated as a biomarker for Alzheimer's disease (AD) and aging in cerebrospinal fluid (CSF). Our study examined Ng abundance in post-mortem human brain tissue in AD, healthy aging (HA), and mid-life (ML) cohorts. Ng levels were quantified using immunohistochemistry in brain regions associated with cognitive change. The results showed significantly reduced Ng levels in AD compared to HA and ML cases, indicating loss of neurogranin in the brain. Our findings support the use of CSF Ng as a biomarker for AD and cognitive decline in healthy aging.
NEUROBIOLOGY OF DISEASE
(2023)
Review
Cell Biology
Yi-Jun Ge, Wei Xu, Ya-Nan Ou, Yi Qu, Ya-Hui Ma, Yu-Yuan Huang, Xue-Ning Shen, Shi-Dong Chen, Lan Tan, Qian-Hua Zhao, Jin-Tai Yu
Summary: The study systematically evaluated retinal imaging and electrophysiological markers in patients with Alzheimer's disease, mild cognitive impairment, and preclinical AD. It found that these retinal biomarkers hold great potential for the diagnosis, prognosis, and risk assessment of AD and MCI. Further development of these biomarkers, especially in diagnostic test accuracy and longitudinal studies, is warranted in the future.
AGEING RESEARCH REVIEWS
(2021)
Article
Clinical Neurology
Olin Janssen, Willemijn J. Jansen, Stephanie J. B. Vos, Merce Boada, Lucilla Parnetti, Tomasz Gabryelewicz, Tormod Fladby, Jose Luis Molinuevo, Sylvia Villeneuve, Jakub Hort, Stephane Epelbaum, Alberto Lleo, Sebastiaan Engelborghs, Wiesje M. van der Flier, Susan Landau, Julius Popp, Anders Wallin, Philip Scheltens, Marcel Olde Rikkert, Peter J. Snyder, Chris Rowe, Gael Chetelat, Agustin Ruiz, Marta Marquie, Elena Chipi, Steffen Wolfsgruber, Michael Heneka, Henning Boecker, Oliver Peters, Jonas Jarholm, Lorena Rami, Adria Tort-Merino, Alexa Pichet Binette, Judes Poirier, Pedro Rosa-Neto, Jiri Cerman, Bruno Dubois, Marc Teichmann, Daniel Alcolea, Juan Fortea, M. Belen Sanchez-Saudinos, Jarith Ebenau, Cornelia Pocnet, Marie Eckerstrom, Louisa Thompson, Victor Villemagne, Rachel Buckley, Samantha Burnham, Marion Delarue, Yvonne Freund-Levi, Asa K. Wallin, Inez Ramakers, Magda Tsolaki, Hilkka Soininen, Harald Hampel, Luiza Spiru, Betty Tijms, Rik Ossenkoppele, Frans R. J. Verhey, Frank Jessen, Pieter Jelle Visser
Summary: In addition to age, setting, and APOE ε4 carriership, specific characteristics of subjective cognitive decline may aid in identifying individuals with amyloid positivity.
ALZHEIMERS & DEMENTIA
(2022)
Article
Neurosciences
Hyejin Ahn, Dahyun Yi, Kyungjin Chu, Haejung Joung, Younghwa Lee, Gijung Jung, Kiyoung Sung, Dongkyun Han, Jun Ho Lee, Min Soo Byun, Dong Young Lee
Summary: This study investigated the neural correlates of semantic verbal fluency test (SVFT) scores in subjects with mild cognitive impairment (MCI) and Alzheimer's disease (AD) dementia using FDG-PET. The results showed that the total score (TS) of SVFT was positively correlated with cerebral glucose metabolism in various brain regions. However, the strategy scores of switching (SW) and cluster switching (CSW) were found to be better indicators of specific language and executive functions. Furthermore, the associations between strategy scores and regional glucose metabolism varied based on the severity of the disease.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Neurosciences
Kristine B. Walhovd, Anders M. Fjell, Yunpeng Wang, Inge K. Amlien, Athanasia M. Mowinckel, Ulman Lindenberger, Sandra Duzel, David Bartres-Faz, Klaus P. Ebmeier, Christian A. Drevon, William F. C. Baare, Paolo Ghisletta, Louise Baruel Johansen, Rogier A. Kievit, Richard N. Henson, Kathrine Skak Madsen, Lars Nyberg, Jennifer R. Harris, Cristina Sole-Padulles, Sara Pudas, Oystein Sorensen, Rene Westerhausen, Eniko Zsoldos, Laura Nawijn, Torkild Hovde Lyngstad, Sana Suri, Brenda Penninx, Ole J. Rogeberg, Andreas M. Brandmaier
Summary: Higher socio-economic status (SES) shows differing relationships with brain volumes and cognitive ability across European and US cohorts, with SES being more strongly related to brain and cognition in the US than in European cohorts. The study suggests that SES-brain volume relationships may be established early in life, with SES more strongly related to intracranial volume than to gray matter volume in adulthood.
Article
Neurosciences
Raihaan Patel, Clare E. Mackay, Michelle G. Jansen, Gabriel A. Devenyi, M. Clare O'Donoghue, Mika Kivimaeki, Archana Singh-Manoux, Eniko Zsoldos, Klaus P. Ebmeier, M. Mallar Chakravarty, Sana Suri
Summary: This study examines the relationship between cognitive decline and brain structure in older age. By analyzing cognitive performance assessments and brain magnetic resonance images of a group of older individuals, the study identifies two distinct brain-cognition associations and highlights the complex relationship between cortical structure and cognitive abilities.
Article
Multidisciplinary Sciences
Kristine B. Walhovd, Lars Nyberg, Ulman Lindenberger, Inge K. Amlien, Oystein Sorensen, Yunpeng Wang, Athanasia M. Mowinckel, Rogier A. Kievit, Klaus P. Ebmeier, David Bartres-Faz, Simone Kuehn, Carl-Johan Boraxbekk, Paolo Ghisletta, Kathrine Skak Madsen, Willliam F. C. Baare, Eniko Zsoldos, Fredrik Magnussen, Didac Vidal-Pineiro, Brenda Penninx, Anders M. Fjell
Summary: This study revealed that higher general cognitive ability (GCA) is positively associated with cortical volume, area, and thickness, and this association is related to both brain reserve and maintenance mechanisms.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, General & Internal
Anya Topiwala, Chaoyue Wang, Klaus P. Ebmeier, Stephen Burgess, Steven Bell, Daniel F. Levey, Hang Zhou, Celeste McCracken, Adriana Roca-Fernandez, Steffen E. Petersen, Betty Raman, Masud Husain, Joel Gelernter, Karla L. Miller, Stephen M. Smith, Thomas E. Nichols
Summary: This study found an association between moderate alcohol consumption and brain iron accumulation. Iron accumulation may represent a potential pathway for alcohol-related cognitive decline.
Article
Neurosciences
Lars Nyberg, Micael Andersson, Anders Lundquist, William F. C. Baare, David Bartres-Faz, Lars Bertram, Carl-Johan Boraxbekk, Andreas M. Brandmaier, Naiara Demnitz, Christian A. Drevon, Sandra Duezel, Klaus P. Ebmeier, Paolo Ghisletta, Richard Henson, Daria E. A. Jensen, Rogier A. Kievit, Ethan Knights, Simone Kuhn, Ulman Lindenberger, Anna Plachti, Sara Pudas, James M. Roe, Kathrine Skak Madsen, Cristina Sole-Padulles, Yasmine Sommerer, Sana Suri, Eniko Zsoldos, Anders M. Fjell, Kristine B. Walhovd
Summary: We found heterogeneity in regional-atrophy patterns through latent-profile analysis of 1,482 longitudinal magnetic resonance imaging observations. The results supported a 2-group solution reflecting differences in atrophy rates in cortical regions and hippocampus along with comparable caudate atrophy. Our findings suggest distinct mechanisms of atrophy in striatal versus hippocampal-cortical systems.
Article
Public, Environmental & Occupational Health
Rebecca B. Carver, Nanna Alida Grit Fredheim, Athanasia Monika Mowinckel, Klaus P. Ebmeier, Barbara Bodorkos Friedman, Tor Atle Rosness, Christian A. Drevon, Sana Suri, William F. C. Baare, Eniko Zsoldos, Cristina Sole-Padulles, David Bartres-Faz, Paolo Ghisletta, Laura Nawijn, Sandra Duezel, Kathrine Skak Madsen, Anders M. Fjell, Ulman Lindenberger, Kristine B. Walhovd, Isabelle Budin-Ljosne
Summary: This study investigated people's willingness and reasons to take a brain health test. The results showed a high public interest in brain health testing, with the main reason being the ability to respond if at risk of brain disease. Men, respondents with lower education levels, and those with poor self-reported cognitive health had higher interest in brain health testing.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Neurosciences
Julia Binnewies, Laura Nawijn, Andreas M. Brandmaier, William F. C. Baare, Carl-Johan Boraxbekk, Naiara Demnitz, Christian A. Drevon, Anders M. Fjell, Ulman Lindenberger, Kathrine Skak Madsen, Lars Nyberg, Anya Topiwala, Kristine B. Walhovd, Klaus P. Ebmeier, Brenda W. J. H. Penninx
Summary: This study found that lifestyle-related risk factors, such as obesity and alcohol use, are negatively associated with hippocampal and total grey matter volumes. Additionally, having multiple unhealthy lifestyle factors leads to a linear reduction in overall brain volume.
BRAIN RESEARCH BULLETIN
(2023)
Article
Health Care Sciences & Services
Isabelle Budin-Ljosne, Barbara B. Friedman, William F. C. Baare, David Bartres-Faz, Rebecca B. Carver, Christian A. Drevon, Klaus P. Ebmeier, Anders M. Fjell, Paolo Ghisletta, Richard N. Henson, Rogier Kievit, Kathrine S. Madsen, Laura Nawijn, Sana Suri, Cristina Sole-Padulles, Kristine B. Walhovd, Eniko Zsoldos
Summary: The involvement of stakeholders in the "Lifebrain" project was seen as meaningful and relevant, benefiting both researchers and stakeholders. However, there were barriers such as lack of time, difficulties in identifying relevant stakeholders, and challenges in communicating scientific issues. Stakeholder engagement in basic brain research requires dedicated resources, clear communication, and defined roles and responsibilities.
HEALTH EXPECTATIONS
(2023)
Article
Multidisciplinary Sciences
Anya Topiwala, Kulveer Mankia, Steven Bell, Alastair Webb, Klaus P. Ebmeier, Isobel Howard, Chaoyue Wang, Fidel Alfaro-Almagro, Karla Miller, Stephen Burgess, Stephen Smith, Thomas E. Nichols
Summary: The potential association between neurodegenerative disease risk and gout is not fully understood. Here the authors showed that gout is causally related to several measures of brain structure which may explain their higher vulnerability to dementia. Studies of neurodegenerative disease risk in gout are contradictory. Relationships with neuroimaging markers of brain structure, which may offer insights, are uncertain. Here we investigated associations between gout, brain structure, and neurodegenerative disease incidence. Gout patients had smaller global and regional brain volumes and markers of higher brain iron, using both observational and genetic approaches. Participants with gout also had higher incidence of all-cause dementia, Parkinson's disease, and probable essential tremor. Risks were strongly time dependent, whereby associations with incident dementia were highest in the first 3 years after gout diagnosis. These findings suggest gout is causally related to several measures of brain structure. Lower brain reserve amongst gout patients may explain their higher vulnerability to multiple neurodegenerative diseases. Motor and cognitive impairments may affect gout patients, particularly in early years after diagnosis.
NATURE COMMUNICATIONS
(2023)
Article
Neurosciences
Anders M. Fjell, Oystein Sorensen, Yunpeng Wang, Inge K. Amlien, William F. C. Baare, David Bartres-Faz, Carl-Johan Boraxbekk, Andreas M. Brandmaier, Ilja Demuth, Christian A. Drevon, Klaus P. Ebmeier, Paolo Ghisletta, Rogier Kievit, Simone Kuehn, Kathrine Skak Madsen, Lars Nyberg, Cristina Sole-Padulles, Didac Vidal-Pineiro, Gerd Wagner, Leiv Otto, Kristine B. Walhovd
Summary: A study found that some people can sleep less than the recommended amount without experiencing daytime sleepiness. These individuals showed larger brain volumes and did not report any sleep problems. However, their performance on general cognitive tests was slightly lower and warrants further investigation.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Geriatrics & Gerontology
Naiara Demnitz, Oliver J. Hulme, Hartwig R. Siebner, Michael Kjaer, Klaus P. Ebmeier, Carl-Johan Boraxbekk, Claire M. Gillan
Summary: Modifiable lifestyle factors are correlated with brain structure, but the associations differ between datasets. Personalized baseline characterization may help achieve targeted lifestyle interventions.
NEUROBIOLOGY OF AGING
(2023)
Article
Psychology, Biological
Anders M. Fjell, Oystein Sorensen, Yunpeng Wang, Inge K. Amlien, William F. C. Baare, David Bartres-Faz, Lars Bertram, Carl-Johan Boraxbekk, Andreas M. Brandmaier, Ilja Demuth, Christian A. Drevon, Klaus P. Ebmeier, Paolo Ghisletta, Rogier Kievit, Simone Kuehn, Kathrine Skak Madsen, Athanasia M. Mowinckel, Lars Nyberg, Claire E. Sexton, Cristina Sole-Padulles, Didac Vidal-Pineiro, Gerd Wagner, Leiv Otto Watne, Kristine B. Walhovd
Summary: Short sleep duration is not directly associated with brain health, and normal brains promote adequate sleep.
NATURE HUMAN BEHAVIOUR
(2023)
Article
Neuroimaging
Louise S. Schindler, Sivaniya Subramaniapillai, Claudia Barth, Dennis van der Meer, Mads L. Pedersen, Tobias Kaufmann, Ivan I. Maximov, Jennifer Linge, Olof Dahlqvist Leinhard, Dani Beck, Tiril P. Gurholt, Irene Voldsbekk, Sana Suri, Klaus P. Ebmeier, Bogdan Draganski, Ole A. Andreassen, Lars T. Westlye, Ann-Marie G. de Lange
Summary: The menopause transition may have an impact on female brain health due to changes in oestrogens and adipose tissue distribution. This study investigated the associations between different types of adipose tissue and brain characteristics in post-menopausal females. The results showed that the relationships between abdominal adipose tissue and brain measures were more prominent in females with a longer reproductive span, suggesting that individual differences in cumulative oestrogen exposure during reproductive years play a role in post-menopausal brain health.
NEUROIMAGE-CLINICAL
(2022)
Article
Neuroimaging
Julia Binnewies, Laura Nawijn, Andreas M. Brandmaier, William F. C. Baare, David Bartres-Faz, Christian A. Drevon, Sandra Duezel, Anders M. Fjell, Laura K. M. Han, Ethan Knights, Ulman Lindenberger, Yuri Milaneschi, Athanasia M. Mowinckel, Lars Nyberg, Anna Plachti, Kathrine Skak Madsen, Cristina Sole-Padulles, Sana Suri, Kristine B. Walhovd, Eniko Zsoldos, Klaus P. Ebmeier, Brenda W. J. H. Penninx
Summary: This study investigated the association between depressive symptoms and depression status with brain structures, and found that in clinical patient-control cohorts, both depressive symptoms and depression status were associated with lower thickness and volume of specific brain regions, while no such associations were observed in the general population.
NEUROIMAGE-CLINICAL
(2022)
Article
Neuroimaging
Anya Topiwala, Klaus P. Ebmeier, Thomas Maullin-Sapey, Thomas E. Nichols
Summary: Moderate alcohol consumption may have impacts on brain structure and function, as evidenced by associations with multiple MRI markers such as grey matter volume, white matter microstructure, and functional connectivity. These associations are stronger than those with other modifiable factors and can be exacerbated by frequent binging, high blood pressure, and BMI.
NEUROIMAGE-CLINICAL
(2022)
Article
Geriatrics & Gerontology
Lum Kastrati, Dion Groothof, Hugo G. Quezada-Pinedo, Hamidreza Raeisi-Dehkordi, Lia Bally, Martin H. De Borst, Stephan J. L. Bakker, Pedro-Marques Vidal, Michele F. Eisenga, Taulant Muka
Summary: The study aimed to examine the association between iron biomarkers and menopausal status and assess whether these biomarkers can help differentiate menopausal status beyond age. The results showed that iron biomarkers were significantly associated with menopausal status in both cohorts and modestly improved a model with age alone for differentiating menopause status.
Article
Geriatrics & Gerontology
Osvaldo P. Almeida, Christopher Etherton-Beer, Frank Sanfilippo, David B. Preen, Amy Page
Summary: The use of antineoplastic medications has been found to be associated with a decreased risk of dementia, which may contribute to the development of novel approaches for dementia prevention.
Article
Geriatrics & Gerontology
Bamini Gopinath, Diana Tang, George Burlutsky, Paul Mitchell
Summary: This study used a cohort of community-dwelling adults to establish the 10-year incidence and predictors of dizziness/vertigo, and its impacts on health-related quality of life. The results showed that age and presence of migraine were significant predictors of incident dizziness/vertigo, and dizziness/vertigo was associated with a significant decrease in quality of life.
Article
Geriatrics & Gerontology
Yuto Kiuchi, Kota Tsutsumimoto, Takehiko Doi, Satoshi Kurita, Kazuhei Nishimoto, Hyuma Makizako, Hiroyuki Shimada
Summary: This study found that high dietary diversity is associated with a lower risk of incident disability among sarcopenic Japanese older adults.
Article
Geriatrics & Gerontology
C. . Tamer Erel, Ipek Betul Ozcivit Erkan, Neslihan Gokmen Inan, Kubra Hamzaoglu Canbolat, Sena Alkan, Dildar Konukoglu, Yalim Dikmen
Summary: This study aimed to compare the clinical course and outcomes of Covid-19 between premenopausal and postmenopausal women, and investigate the factors that influence disease severity. The results showed that premenopausal women had a more favorable prognosis, and age, postmenopausal status, and serum levels of dehydroepiandrosterone sulfate were important predictors of the severity of Covid-19 in women.
Article
Geriatrics & Gerontology
Kazuhei Nishimoto, Kota Tsutsumimoto, Takehiko Doi, Satoshi Kurita, Yuto Kiuchi, Hiroyuki Shimada
Summary: The combination of urinary incontinence and low life-space activity/mobility is associated with an increased risk of incident disability among older adults, while having urinary incontinence but high life-space activity/mobility is not associated with an increased risk of incident disability.
Review
Geriatrics & Gerontology
Nikolaos Evangelinakis, Eleni V. Geladari, Charalampia V. Geladari, Adamantia Kontogeorgi, Georgios-Konstantinos Papaioannou, Melpomeni Peppa, Sophia Kalantaridou
Summary: Premature ovarian insufficiency and ovarian aging are complex conditions that affect women's reproductive health and overall well-being. This review explores the influence of environmental factors, including endocrine-disrupting chemicals and lifestyle choices, on the development and progression of these conditions. Understanding the impact of environmental factors is important for public and clinical health contexts.
Article
Geriatrics & Gerontology
Adela Castello, Miguel Rodriguez-Barranco, Virginia Lope, Marcela Guevara, Sandra Colorado-Yohar, Ane Dorronsoro, Jose Ramon Quiros, Carlota Castro-Espin, Carmen Sayon-Orea, Carmen Santiuste, Pilar Amiano, Cristina Lasheras, Maria-Jose Sanchez, Marina Pollan
Summary: The study found that the intake of foods such as high-fat dairy products, red and processed meats, refined grains, sweets, caloric drinks, convenience food and sauces might be associated with a higher risk of breast cancer.
