Article
Multidisciplinary Sciences
Wei-Chuan Chang, Jen-Hung Wang, Dah-Ching Ding
Summary: This study found that in postmenopausal women in Taiwan, hormone therapy with oral conjugated equine estrogen (CEE) may be associated with a higher risk of ischemic stroke (IS) compared to estradiol (E2), especially when initiated within 5 years of menopause.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Medicinal
Guilherme Renke, Francisco Tostes
Summary: We discussed the CV safety and efficacy of subcutaneous testosterone therapy (STT) in postmenopausal women. Our proposed innovative criteria (IDEALSTT) for recommending STT include total testosterone level, carotid artery intima-media thickness, and calculated SCORE for 10-year CVD risk. While hormone replacement therapy (HRT) with testosterone has gained popularity in treating pre and postmenopausal women, the long-term safety and CV risk of STT in women are still controversial.
Article
Medicine, General & Internal
Jaehoon Lee, Yuntae Kim, Hyunji Park, Changsoo Kim, Sihyun Cho, Jongyoun Kim
Summary: This study investigated the association between different types of hormone replacement therapy (HRT) and atrial fibrillation (AF). The findings showed that current HRT users, except those using estradiol-only HRT, had significantly elevated AF risk, while past users who used estradiol plus progestin HRT had a reduced AF risk.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Multidisciplinary Sciences
Soo-Min Kim, Sung Eun Kim, Dong-Yun Lee, DooSeok Choi
Summary: The study evaluated serum estradiol levels in postmenopausal women using different doses and formulations of oral menopausal hormone therapy. It found that serum estradiol levels were not directly proportional to estrogen dose, with estradiol 2 mg showing significantly higher levels compared to estradiol 1 mg and conjugated estrogen 0.45 mg.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Hayoung Choi, Kyungdo Han, Bumhee Yang, Dong Wook Shin, Jang Won Sohn, Hyun Lee
Summary: This study aimed to evaluate the impacts of endogenous estrogen exposure and hormone replacement therapy (HRT) on the risk of nontuberculous mycobacterial pulmonary disease (NTM-PD) in postmenopausal women. The results showed no significant association between endogenous estrogen exposure and NTM-PD risk, but there was a dose-dependent relationship between the duration of HRT and the risk of NTM-PD.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Obstetrics & Gynecology
H. Kim, M. J. Kang, J. K. Baek, J. K. Lee, E. A. Choi, B. H. Yun, E. H. Kim, S. K. Seo
Summary: This study analyzed the effect of menopausal hormone therapy (MHT) on the incidence of spine and femur fractures in Korean women. The study found that EPT and tibolone significantly reduced the incidence of fractures, while ET only lowered the risk of femur fractures when used for more than 5 years with estradiol.
Article
Dentistry, Oral Surgery & Medicine
Lina Wang, Lilei Zhu, Yao Yao, Yajuan Ren, Hongcan Zhang
Summary: Hormone replacement therapy effectively relieves oral dryness symptoms in postmenopausal women and increases salivary estradiol levels.
Article
Oncology
Hee Joong Lee, Banghyun Lee, Hangseok Choi, Taehee Kim, Yejeong Kim, Yong Beom Kim
Summary: Endometriosis is a risk factor for ovarian cancer, but the effect of hormone replacement therapy (HRT) on postmenopausal endometriosis remains unclear. This study investigated the impact of HRT on ovarian cancer occurrence in postmenopausal women with a history of endometriosis or de novo endometriosis. With the exception of HRT using estrogen alone, HRT did not increase the risk of ovarian cancer in these women.
Article
Orthopedics
Rachael Mary Cowan, Charlotte Louise Ganderton, Jillianne Cook, Adam Ivan Semciw, David Michel Long, Tania Pizzari
Summary: This study aimed to investigate the effects of MHT and exercise on tendon pain and function in postmenopausal women with GTPS. The results showed that MHT combined with exercise and education significantly improved symptom scores, especially for women with BMI <25. Education on avoiding gluteal tendon compression and load management played a crucial role in pain relief and functional improvement.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2022)
Article
Allergy
Bright I. Nwaru, Syed A. Shah, Holly Tibble, Rebecca Pillinger, Susannah McLean, Dermot Ryan, Hilary Critchley, Catherine M. Hawrylowicz, Colin R. Simpson, Ireneous N. Soyiri, Francis Appiagyei, David Price, Aziz Sheikh
Summary: This study found that previous use of HRT, particularly for more than 2 years, combined HRT, and estrogen-only HRT, is associated with an increased risk of severe asthma exacerbation in perimenopausal/postmenopausal women with established asthma. Lean women and smokers are at greater risk than heavier women and nonsmokers, respectively.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2021)
Article
Medical Laboratory Technology
Xiao-kang Dong, Dan Luo, Wen-jing Chen, Rong-rong Wang, Jie Yang, Miao-miao Niu
Summary: The study found a positive association between serum uric acid levels and the presence and progression of carotid atherosclerosis. Long-term hormone replacement therapy (HRT) may be beneficial in preventing the development of carotid atherosclerosis. However, further research is needed to evaluate the safety and long-term outcomes of HRT on carotid atherosclerosis.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2022)
Article
Obstetrics & Gynecology
M. I. Dothard, S. M. Allard, J. A. Gilbert
Summary: Estrogen, a sex steroid hormone, regulates various aspects of female development. Decreased estrogen synthesis during menopause leads to adverse physiological changes and increased disease risk. Hormone replacement therapy (HRT) using exogenous estradiol with progestin can alleviate these changes by re-inducing estrogenic action. The gut and vaginal microbiomes have a bidirectional regulatory relationship with estrogen, and HRT can restore microbial homeostasis. This review discusses the response of the gut and vaginal microbiomes in postmenopausal women to HRT and explores the potential of microbe-based therapeutics for menopausal symptoms.
Article
Dermatology
Jun Ma, Yi-Hsien Chen, Chien-Ping Chiang, Wei-Ming Wang, Chi-Hsiang Chung, Chang-Huei Tsao, Zi-Xeng Weng, Chih-Tsung Hung, Wu-Chien Chien
Summary: A population-based retrospective cohort study in Taiwan found no significant correlation between hormone replacement therapy (HRT) and risk of melanoma. Estrogen plus progesterone combined therapy was associated with a lower risk of melanoma.
JOURNAL OF DERMATOLOGY
(2023)
Article
Endocrinology & Metabolism
Soyeon Kang, Yong-Moon Park, Dong Jin Kwon, Youn-Jee Chung, Jeong Namkung, Kyungdo Han, Seung-Hyun Ko
Summary: In postmenopausal women with type 2 diabetes, a longer reproductive life span is associated with a lower risk of severe hypoglycemia, and every 5-year increment in the reproductive life span reduces the risk of severe hypoglycemia. The use of hormone replacement therapy (HRT) is also associated with a lower risk of severe hypoglycemia.
DIABETES & METABOLISM JOURNAL
(2022)
Editorial Material
Health Care Sciences & Services
Gary S. Donovitz
Summary: Hormone replacement therapy, particularly the use of testosterone in women, continues to be controversial in medicine. However, there is growing evidence to support the use of physiologic doses of testosterone to improve sexual function, prevent osteoporosis, protect the brain, and reduce the incidence of invasive breast cancer in women. The safety of testosterone use in women has been evaluated for 80 years, with recent studies showing long-term safety. It may be time for the FDA to consider approving products that would benefit testosterone-deficient women.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Infectious Diseases
Yasuto Fukushima, Yuzo Tsuyuki, Mieko Goto, Haruno Yoshida, Takashi Takahashi
Summary: This study assessed the biofilm production ability and other microbiological features of Streptococcus canis strains. The results showed a correlation between biofilm producers and other features such as isolation year, SCM allele type, AMR genotypes, and ap1 detection.
JAPANESE JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Infectious Diseases
Takashi Takahashi, Seungjun Lee, Sunjoo Kim
Summary: This study clarified the genomic characteristics of Streptococcus agalactiae by POG analysis, revealing the sizes of pan and core genomes, as well as clusters of genomes grouped by different CPS genotypes. Significant differences were found in invasiveness and CPS genotype in terms of metabolic pathways.
JOURNAL OF INFECTION AND CHEMOTHERAPY
(2021)
Article
Cardiac & Cardiovascular Systems
Hiroyuki Yamamoto, Hiroyuki Yamada, Takahiro Maeda, Mieko Goto, Yoshihiko Ikeda, Takashi Takahashi
Summary: This case report highlights the importance of early treatment of Mitral Valve Aneurysm (MVA) and consideration of Group B Streptococcus (GBS) as a rare but significant causative agent of Infective Endocarditis (IE) in elderly patients with comorbidities.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Infectious Diseases
Takahiro Maeda, Yasuto Fukushima, Haruno Yoshida, Mieko Goto, Tomohiro Fujita, Yuzo Tsuyuki, Takashi Takahashi
Summary: This study evaluated the biofilm production ability of Streptococcus agalactiae isolates from companion animals/humans and found that strains with the pilB gene were more capable of producing biofilms. The inhibitory effect of berberine at subminimum inhibitory concentrations on biofilm production was confirmed.
JOURNAL OF INFECTION AND CHEMOTHERAPY
(2021)
Article
Microbiology
Hiroyuki Yamamoto, Katsuya Hashimoto, Hiroyuki Yamada, Yoshihiko Ikeda, Takashi Takahashi, Toru Hashimoto
Summary: This case study demonstrates the importance of using 4D TEE in diagnosing MAC-related IE and annular abscess, as well as the limitations of the modified Duke criteria in cases of definite IE with dual bacteremia.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Infectious Diseases
Takahiro Maeda, Yuzo Tsuyuki, Mieko Goto, Haruno Yoshida, Tomohiro Fujita, Takashi Takahashi
Summary: This study assessed the characteristics and correlation of quinolone-resistant S. agalactiae of dog and cat origin, providing important implications for veterinary treatment.
JOURNAL OF INFECTION AND CHEMOTHERAPY
(2022)
Article
Microbiology
Takahiro Maeda, Haruno Yoshida, Jung-Min Kim, Yuzo Tsuyuki, Goro Kurita, Jae-Seok Kim, Takashi Takahashi
Summary: We present the draft genome sequence of Pasteurella canis strain PA42, isolated from the blood of a diseased dog in Japan in 2021. The genome size is 2.151 Mbp with a G+C content of 36.6%. Unmapped sequences to the reference genome sequence of NCTC 11621(T) (GenBank accession number UGTV00000000.1) were characterized.
MICROBIOLOGY RESOURCE ANNOUNCEMENTS
(2022)
Article
Infectious Diseases
Goro Kurita, Yuzo Tsuyuki, Sachiko Shibata, Mieko Goto, Takahiro Maeda, Haruno Yoshida, Takashi Takahashi
Summary: The eye and ear canal are major sources of Streptococcus canis in companion animal practice. This study investigates the genotypic and phenotypic features of eye-origin isolates compared to ear-origin isolates and eye-origin isolates collected in different years. The findings reveal unique microbiological features in the eye-origin isolates collected in 2021, including high-level hemolytic activity and antimicrobial resistance.
JAPANESE JOURNAL OF INFECTIOUS DISEASES
(2022)
Review
Infectious Diseases
Eisuke Ogawa, Hirohisa Goto, Hiroyasu Ushimaru, Akemi Matsuo, Satoshi Takeda, Ryohei Nishimura, Takaaki Hondo, Takashi Takahashi
Summary: As COVID-19 pandemic continues, pregnant women are increasingly affected, particularly during the last trimester. This article reports a case of a 39-year-old pregnant woman who showed improvement in COVID-19 pneumonia after receiving casiribimab/ imdevimab treatment and successfully delivered a healthy baby.
JOURNAL OF INFECTION AND CHEMOTHERAPY
(2022)
Article
Infectious Diseases
Yasuto Fukushima, Yoshiko Takayama, Haruno Yoshida, Mieko Goto, Yuzo Tsuyuki, Takashi Takahashi
Summary: This study evaluated the feasibility of using CRISPR array-based genogrouping for the identification of Streptococcus bacteria and compared it to traditional typing methods. The results showed that CRISPR array genogrouping is a reliable method for determining the genetic relationship of Streptococcus isolates.
JOURNAL OF INFECTION AND CHEMOTHERAPY
(2022)
Article
Medical Laboratory Technology
Hyoshim Shin, Takashi Takahashi, Seungjun Lee, Eun Hwa Choi, Takahiro Maeda, Yasuto Fukushima, Sunjoo Kim
Summary: This study used whole-genome sequencing (WGS) datasets to investigate the invasiveness of Streptococcus pyogenes strains collected in Korea between 1997 and 2017. The presence of csn1, ispE, nisK, and citC was found to be associated with streptococcal invasiveness. The emm1 lineage and ST28 clone were specifically associated with invasiveness, while genomic features remained stable over the 20-year period.
ANNALS OF LABORATORY MEDICINE
(2022)
Review
Cardiac & Cardiovascular Systems
Hiroyuki Yamamoto, Yasuto Fukushima, Yoshihiko Ikeda, Tomoyuki Suda, Mieko Goto, Jun Isogai, Toru Hashimoto, Takashi Takahashi, Hidemitsu Ogino
Summary: Infectious aortic aneurysm (IAA) is a rare but potentially fatal consequence of infectious inflammatory disease, which is difficult to diagnose and treat. This article describes a case of an 85-year-old woman with IAA caused by Arthrobacter russicus. It highlights the value of unenhanced magnetic resonance angiography (MRA) in early detection of IAA and the importance of molecular diagnosis for identifying the causative microorganism.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Medical Laboratory Technology
Haruno Yoshida, Jung -Min Kim, Takahiro Maeda, Mieko Goto, Yuzo Tsuyuki, Sachiko Shibata, Kenichi Shizuno, Katsuko Okuzumi, Jae-Seok Kim, Takashi Takahashi
Summary: This study compared the virulence factors (VFs) between Pasteurella canis and Pasteurella multocida, and identified the specific prevalence of toxin genes in clinical isolates of P. canis. These toxin genes may serve as promising targets for the rapid identification of P. canis in clinical settings.
ANNALS OF LABORATORY MEDICINE
(2023)
Article
Infectious Diseases
Nobuaki Mori, Takahiro Katsumata, Takashi Takahashi
Summary: This single-center retrospective cohort study evaluated the CDI-preventive effect of prescribed probiotics in older patients receiving antibiotics. The results showed that the use of prescribed probiotics did not have a significant effect on preventing CDI in situations where the CDI incidence was low.
JOURNAL OF INFECTION AND CHEMOTHERAPY
(2023)
Article
Infectious Diseases
Jung-Min Kim, Yasuto Fukushima, Haruno Yoshida, Jae-Seok Kim, Takashi Takahashi
Summary: This study utilized WGS data to conduct CGH, pan- and core-genome prediction, Venn diagram testing with five ST9 strains, and phylogenetic analysis with ST determination. Comparisons were made between CDSs of seven ST9 and 13 non-ST9 strains, revealing genomic diversity and pathways regulated by CDSs specific to ST9.
JAPANESE JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Geriatrics & Gerontology
Lum Kastrati, Dion Groothof, Hugo G. Quezada-Pinedo, Hamidreza Raeisi-Dehkordi, Lia Bally, Martin H. De Borst, Stephan J. L. Bakker, Pedro-Marques Vidal, Michele F. Eisenga, Taulant Muka
Summary: The study aimed to examine the association between iron biomarkers and menopausal status and assess whether these biomarkers can help differentiate menopausal status beyond age. The results showed that iron biomarkers were significantly associated with menopausal status in both cohorts and modestly improved a model with age alone for differentiating menopause status.
Article
Geriatrics & Gerontology
Osvaldo P. Almeida, Christopher Etherton-Beer, Frank Sanfilippo, David B. Preen, Amy Page
Summary: The use of antineoplastic medications has been found to be associated with a decreased risk of dementia, which may contribute to the development of novel approaches for dementia prevention.
Article
Geriatrics & Gerontology
Bamini Gopinath, Diana Tang, George Burlutsky, Paul Mitchell
Summary: This study used a cohort of community-dwelling adults to establish the 10-year incidence and predictors of dizziness/vertigo, and its impacts on health-related quality of life. The results showed that age and presence of migraine were significant predictors of incident dizziness/vertigo, and dizziness/vertigo was associated with a significant decrease in quality of life.
Article
Geriatrics & Gerontology
Yuto Kiuchi, Kota Tsutsumimoto, Takehiko Doi, Satoshi Kurita, Kazuhei Nishimoto, Hyuma Makizako, Hiroyuki Shimada
Summary: This study found that high dietary diversity is associated with a lower risk of incident disability among sarcopenic Japanese older adults.
Article
Geriatrics & Gerontology
C. . Tamer Erel, Ipek Betul Ozcivit Erkan, Neslihan Gokmen Inan, Kubra Hamzaoglu Canbolat, Sena Alkan, Dildar Konukoglu, Yalim Dikmen
Summary: This study aimed to compare the clinical course and outcomes of Covid-19 between premenopausal and postmenopausal women, and investigate the factors that influence disease severity. The results showed that premenopausal women had a more favorable prognosis, and age, postmenopausal status, and serum levels of dehydroepiandrosterone sulfate were important predictors of the severity of Covid-19 in women.
Article
Geriatrics & Gerontology
Kazuhei Nishimoto, Kota Tsutsumimoto, Takehiko Doi, Satoshi Kurita, Yuto Kiuchi, Hiroyuki Shimada
Summary: The combination of urinary incontinence and low life-space activity/mobility is associated with an increased risk of incident disability among older adults, while having urinary incontinence but high life-space activity/mobility is not associated with an increased risk of incident disability.
Review
Geriatrics & Gerontology
Nikolaos Evangelinakis, Eleni V. Geladari, Charalampia V. Geladari, Adamantia Kontogeorgi, Georgios-Konstantinos Papaioannou, Melpomeni Peppa, Sophia Kalantaridou
Summary: Premature ovarian insufficiency and ovarian aging are complex conditions that affect women's reproductive health and overall well-being. This review explores the influence of environmental factors, including endocrine-disrupting chemicals and lifestyle choices, on the development and progression of these conditions. Understanding the impact of environmental factors is important for public and clinical health contexts.
Article
Geriatrics & Gerontology
Adela Castello, Miguel Rodriguez-Barranco, Virginia Lope, Marcela Guevara, Sandra Colorado-Yohar, Ane Dorronsoro, Jose Ramon Quiros, Carlota Castro-Espin, Carmen Sayon-Orea, Carmen Santiuste, Pilar Amiano, Cristina Lasheras, Maria-Jose Sanchez, Marina Pollan
Summary: The study found that the intake of foods such as high-fat dairy products, red and processed meats, refined grains, sweets, caloric drinks, convenience food and sauces might be associated with a higher risk of breast cancer.