Article
Medicine, General & Internal
Rodney G. Bowden, Kathleen A. Richardson, Luke T. Richardson
Summary: This large cross-sectional study found an association between hyperuricemia and MetS. Even when controlling for other risk factors, hyperuricemia remained independently associated with MetS. These results suggest a need for a better understanding of the role of uric acid in MetS.
FRONTIERS IN MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Woohyeun Kim, Tae Hwa Go, Dong Oh Kang, Jieun Lee, Jah Yeon Choi, Seung-Young Roh, Jin Oh Na, Cheol Ung Choi, Seung-Woon Rha, Chang Gyu Park, Hong Seog Seo, Dae Ryong Kang, Jang-Young Kim, Eung Ju Kim
Summary: The study investigated the association between uric acid and incident hypertension with a focus on age and sex differences. It found that younger women are at the highest risk of developing uric acid-related incident hypertension.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2021)
Article
Cardiac & Cardiovascular Systems
Yannan Zhang, Huanzhen Zhang, Shengzhong Rong, Cailing Bian, Yuexin Yang, Hongzhi Pan
Summary: This study used a metabolomics approach to explore the molecular mechanism of uric acid in the development of MetS. Results showed significant alterations in 20 metabolites in both MetS and MetS & HUA patients, with MetS patients exhibiting a more severe metabolic disorder. Pathway analysis revealed perturbed metabolic pathways in both groups, contributing to a better understanding of MetS progression.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2021)
Article
Endocrinology & Metabolism
Honglin Sun, Xiaona Chang, Nannan Bian, Yu An, Jia Liu, Song Leng, Guang Wang
Summary: Adipose tissue insulin resistance was strongly associated with serum uric acid levels and hyperuricemia regardless of BMI classification. In men with normal BMI, Adipo-IR, rather than HOMA-IR, was closely associated with hyperuricemia. These findings emphasize the critical role of adipose tissue insulin resistance in serum uric acid metabolism and hyperuricemia.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Multidisciplinary Sciences
Qiuhong Li, Xian Shao, Saijun Zhou, Zhuang Cui, Hongyan Liu, Tongdan Wang, Xiaoguang Fan, Pei Yu
Summary: This study found a significant independent correlation between TyG index and the risk of hyperuricemia in diabetic kidney disease patients.
SCIENTIFIC REPORTS
(2022)
Review
Physiology
Zahra Bahadoran, Parvin Mirmiran, Khosrow Kashfi, Asghar Ghasemi
Summary: Hyperuricemia, characterized by elevated serum uric acid levels, is linked to the development of cardiometabolic disorders through induction of endothelial dysfunction. The mechanism involves interference with insulin signaling and reduced NO availability, leading to endothelial insulin resistance. This can result in impaired endothelial function, NO-dependent vasodilation, and systemic insulin resistance, which can potentially be improved with UA-lowering drugs.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Lu Zhang, Chi Zhang, Ze-Nan Zhuang, Chu-Xin Li, Pei Pan, Cheng Zhang, Xian-Zheng Zhang
Summary: The study introduces a novel nanoenzyme with excellent inflammation targeting and uric acid degrading properties for the treatment of gout and hyperuricemia, showing great promise in effectively and safely addressing these conditions.
SCIENCE CHINA-CHEMISTRY
(2021)
Article
Endocrinology & Metabolism
David Primo, Olatz Izaola, Daniel de Luis
Summary: This study found that the high resistin/uric acid index is associated with metabolic syndrome (MS) and is correlated with glucose levels, insulin levels, and insulin resistance (HOMA-IR) in a population of Caucasian females with obesity.
INTERNATIONAL JOURNAL OF OBESITY
(2023)
Article
Rheumatology
Jie Wei, Yuqing Zhang, Nicola Dalbeth, Robert Terkeltaub, Tuo Yang, Yilun Wang, Zidan Yang, Jiatian Li, Ziying Wu, Chao Zeng, Guanghua Lei
Summary: This study found an association between dysbiosis of gut microbiota and hyperuricemia, suggesting a potential role of microbiota dysbiosis in modulating serum urate levels.
ARTHRITIS & RHEUMATOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ye Chen, Chaoying Pei, Ying Chen, Xiaoyi Xiao, Xingyuan Zhang, Kaiwei Cai, Song Deng, Rongyao Liang, Zhiyong Xie, Pei Li, Qiongfeng Liao
Summary: Kidney tea, a Chinese herbal medicine, can lower uric acid levels and alleviate gout, but the mechanism is not clear. This study investigated the changes in intestinal flora and metabolome to explore the mechanism of kidney tea in lowering uric acid. The results showed that kidney tea significantly reduced serum uric acid levels and mitigated renal damage caused by hyperuricemia. Additionally, kidney tea improved the structure of the intestinal flora and regulated metabolic disorders. These findings provide a theoretical basis for the use of kidney tea as a uric acid-lowering drug.
CHEMICO-BIOLOGICAL INTERACTIONS
(2023)
Article
Endocrinology & Metabolism
Yoshiro Tanaka, Tomohisa Nagoshi, Hirotake Takahashi, Yuhei Oi, Akira Yoshii, Haruka Kimura, Keiichi Ito, Yusuke Kashiwagi, Toshikazu D. Tanaka, Michihiro Yoshimura
Summary: The study demonstrates that a novel URAT1-selective inhibitor, dotinurad, has a significant therapeutic effect in HFD-induced obese mice, reducing hepatic steatosis and promoting BAT rebrowning.
MOLECULAR METABOLISM
(2022)
Article
Endocrinology & Metabolism
Maria de Fatima Haueisen Sander Diniz, Alline M. R. Beleigoli, Aline Isabel Rodrigues Galva, Rosa Weiss Telles, Maria Ines Schmidt, Bruce B. Duncan, Isabela M. Bensen, Antonio Luiz P. Ribeiro, Pedro G. Vidigal, Sandhi Maria Barreto
Summary: This study aimed to investigate whether serum uric acid (SUA) levels and hyperuricemia can be predictive biomarkers of incident metabolic syndrome (MS) among different body mass index (BMI) categories, and to find the best SUA cutoffs for distinguishing individuals with incident MS. The results showed that SUA level is an independent predictive biomarker for incident MS at all BMI categories.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2022)
Article
Nutrition & Dietetics
Xiaojing Feng, Yanyi Yang, Huiqi Xie, Siqi Zhuang, Yiyuan Fang, Yufeng Dai, Ping Jiang, Hongzhi Chen, Haoneng Tang, Lingli Tang
Summary: This study found a positive association between hyperuricemia and overweight/obese metabolic phenotypes, regardless of sex and age.
FRONTIERS IN NUTRITION
(2022)
Article
Pharmacology & Pharmacy
Jiankai Dong, Huijie Yang, Yaping Zhang, Quanzhong Hu
Summary: The study demonstrated a significant association between TYG index and hyperuricemia in elderly hypertensive patients, with an increase in TYG index being an independent risk factor for HUA in this population.
CLINICAL AND EXPERIMENTAL HYPERTENSION
(2022)
Article
Endocrinology & Metabolism
Yanjiao Wang, Yongli Zeng, Xuehui Zhang, Qiong Meng, Fei Mi, Songmei Wang, Fang Xu, Yan Sun, Yuemei Feng, Jianzhong Yin
Summary: The study found that longer daytime nap duration was associated with a higher risk of hyperuricemia.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Geriatrics & Gerontology
Lum Kastrati, Dion Groothof, Hugo G. Quezada-Pinedo, Hamidreza Raeisi-Dehkordi, Lia Bally, Martin H. De Borst, Stephan J. L. Bakker, Pedro-Marques Vidal, Michele F. Eisenga, Taulant Muka
Summary: The study aimed to examine the association between iron biomarkers and menopausal status and assess whether these biomarkers can help differentiate menopausal status beyond age. The results showed that iron biomarkers were significantly associated with menopausal status in both cohorts and modestly improved a model with age alone for differentiating menopause status.
Article
Geriatrics & Gerontology
Osvaldo P. Almeida, Christopher Etherton-Beer, Frank Sanfilippo, David B. Preen, Amy Page
Summary: The use of antineoplastic medications has been found to be associated with a decreased risk of dementia, which may contribute to the development of novel approaches for dementia prevention.
Article
Geriatrics & Gerontology
Bamini Gopinath, Diana Tang, George Burlutsky, Paul Mitchell
Summary: This study used a cohort of community-dwelling adults to establish the 10-year incidence and predictors of dizziness/vertigo, and its impacts on health-related quality of life. The results showed that age and presence of migraine were significant predictors of incident dizziness/vertigo, and dizziness/vertigo was associated with a significant decrease in quality of life.
Article
Geriatrics & Gerontology
Yuto Kiuchi, Kota Tsutsumimoto, Takehiko Doi, Satoshi Kurita, Kazuhei Nishimoto, Hyuma Makizako, Hiroyuki Shimada
Summary: This study found that high dietary diversity is associated with a lower risk of incident disability among sarcopenic Japanese older adults.
Article
Geriatrics & Gerontology
C. . Tamer Erel, Ipek Betul Ozcivit Erkan, Neslihan Gokmen Inan, Kubra Hamzaoglu Canbolat, Sena Alkan, Dildar Konukoglu, Yalim Dikmen
Summary: This study aimed to compare the clinical course and outcomes of Covid-19 between premenopausal and postmenopausal women, and investigate the factors that influence disease severity. The results showed that premenopausal women had a more favorable prognosis, and age, postmenopausal status, and serum levels of dehydroepiandrosterone sulfate were important predictors of the severity of Covid-19 in women.
Article
Geriatrics & Gerontology
Kazuhei Nishimoto, Kota Tsutsumimoto, Takehiko Doi, Satoshi Kurita, Yuto Kiuchi, Hiroyuki Shimada
Summary: The combination of urinary incontinence and low life-space activity/mobility is associated with an increased risk of incident disability among older adults, while having urinary incontinence but high life-space activity/mobility is not associated with an increased risk of incident disability.
Review
Geriatrics & Gerontology
Nikolaos Evangelinakis, Eleni V. Geladari, Charalampia V. Geladari, Adamantia Kontogeorgi, Georgios-Konstantinos Papaioannou, Melpomeni Peppa, Sophia Kalantaridou
Summary: Premature ovarian insufficiency and ovarian aging are complex conditions that affect women's reproductive health and overall well-being. This review explores the influence of environmental factors, including endocrine-disrupting chemicals and lifestyle choices, on the development and progression of these conditions. Understanding the impact of environmental factors is important for public and clinical health contexts.
Article
Geriatrics & Gerontology
Adela Castello, Miguel Rodriguez-Barranco, Virginia Lope, Marcela Guevara, Sandra Colorado-Yohar, Ane Dorronsoro, Jose Ramon Quiros, Carlota Castro-Espin, Carmen Sayon-Orea, Carmen Santiuste, Pilar Amiano, Cristina Lasheras, Maria-Jose Sanchez, Marina Pollan
Summary: The study found that the intake of foods such as high-fat dairy products, red and processed meats, refined grains, sweets, caloric drinks, convenience food and sauces might be associated with a higher risk of breast cancer.