Article
Behavioral Sciences
Inyeong Choi, Kristian Beedholm, Vibeke S. Dam, Seong-Ho Bae, Donald J. Noble, Sandra M. Garraway, Christian Aalkjaer, Ebbe Boedtkjer
Summary: Deletion of the NBCn1 gene leads to reduced locomotor activity in mice by affecting their exploratory behaviors or emotionality. The deletion also causes hearing loss, but its effect on vision varies between different lines of knockout mice.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Eunus S. Ali, Anna Liponska, Brendan P. O'Hara, David R. Amici, Michael D. Torno, Peng Gao, John M. Asara, Mee-Ngan F. Yap, Marc L. Mendillo, Issam Ben-Sahra
Summary: The study reveals that mTORC1 regulates the utilization of environmental bicarbonate by controlling the expression of SLC4A7, which promotes nucleotide synthesis and cell growth.
Article
Biochemistry & Molecular Biology
Inyeong Choi, Hansoo Yang, Eunjin Kim, Soojung Lee
Summary: In this study, the researchers found that the channel activity of the sodium bicarbonate cotransporter NBCn1 decreases the function of NMDA receptors (NMDARs), and this effect may involve the interaction between NBCn1 and NMDARs. Furthermore, the results suggest that NBCn1 has dual effects on NMDARs in the brain, stabilizing receptor expression while decreasing receptor function.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Daria Di Molfetta, Stefania Cannone, Maria Raffaella Greco, Rosa Caroppo, Francesca Piccapane, Tiago Miguel Amaral Carvalho, Concetta Altamura, Ilaria Saltarella, Diana Tavares Valente, Jean Francois Desaphy, Stephan J. J. Reshkin, Rosa Angela Cardone
Summary: Intracellular pH (pHi) regulation is crucial for the exocrine pancreas, and dysregulation of ion transporters, including bicarbonate transporters and NHE1, is observed in PDAC. The progression of PDAC is facilitated by the acidosis in Collagen-I rich ECM. Our study on organotypic cultures of normal human pancreatic cells (HPDE), parenchymal cancer cells (CPCs), and cancer stem cells (CSCs) reveals that the ECM composition and pHe fluctuations contribute to pHi dysregulation and the presence of NaHCO3 gradients similar to that in tumors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Hang Yu, Zhina Wu, Xingfu Bao, Xiaoduo Tang, Junhu Zhang, Yi Zhang, Min Hu
Summary: Orthodontic tooth movement (OTM) may cause orthodontically induced inflammatory root resorption (OIIRR), which affects tooth health and treatment stability. In this study, a composite hydrogel named CCOD-Trametinib (CCOD-Tra) was developed to prevent OIIRR. The CCOD-Tra hydrogel exhibited good biocompatibility, injectability, and sustained release of Trametinib (Tra). Animal and cell experiments demonstrated that CCOD-Tra effectively prevented OIIRR by inhibiting osteoclast differentiation and maturation through the ERK1/2 signaling pathway.
Review
Biochemistry & Molecular Biology
Jiayuan Fang, Xunming Zhang, Xi Chen, Zhaoguo Wang, Shuo Zheng, Yunyun Cheng, Songcai Liu, Linlin Hao
Summary: Insulin-like growth factor (IGF)-1 is a polypeptide hormone that plays a vital role in bone cells. Abnormal expression of IGF-1 affects bone growth and remodeling, leading to significant changes in bone mass and development. This review highlights the functions and mechanisms of IGFs in bone and emphasizes the critical role of IGF-1 in bone remodeling through both bone resorption and bone formation. It provides a theoretical basis for further research on the maintenance of bone mass and homeostasis.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Biochemistry & Molecular Biology
Amanda M. Avila-Trejo, Lorena I. Rodriguez-Paez, Veronica Alcantara-Farfan, J. Leopoldo Aguilar-Faisal, Toshio Hattori
Summary: Chronic cases of chikungunya fever pose a public health problem in countries where the virus is present. The disease can persist for years, causing debilitating pain and bone erosion. The mechanisms behind tissue damage and the development of different conditions are not fully understood. This review aims to analyze the molecular and cellular factors that contribute to tissue damage in various infectious conditions caused by the chikungunya virus.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Bin Zhao, Yuning Zhang, Jie Xu, Yuyu Li, Quan Yuan, Chenchen Zhou
Summary: This study demonstrates that Periplaneta americana extract (PAE) inhibits osteoclastogenesis and reduces the expression and secretion of inflammatory factors, suggesting its potential therapeutic alternative for bone diseases.
CELL PROLIFERATION
(2023)
Article
Urology & Nephrology
Jeppe S. M. Olsen, Samuel Svendsen, Peder Berg, Vibeke S. Dam, Mads V. Sorensen, Vladimir V. Matchkov, Jens Leipziger, Ebbe Boedtkjer
Summary: The study demonstrates that the Na+/HCO3- cotransporter NBCn1 plays a crucial role in basolateral HCO3- uptake and NH4+ reabsorption in the renal thick ascending limbs, essential for the rapid recovery of arterial blood pH and [HCO3-] during metabolic acidosis.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Review
Endocrinology & Metabolism
Qing-Chang Chen, Yan Zhang
Summary: Bone diseases are the main causes of disability and impaired quality of life. Neuropeptide Y plays important roles in bone tissue by regulating bone metabolism and disease progression through its receptors. This review provides a brief overview of recent progress in understanding the regulatory mechanism of bone physiology and pathological metabolism.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, Research & Experimental
Ni Su, Cassandra Villicana, Carl Zhang, Jeehee Lee, Sauradeep Sinha, Andrew Yang, Fan Yang
Summary: Mineral particle-coated scaffolds combined with aspirin have a synergistic effect in promoting endogenous bone regeneration and reducing bone resorption. The optimized formulation shows promising potential for repairing critical-sized cranial bone defects.
Article
Endocrinology & Metabolism
Ji Hyun Lee, JooYong Park, Jung Hee Kim, Ji-Yeob Choi, Hyung Jin Choi, Eu Jeong Ku, A. Ram Hong, Chan Soo Shin, Nam H. Cho
Summary: This Korean prospective cohort study found that decreasing waist circumference and lean muscle mass loss were significant risk factors for hip bone loss in both men and women. Other factors may have sex-specific or age-specific effects on hip bone loss. None of the genetic factors tested were associated with hip bone loss after multiple testing adjustments, indicating that modifiable factors may play a larger role in determining bone health.
Article
Medicine, Research & Experimental
Biao Wu, Jie Shang, Shiyuan Lin, Ning Jiang, Baizhou Xing, Rong Peng, Xianghe Xu, Huading Lu
Summary: Increased bone resorption caused by excessive osteoclasts is the main cause of osteoporosis. The expression of RILP, a protein, is induced by receptor activator of NF-KB ligand, and its inhibition decreases the number and function of osteoclasts. Inhibition of RILP also reduces preosteoclast migration and bone resorption. The study suggests that RILP plays a crucial role in osteoclast formation and bone resorption, and could be a therapeutic target for bone diseases caused by excessive osteoclasts.
LABORATORY INVESTIGATION
(2023)
Article
Immunology
Mei-Tzu Su, Karin Ono, Dai Kezuka, Shotaro Miyamoto, Yu Mori, Toshiyuki Takai
Summary: The interaction between LILRB4/gp49B and Fibronectin plays a crucial role in osteoclastogenesis, negatively regulating the signaling pathway induced by RANKL and inhibiting osteoclast formation.
INTERNATIONAL IMMUNOLOGY
(2023)
Review
Endocrinology & Metabolism
Siwang Hu, Shuangshuang Wang
Summary: SIRT3 is an enzyme that regulates mitochondrial morphology and function, and it has been shown to play a role in many aging-related diseases. Osteoporosis, a common aging-related disease, is characterized by decreased bone mass and fragility fractures, but the specific effects and mechanisms of SIRT3 in osteoporosis are not yet clear.
FRONTIERS IN ENDOCRINOLOGY
(2022)