Review
Biochemistry & Molecular Biology
Changhwan Ahn, Eui-Bae Jeung
Summary: Endocrine-disrupting chemicals (EDCs) have significant impacts on biological systems, especially by disrupting hormone balance, affecting reproductive, neurological, and metabolic development and function, and even stimulating tumor growth. EDC exposure during development can disrupt normal development patterns and alter susceptibility to disease. Many chemicals, including bisphenol A, organochlorines, polybrominated flame retardants, alkylphenols, and phthalates, have been identified as risk factors for reproductive, neural, metabolic diseases, and cancers. Endocrine disruption has spread to wildlife and species connected to the food chains. Dietary uptake is an important source of EDC exposure. The relationship and specific mechanism between EDCs and diseases remain unclear. This review focuses on the disease-EDC relationship and disease endpoints associated with endocrine disruption to better understand the EDC-disease relationship, and explores the development of new prevention/treatment opportunities and screening methods.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Leonardo Trasande, Robert M. Sargis
Summary: Rapidly advancing evidence indicates that synthetic chemicals in the environment contribute to disease and disability across the lifespan. Endocrine-disrupting chemicals (EDCs) have a substantial impact on chronic diseases in adulthood, especially metabolic, cardiovascular, and reproductive conditions. The mortality and economic costs of exposure to certain phthalates are significant. Low-income and minority populations are disproportionately affected by these exposures. Government action is necessary to limit hazardous exposures and screen new chemicals. Routine healthcare should include guidance to reduce EDC exposures.
JOURNAL OF INTERNAL MEDICINE
(2023)
Review
Environmental Sciences
Paulina Jedynak, Marta Gallego, Laura Ciaran, Karine Audouze, Maribel Casas, Martine Vrijheid
Summary: Health effects of endocrine disrupting chemicals (EDCs) are difficult to detect in the general population. Omics technologies are commonly used in epidemiological studies to identify early biological changes, explore toxic mechanisms, and enhance the plausibility of associations. This scoping review summarizes the application of omics in EDCs-associated biological effects research, identifying gaps and priorities for future studies. The review highlights the need for larger longitudinal studies, wider coverage of exposures and biomarkers, replication studies, and standardization of research methods and reporting. Rating: 7 out of 10.
ENVIRONMENTAL RESEARCH
(2023)
Review
Environmental Sciences
Xing Guo, Bing Liu, Haohao Liu, Xingde Du, Xinghai Chen, Wenjun Wang, Shumeng Yuan, Bingyu Zhang, Yongshui Wang, Hongxiang Guo, Huizhen Zhang
Summary: Endocrine disrupting chemicals (EDCs) are substances of increasing concern for human health and the environment. The lack of a unified standard for identifying chemicals as EDCs is a controversial issue internationally. This review discusses the procedures for EDC identification in different organizations/countries and summarizes three aspects to be considered, including mechanistic data, animal experiments, and epidemiological information. Scientific data on specific chemicals are collected and evaluated, providing a clearer understanding of their effects on hormones and health hazards. This review contributes to standardizing the identification procedure for EDCs.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Anran Cai, Lutzen Portengen, Gokhan Ertaylan, Juliette Legler, Roel Vermeulen, Virissa Lenters, Sylvie Remy
Summary: This study investigated the molecular mechanisms underlying the association between metabolism-disrupting chemicals (MDCs) and birth weight. Through transcriptome analysis, several metabolism-related gene expressions associated with both an MDC and birth weight were identified, and pathways related to genetic information processing were found to be overlapping. This study provides valuable insights into the potential mechanisms of MDC-induced altered birth weight.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Environmental Sciences
ZhiChao Dang, Maria Arena, Aude Kienzler
Summary: This study summarized and evaluated the effects of TDCs on fish thyroid sensitive endpoints, including thyroid hormones, gene expression, and other aspects. The findings suggest that changes in thyroid sensitive endpoints may be influenced by various factors, such as the balance of different processes and environmental factors.
ENVIRONMENTAL POLLUTION
(2021)
Article
Engineering, Environmental
Jing Guo, Keng Tu, Chengzhuo Zhou, Die Lin, Si Wei, Xiaowei Zhang, Hongxia Yu, Wei Shi
Summary: In order to identify key bioconcentratable EDCs, a method-ology for effect-based identification of bioconcentratable EDCs was established and applied to Taihu Lake. The enrichment characteristics of typical EDCs were observed, and methods using POM and LDPE were developed for the bioconcentration of EDCs. Seven key bioconcentratable EDCs were identified in Taihu Lake using this methodology.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Review
Environmental Sciences
ZhiChao Dang
Summary: Both AMA and LAGDA are used to detect thyroid-mediated modality and adversity based on morphological changes during thyroid hormone-dependent metamorphosis. The EU Guidance recommends their use for investigating the effects of thyroid hormone system disrupting chemicals. However, there is debate over the necessity of using LAGDA as a follow-up to positive AMA results. This study analyzes the similarities, differences, and sensitivity of these two assays in detecting TDCs.
ENVIRONMENTAL POLLUTION
(2022)
Review
Endocrinology & Metabolism
Wiwat Rodprasert, Jorma Toppari, Helena E. Virtanen
Summary: Endocrine disrupting chemicals, particularly antiandrogenic EDCs, may impact male reproductive health, especially when exposed during fetal development at the sensitive 'masculinization programming window'.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Immacolata Cristina Nettore, Fabiana Franchini, Giuseppe Palatucci, Paolo Emidio Macchia, Paola Ungaro
Summary: Research has shown a possible association between obesity and endocrine-disrupting chemicals, which can interfere with energy metabolism and adipose tissue structure regulation. Early exposure to these chemicals may induce epigenetic modifications, making individuals susceptible to obesity and other diseases.
Article
Environmental Sciences
Pooja Tyagi, Tamarra James-Todd, Lidia Minguez-Alarcon, Jennifer B. Ford, Myra Keller, John Petrozza, Antonia M. Calafat, Russ Hauser, Paige L. Williams, Andrea Bellavia
Summary: Exposure to endocrine disrupting chemicals during pregnancy, particularly in the 1st trimester, is associated with excessive gestational weight gain. This highlights the importance of considering the timing and specific chemicals in EDC exposure for maternal and offspring health.
ENVIRONMENTAL RESEARCH
(2021)
Review
Endocrinology & Metabolism
Vasantha Padmanabhan, Wenhui Song, Muraly Puttabyatappa
Summary: Exposure to endocrine-disrupting chemicals (EDCs) in the environment can disrupt the maternal-fetal environment and lead to adverse pregnancy outcomes. Research focuses on the effects of EDCs, the role of environmental and lifestyle factors, related mechanisms, and future research directions.
Article
Environmental Sciences
Sherly Antony, Sham Antony, Sharrel Rebello, Sandhra George, Devika T. Biju, R. Reshmy, Aravind Madhavan, Parameswaran Binod, Ashok Pandey, Raveendran Sindhu, Mukesh Kumar Awasthi
Summary: Endocrine Disrupting Chemicals (EDCs) pose a serious threat to the health and future of humans and the ecosystem. This review provides an overview of various EDCs, their toxic effects, and both conventional and modern remediation methods. The use of sustainable approaches like bioremediation has shown positive impacts in controlling EDC pollution.
ENVIRONMENTAL RESEARCH
(2022)
Article
Environmental Sciences
Viviana Ramirez, Yolanda Galvez-Ontiveros, Pablo Jose Gonzalez-Domenech, Miguel Angel Baca, Lourdes Rodrigo, Ana Rivas
Summary: The study aimed to review limited literature on the effects of postnatal exposure to EDC on child neurodevelopment and behavior. While some research suggests a relationship between postnatal EDC exposure and adverse neurobehavioral outcomes in children, the underlying mechanisms of action remain unclear.
ENVIRONMENTAL RESEARCH
(2022)
Review
Endocrinology & Metabolism
Yan Yan, Fengjun Guo, Kexin Liu, Rixin Ding, Yichao Wang
Summary: Endocrine-disrupting chemicals (EDCs) are naturally occurring or artificial substances released into the environment. Humans are exposed to EDCs through ingestion, inhalation, and skin contact, and they are found in everyday household items. EDCs have negative effects on health, including cancer, cardiovascular risk, and reproductive disorders, and the placenta is particularly sensitive to their impact. This review evaluates the effects of various EDCs on placental development and function, identifies knowledge gaps, and guides future research.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Peripheral Vascular Disease
Daniel A. Duprez, David R. Jacobs, Leah I. B. Andrews, Lyndia C. Brumback, Julie O. Denenberg, Robyn L. Mcclelland, Isac C. Thomas, Michael H. Criqui, Matthew A. Allison
Summary: This study investigated the difference, reproducibility, and incidence of cardiovascular disease (CVD) in inter-arm systolic blood pressure (sIAD). It found that high absolute sIAD values were not persistent over time, but were associated with increased risk for stroke and peripheral arterial disease (PAD). Measuring systolic blood pressure between arms can help identify individuals at higher risk for CVD.
JOURNAL OF HUMAN HYPERTENSION
(2023)
Article
Cardiac & Cardiovascular Systems
Olli Raitakari, Noora Kartiosuo, Katja Pahkala, Nina Hutri-Kahonen, Lydia A. Bazzano, Wei Chen, Elaine M. Urbina, David R. Jacobs Jr, Alan Sinaiko, Julia Steinberger, Trudy Burns, Stephen R. Daniels, Alison Venn, Jessica G. Woo, Terry Dwyer, Markus Juonala, Jorma Viikari
Summary: Elevated Lp(a) level in youth is associated with increased risk of adult atherosclerotic cardiovascular disease outcomes, but not with increased carotid intima-media thickness. This conclusion was derived from two similar studies.
Article
Cardiac & Cardiovascular Systems
Yuni Choi, David R. R. Jacobs Jr, Michael Patrick Bancks, Cora E. E. Lewis, EunSeok Cha, Fengxia Yan, Mercedes R. R. Carnethon, Pamela J. J. Schreiner, Daniel A. A. Duprez
Summary: The study found that the American Heart Association's cardiovascular health (CVH) score is closely associated with early-onset diabetes, later-onset diabetes, and subsequent complications of diabetes. Higher CVH score is associated with lower risk of both early- and later-onset diabetes, as well as diabetic complications. This study highlights the importance of maintaining good cardiovascular health in preventing diabetes and its complications.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Letter
Respiratory System
Motahareh Vameghestahbanati, Coralynn Sack, Artur Wysoczanski, Eric A. Hoffman, Elsa Angelini, Norrina B. Allen, Alain G. Bertoni, Junfeng Guo, David R. Jacobs Jr, Joel D. Kaufman, Andrew Laine, Ching-Long Lin, Daniel Malinsky, Erin D. Michos, Elizabeth C. Oelsner, Steven J. Shea, Karol E. Watson, Andrea Benedetti, R. Graham Barr, Benjamin M. Smith
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Sport Sciences
Tyler D. Quinn, Abbi Lane, Kelley Pettee Gabriel, Barbara Sternfeld, David R. Jacobs, Peter Smith, Bethany Barone Gibbs
Summary: This study examined the associations between fitness and leisure-time physical activity (LTPA) and occupational physical activity (OPA). The results showed a positive correlation between LTPA and fitness, while OPA was negatively correlated with fitness. These findings are important for physical activity research and public health promotion.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2023)
Article
Biochemistry & Molecular Biology
Drew R. R. Nannini, Yinan Zheng, Brian T. Joyce, Kyeezu Kim, Tao Gao, Jun Wang, David R. R. Jacobs, Pamela J. J. Schreiner, Kristine Yaffe, Philip Greenland, Donald M. M. Lloyd-Jones, Lifang Hou
Summary: The study reveals the association between marijuana use and DNA methylation levels, with a stronger correlation in recent and cumulative users. The research also identifies pathways and diseases related to cellular proliferation, hormone signaling, infections, schizophrenia, bipolar disorder, and substance-related disorders.
MOLECULAR PSYCHIATRY
(2023)
Article
Cardiac & Cardiovascular Systems
Alessandro Menotti, Paolo Emilio Puddu, Anthony G. Kafatos, Hanna Tolonen, Hisashi Adachi, David R. Jacobs
Summary: This study aimed to investigate mortality rates from three major cardiovascular diseases (coronary heart disease, cerebrovascular diseases, and other heart diseases of uncertain etiology) in a pooled cohort over a 60-year follow-up period. The results showed that countries with high serum cholesterol levels had higher death rates from coronary heart disease, while countries with low cholesterol levels had higher death rates from stroke and other heart diseases. Differences in lifelong cardiovascular disease mortalities across different countries were smaller than expected.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2023)
Article
Respiratory System
Gabrielle Y. Liu, Laura A. Colangelo, Samuel Y. Ash, Raul San Jose Estepar, David R. Jacobs, Bharat Thyagarajan, J. Michael Wells, Rachel K. Putman, Bina Choi, Christopher S. Stevenson, Mercedes Carnethon, George R. Washko, Ravi Kalhan
Summary: This epidemiological study found that CT lung injury is associated with future interstitial features and restrictive spirometry abnormality. Among 2213 participants, a 10% higher amount of CT lung injury at mean age 40 years was associated with a 4.37% higher amount of lung tissue characterised as interstitial features at mean age 50 years. Compared to those with the lowest quartile of CT lung injury at mean age 40 years, there were higher odds of incident restrictive spirometry at mean age 55 years in quartile 2, quartile 3, and quartile 4.
Letter
Critical Care Medicine
Gabrielle Y. Liu, Laura A. Colangelo, Raul San Jose Estepar, Anthony J. Esposito, Samuel Y. Ash, Bina Choi, David R. Jacobs, Mercedes R. Carnethon, George R. Washko, Ravi Kalhan
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Endocrinology & Metabolism
Brian T. Steffen, David R. Jacobs, So-Yun Yi, Simon J. Lees, James M. Shikany, James G. Terry, Cora E. Lewis, John J. Carr, Xia Zhou, Lyn M. Steffen
Summary: This study aimed to determine whether long-term intake of artificial sweeteners and diet beverages is associated with higher fat deposition and risk of obesity. The results showed that long-term intake of sweeteners and diet beverages was associated with increased fat deposition, weight gain, and higher risk of obesity.
INTERNATIONAL JOURNAL OF OBESITY
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Daniel A. Duprez, David R. Jacobs Jr
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Genetics & Heredity
Maryam Kavousi, Maxime M. Bos, Hanna J. Barnes, Christian L. Lino Cardenas, Doris Wong, Haojie Lu, Chani J. Hodonsky, Lennart P. L. Landsmeer, Adam W. Turner, Minjung Kho, Natalie R. Hasbani, Paul S. de Vries, Donald W. Bowden, Sandesh Chopade, Joris Deelen, Ernest Diez Benavente, Xiuqing Guo, Edith Hofer, Shih-Jen Hwang, Sharon M. Lutz, Leo-Pekka Lyytikaeinen, Lotte Slenders, Albert V. Smith, Maggie A. Stanislawski, Jessica van Setten, Quenna Wong, Lisa R. Yanek, Diane M. Becker, Marian Beekman, Matthew J. Budoff, Mary F. Feitosa, Chris Finan, Austin T. Hilliard, Sharon L. R. Kardia, Jason C. Kovacic, Brian G. Kral, Carl D. Langefeld, Lenore J. Launer, Shaista Malik, Firdaus A. A. Mohamed Hoesein, Michal Mokry, Reinhold Schmidt, Jennifer A. Smith, Kent D. Taylor, James G. Terry, Jeroen van der Grond, Joyce van Meurs, Rozemarijn Vliegenthart, Jianzhao Xu, Kendra A. Young, Nuno R. Zilhao, Robert Zweiker, Themistocles L. Assimes, Lewis C. Becker, Daniel Bos, J. Jeffrey Carr, L. Adrienne Cupples, Dominique P. v. de Kleijn, Menno de Winther, Hester M. den Ruijter, Myriam Fornage, Barry I. Freedman, Vilmundur Gudnason, Aroon D. Hingorani, John E. Hokanson, M. Arfan Ikram, Ivana Isgum, David R. Jacobs, Mika Kaehoenen, Leslie A. Lange, Terho Lehtimaeki, Gerard Pasterkamp, Olli T. Raitakari, Helena Schmidt, P. Eline Slagboom, Andre G. Uitterlinden, Meike W. Vernooij, Joshua C. Bis, Nora Franceschini, Bruce M. Psaty, Wendy S. Post, Jerome I. Rotter, Johan L. M. Bjoerkegren, Christopher J. O'Donnell, Lawrence F. Bielak, Patricia A. Peyser, Rajeev Malhotra, Sander W. van der Laan, Clint L. Miller
Summary: This study conducted a large-scale analysis and identified eleven new risk loci for coronary artery calcification (CAC), a measure of subclinical atherosclerosis. These new loci are related to bone mineralization, phosphate catabolism, and hormone metabolic pathways. The findings contribute to a better understanding of the genetic architecture of CAC and provide potential targets for therapeutic interventions.
Article
Medicine, General & Internal
Junia N. de Brito, Daniel J. McDonough, Mahesh Mathew, Lisa B. VanWagner, Pamela J. Schreiner, Kelley Pettee Gabriel, David R. Jacobs Jr, James G. Terry, John Jeffrey Carr, Mark A. Pereira
Summary: This study found that higher levels of vigorous-intensity physical activity (VPA) throughout young to middle adulthood were associated with a reduced risk of nonalcoholic fatty liver disease (NAFLD) in middle age.
Article
Peripheral Vascular Disease
Gabor Szalo, Margareta I. Hellgren, Matthew Allison, Ying Li, Lennart Rastam, Karin Radholm, Entela Bollano, Daniel A. Duprez, David R. Jacobs, Ulf Lindblad, Bledar Daka
Summary: The association between arterial elasticity obtained by radial artery pulse wave analysis and risk for cardiovascular diseases (CVD) was investigated. The study found a significant increase in the risk for incident CVD with each quartile decrease in arterial elasticity.
JOURNAL OF HUMAN HYPERTENSION
(2023)
Article
Geriatrics & Gerontology
Paolo Emilio Puddu, Alessandro Menotti, David R. Jacobs, Hisashi Adachi, Antony Kafatos, Hanna Tolonen
Summary: This study examined the age at death and its determinants in cohorts of middle-aged men. The results showed that cardiovascular disease risk factors were strongly associated with age at death. Other factors such as age, physical activity, and smoking status were also related to age at death.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2023)