Review
Pharmacology & Pharmacy
Mariana F. P. Graca, Duarte de Melo-Diogo, Ilidio J. Correia, Andre F. Moreira
Summary: Researchers have been developing new wound dressings to mimic all the features of native skin, with asymmetric electrospun membranes emerging as a promising solution. Electrospinning technique allows for the development of multifunctional dressings using natural and/or synthetic polymers. Various therapeutic or antimicrobial agents have been loaded within nanofibers to enhance wound healing performance.
Article
Chemistry, Multidisciplinary
Tao Li, Mingchao Sun, Shaohua Wu
Summary: Electrospun nanofiber materials, particularly those based on gelatin, have shown promise as advanced dressings for wound healing and skin regeneration. They possess high porosity, excellent barrier performance against pathogens, and a mimicry of extracellular matrix fibrils. Various crosslinking approaches and innovative electrospinning strategies have been used to enhance their mechanical properties. Additionally, bioactive components and therapeutic agents can be incorporated to impart multiple functions to these nanofiber dressings. This review provides a comprehensive overview of gelatin-based nanofiber dressings and their applications in wound healing and skin regeneration.
Review
Polymer Science
Blessing Atim Aderibigbe
Summary: Most commercialized wound dressings are polymer-based, with synthetic and natural polymers utilized widely. The poor mechanical properties of natural polymers restrict their use, often necessitating combination with synthetic polymers and other materials to enhance their properties.
Article
Engineering, Multidisciplinary
Yan Li, Juan Wang, Yan Wang, Wenguo Cui
Summary: Hydrogel fibers, derived from the combination of hydrogel and electrospinning, have shown great potential in tissue regeneration and wound healing due to their structural properties and biological functions. Researchers have been particularly interested in the high specific surface area and mechanical advantages provided by these materials, making them promising for various biomedical applications.
COMPOSITES PART B-ENGINEERING
(2021)
Article
Engineering, Biomedical
Athanasios S. Arampatzis, Konstantinos N. Kontogiannopoulos, Konstantinos Theodoridis, Eleni Aggelidou, Angelique Rat, Anne Willems, Ioannis Tsivintzelis, Vassilios P. Papageorgiou, Aristeidis Kritis, Andreana N. Assimopoulou
Summary: Current research focuses on skin tissue engineering for managing chronic wounds, aiming to develop scaffolds that promote cell growth, offer protection, and deliver drugs. Polymeric nanofibers containing A/S derivatives were fabricated successfully, with CA fiber mats showing favorable properties for cell attachment and migration. A/S ester derivatives and dimeric A/S enhanced cell proliferation, while shikonin and alkannin exhibited toxicity. Alkannin, shikonin, and acetyl-shikonin demonstrated potent antibacterial properties compared to other compounds.
BIOMATERIALS RESEARCH
(2021)
Review
Materials Science, Multidisciplinary
Martina Gruppuso, Gianluca Turco, Eleonora Marsich, Davide Porrelli
Summary: Chronic wounds have a significant impact on patients' quality of life and incur high costs for the medical system. Active wound dressings like electrospun wound dressings mimic the extracellular matrix to promote tissue regeneration and wound closure, utilizing polysaccharides for their biomimicry and bioactive properties to enhance the healing process. This review focuses on the features of ideal wound dressings, traditional and current strategies, and the commercialization of wound dressings, with an emphasis on polysaccharide-based electrospun nanofibrous devices and strategies for improving membrane stability and bioactivity.
APPLIED MATERIALS TODAY
(2021)
Review
Pharmacology & Pharmacy
Sumama Nuthana Kalva, Robin Augustine, Abdulla Al Mamun, Yogesh Bharat Dalvi, Namitha Vijay, Anwarul Hasan
Summary: Healing chronic diabetic ulcers, burn wounds, and large traumatic wounds is a significant clinical challenge, but submicron fiber-based membranes can mimic the natural extracellular matrix, promoting wound healing and tissue regeneration. Various active components can be incorporated into electrospun fibers to improve ECM mimetic features and provide additional advantages.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Review
Polymer Science
Sindi P. Ndlovu, Kwanele Ngece, Sibusiso Alven, Blessing A. Aderibigbe
Summary: Wound care is a challenging field due to delayed wound healing process caused by various factors. Biopolymer-based wound dressings show promising properties such as good biocompatibility and antimicrobial activity, but they often lack mechanical strength. Gelatin, a biopolymer with excellent biocompatibility, can be improved by crosslinking with other polymers and incorporating antimicrobial agents for enhanced antimicrobial activity.
Article
Medicine, Research & Experimental
Kairi Lorenz, Liis Preem, Kadi Sagor, Marta Putrins, Tanel Tenson, Karin Kogermann
Summary: Increasing evidence suggests that chronic wounds are associated with bacterial biofilms. New wound care products are being developed to inhibit biofilm formation and treat existing ones. In order to analyze these new antibacterial drug delivery systems, standardized assays and appropriate tools and models are needed. This study demonstrates that optimized in vitro and ex vivo wound infection and biofilm models provide a convenient approach for testing the antibacterial and antibiofilm properties of novel wound dressings. The results can be used to design more effective wound care products and screen different formulations and active substances.
MOLECULAR PHARMACEUTICS
(2023)
Article
Biochemistry & Molecular Biology
Aysegul Gul, Izabela Gallus, Akshat Tegginamath, Jiri Maryska, Fatma Yalcinkaya
Summary: This review discusses the recent advances in using electrospun antibacterial nanomaterials for wound dressings, highlighting the importance of this technology in wound healing and discussing the current research and patent situation.
Article
Materials Science, Multidisciplinary
Zhengchao Yuan, Yue Zhao, Muhammad Shafiq, Jiahui Song, Jing Hou, Yuqing Liang, Xiao Yu, Yujie Chen, Fan Yu, Mohamed EL-Newehy, Hany EL-Hamshary, Yosry Morsi, Shichao Jiang, Hui Zheng, Xiumei Mo
Summary: Skin burns commonly cause edema pain, infection, slow tissue regeneration, and severe scar formation, which significantly affect wound healing. We developed multifunctional electrospun P/G-based dressings incorporated with peppermint essential oil, burn ointment, and Oregano essential oil (P/G@TBO) to promote skin regeneration. P/G@TBO showed sustained release of bioactive cues, increased cell migration, angiogenic effect, antibacterial and anti-inflammatory properties. It also facilitated fast wound healing, pain and itching relief, and scarless healing in different animal models. Harnessing the therapeutic benefits of T, B, and O in fibrous dressings holds promise for burn wound healing.
ADVANCED FIBER MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Yu-Long Zhang, Chen Wang, Xiao-Qian Yuan, Huan-Huan Yan, Cheng-Bo Li, Chun-Hua Wang, Xian-Rui Xie, Gui-Ge Hou
Summary: In this study, a multifunctional electrospun nanofiber dressing (PCQX-M) was prepared for infected wound healing. PCQX-M demonstrated excellent absorption, moisturizing, mechanical, thermodynamic, biocompatible, and antibacterial properties. It significantly promoted cell proliferation, angiogenesis, and healing of infected wounds in a mouse model.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Multidisciplinary
Hongyu Lv, Meng Zhao, Yiran Li, Kun Li, Shaojuan Chen, Wenwen Zhao, Shaohua Wu, Yantao Han
Summary: This study developed a novel nanofibrous dressing for the treatment of hard-to-heal diabetic wounds. The dressing exhibited multiple biological functions, including anti-inflammation, antioxidation, pro-angiogenesis, and hemostasis.
Review
Materials Science, Multidisciplinary
Biruk Fentahun Adamu, Jing Gao, Abdul Khalique Jhatial, Degu Melaku Kumelachew
Summary: Modern wound dressings are now incorporating functional materials like electrospun nanofibers to assist in wound healing and tissue regeneration. These dressings also provide breathability for cellular growth and have potential applications in drug delivery systems.
MATERIALS & DESIGN
(2021)
Article
Engineering, Biomedical
Chaima Merzougui, Fenyan Miao, Ziming Liao, Longfei Wang, Yan Wei, Di Huang
Summary: Antibacterial nanofibers, with their unique features and structural similarities, have been proposed as an interesting material for wound healing management. They can be loaded with antibacterial compounds using various methods, making them suitable for electrospun wound dressings.
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2022)
Article
Pharmacology & Pharmacy
Ana R. Fernandes, Tiago dos Santos, Pedro L. Granja, Elena Sanchez-Lopez, Maria L. Garcia, Amelia M. Silva, Eliana B. Souto
Summary: This study found that using cationic nanoemulsions to deliver triamcinolone acetonide (TA) can reduce the production of tumor necrosis factor alpha (TNF-alpha), which in turn decreases VEGF levels, indicating the potential use of these nanoemulsions for the treatment of age-related macular degeneration (AMD).
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Engineering, Industrial
Paulo Bartolo, Ajay Malshe, Eleonora Ferraris, Bahattin Koc
Summary: Ageing population and new diseases require the development of novel therapeutic strategies. 3D bioprinting, as a potential transformative strategy in tissue engineering and regenerative medicine, is introduced. The concept of 3D bioprinting is discussed, and the key requirements of bio-inks and main materials used for cell encapsulation are detailed. Recent advances in the use of smart materials and the concept of 4D printing are also explored. The main techniques of 3D bioprinting are described in detail and key limitations are highlighted. Successful cases that demonstrate the relevance of 3D bioprinting are presented. Finally, the paper addresses the main research challenges and future perspectives in the field of 3D bioprinting.
CIRP ANNALS-MANUFACTURING TECHNOLOGY
(2022)
Article
Ecology
Maria Joao Carvalho, Ana L. S. Oliveira, Silvia Santos Pedrosa, Manuela Pintado, Ines Pinto-Ribeiro, Ana Raquel Madureira
Summary: The skin microbiota is crucial for human health, but cosmetic products may disrupt its balance and lead to the development of skin diseases. Therefore, it is important to assess the impact of cosmetics on the skin microbiota in the cosmetic industry.
Review
Biotechnology & Applied Microbiology
Marco Duarte, Ana L. Oliveira, Carla Oliveira, Manuela Pintado, Ana Amaro, Ana Raquel Madureira
Summary: Postbiotics, derived from probiotics, are a new class of health-promoting molecules that offer benefits to the host. They are mainly obtained through fermentative processes and have diverse applications such as antioxidant, anti-inflammatory, anti-proliferative, and immunomodulatory properties, making them an innovative approach within the cosmetic ingredients market.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Article
Agricultural Engineering
Luis Carlos Carvalho, Ana L. S. Oliveira, Erdem Carsanba, Manuela Pintado, Carla Oliveira
Summary: This study investigated the transfer of phenolic compounds from sugarcane syrup to the broth during beta-farnesene fermentation. The concentrations of most phenolic compounds increased until day 3 of fermentation and then remained constant. The Weibull model showed a better fit to the data.
INDUSTRIAL CROPS AND PRODUCTS
(2022)
Article
Agriculture, Multidisciplinary
Srishti Singh, Joel Pereira, Teresa Brandao, Ana Leite Oliveira, Fatima Pocas
Summary: This study demonstrates that supercritical CO2 extraction can be used to efficiently remove contaminants from discarded polypropylene (PP) beverage cups, without significantly affecting their physical and sensory properties.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2023)
Article
Polymer Science
Juliana R. Dias, Aureliana Sousa, Ana Augusto, Paulo J. Bartolo, Pedro L. Granja
Summary: PCL is widely used in tissue engineering due to its unique properties. PCL electrospun fiber meshes are expected to have a fast degradation rate. In vitro and in vivo studies showed that lipase can promote the degradation rate of PCL meshes up to 97% in a static medium, while the degradation rate was slower in vivo but the samples were well-integrated with the surrounding tissues.
Article
Biochemistry & Molecular Biology
Mariana Luz-Veiga, Manuela Amorim, Ines Pinto-Ribeiro, Ana L. S. Oliveira, Sara Silva, Ligia L. Pimentel, Luis M. Rodriguez-Alcala, Raquel Madureira, Manuela Pintado, Joao Azevedo-Silva, Joao Fernandes
Summary: Cannabidiol (CBD) and cannabigerol (CBG) are phytocannabinoids found in Cannabis sativa L. They have antimicrobial activity against bacteria and biofilms, with CBG showing higher activity than CBD. These findings suggest that phytocannabinoids could be promising topical antimicrobial agents for treating various skin conditions. Further research is needed to understand their mechanisms of action and develop practical applications in dermatology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemical Research Methods
Daniel A. Ferreira, Joao P. Conde, Mario Rothbauer, Peter Ertl, Pedro L. Granja, Carla Oliveira
Summary: The lack of biomimetic in vitro models delay the development of diagnostic and therapeutic tools for the gastric mucosa. However, recent advances in microengineering have made it possible to create bioinspired microdevices that replicate the physiological properties of an organ. In this study, a bioinspired stomach-on-a-chip (SoC) device is described, which recreates the structure and function of the gastric mucosa. The device simulates the upper epithelial interface and allows for the development of gastric barrier function.
Article
Biochemistry & Molecular Biology
Ana P. Capeto, Joao Azevedo-Silva, Sergio Sousa, Manuela Pintado, Ana S. Guimaraes, Ana L. S. Oliveira
Summary: In the last decade, bio-based polyesters have gained increasing attention for their potential in various biomedical applications. A flexible polyester was produced from microbial oil residue obtained from genetically modified yeast. The polyester exhibited excellent mechanical properties, biodegradability, and biocompatibility, making it a promising candidate for controlled release of active substances in wound dressing applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Ines Guimaraes, Raquel Costa, Sara Madureira, Sandra Borges, Ana L. Oliveira, Manuela Pintado, Sara Baptista-Silva
Summary: Difficult-to-treat infections make complex wounds a problem of great clinical and socio-economic impact. Phytochemicals are promising alternatives for wound care, with antimicrobial and antioxidant activities. Chitosan-based microparticles were developed as carriers of tannic acid to improve its stability, bioavailability, and delivery. These microparticles showed high encapsulation efficiency, antimicrobial potential against common wound pathogens, and improved cell viability and proliferation compared to free tannic acid.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Maura Cimino, Paula Parreira, Victoria Leiro, Aureliana Sousa, Raquel M. Goncalves, Cristina C. Barrias, M. Cristina L. Martins
Summary: Efforts have been made to optimize hMSC culture protocols by mimicking the cell physiological microenvironment. The use of pKL surfaces can improve hMSC adhesion and proliferation through selective binding of heparin and fibronectin.
Article
Chemistry, Applied
Izabela Lima, Lina Moreno, Savia Dias, Durcilene Silva, Antonia Carla Oliveira, Lamartine Soares, Rayran Sousa, Dalton Dittz, Hercilia Rolim, Livio Nunes
Summary: In this study, mesalazine (MSZ) was encapsulated in nanoparticles (NP) of acetylated cashew gum (ACG) to improve its absorption in the colon. NPs were synthesized using the dialysis method and different polymer:drug ratios were investigated. The results showed that NP-ACG is a promising vector for the sustained release of MSZ in the colon when administered orally.
CARBOHYDRATE POLYMER TECHNOLOGIES AND APPLICATIONS
(2023)
Review
Engineering, Electrical & Electronic
Idil Tartici, Zekai Murat Kilic, Paulo Bartolo
Summary: Three-dimensional printing, or additive manufacturing, has the potential to revolutionize traditional manufacturing systems by producing high-value-added complex products at reduced costs, making it a key technology in the Industry 4.0 era. This systematic literature review analyzes ongoing research on 3D technologies in the field of monitoring and control to facilitate their adoption in Industry 4.0.
Article
Chemistry, Multidisciplinary
Marta Redondo, Rafaela Presa, Pedro L. Granja, Marco Araujo, Aureliana Sousa
Summary: This study successfully developed degradable Konjac glucomannan (KGM) hydrogels for 3D cell culture and achieved cell-material interactions by modifying and grafting bioactive peptides into KGM. The results show great potential for the further application of KGM in tissue engineering.
MATERIALS TODAY CHEMISTRY
(2023)
Article
Materials Science, Biomaterials
Mohammadreza Kasravi, Alireza Yaghoobi, Tahereh Tayebi, Mahsa Hojabri, Abdolkarim Talebi Taheri, Fatemeh Shirzad, Bahram Jambar Nooshin, Radman Mazloomnejad, Armin Ahmadi, Fatemeh A. Tehrani, Ghasem Yazdanpanah, Mohammad Hadi Farjoo, Hassan Niknejad
Summary: As a promising approach in translational medicine, the decellularization of discarded livers to produce bioscaffolds that support recellularization has potential in overcoming the limitations of conventional liver transplantation. In this study, the researchers investigated the use of matrix metalloproteinase (MMP) inhibition to preserve the extracellular matrix (ECM) during liver decellularization. The results demonstrated that the application of an MMP inhibitor significantly improved the preservation of ECM components and mechanical properties of the bioscaffolds, which supported cell viability and function in vitro. The study also confirmed that the MMP inhibition led to the inhibition of MMP2 and MMP9, providing a novel method to enhance ECM preservation during liver decellularization.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Mohammadsadegh Nadimifar, Weiguang Jin, Clara Coll-Satue, Gizem Bor, Paul Joseph Kempen, Ali Akbar Moosavi-Movahedi, Leticia Hosta-Rigau
Summary: This study presents a metal-phenolic self-assembly approach that can prepare nanoparticles fully made of hemoglobin. The nanoparticles exhibit good oxygen binding and releasing capabilities.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jyoti Kumari, Roel Hammink, Jochem Baaij, Frank A. D. T. G. Wagener, Paul H. J. Kouwer
Summary: Fibrosis is the formation of fibrous connective tissue in response to injury, leading to organ dysfunction. A novel hybrid hydrogel combining synthetic polyisocyanide with hyaluronic acid has been developed, showing strong antifibrotic properties.
BIOMATERIALS ADVANCES
(2024)
Letter
Materials Science, Biomaterials
Melissa Machado Rodrigues, Cristian Padilha Fontoura, Charlene Silvestrin Celi Garcia, Sandro Tomaz Martins, Joao Antonio Pegas Henriques, Carlos Alejandro Figueroa, Mariana Roesch Ely, Cesar Aguzzoli
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jessica Polak, David Sachs, Nino Scherrer, Adrian Suess, Huan Liu, Mitchell Levesque, Sabine Werner, Edoardo Mazza, Gaetana Restivo, Mirko Meboldt, Costanza Giampietro
Summary: Human skin equivalents (HSEs) play a crucial role in tissue engineering. This study introduces a 3D-printed culture insert to apply a static radial constraint on HSEs and examines its effects on tissue characteristics. The results show that the diameter of the culture insert significantly influences tissue contraction, fibroblast and matrix organization, keratinocyte differentiation, epidermal stratification, and basement membrane formation. This study provides important insights for the design of skin tissue engineering.
BIOMATERIALS ADVANCES
(2024)
Review
Materials Science, Biomaterials
Shiliang Chen, Tianming Du, Hanbing Zhang, Jing Qi, Yanping Zhang, Yongliang Mu, Aike Qiao
Summary: This paper reviewed the primary methods for improving the overall properties of biodegradable zinc stents. It discussed the mechanical properties, degradation behavior, and biocompatibility of various improvement strategies. Alloying was found to be the most common, simple, and effective method for improving mechanical properties. Deformation processing and surface modification further improved the mechanical properties and biological activity of zinc alloys. Meanwhile, structural design could endow stents with special properties. Manufacturing zinc alloys with excellent properties and exploring their interaction mechanism with the human body are areas for future research.
BIOMATERIALS ADVANCES
(2024)
