Article
Materials Science, Biomaterials
Kiruthiga Kaliyamoorthy, Archana Sumohan Pillai, Aleyamma Alexander, Anitha Arivarasu, Israel V. M. V. Enoch, Sivaraj Ramasamy
Summary: This study focuses on the design of biocompatible polymer-coated magnetic nanoparticles for efficient delivery of anticancer drugs, demonstrating sustained release in vitro and enhanced inhibition of cancer cell lines. The results suggest great potential for magnetic nanocarriers in drug transport.
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2021)
Article
Polymer Science
Chengyuan Xing, Xia Xu, Lei Song, Xiaoling Wang, Bangjing Li, Kun Guo
Summary: PVA/CD composite fibers prepared by wet spinning and hot stretching, further crosslinked with glutaraldehyde, show potential for mass production of wearable long-term scented fabrics with enhanced fragrance loading and sustained release.
Article
Pharmacology & Pharmacy
Chotima Seripracharat, Chomdao Sinthuvanich, Thitinun Karpkird
Summary: In this study, an inclusion complex of cationic beta-cyclodextrins and adamantane conjugated poly (vinyl alcohol) was successfully designed and synthesized as a siRNA carrier. The nanoparticles formed by this complex and siRNA showed efficient gene knockdown in vitro, indicating its potential as a siRNA delivery system.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Materials Science, Multidisciplinary
Lei Liu, Xiaodong Xu, Menghe Zhu, Xihua Cui, Jiabing Feng, Zahra Faraji Rad, Hao Wang, Pingan Song
Summary: Inspired by the hydrogen-bond cross-linking structure of spider silk, strong and tough PVA composites with beta-cyclodextrin as a cross-linker are developed, showing high tensile strength, elastic modulus, and toughness. The addition of beta-cyclodextrin also improves the biodegradability of the PVA composite. Furthermore, the PVA/beta-cyclodextrin composite combined with MXene has great potential as a sensor material for humidity and strain detection.
ADVANCED MATERIALS TECHNOLOGIES
(2023)
Article
Polymer Science
Ekkachai Martwong, Santi Chuetor, Jatupol Junthip
Summary: The study successfully removed a hazardous agrochemical from water using poly(vinyl alcohol)-cyclodextrin nanosponges, displaying good physicochemical properties and high recyclability after multiple regenerations. The adsorption process followed the pseudo second-order kinetics and Langmuir isotherm, with a maximum adsorption capacity of 112.2 mg/g.
Article
Polymer Science
Seong Baek Yang, Mohammad Rezaul Karim, Jungeon Lee, Jeong Hyun Yeum, Sabina Yeasmin
Summary: Novel poly(vinyl alcohol)/poly(vinyl butyral-vinyl alcohol) films with improved hydrophobicity were prepared by saponification of poly(vinyl acetate)/poly(vinyl butyral) blend films. The saponification process was confirmed by various analysis techniques. The hydrophobicity of the films increased with increasing poly(vinyl butyral) content. The saponified films exhibited improved mechanical properties and unique surface characteristics. These films have potential applications in biomaterials, filters, and medical devices.
Article
Materials Science, Ceramics
Zhila Shaterabadi, Gholamreza Nabiyouni, Zakye Mirali Asadi, Guillermo R. Iglesias, Meysam Soleymani
Summary: This study investigates the effect of zinc substitution on the magnetic properties and heat-generating ability of PVA-coated zinc-substituted cobalt ferrite nanoparticles (PZC NPs). The results reveal the significant impact of the interrelation between chemical composition and magnetic field strength on the heating efficiency of the nanoparticles.
CERAMICS INTERNATIONAL
(2023)
Article
Chemistry, Applied
Xi Chen, Tetsushi Taguchi
Summary: This study successfully fabricated an inclusion complex film containing β-cyclodextrin and nonanyl group-modified PVA, showing good water vapor transmission rate and ion permeability, making it suitable for adhesive use in skin contact medical devices.
CARBOHYDRATE POLYMERS
(2021)
Article
Engineering, Environmental
Pakakrong Sangsanoh, Sonthaya Chaiarwut, Chasuda Choipang, Jitti Niyompanich, Orawan Suwantong, Kriengsak Lirdprapamongkol, Jisnuson Svasti, Piyachat Chuysinuan, Supanna Techasakul, Pitt Supaphol
Summary: Semi-solid PVA-borax hydrogels containing CBD/β-CD inclusion complex were prepared for wound management. The inclusion complex was successfully prepared and loaded into PVA hydrogels. The hydrogels showed antibacterial capability against S. aureus and MRSA and improved antioxidant properties when CBD was added. The hydrogels were non-cytotoxic and suppressed NO production in cells. These findings highlight the potential biomedical application of these hydrogels.
JOURNAL OF POLYMERS AND THE ENVIRONMENT
(2023)
Article
Chemistry, Multidisciplinary
Yingxu Song, Sumei Zhang, Jian Kang, Jinyao Chen, Ya Cao
Summary: Annealing PVA films at different temperatures affects the water absorption, leading to changes in the formation of PVA-iodine complexes. The amount of PVA segments with moderate hydration has a significant impact on the complexation process.
Article
Polymer Science
Hamid Reza Hedayati, Manounchehr Khorasani, Mostafa Ahmadi, Nicholas Ballard
Summary: In this study, well-defined and linear PVAc was synthesized using RAFT polymerization method, overcoming the difficulties in controlling molecular weight distribution during the hydrolysis of PVAc. This offers a potential route to the production of PVAc and PVA products with uniform properties.
Review
Polymer Science
Nadia Guajardo
Summary: Lipases are versatile enzymes that can catalyze various hydrolysis and synthesis reactions with selectivity. Immobilization techniques, such as using polyvinyl alcohol (PVA) as a support material, can recover and stabilize the enzymes for their application in different types of bioreactors. This review analyzes the potential of PVA in immobilizing lipases by combining it with alginate, chitosan, and hydroxypropylmethylcellulose (HPMC), resulting in the formation of magnetic fibers and microspheres. The review includes 42 articles published between 1999 and 2023, selected from the Scopus database. Expanding knowledge in this area is crucial due to the versatility and scalability of PVA as a support material for lipase immobilization in various bioreactor configurations.
Article
Polymer Science
Alessandro Angelini, Anja Car, Ionel Adrian Dinu, Luigi Leva, Wilfredo Yave
Summary: Tailor-made poly(vinyl alcohol)-b-poly(styrene) copolymers (PVA-b-PS) for separation membranes are synthesized using reversible-deactivation radical polymerization techniques. These di-block copolymers have high molecular weight (>70 kDa), high PVA content (>80 wt%), and good film-forming property. They self-assemble in aqueous media to form micelles, which when cast on a porous substrate, result in thin-film membranes with higher water permeance than that of PVA homopolymer. The PS nanodomains within the PVA matrix act as cross-linking points, eliminating the need for chemical cross-linkers and acid catalysts. Thermal annealing further enhances membrane selectivity through improved microphase separation.
MACROMOLECULAR RAPID COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Yajun Ren, Xiaofeng Song, Youhua Chen, Wen Xin, Chuanming Zhu, Yuan Huang, Na Tian, Yuling Huang
Summary: Self-healable polymers are promising intelligent materials that can repair physical damage autonomously, extending their lifetime and reducing maintenance costs. In this study, a series of polymers with switching phase and healing accelerator properties were synthesized and blended with poly(vinyl alcohol). The resulting blend demonstrated good self-healing behavior and hydrothermal-response shape memory effect.
Article
Engineering, Chemical
Yifan Xia, Sinu C. Rajappan, Dmytro Serhiichuk, Mikkel Rykaer Kraglund, Jens Oluf Jensen, David Aili
Summary: A series of poly(vinyl alcohol-co-vinyl acetal) gel electrolytes were prepared and assessed for their performance as electrode separators in alkaline water electrolysis. The membrane properties could be tuned by varying the degree of functionalization, and a membrane with moderate vinyl acetal content showed good mechanical robustness and ion conductivity. The membrane effectively prevented hydrogen crossover during alkaline water electrolysis tests. The strategies presented in this work have general relevance to the field for the development of new ion-solvating membrane systems.
JOURNAL OF MEMBRANE SCIENCE
(2023)
Article
Biophysics
Ashish Kalkal, Sachin Kadian, Sumit Kumar, Gaurav Manik, Prosenjit Sen, Saurabh Kumar, Gopinath Packirisamy
Summary: A nanohybrid of ultrathin Ti3C2-MXene nanosheets and silver nanoparticles (Ag@Ti3C2-MXene) has been reported as a dual-energy acceptor for ultrahigh fluorescence quenching in the fabrication of an efficient fluorescent immunosensor.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Biochemistry & Molecular Biology
Suganthi Soundarapandian, Aleyamma Alexander, Archana Sumohan Pillai, Varnitha Manikandan, Israel V. M. V. Enoch, Sameena Yousuf
Summary: This study investigated the DNA binding behavior of Berberine encapsulated in the Fluorescein-beta-cyclodextrin conjugate. The results showed that the binding mode and strength varied depending on the conformation of the G-quadruplexes.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Editorial Material
Biotechnology & Applied Microbiology
Sameer Hussain, Gopinath Packirisamy, Krishna Misra, Mohammad Tariq, Md Palashuddin Sk
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Aishwarya Muruganantham, Arokya Nithya Deva Sahayam, Soundarapandian Suganthi, Aleyamma Alexander, Archana Sumohan Pillai, Israel V. M. V. Enoch
Summary: DNA forms non-canonical Guanine-rich-quadruplex structures that play crucial roles in cellular processes. Selective binding and stabilization of these structures with small molecular ligands are important for controlling cell proliferation and developing therapeutics. This study reports the synthesis of a complex and its evaluation of binding interactions with various DNAs.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Review
Agriculture, Multidisciplinary
Dravin Pratap Singh, Gopinath Packirisamy
Summary: Modern lifestyle diseases (LSD) such as cancer, diabetes, hypertension, cardiovascular, and thyroid disease are commonly seen among people of different age groups. One of the root causes of these diseases is the type of food that we consume. Staple crops are grown with the use of agrochemicals, which leave traces in our food. Additionally, the food is processed using saturated fats, toxic chemicals, and additives, compromising its nutritional value and weakening the immune system.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2023)
Article
Materials Science, Multidisciplinary
Rajkumar Sadasivam, Gopinath Packirisamy, Mayank Goswami
Summary: Fashionable contact lenses can be transformed into innovative drug delivery devices. These drug-loaded hydrogel lenses have the potential to be used as non-invasive implants for treating ocular diseases such as diabetic retinopathy.
Article
Chemistry, Applied
Peter Daniel Nixon, V. Vinesh, Elangovan Jayaseelan, Asir Eliet Magdalin, Mani Preeyanghaa, Israel V. M. V. Enoch, B. Neppolian, Nallamuthu Ananthi
Summary: In this study, a silver-based magnetic nanocomposite was loaded in KIT-5 mesoporous silica to prepare an efficient photocatalytic material for the degradation of toxic tetracycline. The material's morphology, magnetic properties, and recyclability in pharmaceutical waste degradation were investigated. A mechanism for the degradation of tetracycline by the material was also discussed based on its structural characteristics.
JOURNAL OF POROUS MATERIALS
(2023)
Article
Chemistry, Physical
Aleyamma Alexander, Archana Sumohan Pillai, Govindaraj Sri Varalakshmi, Nallamuthu Ananthi, Haridas Pal, Israel V. M. V. Enoch, Mhejabheen Sayed
Summary: Non-canonical nucleic acid forms, such as G-quadruplexes, play a significant role in biological processes and have been targeted for cancer therapy. This article presents the synthesis and characterization of benzimidazole derivatives and their binding interactions with G-quadruplex and double-stranded DNAs.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Chemistry, Physical
Aleyamma Alexander, Archana Sumohan Pillai, Bose Allben Akash, Nallamuthu Ananthi, Haridas Pal, Israel V. M. V. Enoch, Mhejabeen Sayed
Summary: This study reports the synthesis and characterization of a novel diguanidine derivative containing a benzimidazole moiety. The structure of the compound's inclusion complex with a porphyrin-tethered β-cyclodextrin was optimized using rotating-frame Overhauser effect spectroscopy. The binding affinity of the complex to different DNAs was analyzed, and it showed stronger binding to G-quadruplexes compared to duplex DNA.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Biochemistry & Molecular Biology
Vinay Kumar, Gopinath Packirisamy
Summary: The development of 3D scaffold-based in vitro tumor models using sodium alginate and sodium alginate/silk fibroin porous beads allows for improved drug screening and tissue engineering. The tumor models showed a high tendency for cell adhesion, proliferation, and formation of tumor-like aggregates, outperforming the 2D cell culture model. Additionally, the use of superparamagnetic iron oxide nanoparticles loaded into the porous beads demonstrated the ability to induce apoptosis under high magnetic fields.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Chemistry, Physical
Bose Allben Akash, Suganya Kanagaraj, Sumathi Sundaravadivelu, Govindaraj Varalakshmi, Varnitha Manikantan, Archana Sumohan Pillai, Aleyamma Alexander, Israel V. M. V. Enoch
Summary: In this study, we reported the surface modification of nanoscale cobalt-nickel alloy nanoparticles with a biocompatible ss-cyclodextrin citrate for magnetic field-guided anticancer drug transport. The surface-modified nanoparticles showed properties suitable for drug delivery, including high saturation magnetization, narrow hysteresis loops, and sustained release of the loaded drug. The loaded nanoparticles demonstrated efficient anticancer activity against breast carcinoma cells, making them a promising chemotherapeutic carrier.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Engineering, Electrical & Electronic
Keenan Zhihong Yap, Wei Yin Lim, Ashish Kalkal, P. Gopinath, Narayanan Ramakrishnan
Summary: In this study, a capacitive sensor coated with graphene oxide (GO) was developed for humidity sensing. The GO was directly deposited on gold interdigital electrodes (IDE) using electrophoretic deposition (EPD) technique, and functionalized with magnesium ions. The sensor exhibited ultrahigh sensitivity and stability at different humidity levels.
IEEE TRANSACTIONS ON INSTRUMENTATION AND MEASUREMENT
(2023)
Article
Chemistry, Analytical
Srushti Gadiyaram, Nancy Sharma, Israel V. M. V. Enoch, D. Amilan Jose
Summary: A liposome based nanosensor, Lipo-1, has been developed for efficient detection of copper, cyanide, and ATP in pure aqueous medium. Lipo-1 exhibits a fluorescence ON-OFF response with copper and enables detection of ATP and CN- below the WHO permissible level for safe drinking water.
ANALYTICAL METHODS
(2022)
Article
Food Science & Technology
Dravin Pratap Singh, Gopinath Packirisamy
Summary: According to the report of the United Nations, half of the fruits and vegetables are lost annually. Coatings, particularly edible films made from natural polymers, are being used to reduce postharvest loss and extend the shelf life of food. However, the cost of these films is high, making them inaccessible to local fruit and vegetable vendors.
FOOD CHEMISTRY: MOLECULAR SCIENCES
(2022)
Article
Chemistry, Analytical
P. Sumathi, K. Kiruthiga, R. Sivaraj, P. Mosae Selvakumar, Israel V. M. V. Enoch
Summary: Nickel ions are toxic to the environment and biology. Fluorescence sensing can be used to detect them using simple and synthesized molecules. This study presents a semicarbazone derivative as a nickel ion sensor in water. The compound forms a 1:1 stoichiometric complex with nickel ions and shows high selectivity and sensitivity.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY RESEARCH
(2022)
Article
Materials Science, Biomaterials
Mohammadreza Kasravi, Alireza Yaghoobi, Tahereh Tayebi, Mahsa Hojabri, Abdolkarim Talebi Taheri, Fatemeh Shirzad, Bahram Jambar Nooshin, Radman Mazloomnejad, Armin Ahmadi, Fatemeh A. Tehrani, Ghasem Yazdanpanah, Mohammad Hadi Farjoo, Hassan Niknejad
Summary: As a promising approach in translational medicine, the decellularization of discarded livers to produce bioscaffolds that support recellularization has potential in overcoming the limitations of conventional liver transplantation. In this study, the researchers investigated the use of matrix metalloproteinase (MMP) inhibition to preserve the extracellular matrix (ECM) during liver decellularization. The results demonstrated that the application of an MMP inhibitor significantly improved the preservation of ECM components and mechanical properties of the bioscaffolds, which supported cell viability and function in vitro. The study also confirmed that the MMP inhibition led to the inhibition of MMP2 and MMP9, providing a novel method to enhance ECM preservation during liver decellularization.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Mohammadsadegh Nadimifar, Weiguang Jin, Clara Coll-Satue, Gizem Bor, Paul Joseph Kempen, Ali Akbar Moosavi-Movahedi, Leticia Hosta-Rigau
Summary: This study presents a metal-phenolic self-assembly approach that can prepare nanoparticles fully made of hemoglobin. The nanoparticles exhibit good oxygen binding and releasing capabilities.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jyoti Kumari, Roel Hammink, Jochem Baaij, Frank A. D. T. G. Wagener, Paul H. J. Kouwer
Summary: Fibrosis is the formation of fibrous connective tissue in response to injury, leading to organ dysfunction. A novel hybrid hydrogel combining synthetic polyisocyanide with hyaluronic acid has been developed, showing strong antifibrotic properties.
BIOMATERIALS ADVANCES
(2024)
Letter
Materials Science, Biomaterials
Melissa Machado Rodrigues, Cristian Padilha Fontoura, Charlene Silvestrin Celi Garcia, Sandro Tomaz Martins, Joao Antonio Pegas Henriques, Carlos Alejandro Figueroa, Mariana Roesch Ely, Cesar Aguzzoli
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jessica Polak, David Sachs, Nino Scherrer, Adrian Suess, Huan Liu, Mitchell Levesque, Sabine Werner, Edoardo Mazza, Gaetana Restivo, Mirko Meboldt, Costanza Giampietro
Summary: Human skin equivalents (HSEs) play a crucial role in tissue engineering. This study introduces a 3D-printed culture insert to apply a static radial constraint on HSEs and examines its effects on tissue characteristics. The results show that the diameter of the culture insert significantly influences tissue contraction, fibroblast and matrix organization, keratinocyte differentiation, epidermal stratification, and basement membrane formation. This study provides important insights for the design of skin tissue engineering.
BIOMATERIALS ADVANCES
(2024)
Review
Materials Science, Biomaterials
Shiliang Chen, Tianming Du, Hanbing Zhang, Jing Qi, Yanping Zhang, Yongliang Mu, Aike Qiao
Summary: This paper reviewed the primary methods for improving the overall properties of biodegradable zinc stents. It discussed the mechanical properties, degradation behavior, and biocompatibility of various improvement strategies. Alloying was found to be the most common, simple, and effective method for improving mechanical properties. Deformation processing and surface modification further improved the mechanical properties and biological activity of zinc alloys. Meanwhile, structural design could endow stents with special properties. Manufacturing zinc alloys with excellent properties and exploring their interaction mechanism with the human body are areas for future research.
BIOMATERIALS ADVANCES
(2024)
