Journal
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 93, Issue -, Pages 96-105Publisher
ELSEVIER
DOI: 10.1016/j.msec.2018.07.062
Keywords
Silk fibroln; Facile incorporation; REDV; Vascularization; Thick tissues
Categories
Funding
- National Natural Science Foundation of China [31771058, 31470938, 11421202, 61227902, 11120101001]
- National Key Technology RD Program [2014BAI11B02, 2014BAI11B03, 2016YFC1100704, 2016YFC1101101]
- International Joint Research Center of Aerospace Biotechnology and Medical Engineering from Ministry of Science and Technology of China
- 111 Project [B13003]
- Research Fund for the Doctoral Program of Higher Education of China [20131102130004]
- transformation project for major achievements of Central Universities in Beijing [ZDZH20141000601]
- Beijing Municipal Science and Technology Project [Z151100003715006]
- Fundamental Research Funds for the Central Universities
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Rapid neovascularization within scaffolds is critical for the regeneration of thick complex tissues. The surface immobilization of peptides and other active molecules have been explored to improve the vascularization capacity of implants. However, the rapid degradation of these molecules, the reaction conditions and cross-linking usually result in decreased vascularization capability. Here, we introduced a temperate, all-aqueous process to achieve bulk porous silk fibroin (SF) scaffolds. A temperature controlled process was used to induce the water stable structure by SF self-assembly. Arg-Glu-Asp-Val (REDV) peptides were added into SF solution and fixed within SF scaffolds during the self-assembly process. The results showed that the functionalized scaffolds markedly promoted the adhesion of endothelial cells in vitro. Moreover, the in vivo studies indicated enhanced cell infiltration in the bulk functionalized SF scaffolds and impressive vaseularization at 4 weeks post-implantation. The functionalized scaffolds demonstrated excellent vascularization capability, providing an exciting biomaterial option for thick tissue regeneration.
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