Journal
MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 42, Issue -, Pages 489-499Publisher
ELSEVIER
DOI: 10.1016/j.msec.2014.05.074
Keywords
Electrospinning; Bioresorbable polyurethane; Polymer blends; Vascular grafts; Morphology
Categories
Funding
- CONICET
- Argentinean National Agency of Scientific and Technological Promotion [PICT 448]
- National Research Council [PIP 522]
- National University of Mar del Plata [15/G359, 15/G328]
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The present study is focused on the electrospinning process as a versatile technique to obtain nanofibrous tubular structures for potential applications in vascular tissue engineering. A bilayered scaffolding structure composed of poly(L-lactic add) (PLLA)/bioresorbable segmented polyurethane (SPEU) blends for small-diameter (5 mm) vascular bypass grafts was obtained by multilayering electrospinning. Polymer blend ratios were chosen to mimic the media and adventitia layers. The influence of the different electrospinning parameters into the fiber formation, fiber morphology and fiber mean diameter for PLLA, SPEU and two PLLA/SPEU blends were studied. Flat and two-parallel plate collectors were used to analyze the effect of the electrostatic field on the PLLA nanofiber alignment in the rotating mandrel. Membrane topography resulted in random or aligned nanofibrous structures depending on the auxiliary collector setup used. Finally, composition, surface hydrophilicity, thermal properties and morphology of nanofibrous scaffolds were characterized and discussed. Since the development of tissue engineered microvascular prostheses is still a challenge, the prepared scaffolding tubular structures are promising candidates for vascular tissue engineering. (C) 2014 Elsevier B.V. All rights reserved.
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