Journal
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 43, Issue -, Pages 641-648Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.msec.2014.06.038
Keywords
High nitrogen nickel-free austenitic stainless steel Biocompatibility; Coronary stent
Categories
Funding
- Key Project of National Science and Technology Support Program [2012BAI18B02]
- National Natural Science Foundation of China [11332003]
- Chongqing Science and Technology Commission [cstc2013kjrc-ljrccj10003]
- National 111 plan Base [B06023]
- Public Experiment Center of State Bioindustrial Base (Chongqing), China
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Adverse effects of nickel ions being released into the living organism have resulted in development of high nitrogen nickel-free austenitic stainless steels for medical applications. Nitrogen not only replaces nickel for austenitic structure stability but also improves steel properties. The cell cytocompatibility, blood compatibility and cell response of high nitrogen nickel-free austenitic stainless steel were studied in vitro. The mechanical properties and microstructure of this stainless steel were compared to the currently used 316L stainless steel. It was shown that the new steel material had comparable basic mechanical properties to 316L stainless steel and preserved the single austenite organization. The cell toxicity test showed no significant toxic side effects for MC3T3-E1 cells compared to nitinol alloy. Cell adhesion testing showed that the number of MC3T3-E1 cells was more than that on nitinol alloy and the cells grew in good condition. The hemolysis rate was lower than the national standard of 5% without influence on platelets. The total intracellular protein content and ALP activity and quantification of mineralization showed good cell response. We conclude that the high nitrogen nickel-free austenitic stainless steel is a promising new biomedical material for coronary stent development. (C) 2014 Elsevier B.V. All rights reserved.
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