Article
Materials Science, Multidisciplinary
Abhishek Singh, Satish Kumar, Tusar Kanta Acharya, Chandan Goswami, Luna Goswami
Summary: This study developed a polysaccharide-based biomaterial with nanohydroxyapatite as a filler. The physicochemical characterization showed that the material is biocompatible towards nonosteoblasts and osteoblasts cells and exhibit no cytotoxic effects. Furthermore, this biomaterial enhances the in vitro biomineralization of osteoblast cells under osteoinductive conditions.
MATERIALS TODAY COMMUNICATIONS
(2022)
Article
Instruments & Instrumentation
Parisa Ghandforoushan, Jalal Hanaee, Zahra Aghazadeh, Mohammad Samiei, Amir Mohammad Navali, Ali Khatibi, Soodabeh Davaran
Summary: Treating cartilage degenerative disorders is a longstanding challenge in orthopedic medicine due to the limited capacity for self-regeneration in cartilage. This study aimed to develop a nanocomposite biomaterial that enhances growth factor delivery to injured cartilage sites. The findings suggest that the developed nanocomposite hydrogel can serve as a supportive platform for promoting differentiation of human dental pulp stem cells.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2022)
Article
Polymer Science
Kiran M. Ali, Yihan Huang, Alaowei Y. Amanah, Nasif Mahmood, Taylor C. Suh, Jessica M. Gluck
Summary: This study evaluates the potential use of traditional textile methods in the tissue engineering industry and proves the safety and efficacy of the material and fabrication method by creating collagen yarns using the traditional ring spinning method. The process is not only simple and efficient but also results in standardized products.
Article
Biophysics
Vinu Vijayan, Rachita Lakra, Purna Sai Korrapati, Manikantan Syamala Kiran
Summary: In this study, a rare earth lanthanum oxide nanoparticle reinforced collagen biomatrix was developed and evaluated for its bioactivity. The results showed that the biomatrix had good structural integrity, mechanical strength, and resistance to degradation. The lanthanum oxide nanoparticle promoted endothelial cell activation and angiogenesis, and enhanced cell migration. Therefore, this study provides a new approach for developing rare earth-based biomaterials with biological effects.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Review
Biochemistry & Molecular Biology
Ibrahim N. Amirrah, Yogeswaran Lokanathan, Izzat Zulkiflee, M. F. Mohd Razip Wee, Antonella Motta, Mh Busra Fauzi
Summary: Collagen is the most abundant structural protein found in humans and mammals, primarily responsible for holding the body together. Among the various types of collagen, type I is the major component in many tissues and has been extensively used in medical and biological applications. It possesses advantageous characteristics such as varied sources, biocompatibility, sustainability, and biodegradability, making it an ideal biomaterial for tissue engineering.
Article
Biochemistry & Molecular Biology
Hsu-Hsiang Lin, Pen-Hsiu Grace Chao, Wei-Chiu Tai, Po-Chun Chang
Summary: This study successfully developed a biomimetic microfibrous system to assist PDL regeneration and withstand functional load. Collagen-based microfibers were fabricated and PDL cells seeded on waveform microfibers showed enhanced growth and gene expression levels, indicating potential for promoting healing and regeneration under shear stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Polymer Science
Mina Ghafouri Azar, Lucie Wiesnerova, Jana Dvorakova, Petra Chocholata, Omid Moztarzadeh, Jiri Dejmek, Vaclav Babuska
Summary: This research introduces a novel approach of incorporating different types of gelatins into polycaprolactone and poly (lactic-co-glycolic acid) films. The evaluation of these films includes morphology, mechanical properties, thermal stability, biodegradability, hemocompatibility, cell adhesion, proliferation, and cytotoxicity. The results show that the addition of gelatins alters the mechanical properties, biodegradability, and cell behavior of the films. These findings provide valuable insights for future tissue engineering applications involving gelatin incorporation.
Article
Green & Sustainable Science & Technology
Gopika Selvakumar, Iyappan Kuttalam, Sankari Mukundan, Suguna Lonchin
Summary: Fish discards are thrown into the sea during fishing activities, resulting in loss of valuable nutrients and negatively impacting marine habitats. This study aims to extract value-added components from discarded fish skin, such as collagen, for waste utilization and a cleaner ecosystem. The extracted collagen showed high biocompatibility and potential for biomedical applications.
JOURNAL OF CLEANER PRODUCTION
(2021)
Article
Polymer Science
D. Switha, S. Khaleel Basha, V. Sugantha Kumari
Summary: The study optimized a conductive PANI-PVA-NS biocomposite by adding different concentrations of nanostarch and investigated its properties using various techniques such as FTIR, XRD, SEM, and TEM. The results showed promising potential for application in tissue engineering.
EUROPEAN POLYMER JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Igor Rzhepakovsky, Sergey Piskov, Svetlana Avanesyan, Marina Sizonenko, Lyudmila Timchenko, Oxana Anfinogenova, Andrey Nagdalian, Andrey Blinov, Evgeniya Denisova, Stanislav Kochergin, Sergey Kubanov, Magomed Shakhbanov, Mohammad Ali Shariati, Mohammad S. Mubarak
Summary: Pure and porous bacterial cellulose scaffolds were synthesized using Medusomyces gisevii Sa-28 bacterial strain. Modification with gelatin increased the biocompatibility and solubility of the scaffolds. The scaffolds exhibited uniform distribution of pores, promoting new blood vessel growth and collagen fiber formation. The results suggest that these scaffolds can be used for engineering hard and soft tissues.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Nivethitha Panneerselvam Manimegalai, Giriprasath Ramanathan, Deebasuganya Gunasekaran, Grace Felciya Sekar Jeyakumar, Uma Tiruchirapalli Sivagnanam
Summary: This paper focuses on the design of a seamless technique for the extraction of collagenous proteins with complete solubilization, which can be applied in clinical and healthcare settings. The results show that the collagen scaffold has excellent biocompatibility and cell proliferation ability, indicating its promising value in the healthcare industry.
PROCESS BIOCHEMISTRY
(2022)
Article
Materials Science, Multidisciplinary
Zahra Khodabandeh, Nader Tanideh, Fatemeh Sari Aslani, Iman Jamhiri, Shahrokh Zare, Narges Alizadeh, Anahid Safari, Nima Farshidfar, Mahintaj Dara, Moein Zarei
Summary: This study optimized collagen-hydroxyapatite scaffolds loaded with curcumin and hydro-alcoholic ginger extract for bone tissue engineering. The scaffolds showed promising mechanical and biological properties, with increased cell compatibility and osteogenic ability. In vivo implantation in animal models also indicated reduced inflammatory reactions.
MATERIALS TODAY COMMUNICATIONS
(2022)
Article
Materials Science, Multidisciplinary
P. N. Blessy Rebecca, D. Durgalakshmi, S. Balakumar, R. Ajay Rakkesh
Summary: In this study, type I collagen is extracted from fish scales and crosslinked with negatively charged graphene using an electrostatic self-assembly technique. The incorporation of graphene significantly enhances the mechanical strength, conductivity, and 3D porous structure of the scaffolds. The hybrid graphene-collagen nanocomposite scaffold shows excellent biocompatible properties and stability in a biological medium.
JOURNAL OF MATERIALS RESEARCH
(2023)
Article
Materials Science, Multidisciplinary
P. N. Blessy Rebecca, D. Durgalakshmi, S. Balakumar, R. Ajay Rakkesh
Summary: In this study, type I collagen was extracted from fish scales and crosslinked with negatively charged graphene using an electrostatic self-assembly technique. Incorporating different weight percentages of graphene significantly enhanced the mechanical properties, conductivity, and 3D structure of the scaffolds. Cell viability and osteogenic differentiation potential were also confirmed, indicating the potential of the hybrid graphene-collagen nanocomposite scaffold in biomedical applications.
JOURNAL OF MATERIALS RESEARCH
(2023)
Review
Pharmacology & Pharmacy
Samantha Lo, Mh Busra Fauzi
Summary: Collagen, as a widely studied natural component, plays a major role in tissue repair and regeneration in tissue engineering. Nano collagen, a relatively new material involved in nanotechnology, has potential advantages over traditional collagen design due to its nano-size, making it suitable for various medical applications and cosmetic purposes.
Article
Chemistry, Physical
Punuri Jayasekhar Babu, Mukesh Doble, Ashok M. Raichur
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2018)
Article
Chemistry, Analytical
Punuri Jayasekhar Babu, Ashok M. Raichur, Mukesh Doble
SENSORS AND ACTUATORS B-CHEMICAL
(2018)
Article
Biochemistry & Molecular Biology
Rajendran Selvakumar, Dhanabalan Anantha Krishnan, Chandrasekaran Ramakrishnan, Devadasan Velmurugan, Krishnasamy Gunasekaran
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2020)
Article
Materials Science, Multidisciplinary
A. Sandeep Kranthi Kiran, Merum Sireesha, Raghavendra Ramalingam, Atish Kizhakeyil, Navin Kumar Verma, Rajamani Lakshminarayanan, T. S. Sampath Kumar, Mukesh Doble, Seeram Ramakrishna
JOURNAL OF MATERIALS SCIENCE
(2019)
Article
Biochemistry & Molecular Biology
Kartik Mitra, Prasanth Ghanta, Sushank Acharya, Gayathri Chakrapani, Basavaraju Ramaiah, Mukesh Doble
Summary: The study presents a pharmacophore and molecular dynamics-based approach for drug repositioning and lead identification against SARS-CoV-2 dual targets. Six FDA-approved drugs and twelve natural products were identified through pharmacophore-based virtual screening. Molecular dynamics analysis revealed the importance of flexibility of the 3CLp connecting loop and the correlation between van der Waals size and binding affinity with 3CLp, as well as the negative correlation between total polar surface area and binding affinity with PLp.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2021)
Article
Biochemistry & Molecular Biology
Prasanth Ghanta, Shweta Sinha, Mukesh Doble, Basavaraju Ramaiah
Summary: Inflammation plays a crucial role in respiratory diseases. The alkaloids vasicine, vasicinone, and deoxyvasicine from Adhatoda vasica have bronchodilatory activity. The study found that vasicinone has potential as a competitive inhibitor, while vasicine and deoxyvasicine may act as allosteric inhibitors. These alkaloids could be potential leads for designing novel 5-LOX inhibitors.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Biochemistry & Molecular Biology
Prasanth Ghanta, Mukesh Doble, Basavaraju Ramaiah
Summary: The study evaluated the potential of major alkaloids of A. vasica as inhibitors of COXs, with promising results showing that these alkaloids could be leads for the design of Eicosanoid pathway modulators.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Biochemistry & Molecular Biology
Gandarvakottai Senthilkumar Arumugam, Asmita Sen, Swati S. Dash, Kartik Mitra, Mukesh Doble, Gopalan Rajaraman, Sathyanarayana N. Gummadi
Summary: The ethanolic bark extract of Terminalia arjuna tree contains bio-active compound arjunetin, which exhibits inhibition of catalase activity and potential antiviral activity, particularly against SARS-CoV-2. Molecular docking and dynamics studies show that arjunetin has higher binding affinity than Remdesivir in targeting key proteins of the virus. These findings suggest that arjunetin could be a promising drug candidate against Covid-19.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Water Resources
Divakar Raj Dinakaran, Hemaiswarya Shanmugam, Indumathi M. Nambi, Mukesh Doble
Summary: This study used uidA and lacZ genes as distinctive biomarkers for rapid and efficient detection of contaminated water resources. A total of 39 water samples from the metropolitan city of Chennai, India were collected and analyzed. The results showed that the performance and amplification efficiency of uidA and lacZ were 99.6% and 103.4% respectively. The qPCR method had a sensitivity of 71.4% in selectively identifying E. coli.
WATER PRACTICE AND TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Arthi Venkatesan, Anantha Krishnan Dhanabalan, Selvakumar Rajendran, Shyamala Gowri Shanmugasundharam, Krishnasamy Gunasekaran, J. Febin Prabhu Dass
Summary: Hepatitis C is an infectious disease that leads to liver illnesses. There are no effective vaccines against this virus. Through structure-based docking study, potential compounds that bind well to the HCV protease and polymerase proteins were identified, potentially serving as effective drugs for treating HCV.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2022)
Article
Materials Science, Ceramics
Vimal Kumar Dewangan, T. S. Sampath Kumar, Mukesh Doble, Viju Daniel Varghese
Summary: A novel injectable macroporous apatite bone cement derived from eggshell was developed using gelatin and chitosan as a biopolymeric solution, along with disodium hydrogen phosphate and acetic acid. The cement exhibited good injectability, stability, and degradation properties, and showed potential for repairing low or non-load bearing defects in orthopaedic applications.
CERAMICS INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Anantha Krishnan Dhanabalan, Sriram Srinivasa Raghavan, Selvakumar Rajendran, Velavan Ramasamy, Shaik Abdul Azeez Abdul, Nandhagopal Narayanasamy, Gunasekaran Krishnasamy
Summary: This study aimed to identify potential anti-viral agents against SARS-CoV-2 through computational approaches and validate their binding properties through molecular dynamics simulation. The study used a database of steroid-like compounds and performed molecular docking and simulation analysis to identify compounds that could be used as therapeutics or as precursors for designing new anti-viral agents against COVID-19. The compounds showed favorable drug-like properties and could potentially be effective in combating the virus.
MOLECULAR DIVERSITY
(2023)
Review
Chemistry, Multidisciplinary
Kannan Damodharan, Gandarvakottai Senthilkumar Arumugam, Suresh Ganesan, Mukesh Doble, Sathiah Thennarasu
Summary: Researchers are working tirelessly to develop new vaccines for COVID-19, with over 250 candidates currently in progress, including various types like RNA, DNA, and inactivated virus vaccines. The vaccines work by stimulating immune effectors to target and neutralize pathogens, showcasing a global effort to combat the pandemic.
Article
Chemistry, Multidisciplinary
Swayamsiddha Kar, Gayathri Ramamoorthy, Shweta Sinha, Meera Ramanan, Jeevan Kumar Pola, Nageswara Rao Golakoti, Jagadeesh Babu Nanubolu, Suraj Kumar Sahoo, Rajesh Babu Dandamudi, Mukesh Doble
NEW JOURNAL OF CHEMISTRY
(2019)
Article
Chemistry, Multidisciplinary
Ayarivan Puratchikody, Appavoo Umamaheswari, Navabshan Irfan, Shweta Sinha, S. L. Manju, Meera Ramanan, Gayathri Ramamoorthy, Mukesh Doble
NEW JOURNAL OF CHEMISTRY
(2019)
Article
Materials Science, Biomaterials
Mohammadreza Kasravi, Alireza Yaghoobi, Tahereh Tayebi, Mahsa Hojabri, Abdolkarim Talebi Taheri, Fatemeh Shirzad, Bahram Jambar Nooshin, Radman Mazloomnejad, Armin Ahmadi, Fatemeh A. Tehrani, Ghasem Yazdanpanah, Mohammad Hadi Farjoo, Hassan Niknejad
Summary: As a promising approach in translational medicine, the decellularization of discarded livers to produce bioscaffolds that support recellularization has potential in overcoming the limitations of conventional liver transplantation. In this study, the researchers investigated the use of matrix metalloproteinase (MMP) inhibition to preserve the extracellular matrix (ECM) during liver decellularization. The results demonstrated that the application of an MMP inhibitor significantly improved the preservation of ECM components and mechanical properties of the bioscaffolds, which supported cell viability and function in vitro. The study also confirmed that the MMP inhibition led to the inhibition of MMP2 and MMP9, providing a novel method to enhance ECM preservation during liver decellularization.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Mohammadsadegh Nadimifar, Weiguang Jin, Clara Coll-Satue, Gizem Bor, Paul Joseph Kempen, Ali Akbar Moosavi-Movahedi, Leticia Hosta-Rigau
Summary: This study presents a metal-phenolic self-assembly approach that can prepare nanoparticles fully made of hemoglobin. The nanoparticles exhibit good oxygen binding and releasing capabilities.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jyoti Kumari, Roel Hammink, Jochem Baaij, Frank A. D. T. G. Wagener, Paul H. J. Kouwer
Summary: Fibrosis is the formation of fibrous connective tissue in response to injury, leading to organ dysfunction. A novel hybrid hydrogel combining synthetic polyisocyanide with hyaluronic acid has been developed, showing strong antifibrotic properties.
BIOMATERIALS ADVANCES
(2024)
Letter
Materials Science, Biomaterials
Melissa Machado Rodrigues, Cristian Padilha Fontoura, Charlene Silvestrin Celi Garcia, Sandro Tomaz Martins, Joao Antonio Pegas Henriques, Carlos Alejandro Figueroa, Mariana Roesch Ely, Cesar Aguzzoli
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jessica Polak, David Sachs, Nino Scherrer, Adrian Suess, Huan Liu, Mitchell Levesque, Sabine Werner, Edoardo Mazza, Gaetana Restivo, Mirko Meboldt, Costanza Giampietro
Summary: Human skin equivalents (HSEs) play a crucial role in tissue engineering. This study introduces a 3D-printed culture insert to apply a static radial constraint on HSEs and examines its effects on tissue characteristics. The results show that the diameter of the culture insert significantly influences tissue contraction, fibroblast and matrix organization, keratinocyte differentiation, epidermal stratification, and basement membrane formation. This study provides important insights for the design of skin tissue engineering.
BIOMATERIALS ADVANCES
(2024)
Review
Materials Science, Biomaterials
Shiliang Chen, Tianming Du, Hanbing Zhang, Jing Qi, Yanping Zhang, Yongliang Mu, Aike Qiao
Summary: This paper reviewed the primary methods for improving the overall properties of biodegradable zinc stents. It discussed the mechanical properties, degradation behavior, and biocompatibility of various improvement strategies. Alloying was found to be the most common, simple, and effective method for improving mechanical properties. Deformation processing and surface modification further improved the mechanical properties and biological activity of zinc alloys. Meanwhile, structural design could endow stents with special properties. Manufacturing zinc alloys with excellent properties and exploring their interaction mechanism with the human body are areas for future research.
BIOMATERIALS ADVANCES
(2024)