Review
Engineering, Multidisciplinary
Muhammad Aqib, Aneela Anwar, Humayun Ajaz, Samina Akbar, Ahsan Manzoor, Maham Abid, Zohaib Waheed, Qudsia Kanwal
Summary: In recent years, calcium phosphate cement has been widely used in biomedical applications due to its excellent biocompatibility, bioactivity, self-setting qualities, minimal setting degree, suitable toughness, and versatility in shape. Brushite, a type of calcium phosphate, is particularly attractive for bone repair and can also potentially serve as a drug delivery device. The addition of metal ions, such as magnesium, zinc, and strontium, into the calcium phosphate structure has become a major research focus. This paper provides a comprehensive analysis of the advancements and prospects of metal-doped brushite cement, including its impact on physical and chemical properties, as well as its potential applications in regenerative medicine.
JOURNAL OF BIONIC ENGINEERING
(2023)
Article
Engineering, Multidisciplinary
Wenjuan Liu, Zhiguang Huan, Chengtie Wu, Zhihua Zhou, Jiang Chang
Summary: This study developed a composite bone cement with high compressive strength and desirable bioactivity by incorporating calcium silicate bioceramic into magnesium phosphate bone cement. The composite bone cement showed significantly higher compressive strength compared to traditional bone cements and demonstrated apatite mineralization ability and moderate degradation behavior.
COMPOSITES PART B-ENGINEERING
(2022)
Article
Materials Science, Ceramics
Manqi Yan, Yanan Zhao, Yue Dai, Xiaokang Yao, Honglian Dai
Summary: In this study, modified calcium magnesium phosphate bone cement (MCPC) composites were constructed by introducing gelatin solutions. The modified MCPC composites exhibited improved microenvironment, enhanced osteogenic differentiation and biomineralization. When incorporated with 1% and 5% of gelatin, the MCPC composites showed higher mechanical properties and osteogenic ability of BMSCs.
CERAMICS INTERNATIONAL
(2022)
Article
Engineering, Biomedical
Julia Gao, Yingchao Su, Yi-Xian Qin
Summary: This study compared the in vitro and in vivo degradation and biocompatibility behaviors of magnesium alloys with calcium phosphate coatings, showing that the CaP coating significantly improved biodegradation behavior and biocompatibility of the Mg alloy. In vitro tests were found to be a quick screening tool for biodegradation rate, with the in vivo degradation rate being slower than in vitro immersion degradation rate.
BIOACTIVE MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Guan-Yin Zhu, Ya-Hui Liu, Wei Liu, Xin-Qi Huang, Bo Zhang, Zi-Li Zheng, Xin Wei, Jia-Zhuang Xu, Zhi-He Zhao
Summary: The study utilized surface-directed epitaxial crystallization to construct a specific nano-topographical structure on a poly(epsilon-caprolactone) substrate, enhancing the formation of the CaP layer. Experimental results demonstrated a significant enhancement in osteogenic differentiation and proliferation of bone marrow mesenchymal stromal cells on the biomineralized nano-topological surface, showing potential for designing bone repair scaffolds.
Article
Engineering, Biomedical
Jiawen Wang, Ziqing Cheng, Duanjing Chen, Guangyue Li, Jie Chen, Kai Wang, Ling Xu, Jiao Huang
Summary: Magnesium phosphate cement (MPC) has been modified to be porous by using calcium carbonate and citric acid as foaming agents. The resulting MPC with 3% CaCO3/CA showed improved physicochemical properties and enhanced biocompatibility. In animal experiments, 3%CaCO3/CA-MPC exhibited better bone regeneration compared to the blank group, and slightly lower regeneration compared to the Bio-Oss(R) group. This study suggests that porous MPC foamed with calcium carbonate and CA is a promising material for bone regeneration.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2023)
Article
Engineering, Biomedical
Yanan Zhao, Honglei Kang, Xiaopei Wu, Pengzhen Zhuang, Rong Tu, Takashi Goto, Feng Li, Honglian Dai
Summary: A drug carrier system composed of gelatin-coated hollow mesoporous silica nanoparticles loaded with pro-osteogenic parathyroid (PTH) and anti-osteoclastogenic alendronate (ALN) is constructed and compounded into calcium magnesium phosphate cement (MCPC). It enhances osteoporotic bone regeneration in ovariectomized rats by promoting osteogenic differentiation, inhibiting osteoclastogenesis, and accelerating vascularization. The MCPC/HMSNs@ALN-PTH/GM demonstrates a synergistic effect on osteogenesis, osteoclastogenesis, and angiogenesis, holding potential for other biomaterials design and clinical management.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Materials Science, Ceramics
Ziyu Wang, Qinghui Li, Shangxuan Ren, Hengshuo Zhang, Jie Chen, Aimin Li, Yunzhen Chen
Summary: In this study, Monetite (MC) was combined with amorphous calcium phosphate (ACP) at different ratios to form new types of bone cements. The results showed that MC75 (75% MC and 25% ACP) had better biocompatibility and osteogenic induction ability, and it met the clinical application requirements, making it a promising bone cement for repairing bone defects.
CERAMICS INTERNATIONAL
(2023)
Review
Engineering, Biomedical
Oznur Demir-Oguz, Aldo R. Boccaccini, Dagnija Loca
Summary: Calcium phosphate bone cements (CPCs) have valuable properties such as bioactivity, osteoconductivity, injectability, and moldability, but their low mechanical performance limits their clinical application. Adding bioactive glasses (BGs) as a secondary powder phase can improve the injectable properties of CPCs and enhance the degradation rate, in vitro osteogenic differentiation, cell response, and tissue-material interaction.
BIOACTIVE MATERIALS
(2023)
Article
Biotechnology & Applied Microbiology
Jun Wu, Feihong Liu, Zejin Wang, Yuan Liu, Xiaoli Zhao, Christian Fang, Frankie Leung, Kelvin W. K. Yeung, Tak Man Wong
Summary: Bone grafts are commonly used for the treatment of critical sized bone defects, but the poor osteogenic property of allogeneic bone grafts and limitations of calcium phosphate cement hinder their clinical applications. In this study, a novel magnesium contained calcium phosphate bone cement (Mg-CPC) was developed, which showed sustained release of magnesium and exhibited long-term mechanical stability and osteogenic effects. Mg-CPC could enhance osteogenic differentiation and suppress inflammatory response in vitro. In vivo studies demonstrated that Mg-CPC promoted new bone formation and maturation. These results suggest that Mg-CPC could be a good substitute material for bone grafts in clinical use.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Vetharaj HephzibahRajam Arkin, Uttamchand Narendrakumar, Harishkumar Madhyastha, Inderchand Manjubala
Summary: Injectable calcium phosphate cement is a promising biomaterial for hard tissue repair, with recent developments in magnesium and strontium-doped cements showing improved setting time, mechanical strength, and cell attachment. The research aims to develop suitable self-setting cements with good biocompatibility, utilizing synthesized hydroxyapatite and additives for enhanced properties.
Review
Materials Science, Multidisciplinary
Yuanliang Xia, Hengyi Wang, Yuehong Li, Changfeng Fu
Summary: Bone defects caused by trauma, tumor, or osteomyelitis are common and can cause severe pain and limited weight-bearing ability. While bone transplantation is the gold standard, it is not suitable for all patients. Bone cement can fill any shape of bone defect and provide mechanical strength, but lacks the ability to induce bone regeneration. Various methods, such as adding bone morphogenetic proteins and mesenchymal stem cells, have been developed to enhance the bone regeneration ability of bone cement. This review aims to overview bone regeneration process, introduce improved bone cement formulations, and discuss the clinical application and future improvement of bone cement.
FRONTIERS IN MATERIALS
(2022)
Article
Engineering, Biomedical
Peihao Cai, Shunyi Lu, Jieqin Yu, Lan Xiao, Jiayi Wang, Haifeng Liang, Lei Huang, Guanjie Han, Mengxuan Bian, Shihao Zhang, Jian Zhang, Changsheng Liu, Libo Jiang, Yulin Li
Summary: Injectable calcium phosphate bone cement with a porous structure and improved robustness has been developed by incorporating PLGA nanofiber and CMC. The reinforced biodegradable cement showed promising results in promoting new bone formation and osteo-integration in vivo.
BIOACTIVE MATERIALS
(2023)
Article
Metallurgy & Metallurgical Engineering
Jiawen Si, Hongzhou Shen, Hongwei Miao, Yuan Tian, Hua Huang, Jun Shi, Guangyin Yuan, Guofang Shen
Summary: In this study, a biodegradable membrane with guided bone regeneration (GBR) was successfully developed using a Mg-2.0Zn-1.0Gd alloy (wt.%, MZG) membrane with Ca-P coating. The membrane demonstrated enhanced hydrophilicity, good cytocompatibility, excellent antibacterial effect, and improved new bone formation, indicating great potential for clinical application as GBR membranes.
JOURNAL OF MAGNESIUM AND ALLOYS
(2021)
Article
Biophysics
Fupo He, Jin Rao, Jielin Zhou, Wenhao Fu, Yao Wang, Yihang Zhang, Fei Zuo, Haishan Shi
Summary: Magnesium calcium phosphate composite bioceramic scaffolds were fabricated using 3D printing technology with Mg3(PO4)2 and β-Ca3(PO4)2 as starting materials. The porosity and compressive strength of the scaffolds could be adjusted by altering the sintering temperature and the formula of starting materials. The Ca3Mg3(PO4)4-based bioceramic scaffolds, prepared from 60 wt% Mg3(PO4)2 and 40 wt% β-Ca3(PO4)2, showed the highest compressive strength and stimulated cellular growth and osteoblastic differentiation.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Review
Dentistry, Oral Surgery & Medicine
Oscar Iglesias-Velazquez, Rosa Maria Lopez-Pintor, Jose Gonzalez-Serrano, Elisabeth Casanas, Jesus Torres, Gonzalo Hernandez
Summary: This study evaluated the increase in salivary lactate dehydrogenase (LDH) levels in patients with oral cancer (OC) or oral potentially malignant disorders (OPMD) compared to a healthy control group (CG). Results showed that LDH levels were higher in the OC group and patients with oral leucoplakia and oral submucous fibrosis also had higher levels. Salivary LDH determination may be a useful method for screening and tracking OC and OPMD, but further studies are needed to establish precise cutoff values.
Letter
Dentistry, Oral Surgery & Medicine
F. Perez-Gonzalez, L. Sanchez-Labrador, P. Molinero-Mourelle, L. M. Saez-Alcaide, J. Cortes-Breton-Brinkmann, J. Torres Garcia-Denche, J. Lopez-Quiles, J. M. Martinez-Gonzalez
BRITISH JOURNAL OF ORAL & MAXILLOFACIAL SURGERY
(2022)
Article
Nutrition & Dietetics
Eduardo Anitua, Roberto Tierno, Mohammad Hamdan Alkhraisat
Summary: This study systematically evaluated the prophylactic and therapeutic effects of vitamin D supplementation on respiratory infections, and found a significant reduction in the incidence of respiratory infections with vitamin D supplementation, especially when administered daily.
CLINICAL NUTRITION
(2022)
Review
Biochemistry & Molecular Biology
Eduardo Anitua, Mar Zalduendo, Maria Troya, Mohammad H. Alkhraisat, Leticia Alejandra Blanco-Antona
Summary: This systematic review examines the feasibility of using PRP as a substitute for xenogeneic sera in cell therapy. The study found that PRP has a positive impact on various indicators of MSC, but there is still a need to improve the description of PRP composition and preparation methods.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Gustavo G. Diez, Eduardo Anitua, Nazareth Castellanos, Carmelo Vazquez, Purificacion Galindo-Villardon, Mohammad H. Alkhraisat
Summary: The study found that mindfulness-based program has significant effects on the psychological, biomechanical, and inflammatory domains of patients with chronic lower back pain. It can improve patients' psychological well-being, reduce pain, and enhance their quality of life and physical function.
Editorial Material
Cell & Tissue Engineering
Eduardo Anitua, Sabino Padilla, Roberto Prado, Mohammad H. Alkhraisat
REGENERATIVE MEDICINE
(2022)
Review
Biotechnology & Applied Microbiology
Eduardo Anitua, Mikel Allende, Asier Eguia, Mohammad Hamdan Alkhraisat
Summary: This systematic review assessed the effect of adjuvant use of platelet-rich plasma (PRP) on new bone formation during maxillary sinus floor augmentation. After analyzing six clinical trials, it was found that mixing anorganic bovine bone with plasma rich in growth factors (PRGF) significantly increased new bone formation.
BIOENGINEERING-BASEL
(2022)
Article
Biochemistry & Molecular Biology
Eduardo Anitua, Francisco Muruzabal, Maria de la Fuente, Susana Del Olmo-Aguado, Mohammad H. H. Alkhraisat, Jesus Merayo-Lloves
Summary: This study evaluates the effectiveness of a novel plasma rich in growth factors (PRGF) membrane in reducing oxidative stress in retinal pigment epithelial cells (ARPE-19 cells) exposed to blue light. Different formulations derived from PRGF were tested on ARPE-19 cells, and it was found that they increased mitochondrial viability, cell survival, and decreased reactive oxygen species (ROS) production and heme oxygenase -1 (HO-1) expression. The PRGF membrane also increased ZO-1 expression in ARPE-19 cells exposed to blue light.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Eduardo Anitua, Maria Troya, Juan Manuel Falcon-Perez, Silvia Lopez-Sarrio, Esperanza Gonzalez, Mohammad H. Alkhraisat
Summary: The use of platelet-rich plasma (PRP) has attracted increasing interest due to its rich content of growth factors, cytokines, chemokines, and other biomolecules. Recent research has focused on platelets' released extracellular vesicles (EVs) and their role in intercellular communication. This review aims to compile the current evidence on PRP-derived EVs and evaluate their advantages and limitations for clinical applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Eduardo Anitua, Roberto Prado, Jorge Guadilla, Mohammad H. Alkhraisat, Patricia Laiz, Sabino Padilla, Montserrat Garcia-Balletbo, Ramon Cugat
Summary: The treatment of chondral and osteochondral defects is challenging and tissue engineering offers a potential solution. In this study, the use of an autologous cartilage construct embedded in plasma rich in growth factors (PRGF) was investigated. The research found that the cartilage fragments contained viable chondrocytes that could proliferate and synthesise extracellular matrix, suggesting a potential mechanism behind the clinical success of this technique.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Dentistry, Oral Surgery & Medicine
Marc Du Duval, Mohammad Hamdan Alkhraisat
Summary: Osteomyelitis of the jaws and large odontogenic cysts often require multiple surgical interventions and can lead to deformity. This case report shows that combining conventional surgical debridement and oral antibiotics with plasma rich in growth factors (PRGF) can result in successful regeneration and implant rehabilitation. Future trials are needed to confirm these results compared to conventional treatment alone.
Article
Dentistry, Oral Surgery & Medicine
Eduardo Anitua, Pedro Mayoral, Gabriela Zamora Almeida, Joaquin Duran-Cantolla, Mohammad Hamdan Alkhraisat
Summary: The objective of this prospective study was to evaluate the effectiveness of 1 mm step titration of mandible advancement in treating obstructive sleep apnea. The study found that gradual titration of mandibular advancement resulted in a reduction in the apnea-hypopnea index (AHI) for 93% of the patients, with a success rate of 69% achieving a reduction of 50% or more in the AHI.
Article
Dentistry, Oral Surgery & Medicine
Jose Gonzalez-Serrano, Julia Serrano, Mariano Sanz, Jesus Torres, Gonzalo Hernandez, Rosa Maria Lopez-Pintor
Summary: This study evaluated the efficacy of a gel containing propolis extract, nanovitamin C, and nanovitamin E as adjuvants for the treatment of desquamative gingivitis. The results showed that the gel can alleviate DG and improve quality of life without significant side effects.
CLINICAL ORAL INVESTIGATIONS
(2023)
Review
Biotechnology & Applied Microbiology
Eduardo Anitua, Mikel Allende, Mohammad Hamdan Alkhraisat
Summary: This systematic review evaluates the efficacy of platelet-rich plasma (PRP) products and composition in regenerating alveolar bone after tooth extraction. The meta-analysis shows significant effects of pure-platelet rich plasma (P-PRP) on new bone formation and bone density, while the effects of leukocyte-rich plasma (L-PRP) are unclear. Despite limitations in the included studies, the data suggests that P-PRP can improve alveolar bone regenerative potential compared to unassisted healing.
BIOENGINEERING-BASEL
(2022)
Article
Dentistry, Oral Surgery & Medicine
Fabian Perez-Gonzalez, Mohammad Abusamak, Luis Miguel Saez-Alcaide, Jesus Torres Garcia-Denche, Faleh Ahmad Tamimi Marino
Summary: The purpose of this study was to evaluate the time-dependent administration of ibuprofen in a lower third molar extraction model. The results showed that there were no significant differences in postoperative swelling and pain perception between the control group, which took ibuprofen every 8 hours, and the experimental group, which took ibuprofen only at breakfast and lunch and replaced dinner intake with a placebo. However, trismus was significantly higher in the experimental group at 72 hours postoperatively.
ORAL AND MAXILLOFACIAL SURGERY-HEIDELBERG
(2022)
Article
Materials Science, Biomaterials
Mohammadreza Kasravi, Alireza Yaghoobi, Tahereh Tayebi, Mahsa Hojabri, Abdolkarim Talebi Taheri, Fatemeh Shirzad, Bahram Jambar Nooshin, Radman Mazloomnejad, Armin Ahmadi, Fatemeh A. Tehrani, Ghasem Yazdanpanah, Mohammad Hadi Farjoo, Hassan Niknejad
Summary: As a promising approach in translational medicine, the decellularization of discarded livers to produce bioscaffolds that support recellularization has potential in overcoming the limitations of conventional liver transplantation. In this study, the researchers investigated the use of matrix metalloproteinase (MMP) inhibition to preserve the extracellular matrix (ECM) during liver decellularization. The results demonstrated that the application of an MMP inhibitor significantly improved the preservation of ECM components and mechanical properties of the bioscaffolds, which supported cell viability and function in vitro. The study also confirmed that the MMP inhibition led to the inhibition of MMP2 and MMP9, providing a novel method to enhance ECM preservation during liver decellularization.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Mohammadsadegh Nadimifar, Weiguang Jin, Clara Coll-Satue, Gizem Bor, Paul Joseph Kempen, Ali Akbar Moosavi-Movahedi, Leticia Hosta-Rigau
Summary: This study presents a metal-phenolic self-assembly approach that can prepare nanoparticles fully made of hemoglobin. The nanoparticles exhibit good oxygen binding and releasing capabilities.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jyoti Kumari, Roel Hammink, Jochem Baaij, Frank A. D. T. G. Wagener, Paul H. J. Kouwer
Summary: Fibrosis is the formation of fibrous connective tissue in response to injury, leading to organ dysfunction. A novel hybrid hydrogel combining synthetic polyisocyanide with hyaluronic acid has been developed, showing strong antifibrotic properties.
BIOMATERIALS ADVANCES
(2024)
Letter
Materials Science, Biomaterials
Melissa Machado Rodrigues, Cristian Padilha Fontoura, Charlene Silvestrin Celi Garcia, Sandro Tomaz Martins, Joao Antonio Pegas Henriques, Carlos Alejandro Figueroa, Mariana Roesch Ely, Cesar Aguzzoli
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jessica Polak, David Sachs, Nino Scherrer, Adrian Suess, Huan Liu, Mitchell Levesque, Sabine Werner, Edoardo Mazza, Gaetana Restivo, Mirko Meboldt, Costanza Giampietro
Summary: Human skin equivalents (HSEs) play a crucial role in tissue engineering. This study introduces a 3D-printed culture insert to apply a static radial constraint on HSEs and examines its effects on tissue characteristics. The results show that the diameter of the culture insert significantly influences tissue contraction, fibroblast and matrix organization, keratinocyte differentiation, epidermal stratification, and basement membrane formation. This study provides important insights for the design of skin tissue engineering.
BIOMATERIALS ADVANCES
(2024)
Review
Materials Science, Biomaterials
Shiliang Chen, Tianming Du, Hanbing Zhang, Jing Qi, Yanping Zhang, Yongliang Mu, Aike Qiao
Summary: This paper reviewed the primary methods for improving the overall properties of biodegradable zinc stents. It discussed the mechanical properties, degradation behavior, and biocompatibility of various improvement strategies. Alloying was found to be the most common, simple, and effective method for improving mechanical properties. Deformation processing and surface modification further improved the mechanical properties and biological activity of zinc alloys. Meanwhile, structural design could endow stents with special properties. Manufacturing zinc alloys with excellent properties and exploring their interaction mechanism with the human body are areas for future research.
BIOMATERIALS ADVANCES
(2024)
