Article
Materials Science, Ceramics
Zepeng Cai, Yi Xiong, Yi Zhang, Tao Yu, Changren Zhou
Summary: This study investigates the importance of Zn as an essential trace element in biomedical applications and the research progress of incorporating Zn into biomaterials, exploring the effects of Zn2+ on the hydration crystallization behavior of calcium phosphate and calcium sulfate cements. Furthermore, in vitro experiments show the regulatory effect of Zn on cell inflammation.
CERAMICS INTERNATIONAL
(2022)
Article
Materials Science, Ceramics
Manqi Yan, Yanan Zhao, Yue Dai, Xiaokang Yao, Honglian Dai
Summary: In this study, modified calcium magnesium phosphate bone cement (MCPC) composites were constructed by introducing gelatin solutions. The modified MCPC composites exhibited improved microenvironment, enhanced osteogenic differentiation and biomineralization. When incorporated with 1% and 5% of gelatin, the MCPC composites showed higher mechanical properties and osteogenic ability of BMSCs.
CERAMICS INTERNATIONAL
(2022)
Article
Materials Science, Ceramics
Zepeng Cai, Zhiwen Wu, Yi Wan, Tao Yu, Changren Zhou
Summary: The study prepared micronano calcium phosphate (MNC) with different Ca/P ratio and added it to CPC and CSC, showing significant improvements in mechanical properties and setting time of the cement. MNC promoted hydration reaction, affected crystal growth, and reduced porosity in the cement, delaying degradation.
CERAMICS INTERNATIONAL
(2021)
Article
Engineering, Multidisciplinary
Wenjuan Liu, Zhiguang Huan, Chengtie Wu, Zhihua Zhou, Jiang Chang
Summary: This study developed a composite bone cement with high compressive strength and desirable bioactivity by incorporating calcium silicate bioceramic into magnesium phosphate bone cement. The composite bone cement showed significantly higher compressive strength compared to traditional bone cements and demonstrated apatite mineralization ability and moderate degradation behavior.
COMPOSITES PART B-ENGINEERING
(2022)
Article
Engineering, Biomedical
Xiaomei Wang, Yongfeng Zhu, Bin Mu, Aiqin Wang
Summary: To address the poor mechanical strength and bioactivity of magnesium phosphate bone cements (MPCs), clay minerals were incorporated to fabricate MPCs composite. The resulting MPCs composite showed appropriate setting time, high mechanical strength, and good thermal stability. In particular, the MPCs composite containing 3.0 wt.% of sepiolite exhibited the highest compressive strength and the best thermal stability.
BIOMEDICAL MATERIALS
(2023)
Review
Clinical Neurology
Quan Qi, Gongping Xu, Ruisi Na, Shiwen Li
Summary: Percutaneous vertebroplasty and percutaneous kyphoplasty are effective methods for treating acute osteoporotic vertebral compression fractures, providing pain relief, preventing further height loss of the vertebral body, and correcting kyphosis. Bone cement, an injected biomaterial, must have good biocompatibility and biosafety. There are three main types of bone cement: polymethyl methacrylate, calcium phosphate cement, and calcium sulfate cement, each with their own advantages and disadvantages. The performance of bone cement has greatly improved in the past decade through various methods. This review provides an overview of the progress in modified bone cement types and summarizes key clinical findings.
WORLD NEUROSURGERY
(2023)
Article
Engineering, Biomedical
Zhangling Nie, Zhiqiao Hu, Xiaodong Guo, Yu Xiao, Xian Liu, Joost D. de Bruijn, Chongyun Bao, Huipin Yuan
Summary: Innate immune responses, specifically M2 macrophages and osteoclastogenesis, play important roles in material-induced bone formation. The study found that M0 macrophages fused to osteoclasts when treated with M-CSF, RANKL, and IL-4, and this osteoclast formation was enhanced with IL-4 treatment. M2 macrophages and osteoclasts produced osteogenic factors that induced osteogenic differentiation of osteogenic precursor cells and led to bone formation.
ACTA BIOMATERIALIA
(2023)
Article
Biotechnology & Applied Microbiology
Xin Chen, Jiajun Yan, Yingying Jiang, Yunshan Fan, Zhengran Ying, Shuo Tan, Zhi Zhou, Junjian Liu, Feng Chen, Shisheng He
Summary: This study presents a biomimetic strategy for developing an injectable biomaterial composed of platelets, fibrins, and biominerals to repair bone defects. The biomaterial showed high biocompatibility and promoted the osteogenic differentiation of bone marrow stem cells. In vivo studies demonstrated that the biomaterial induced the formation of new collagen and blood vessels, leading to faster bone defect regeneration. This research provides a strategy for designing new biomimetic materials and holds significant importance for the treatment of refractory bone fractures.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Vetharaj HephzibahRajam Arkin, Uttamchand Narendrakumar, Harishkumar Madhyastha, Inderchand Manjubala
Summary: Injectable calcium phosphate cement is a promising biomaterial for hard tissue repair, with recent developments in magnesium and strontium-doped cements showing improved setting time, mechanical strength, and cell attachment. The research aims to develop suitable self-setting cements with good biocompatibility, utilizing synthesized hydroxyapatite and additives for enhanced properties.
Article
Biophysics
Fupo He, Jin Rao, Jielin Zhou, Wenhao Fu, Yao Wang, Yihang Zhang, Fei Zuo, Haishan Shi
Summary: Magnesium calcium phosphate composite bioceramic scaffolds were fabricated using 3D printing technology with Mg3(PO4)2 and β-Ca3(PO4)2 as starting materials. The porosity and compressive strength of the scaffolds could be adjusted by altering the sintering temperature and the formula of starting materials. The Ca3Mg3(PO4)4-based bioceramic scaffolds, prepared from 60 wt% Mg3(PO4)2 and 40 wt% β-Ca3(PO4)2, showed the highest compressive strength and stimulated cellular growth and osteoblastic differentiation.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Biotechnology & Applied Microbiology
Yan Chen, Tie Zhang, Qi Zhang, QingJian Lei, ShiJie Gao, KangWen Xiao, FeiFei Yan, Lin Cai
Summary: A composite bone cement, cubic crystalline magnesium-doped calcium sulfate/bioglass (MgCS/BG), was prepared and found to have increased compressive strength and good bioactivity. It promotes the adhesion and differentiation of mesenchymal stem cells, and enhances bone defect repair and new bone formation.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Construction & Building Technology
Danqian Wang, Zhicheng Liu, Changhui Yang
Summary: This study explores the passivation of mild steel embedded in magnesium potassium phosphate cement-calcium sulphoaluminate cement blended paste. The results show that adding 30% calcium sulphoaluminate in magnesium potassium phosphate cement leads to higher passivity of mild steel compared to Portland cement paste. The increased passivity is attributed to the higher pH and phosphate concentration in the pore solution, as well as the formation of iron phosphate and Fe2+ oxide in the passive film of MKPC-30%CSA.
CONSTRUCTION AND BUILDING MATERIALS
(2022)
Article
Materials Science, Multidisciplinary
Dzi Shing Aaron Lau, Herng Ee Chieng, Chenmin Wang, Zhaoyang Li, Xiaoting Zhang, Dick Ho Kiu Chow, Ling Qin, William Weijia Lu
Summary: This study investigated the effects of magnesium chloride on the degradation and bone regeneration of calcium sulfate/phosphate cement (CSPC). The results showed that magnesium chloride enhanced the degradation rate and osteogenic capacity of CSPC, leading to improved bone defect repair.
Article
Chemistry, Multidisciplinary
Vianni Chopra, Jijo Thomas, Swati Kaushik, Swati Rajput, Rajdeep Guha, Bidya Mondal, Sudip Naskar, Dipankar Mandal, Gaurav Chauhan, Naibedya Chattopadhyay, Deepa Ghosh
Summary: The development of new injectable bone cements with appropriate properties has gained interest in the field of nanoscience. Injectable bone cements made with calcium sulfate (CS) are compatible and self-setting, but have limitations in terms of resorption, bioactivity, and mechanical strength. This study presents a modified CS-based injectable bone cement (CSmod) reinforced with a conductive nanocomposite and functionalized with vancomycin. The cement exhibits favorable injectability, setting times, and improved mechanical properties, as well as antimicrobial and osteoinductive properties. The ability of CSmod to recruit endothelial cells and enhance bone regeneration is demonstrated in rat models.
Article
Engineering, Biomedical
Yubo Shi, Ling Yu, Changtian Gong, Wei Li, Yingchun Zhao, Weichun Guo
Summary: The novel CS-MPCs developed in this study have improved physiochemical properties that enhance compatibility in vitro and bone regeneration in vivo. Compared to MPC, CS-MPCs exhibit a longer setting time, higher compressive strength, and more neutral pH.
BIOMEDICAL MATERIALS
(2021)
Article
Materials Science, Ceramics
Teng Yu, Heejin Kwon, Linkun Shi, Xiaobing Zhou, Dang-Hyok Yoon, Peter Tatarko, Xin Xu, Zhengren Huang, Qing Huang
Summary: Monolithic SiC was successfully joined using a SiC whisker-reinforced Ti3SiC2 composite filler via electric field-assisted sintering technique, achieving a joint strength higher than 250 MPa. Optimization of process parameters and the addition of up to 15 wt. % SiC whiskers improved joint strength, but a lower joint strength was observed with 20 wt. % SiC whisker addition due to thermal expansion mismatch.
JOURNAL OF THE EUROPEAN CERAMIC SOCIETY
(2021)
Editorial Material
Chemistry, Multidisciplinary
Yury Gogotsi, Qing Huang
Article
Materials Science, Ceramics
Ke Chen, Xudong Wang, Jianning Zhang, Haoming Ding, Youbing Li, Yujie Song, Fangfang Ge, Xiaobing Zhou, Shiyu Du, Qing Huang
Summary: MAX phases are a family of damage-tolerant structural materials used in the nuclear energy industry. Ti2SC phase has shown good corrosion resistance to concentrated hydrofluoric acid, potentially making it suitable for use in molten salt reactors.
JOURNAL OF THE AMERICAN CERAMIC SOCIETY
(2022)
Article
Polymer Science
Lihua Zhao, Tianhao Li, Bijie Wang, Ke Chen, Xiao Hu, Ming Liu, Liu He, Qing Huang, Yujie Song
Summary: Poly(siloxane-carborane)s are polymeric materials with good thermal stability and anti-oxidation properties, which can be used to protect carbon fiber and carbon foam from damage in harsh environments.
Article
Nanoscience & Nanotechnology
Xiaozhen Ma, Ke Chen, Shuqi Li, Pitchaimari Gnanasekar, Yinyan Zhong, Yupeng An, Qing Luo, Qing Huang, Jin Zhu, Jing Chen, Ning Yan
Summary: In this study, MXene nanosheets were used to modify a lignin-based polyurethane foam, creating an adsorbent with high photothermal conversion performance for heavy oil recovery. The adsorbent showed high solar absorption rate and thermal conductivity, allowing it to adsorb a large amount of heavy crude oil in a short time. Moreover, the adsorbent containing MXene nanosheets can easily degrade in alkaline solutions, leaving harmless titanium dioxide nanoparticles as residues. These bio-based adsorbents exhibit excellent performance in rapid heavy oil removal, degradability, and environmental friendliness, offering a promising solution for cleaning up high-viscous crude oil spills.
ACS APPLIED NANO MATERIALS
(2022)
Article
Materials Science, Ceramics
Jie Xu, Xiaobing Zhou, Shunrui Zou, Lu Chen, Peter Tatarko, Jian-Qing Dai, Zhengren Huang, Qing Huang
Summary: In this study, a novel Pr3Si2C2 additive was prepared and successfully applied in the liquid-phase sintering of SiC ceramics. It was found that an appropriate amount of additive could improve the sintering rate and thermal conductivity of SiC, while excessive additive could decrease the thermal conductivity due to increased interfacial thermal resistance. SiC materials with optimized amount of additive and grain boundary structure exhibited the highest thermal conductivity.
JOURNAL OF THE AMERICAN CERAMIC SOCIETY
(2022)
Article
Chemistry, Physical
Junhui Sun, Ziwen Cheng, Qing Huang, Heming He, Joseph S. Francisco, Shiyu Du
Summary: Based on the intrinsic characteristics of layered materials, this study introduces a universal principle for the production of intact monolayers through layer-by-layer exfoliation via positive charge doping. The universality of this exfoliation method stems from the common electronic structures of layered materials. This strategy opens the possibility of producing diverse high-quality two-dimensional monolayers on a large scale with minimal defects.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2022)
Article
Materials Science, Ceramics
Yuanjie Wang, Jian Gong, Xueliang Pei, Liu He, Zhengren Huang, Qing Huang
Summary: In this study, an SiC ceramic precursor, VE-LHBPCS, was designed and synthesized. The ceramic precursor was cross-linked via thiol-ene click reaction. The results showed that the VE-LHBPCS mixture could be cured within a short period of time, forming a high yield ceramic at high temperatures.
JOURNAL OF THE AMERICAN CERAMIC SOCIETY
(2022)
Article
Materials Science, Ceramics
Tianhao Li, Wei Zhang, Liantai Duan, Ke Chen, Qing Huang, Yinsheng Li, Zhengren Huang, Liu He, Yujie Song
Summary: Trimethylsilyl-substituted polysilazanes were synthesized and utilized to fabricate high-purity stoichiometric Si3N4 ceramics through pyrolysis process. The presence of trimethylsilyl groups enhanced the stability of polysilazanes and facilitated their escape during pyrolysis, leading to reduced oxygen and carbon content in the final polymer-derived Si3N4. The resulting Si3N4 ceramics exhibited amorphous structure up to 1400 degrees C and transformed into alpha-Si3N4 at 1500 degrees C. The synergistic effect of low oxygen and carbon content contributed to the high stability of the amorphous Si3N4 ceramics at high temperatures.
JOURNAL OF THE AMERICAN CERAMIC SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Xiaojing Bai, Yuanbin Xue, Kan Luo, Ke Chen, Qing Huang, Xian-Hu Zha, Shiyu Du
Summary: As a large family of two-dimensional materials, MXenes have attracted intensive attention in recent years. In this study, the researchers expanded the M elements of MXenes to the lanthanide series and investigated the electronic properties of lanthanide-based MXenes. The results suggest that lanthanide-based MXenes could have potential applications in spintronics and information storage, among others.
Article
Chemistry, Physical
Shuairu Zhu, Youbing Li, Deyu Liu, Qing Huang, Yongbo Kuang
Summary: This study proposes a potentially generalizable strategy for constructing more compact, stable, and highly active transition metal-based composite materials by alloying transition metals with carbon elements to form high-activity sites.
ACS APPLIED ENERGY MATERIALS
(2022)
Article
Chemistry, Inorganic & Nuclear
Liantai Duan, Tianhao Li, Yangzhong Zhao, Yanpei Dang, Jianning Zhang, Ke Chen, Jian Xu, Qing Huang, Chuanzhuang Zhao, Yujie Song
Summary: The high-temperature durability of SiBCN ceramics is significantly influenced by boron concentration and synthesis methods. Carborane-substituted polyborosilazanes were synthesized with a broad range of boron content up to 40 wt %, which improved the thermal stability and functional properties of the ceramics. The introduction of boron inhibited Si3N4 crystallization and increased the crystallization temperature of SiC, while B4C appeared as a new crystalline phase.
INORGANIC CHEMISTRY
(2023)
Article
Polymer Science
Chongwen Yu, Tianhao Li, Xiao Hu, Ming Liu, Qing Huang, Liu He, Yujie Song
Summary: High-performance polymers (HPPs) have good thermal and mechanical properties and are widely used in various fields. However, traditional highly cross-linked HPPs tend to fail at high temperatures due to structural defects. This study introduced a new design strategy using a cyclosiloxane hybrid polymer (CHP) to compensate for the structural defects and improve the performance of HPPs at high temperatures.
Article
Chemistry, Physical
Lu Chen, Youbing Li, Kun Liang, Ke Chen, Mian Li, Shiyu Du, Zhifang Chai, Michael Naguib, Qing Huang
Summary: This study reports the design and synthesis of Ga-containing medium/high entropy MAX phases and their corresponding MXenes. Ga atomic layer etching is carried out using a Lewis acid molten salt (CuCl2). The as-prepared (Ti1/4V1/4Nb1/4Ta1/4)(2)CTx exhibits a Li+ specific capacity of approximately 400 mAh g(-1). For (Ti1/5V1/5Nb1/5Ta1/5Mo1/5)(2)CTx, a specific capacity of 302 mAh g(-1) is achieved after 300 cycles, and high cycling stability is observed at high current densities. This work is of great significance for expanding the family members of MXenes with tunable chemistries and structures.
Article
Chemistry, Physical
Lu Chen, Youbing Li, Ke Chen, Xiaojing Bai, Mian Li, Shiyu Du, Zhifang Chai, Qing Huang
Summary: Entropy stabilization is an effective method to design and explore MAX phases with outstanding properties. In this study, medium-/high-entropy MAX phases with different A elements were synthesized and their crystal structures were verified. The electrical conductivity and charge carrier mobility of these MAX phases are lower than previously reported MAX phases. The electron contribution to thermal conductivity decreases with temperature, while the phonon contribution increases. These findings suggest a composition design route for discovering new MAX phases and tuning their properties.
Article
Materials Science, Biomaterials
Mohammadreza Kasravi, Alireza Yaghoobi, Tahereh Tayebi, Mahsa Hojabri, Abdolkarim Talebi Taheri, Fatemeh Shirzad, Bahram Jambar Nooshin, Radman Mazloomnejad, Armin Ahmadi, Fatemeh A. Tehrani, Ghasem Yazdanpanah, Mohammad Hadi Farjoo, Hassan Niknejad
Summary: As a promising approach in translational medicine, the decellularization of discarded livers to produce bioscaffolds that support recellularization has potential in overcoming the limitations of conventional liver transplantation. In this study, the researchers investigated the use of matrix metalloproteinase (MMP) inhibition to preserve the extracellular matrix (ECM) during liver decellularization. The results demonstrated that the application of an MMP inhibitor significantly improved the preservation of ECM components and mechanical properties of the bioscaffolds, which supported cell viability and function in vitro. The study also confirmed that the MMP inhibition led to the inhibition of MMP2 and MMP9, providing a novel method to enhance ECM preservation during liver decellularization.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Mohammadsadegh Nadimifar, Weiguang Jin, Clara Coll-Satue, Gizem Bor, Paul Joseph Kempen, Ali Akbar Moosavi-Movahedi, Leticia Hosta-Rigau
Summary: This study presents a metal-phenolic self-assembly approach that can prepare nanoparticles fully made of hemoglobin. The nanoparticles exhibit good oxygen binding and releasing capabilities.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jyoti Kumari, Roel Hammink, Jochem Baaij, Frank A. D. T. G. Wagener, Paul H. J. Kouwer
Summary: Fibrosis is the formation of fibrous connective tissue in response to injury, leading to organ dysfunction. A novel hybrid hydrogel combining synthetic polyisocyanide with hyaluronic acid has been developed, showing strong antifibrotic properties.
BIOMATERIALS ADVANCES
(2024)
Letter
Materials Science, Biomaterials
Melissa Machado Rodrigues, Cristian Padilha Fontoura, Charlene Silvestrin Celi Garcia, Sandro Tomaz Martins, Joao Antonio Pegas Henriques, Carlos Alejandro Figueroa, Mariana Roesch Ely, Cesar Aguzzoli
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jessica Polak, David Sachs, Nino Scherrer, Adrian Suess, Huan Liu, Mitchell Levesque, Sabine Werner, Edoardo Mazza, Gaetana Restivo, Mirko Meboldt, Costanza Giampietro
Summary: Human skin equivalents (HSEs) play a crucial role in tissue engineering. This study introduces a 3D-printed culture insert to apply a static radial constraint on HSEs and examines its effects on tissue characteristics. The results show that the diameter of the culture insert significantly influences tissue contraction, fibroblast and matrix organization, keratinocyte differentiation, epidermal stratification, and basement membrane formation. This study provides important insights for the design of skin tissue engineering.
BIOMATERIALS ADVANCES
(2024)
Review
Materials Science, Biomaterials
Shiliang Chen, Tianming Du, Hanbing Zhang, Jing Qi, Yanping Zhang, Yongliang Mu, Aike Qiao
Summary: This paper reviewed the primary methods for improving the overall properties of biodegradable zinc stents. It discussed the mechanical properties, degradation behavior, and biocompatibility of various improvement strategies. Alloying was found to be the most common, simple, and effective method for improving mechanical properties. Deformation processing and surface modification further improved the mechanical properties and biological activity of zinc alloys. Meanwhile, structural design could endow stents with special properties. Manufacturing zinc alloys with excellent properties and exploring their interaction mechanism with the human body are areas for future research.
BIOMATERIALS ADVANCES
(2024)
