Journal
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 44, Issue -, Pages 400-410Publisher
ELSEVIER
DOI: 10.1016/j.msec.2014.08.049
Keywords
Bulk metallic glass; Zr-based alloy; Toughness; Bio-corrosion; Cellular response
Categories
Funding
- National Natural Science Foundation of China [51161130526]
- Scientific Research Project of the Education Department of Fujian Province [JA13224]
- Natural Science Foundation of Fujian Province [2014J05053]
- US National Science Foundation (NSF) [CMMI-1100080]
- Directorate For Engineering
- Div Of Civil, Mechanical, & Manufact Inn [1100080] Funding Source: National Science Foundation
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The present study designs and prepares Ni-free Zr-60+ chi Ti2.5Al10Fe12.5-chi Cu10Ag5 (at.%, x = 0, 2.5, 5) bulk metallic glasses (BMGs) by copper mold casting for potential biomedical application. The effects of Zr content on the in vitro biocompatibility of the Zr-based BMGs are evaluated by investigating mechanical properties, biocorrosion behavior, and cellular responses. It is found that increasing the content of Zr is favorable for the mechanical compatibility with a combination of low Young's modulus, large plasticity, and high notch toughness. Electrochemical measurements demonstrate that the Zr-based BMG are corrosion resistant in a phosphate buffered saline solution. The bio-corrosion resistance of BMGs is improved with the increase in Zr content, which is attributed to the enrichment in Zr and decrease in Al concentration in the surface passive film of alloys. Regular cell responses of mouse MC3T3-E1 cells, including cell. adhesion and proliferation, are observed on the Zr-Ti-Al-Fe-Cu-Ag BMGs, which reveals their general biosafety. The high-Zr-based BMGs exhibit a higher cell proliferation activity in comparison with that of pure Zr and Ti-6A1-4V alloy. The effects of Zr content on the in vitro biocompatibility can be used to guide the future design of biocompatible Zr-based BMGs. (C) 2014 Elsevier B.V. All rights reserved.
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