Journal
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 36, Issue -, Pages 42-48Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.msec.2013.11.038
Keywords
Zwitterions; Poly(dopamine); Hemocompatibility; Poly(ethylene terephthalate); Surface modification
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Funding
- Nanjing Normal University [2011103XGQ0055]
- Jiangsu Higher Education Institutions of China [11KJD430003, 10KJA430026]
- National Natural Science Foundation [21274063]
- Jiangsu Co-Innovation Center for Biomedical Functional Materials
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Poly (ethylene terephthalate) (PET) has been widely adopted as a scaffold biomaterial, but further hemocompatibility improvement is still needed for wide biomedical applications. Inspired by the composition of adhesive proteins in mussels, we propose to use self-polymerized dopamine to form a surface-adherent polydopamine layer onto PET sheet, followed by Michael addition with N,N-dimethylethylenediamine (DMDA) to build tertiary amine, and final zwitterions(sulfobetaine and carboxybetaine) construction through ring-opening reaction. Physicochemical properties of substrates were demonstrated by water contact angle measurement, attenuated total reflection Fourier transform infrared spectroscopy (ATR-FTIR) and X-ray photoelectron spectroscopy (XPS). The hemocompatibility was evaluated by platelet adhesion, hemolytic, and protein adsorption. The results showed that the zwitterions immobilized PET endowed with improved resistance to nonspecific protein adsorption and platelet adhesion as well as nonhemolytic. The zwitterions with desirable hemocompatibility can be readily tailored to catheter for various biomedical applications. (C) 2013 Elsevier B.V. All rights reserved.
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