Review
Infectious Diseases
Elham Zarenezhad, Hussein T. Abdulabbas, Mahrokh Marzi, Esraa Ghazy, Mohammad Ekrahi, Babak Pezeshki, Abdolmajid Ghasemian, Amira A. Moawad
Summary: Methicillin-resistant Staphylococcus aureus (MRSA) has developed extensive antibiotic resistance and contains virulence factors for severe infections. Nickel nanoparticles (NiNPs) have shown potential as a cheap prognostic and therapeutic agent, exerting antibacterial effects through disrupting cell membranes, deforming proteins, and inhibiting DNA replication.
Article
Microbiology
Mohamad Hamad, Farah Al-Marzooq, Vunnam Srinivasulu, Hany A. Omar, Ashna Sulaiman, Dana M. Zaher, Gorka Orive, Taleb H. Al-Tel
Summary: We report the discovery of a new class of potent antimicrobial compounds effective against Gram-positive bacteria, including MRSA. These compounds exhibit low minimum inhibitory concentrations and rapid killing ability, without inducing bacterial resistance. Furthermore, they show minimal toxicity to human red blood cells. The study suggests that these small molecules hold promise as new antibacterial agents against MRSA infections.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
William B. Wang, Jude C. Clapper
Summary: This study investigates the antibacterial properties of polyacrylonitrile-based nanofibers coated with different concentrations of copper nanoparticles. The research found that these nanofibers demonstrated antibacterial activity against resistant bacteria. These nanofibers have the potential to be used on contact surfaces that are at risk of contracting bacterial infections.
Article
Chemistry, Medicinal
Dingyi Shen, Songpo Duan, Yuhan Hu, Jintong Liang, Youzhi Tang
Summary: This study found that the phloroglucinol derivative TPG and 2-nitrophloroglucinol exhibited potent synergistic antibacterial activity with penicillin or bacitracin against MRSA. The combination disrupted the MRSA cell membrane and inhibited the expression of related proteins, effectively inhibiting MRSA growth.
PHYTOTHERAPY RESEARCH
(2023)
Article
Chemistry, Analytical
Wenjing Gao, Bin Li, Ling Ling, Li Zhang, Shaoning Yu
Summary: This study demonstrates that MALDI-TOF MS can differentiate MRSA and MSSA efficiently by utilizing CHCA-C3 as the matrix, showing good reproducibility and interference resistance. This provides strong support for clinical diagnosis and treatment.
Article
Biochemistry & Molecular Biology
Zhen Zhang, Zhujun Luo, Ying Sun, Duanyu Deng, Kaize Su, Jinxuan Li, Zhenping Yan, Xu Wang, Jifan Cao, Wende Zheng, Song Ang, Yanxian Feng, Kun Zhang, Hang Ma, Panpan Wu
Summary: This study designed and synthesized a series of novel CBD derivatives, among which derivative 21f showed enhanced antibacterial activity against MRSA without cytotoxic effect. Mechanistic studies further revealed that 21f inhibited biofilm formation, induced reactive oxygen species, and reduced bacterial metabolism, leading to accelerated bacterial death.
BIOORGANIC CHEMISTRY
(2023)
Article
Engineering, Environmental
Nuttaporn Chokesawatanakit, Pasakorn Jutakridsada, Sophon Boonlue, Jesper T. N. Knijnenburg, Phillip C. Wright, Mika Sillanpaa, Khanita Kamwilaisak
Summary: Hydrothermal reaction and photodeposition were used to transform TiO2 nanoparticles to TiO2 nanotubes loaded with Ag, showing increased surface area and antibacterial activity. Ag/TNTs exhibited antibacterial activity under UV light and could also reduce bacteria growth in the dark.
JOURNAL OF ENVIRONMENTAL CHEMICAL ENGINEERING
(2021)
Article
Immunology
Yifei Lu, Yingran Wang, Jing Wang, Yan Zhao, Qiu Zhong, Gang Li, Zhifeng Fu, Shuguang Lu
Summary: Endolysin LysP108 demonstrates promising antibacterial potential as it can lyse bacterial cell walls, inhibit bacterial biofilms, and work synergistically with vancomycin to reduce abscess size in MRSA-infected mice. The results indicate strong bactericidal effects against MRSA and the ability to significantly reduce subcutaneous abscess size when used in combination with vancomycin.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2021)
Article
Chemistry, Medicinal
Onanong Vorasin, Khanchyd Momphanao, Praewpan Katrun, Chutima Kuhakarn, Chutima Jiarpinitnun
Summary: The study identified a range of potential antibacterial vinyl sulfone derivatives, with nitrile-substituted vinyl phenyl sulfones showing the strongest activity and potentially functioning through sulfhydryl conjugation. Additionally, these compounds could also affect host cell adhesion, suggesting promising therapeutic potential for S. aureus and MRSA.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2022)
Article
Biochemistry & Molecular Biology
In-Geun Jung, Jae-Young Jeong, Seung-Hoon Yum, You-Jin Hwang
Summary: This study screened 16 medicinal plants and found that some extracts and fractions showed significant inhibitory effects on Staphylococcus aureus, including multidrug-resistant strains, with low cytotoxicity to human cells.
Review
Chemistry, Physical
Wendy Wai Yeng Yeo, Sathiya Maran, Amanda Shen-Yee Kong, Wan-Hee Cheng, Swee-Hua Erin Lim, Jiun-Yan Loh, Kok-Song Lai
Summary: This review summarizes the current insights of using Metal-Containing NPs in treating MRSA and provides an in-depth appraisal of the opportunities and challenges in utilizing metal-NPs to treat MRSA.
Article
Chemistry, Analytical
Geunyoung Nam, Muhwan Kim, Yeonsook Jang, Sungbo Cho
Summary: A cold atmospheric pressure microplasma pipette (CAPMP) has been developed for targeted disinfection, demonstrating effective antibacterial ability that depends on treatment time and the number of layers of covering material.
Article
Acoustics
Qin Shu, Hanghang Lou, Tianyu Wei, Xinglin Zhang, Qihe Chen
Summary: The synergistic treatment of ultrasound and MEL-A showed remarkable antibacterial effect against MRSA, as evidenced by enumeration of viable microbes.
ULTRASONICS SONOCHEMISTRY
(2021)
Article
Immunology
Abderrahmen Merghni, Mohamed Ali Lassoued, Bakoliarisoa Nivomalala Voahangy Rasoanirina, Sarra Moumni, Maha Mastouri
Summary: This study analyzed the chemical composition of turpentine essential oil and developed a nanoemulsion with enhanced antibacterial and antibiofilm potential against MRSA. The nanoemulsion showed promising biofilm disruption activity.
MICROBIAL PATHOGENESIS
(2022)
Article
Biochemistry & Molecular Biology
Yong Guo, Ruige Yang, Fangfang Chen, Tingting Yan, Tingyu Wen, Fang Li, Xiaoyu Su, Lei Wang, Juan Du, Jifeng Liu
Summary: In this study, three triphenyl-sesquineolignans were isolated and seven derivatives were prepared. Compound 6 showed the best antibacterial activity against Gram-positive bacteria and clinical MRSA strains, with low drug resistance development probability and hemolysis. Mechanism studies revealed that compound 6 kills bacterial strains by disrupting membranes, indicating its potential as a new antibacterial candidate for combating MRSA infections.
BIOORGANIC CHEMISTRY
(2021)
Article
Microbiology
Jan Hodek, Veronika Zajicova, Irena Lovetinska-Slamborova, Ivan Stibor, Jana Muellerova, Jan Weber
Article
Nanoscience & Nanotechnology
Irena Lovetinska-Slamborova, Petr Holy, Petr Exnar, Ivana Veverkova
JOURNAL OF NANOMATERIALS
(2016)
Article
Nanoscience & Nanotechnology
Ivana Veverkova, Irena Lovetinska-Slamborova
JOURNAL OF NANOMATERIALS
(2016)
Article
Materials Science, Biomaterials
Pavlina Zakova, Nikola Slepickova Kasalkova, Zdenka Kolska, Jindrich Leitner, Jana Karpiskova, Ivan Stibor, Petr Slepicka, Vaclav Svorcik
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2016)
Article
Materials Science, Ceramics
Veronika Makova, Michal Spina, Jana Mullerova, Petr Exnar
Article
Materials Science, Ceramics
Marianna Ciernikova, Petra Balazova, Alfonz Plsko, Petr Exnar, Jana Pagacova, Iveta Papucova
JOURNAL OF SOL-GEL SCIENCE AND TECHNOLOGY
(2018)
Article
Materials Science, Multidisciplinary
Nikola Slepickova Kasalkova, Pavlina Zakova, Ivan Stibor, Petr Slepicka, Zdenka Kolska, Jana Karpiskova, Vaclav Svorcik
MATERIALS TECHNOLOGY
(2019)
Article
Chemistry, Applied
Kai Yang, Mohanapriya Venkataraman, Jana Karpiskova, Yuji Suzuki, Sana Ullah, Ick-Soo Kim, Jiri Militky, Yuanfeng Wang, Tao Yang, Jakub Wiener, Guocheng Zhu, Juming Yao
Summary: Embedding of functional materials into aerogel powders was achieved via the filtration method. The aerogel had an impact on the molecular structure of the embedded polyethylene glycol (PEG). The crystallinity of PEG was reduced in aerogel powders, leading to a decrease in decomposed temperature and thermal capacity.
MICROPOROUS AND MESOPOROUS MATERIALS
(2021)
Article
Chemistry, Physical
David Tetour, Tomas Paska, Veronika Makova, Barbora Nikendey Holubova, Jana Karpiskova, Michal Rezanka, Jiri Brus, Jana Hodacova
Summary: Two hybrid organosilica materials containing bis-cinchonine-phthalazine bridging organic unit were synthesized and used as heterogenized ligands in catalysis of enantioselective Sharpless alkene dihydroxylation. The nanostructured material exhibited higher enantioselectivities than the bulk material and could be used at least five times without loss of enantioselectivity.
JOURNAL OF CATALYSIS
(2021)
Article
Chemistry, Applied
Kai Yang, Qingyan Peng, Mohanapriya Venkataraman, Jana Novotna, Jana Karpiskova, Jana Mullerova, Jakub Wiener, Martina Vikova, Guocheng Zhu, Juming Yao, Jiri Militky
Summary: In this study, PTFE-coated viscose fabrics were prepared using electrospraying technology and stabilized through sintering at different temperatures. Increasing sintering temperature led to denser PTFE coating and reduced breathability, with stable hydrophobicity achieved at 190 degrees C or higher.
PROGRESS IN ORGANIC COATINGS
(2022)
Article
Chemistry, Physical
Pavlina Zakova, Nikola Slepickova Kasalkova, Petr Slepicka, Zdenka Kolska, Jana Karpiskova, Ivan Stibor, Vaclav Svorcik
APPLIED SURFACE SCIENCE
(2017)
Proceedings Paper
Engineering, Electrical & Electronic
B. Hnatiuc, P. Exnar, A. Sabau, P. Spatenka, C. L. Dumitrache, M. Hnatiuc, S. Ghita
ADVANCED TOPICS IN OPTOELECTRONICS, MICROELECTRONICS, AND NANOTECHNOLOGIES VIII
(2016)
Proceedings Paper
Nanoscience & Nanotechnology
Irena Lovetinska-Slamborova, Petr Exnar, Iveta Danilova, Ivana Veverkova
NART 2015-Nanofibers, Applications and Related Technologies
(2015)
Proceedings Paper
Nanoscience & Nanotechnology
Petr Exnar, Irena Lovetinska-Slamborova
NART 2015-Nanofibers, Applications and Related Technologies
(2015)
Proceedings Paper
Nanoscience & Nanotechnology
Petr Exnar, Irena Lovetinska-Slamborova, Ivana Veverkova, Iveta Danilova
NANOCON 2015: 7TH INTERNATIONAL CONFERENCE ON NANOMATERIALS - RESEARCH & APPLICATION
(2015)
Article
Materials Science, Biomaterials
Mohammadreza Kasravi, Alireza Yaghoobi, Tahereh Tayebi, Mahsa Hojabri, Abdolkarim Talebi Taheri, Fatemeh Shirzad, Bahram Jambar Nooshin, Radman Mazloomnejad, Armin Ahmadi, Fatemeh A. Tehrani, Ghasem Yazdanpanah, Mohammad Hadi Farjoo, Hassan Niknejad
Summary: As a promising approach in translational medicine, the decellularization of discarded livers to produce bioscaffolds that support recellularization has potential in overcoming the limitations of conventional liver transplantation. In this study, the researchers investigated the use of matrix metalloproteinase (MMP) inhibition to preserve the extracellular matrix (ECM) during liver decellularization. The results demonstrated that the application of an MMP inhibitor significantly improved the preservation of ECM components and mechanical properties of the bioscaffolds, which supported cell viability and function in vitro. The study also confirmed that the MMP inhibition led to the inhibition of MMP2 and MMP9, providing a novel method to enhance ECM preservation during liver decellularization.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Mohammadsadegh Nadimifar, Weiguang Jin, Clara Coll-Satue, Gizem Bor, Paul Joseph Kempen, Ali Akbar Moosavi-Movahedi, Leticia Hosta-Rigau
Summary: This study presents a metal-phenolic self-assembly approach that can prepare nanoparticles fully made of hemoglobin. The nanoparticles exhibit good oxygen binding and releasing capabilities.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jyoti Kumari, Roel Hammink, Jochem Baaij, Frank A. D. T. G. Wagener, Paul H. J. Kouwer
Summary: Fibrosis is the formation of fibrous connective tissue in response to injury, leading to organ dysfunction. A novel hybrid hydrogel combining synthetic polyisocyanide with hyaluronic acid has been developed, showing strong antifibrotic properties.
BIOMATERIALS ADVANCES
(2024)
Letter
Materials Science, Biomaterials
Melissa Machado Rodrigues, Cristian Padilha Fontoura, Charlene Silvestrin Celi Garcia, Sandro Tomaz Martins, Joao Antonio Pegas Henriques, Carlos Alejandro Figueroa, Mariana Roesch Ely, Cesar Aguzzoli
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jessica Polak, David Sachs, Nino Scherrer, Adrian Suess, Huan Liu, Mitchell Levesque, Sabine Werner, Edoardo Mazza, Gaetana Restivo, Mirko Meboldt, Costanza Giampietro
Summary: Human skin equivalents (HSEs) play a crucial role in tissue engineering. This study introduces a 3D-printed culture insert to apply a static radial constraint on HSEs and examines its effects on tissue characteristics. The results show that the diameter of the culture insert significantly influences tissue contraction, fibroblast and matrix organization, keratinocyte differentiation, epidermal stratification, and basement membrane formation. This study provides important insights for the design of skin tissue engineering.
BIOMATERIALS ADVANCES
(2024)
Review
Materials Science, Biomaterials
Shiliang Chen, Tianming Du, Hanbing Zhang, Jing Qi, Yanping Zhang, Yongliang Mu, Aike Qiao
Summary: This paper reviewed the primary methods for improving the overall properties of biodegradable zinc stents. It discussed the mechanical properties, degradation behavior, and biocompatibility of various improvement strategies. Alloying was found to be the most common, simple, and effective method for improving mechanical properties. Deformation processing and surface modification further improved the mechanical properties and biological activity of zinc alloys. Meanwhile, structural design could endow stents with special properties. Manufacturing zinc alloys with excellent properties and exploring their interaction mechanism with the human body are areas for future research.
BIOMATERIALS ADVANCES
(2024)