Journal
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 33, Issue 4, Pages 2386-2391Publisher
ELSEVIER
DOI: 10.1016/j.msec.2013.02.002
Keywords
Mangiferin; beta-Cyclodextrins; Inclusion complexation; Binding ability
Categories
Funding
- National Natural Science Foundation of China (NNSFC) [21062009]
- Science Foundation of Kunming University of Science and Technology
- Natural Science Foundation of Yunnan Province [2011FZ0 59]
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The characterization, inclusion complexation behavior and binding ability of the inclusion complexes of mangiferin (MGF) with beta-cyclodextrin and its derivatives (hydroxypropyl-beta-cyclodextrin (HP beta CD), sulfobutyl ether beta-cyclodextrin (SBE beta CD) and mono (6-ethylene-diamino-6-deoxy)-beta-cyclodextrin (EN beta CD)) were investigated in both solution and solid state by means of PL spectroscopy, H-1 and 2D NMR, XRD, TG and DSC. The results showed that the water solubility and thermal stability of MGF were significantly increased in the inclusion complex with cyclodextrins. The MGF/CDs complexes will be potentially useful for the design of a novel formulation of mangiferin for herbal medicine. (C) 2013 Elsevier B.V. All rights reserved.
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