Journal
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 33, Issue 5, Pages 3001-3009Publisher
ELSEVIER
DOI: 10.1016/j.msec.2013.03.030
Keywords
UHMWPE; Bisphosphonates; Wear; Wear conditions; Osteolysis; Friction
Categories
Funding
- National Basic Research Program of China (973 Program) [2012CB933602]
- National Natural Science Foundation of China [50975239]
- Key Project of Chinese Ministry of Education [109137]
- Fundamental Research Funds for the Central Universities [SWJTU11CX118, SWJTU11ZT05]
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The aim of this study is to investigate the tribological behaviors and wear mechanisms of ultra-high molecular weight polyethylene (UHMWPE) loaded with alendronate sodium (ALN), a potential drug to treat osteolysis, under different normal loads and lubrication conditions. A mixture of UHMWPE powder and ALN (1.0 wt.%) solution was dried and hot pressed. The static and dynamic friction coefficients of UHMWPE-ALN were slightly higher than those of UHMWPE except under normal load as 10 N and in 25 v/v % calf serum. The specific wear rates of UHMWPE-ALN and UHMWPE were the lowest in 25 v/v % calf serum compared to those in deionized water or physiological saline. In particular, the specific wear rate of UHMWPE-ALN was lower than that of UHMWPE at 50 N in 25 v/v % calf serum. The main wear mechanisms of UHMWPE and UHMWPE-ALN in deionized water and UHMWPE in physiological saline were abrasive. The main wear mechanism of UHMWPE-ALN in physiological saline was micro-fatigue. In 25 v/v % calf serum, the main wear mechanism of UHMWPE and UHMWPE-ALN was abrasive wear accompanied with plastic deformation. The results of Micro-XRD indicated that the molecular deformation of UHMWPE-ALN and UHMWPE under the lower stress were in the amorphous region but in the crystalline region at the higher stress. These results showed that the wear of UHMWPE-ALN would be reduced under calf serum lubricated, which would be potentially applied to treat osteolysis. (C) 2013 Elsevier B.V. All rights reserved.
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