Journal
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 33, Issue 4, Pages 1860-1866Publisher
ELSEVIER
DOI: 10.1016/j.msec.2013.01.064
Keywords
Esophageal tissue engineering; Materials; Scaffold fabrication; Research progress
Categories
Funding
- National Science Foundation [81171476]
- Natural Science Funds for Distinguished Youth Team of Zhejiang Province [R2101166]
- Scientific Innovation Team Project of Ningbo, China [2011B82014]
- K.C. Wang Magna Fund of Ningbo University
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The mortality rate from esophageal disease like atresia, carcinoma, tracheoesophageal fistula, etc. is increasing rapidly all over the world. Traditional therapies such as surgery, radiotherapy or chemotherapy have been met with very limited success resulting in reduced survival rate and quality of patients' life. Tissue-engineered esophagus, a novel substitute possessing structure and function similar to native tissue, is believed to be an effective therapy and a promising replacement in the future. However, research on esophageal tissue engineering is still at an early stage. Considerable research has been focused on developing ideal scaffolds with optimal materials and methods of fabrication. This article gives a review of materials and scaffold fabrications currently applied in esophageal tissue engineering research. (C) 2013 Elsevier B.V. All rights reserved.
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