Journal
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 32, Issue 6, Pages 1366-1374Publisher
ELSEVIER
DOI: 10.1016/j.msec.2012.04.012
Keywords
Cryogenic grinding; Poly-epsilon-caprolactone; Nano/micro-mesh; Microsystem; Characterization
Categories
Funding
- EU [214539]
- [VZ 0021627501]
- [MSM 0021627502]
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In this paper, the treatment of poly-epsilon-caprolactone (PCL) nano/micro-mesh system by cryogenic grinding and subsequent characterization of obtained product is described. The PCL nano/micro-mesh layer submerged in appropriate liquid was cryogenically ground and obtained particles were characterized employing mainly laser diffraction and scanning electron microscopy (SEM). In the ground sample, different types of particles (fibrous particles, fibrous fragments, agglomerates with and without an internal fibrous structure, lamellae and nanoparticles) were identified, described and quantified. Parameters of cryogenic grinding (weight of sample, type of liquid medium, and influence of sample storage) were optimized to maximize the yield of particles with desired features. The potential of the system for cell scaffolding was demonstrated by cultivation of 3T3 fibroblasts on the produced microparticles. (C) 2012 Elsevier B.V. All rights reserved.
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