Article
Polymer Science
Xiaohua Chang, Dengwen Hu, Liangren Chen, Yaping Wang, Yutian Zhu
Summary: Thermoresponsive block copolymer micelles have potential in biological applications, with studies showing that changes in hydrophobic/hydrophilic block ratio, micelle concentration and addition of salt can alter the cloud point. Increasing the amount of PLGA hydrophobic block significantly decreases the cloud point, while higher micelle concentration and salt addition also lower the cloud point.
Article
Polymer Science
Jidong Dai, Min Liang, Zhigang Zhang, Katrien Bernaerts, Tianzhu Zhang
Summary: By crosslinking nucleation to prepare crystalline 4arm-PLGA, the degradation rate of PLGA can be effectively controlled, promoting cell growth and potentially having ideal performance in tissue engineering.
Article
Chemistry, Physical
Bong-Seop Lee
Summary: In a polymer-based drug delivery system, the polymer material entwines the drug and transports it to the desired target. Poly(lactide-co-glycolide) (PLGA) is a widely utilized controlled-release system for drugs with short half-lives, low stability, easy decomposition, and non-toxic side effects. Supercritical fluid (SCF) technology can be employed to prepare or micronize drug-loaded particles without the need for additional purification or cleaning procedures. The liquid-liquid phase transition behavior of PLGA in several supercritical fluids, including dimethyl ether (DME), CO2, chlorodifluoromethane (HCFC-22), and trifluoromethane (HFC-23), has been investigated. The phase behavior of PLGA is primarily controlled by the lactide-to-glycolide ratio in the copolymer backbone.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Engineering, Biomedical
Yang Zhou, Yuecheng Cui, Li-Qun Wang
Summary: A dual-sensitive hydrogel was developed by introducing a photocrosslinkable group into triblock copolymers, allowing for excellent shear thinning properties and rapid elastic recovery properties. Through a two-step crosslinking strategy, tissue-like constructs with high shape fidelity can be printed using the dual-sensitive inks.
INTERNATIONAL JOURNAL OF BIOPRINTING
(2021)
Article
Engineering, Biomedical
Lucy Geddes, Efrosyni Themistou, James F. Burrows, Fraser J. Buchanan, Louise Carson
Summary: This study aimed to develop an in vitro protocol for assessing the long-term cytotoxicity of bioresorbable polymers. Results showed that PDLLGA samples exhibited increasing cytotoxicity at later degradation stages, while PLLGA samples demonstrated significantly less cytotoxic behavior. Additionally, a new dynamic flow culture methodology was developed and validated to test the cytotoxicity of these degradable materials, along with profiling of inflammatory cytokines released by cells in response to degraded PDLLGA and PLLGA.
ACTA BIOMATERIALIA
(2021)
Article
Chemistry, Multidisciplinary
Kinam Park, Andrew Otte, Farrokh Sharifi, John Garner, Sarah Skidmore, Haesun Park, Young Kuk Jhon, Bin Qin, Yan Wang
Summary: Injectable long-acting formulations, particularly those based on poly(lactide-co-glycolide) (PLGA), have been utilized for systemic drug delivery for up to 6 months, but the development of clinical products and generics has been slow. The limited understanding of PLGA polymers and the complex variables involved in composition and manufacturing processes hinder the control over formulation properties and drug efficacy. Factors such as formulation composition, manufacturing processes, and surface morphology play crucial roles in determining the pharmacokinetic profile of the formulations, highlighting the importance of proper characterization and control of these parameters for desired drug release kinetics and efficacy.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Polymer Science
Nantaprapa Tuancharoensri, Gareth Ross, Winita Punyodom, Sararat Mahasaranon, Jirapas Jongjitwimol, Paul D. Topham, Sukunya Ross
Summary: Core-shell fibres (CSFs) offer a simple route to multifunctional hybrid materials for a wide range of applications. The CSFs in this study were designed with a hydrophilic core and hydrophobic shell, serving as potential carriers for water-soluble bioactive agents and providing protective antibacterial properties. The fibres were shown to be non-toxic to normal human dermal fibroblast cell lines and have the potential for smart delivery fabrics/dressings.
POLYMER INTERNATIONAL
(2022)
Article
Chemistry, Multidisciplinary
Yihua Pei, Jianping Wang, Nisar Ul Khaliq, Fanfei Meng, Kaoutar A. Oucherif, Jie Xue, Sarena D. Horava, Amy L. Cox, Coralie A. Richard, Monica R. Swinney, Kinam Park, Yoon Yeo
Summary: Poly(lactide-co-glycolide) (PLGA) polymers are commonly used for drug delivery due to their biodegradability and biocompatibility. This study focused on achieving sustained drug release from PLGA microparticles (MPs) for two weeks using meloxicam. By encapsulating meloxicam as a solid and incorporating magnesium hydroxide (Mg(OH)2), the researchers were able to control the drug release kinetics of the MPs. The study demonstrated the feasibility of controlling drug release from PLGA MPs over weeks based on the physical state of the drug and the inclusion of Mg(OH)2 to neutralize the microenvironmental pH of the MPs.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Polymer Science
M. Margarida Cardoso, Ines N. Peca, Telma Lopes, Rui Gardner, A. Bicho
Summary: DWNPs were produced with PLGA and PLLA containing doxorubicin as a model drug. Optical and fluorescence microscopy were used to examine the inner morphology and drug distribution of the double-walled microparticles. The study showed that the double-walled nanoparticles exhibited sustained drug release and the PLLA layer acted as a rate control barrier.
Article
Pharmacology & Pharmacy
Anton Iemtsev, Fatima Hassouna, Martin Klajmon, Alex Mathers, Michal Fulem
Summary: This study evaluates the compatibility between biodegradable polyesters and active pharmaceutical ingredients (APIs) and investigates the physical stability of drug carriers using phase diagrams. The results show varying levels of compatibility between different ratios of PLGA and model APIs, with only the IND-PLGA75 formulation remaining stable after storage.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2022)
Article
Materials Science, Multidisciplinary
Liuyun Jiang, Yingjun Ma, Shuo Tang, Yan Zhang, Shengpei Su
Summary: In this study, a functionalized hybrid nanohydroxyapatite (n-HA) was proposed to obtain a high-performance poly(lactide-co-glycolide) (PLGA)-based composite. By introducing carboxymethyl-beta-cyclodextrin (CMCD) and zoledronic acid (ZA), the mechanical and degradation properties of PLGA were improved, and the CMCD-ZA-n-HA also exhibited good biocompatibility and the ability to promote bone-like apatite deposition and cell proliferation in vitro.
JOURNAL OF MATERIALS SCIENCE
(2023)
Article
Chemistry, Multidisciplinary
Lukasz Lamch, Kazimiera A. Wilk, Imre Dekany, Agota Deak, Viktoria Hornok, Laszlo Janovak
Summary: The encapsulation of hydrophilic and amphiphilic drugs in colloidal carrier systems for sustained release is a growing concern. The use of a core-shell approach with nanocarriers can provide a solution for hydrophilic/amphiphilic drugs. Amphiphilic polymers play a key role in stabilizing the system and enhancing the chemical stability and sustained release profiles.
Article
Polymer Science
Atsushi Nishimae, Harumi Sato
Summary: The co-crystallization and intermolecular hydrogen bonding of P(GA-co-LLA) copolymers were studied, revealing a linear decrease in melting point with decreasing PGA concentration, as well as expansion of plane spacing with increasing PLA concentration. The copolymers showed two types of hydrogen bondings: C=O center dot center dot center dot H3C and C-H center dot center dot center dot O(ether) hydrogen bondings.
Article
Biochemistry & Molecular Biology
Monika Smiga-Matuszowicz, Jakub Wlodarczyk, Malgorzata Skorupa, Dominika Czerwinska-Glowka, Kaja Folta, Malgorzata Pastusiak, Malgorzata Adamiec-Organisciok, Magdalena Skonieczna, Roman Turczyn, Michal Sobota, Katarzyna Krukiewicz
Summary: This paper introduces a scaffold material made of PLGA/PISEB fibers and confirms its biocompatibility towards HUVEC. During a 12-week hydrolytic degradation process, the PLGA/PISEB fibers swell and disintegrate, resulting in the formation of highly developed structures resembling seaweeds. The change in the scaffold structure is expected to have a positive effect on blood vessel regeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Pejman Ghaffari-Bohlouli, Hafez Jafari, Alireza Khatibi, Mamak Bakhtiari, Beeta Tavana, Payam Zahedi, Amin Shavandi
Summary: By reinforcing electrospun PLDLLA/PVA nanofibers with PCCNWs, the hydrophilicity, degradation rate, and mechanical properties of the composite material were enhanced, promoting cellular activity and showing potential for bone tissue engineering applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Materials Science, Multidisciplinary
Peng Yu, Guoxin Tan, Xuliang Deng, Zhengao Wang, Chengyun Ning, Liming Ding
SCIENCE CHINA-MATERIALS
(2022)
Article
Engineering, Biomedical
Yunfan Zhang, Xueyu Dou, Lingyun Zhang, Hufei Wang, Ting Zhang, Rushui Bai, Qiannan Sun, Xing Wang, Tingting Yu, Decheng Wu, Bing Han, Xuliang Deng
Summary: In this study, a semi-interpenetrating network composite gel was prepared to fulfill the mechanical and cell compatibility requirements of hydrogels. The gel successfully encapsulated ASA via electrostatic interactions and achieved sustained release, promoting stem cell proliferation and differentiation. In vivo studies confirmed the potential of this gel in bone tissue engineering.
BIOACTIVE MATERIALS
(2022)
Article
Cell Biology
Zhewen Hu, Yiming Chen, Min Gao, Xiaopei Chi, Ying He, Chenguang Zhang, Yue Yang, Yuman Li, Yan Lv, Ying Huang, Xuliang Deng
Summary: This study developed a modified method for the isolation of primary epithelial cells, which showed better cell viability, morphology, and stemness. The modified method also allowed for stable passaging of the cells and facilitated organoid formation. Furthermore, the modified method outperformed the conventional method in isolating different types of epithelial cells.
CELL PROLIFERATION
(2023)
Article
Dentistry, Oral Surgery & Medicine
Wenjing Li, Ying He, Qiwen Zheng, Xuliang Deng
Summary: The study found that higher body mass index (BMI) and body fat percentage (BF%) in adulthood are associated with an increased risk of periodontitis. However, there is no causal association between BMI in childhood, birth weight, waist-hip ratio (WHR), and the risk of periodontitis.
JOURNAL OF PERIODONTOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Wenjing Li, Qiwen Zheng, Mingming Xu, Changqing Zeng, Xuliang Deng
Summary: This study investigated the association between 25-hydroxyvitamin D metabolites and periodontitis. Observational analysis found significant relationships, but Mendelian randomization study did not support a causal role.
JOURNAL OF CLINICAL PERIODONTOLOGY
(2023)
Article
Chemistry, Physical
Nuo Chen, Jingjing Deng, Shengjie Jiang, Xiang-Yu Kong, Teng Zhou, Kai Zhao, Zuohui Xiao, Huimin Zheng, Weipeng Chen, Congcong Zhu, Xinyu Liu, Liping Wen, Yan Wei, Xuliang Deng, Lei Jiang
Summary: This study demonstrates that stimuli-induced directional cation transport, rather than fluid-flow, through dentinal tubules actually leads to dentine hypersensitivity. The research provides evidence that external stimuli (pressure, pH, and temperature) can induce ion currents through negatively charged dentinal tubules, triggering nerve impulses and causing dentine hypersensitivity. Blocking these tubules with cationic hydrogels can significantly reduce nerve action potentials, while anionic hydrogels enhance them, supporting the role of cation-flow in dentine hypersensitivity.
Article
Chemistry, Multidisciplinary
Minzheng Yang, Feng Yuan, Wenxiong Shi, Weibin Ren, Mengfan Guo, Ouyang Chen, Le Zhou, Nannan Sun, Yao Xiao, Erxiang Xu, Xuanhe Zhang, Yan Wei, Xuliang Deng, Cewen Nan, Xun Wang, Yang Shen
Summary: Polymer dielectrics with high breakdown strength and energy density are in demand but limited by low dielectric constant and high loss at elevated temperatures. In this study, sub-nanowires of hydroxyapatite were incorporated into a polyetherimide matrix, resulting in enhanced dielectric properties and high-temperature stability. The sub-nanowires induced increased mobility of polymer chains and formed dense traps for charge carriers. This research expands the scope of polymer-inorganics composite dielectrics and provides a novel strategy for high-performance polymer dielectrics.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Feng Yuan, Chen Ouyang, Minzheng Yang, Wenxiong Shi, Weibin Ren, Yang Shen, Yan Wei, Xuliang Deng, Xun Wang
Summary: In this study, hydroxyapatite sub-nanowires/polyimide (HSP) gels and films were successfully synthesized. These nanocomposites exhibited high viscosity and modulus, as well as high transparency, high haze, and enhanced Young's modulus.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Longshuai Zhang, Jiawei Sun, Wenchao Huang, Sanke Zhang, Xuliang Deng, Weiping Gao
Summary: PEGylation extends the blood circulation time of drugs, but reduces their tumor penetration. This study introduces the in situ growth of a bioreducible polymer, poly(N-oxide), from the protein drug interferon alpha (IFN) to generate IFN-poly(N-oxide) conjugates with higher bioactivity than PEGylated IFN. The conjugate exhibits long circulation half-life and superior tumor penetration and antitumor efficacy compared to PEGylated IFN.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Materials Science, Biomaterials
Yiping Li, Yanze Meng, Yunyang Bai, Yijun Wang, Jiaqi Wang, Boonchin Heng, Jinqi Wei, Xi Jiang, Min Gao, Xiaona Zheng, Xuehui Zhang, Xuliang Deng
Summary: The study investigated the concept of restoring the electrical microenvironment to improve alveolar ridge preservation (ARP) in a mini-pig preclinical model. A biomimetic ferroelectric BaTiO3/poly(vinylidene fluoridetrifluoroethylene) (BTO/P(VDF-TrFE)) nanocomposite membrane was fabricated to recapitulate the endogeneous electrical microenvironment of the dental alveolar socket. After three months of implantation, the charged membrane significantly prevented vertical and horizontal dimension resorption and induced enhanced bone regeneration at the tooth extraction sites.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Multidisciplinary Sciences
Zhaoqiang Meng, Yujia Ma, Wenjing Li, Xuliang Deng
Summary: This study used Two-sample Mendelian randomization analyses to assess the associations between COVID-19 susceptibility and periodontitis. The findings suggest that periodontitis and higher gingival crevicular fluid interleukin-1 beta levels are causally related to increased susceptibility to COVID-19. However, further randomized controlled trials are needed to confirm these findings due to limitations of the study.
Review
Chemistry, Multidisciplinary
Boon Chin Heng, Yunyang Bai, Xiaochan Li, Lee Wei Lim, Wang Li, Zigang Ge, Xuehui Zhang, Xuliang Deng
Summary: Bone degeneration associated with various diseases is on the rise due to factors such as aging, sedentary lifestyles, and unhealthy diets. This review focuses on the etiology of degenerative bone conditions associated with diseases like diabetes, osteoporosis, periodontitis, arthritis, osteomyelitis, and metastatic osteolysis. It also explores the potential of using biomimetic electroactive biomaterials to promote bone repair by examining their mechanisms of action, such as enhancing osteogenesis and angiogenesis, suppressing inflammation and osteoclastogenesis, and having anti-bacterial effects. The review highlights the need for further research on the use of electroactive biomaterials in treating degenerative bone conditions.
Article
Chemistry, Multidisciplinary
Jia Song, Xin Zhang, Yue Yin, Mengfan Guo, Xuyang Zhao, Likun Wang, Caixia Ren, Yuxin Yin, Xuehui Zhang, Xuliang Deng, Dan Lu
Summary: The peripheral T cell pool is maintained through thymic output and self-renewal of naive T cells. Loss of RPA1 leads to lymphopenia, limited TCR repertoire diversity and increased susceptibility to inflammatory diseases. Mechanistically, RPA1 deficiency triggers genomic DNA leakage, activates ZBP1-RIPK3 signaling, and induces necroptotic T cell death and release of DAMPs, contributing to inflammation.
Article
Engineering, Biomedical
Xiaochan Li, Boon Chin Heng, Yunyang Bai, Qianqian Wang, Min Gao, Ying He, Xinwen Zhang, Xuliang Deng, Xuehui Zhang
Summary: The study confirms the dose-response effect of surface electrical charge on SHED neural differentiation and provides insights into the underlying molecular mechanisms and signaling pathways involved.
BIOACTIVE MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Huimin Zheng, Shengjie Jiang, Meijun Li, Jinying Liu, Xiaowei Wang, Minghua Liu, Chuanliang Feng, Yan Wei, Xuliang Deng
Summary: This study reveals the molecular architecture of chirality-guided mesenchymal stem cell lineage diversification through high-throughput transcriptional-metabolic profiling and pipeline network analysis. The research identifies genes and metabolites that are significantly biased by the biomimetic chiral extracellular microenvironment (ECM) and uncovers the preference for glycolysis during left-handed ECM-facilitated osteogenic differentiation and oxidative phosphorylation during right-handed ECM-promoted adipogenic differentiation. Furthermore, the study establishes chirality-ordered transcriptomic-metabolic regulatory networks and highlights the importance of genotype-phenotype integration in regenerative material design.
Article
Materials Science, Biomaterials
Mohammadreza Kasravi, Alireza Yaghoobi, Tahereh Tayebi, Mahsa Hojabri, Abdolkarim Talebi Taheri, Fatemeh Shirzad, Bahram Jambar Nooshin, Radman Mazloomnejad, Armin Ahmadi, Fatemeh A. Tehrani, Ghasem Yazdanpanah, Mohammad Hadi Farjoo, Hassan Niknejad
Summary: As a promising approach in translational medicine, the decellularization of discarded livers to produce bioscaffolds that support recellularization has potential in overcoming the limitations of conventional liver transplantation. In this study, the researchers investigated the use of matrix metalloproteinase (MMP) inhibition to preserve the extracellular matrix (ECM) during liver decellularization. The results demonstrated that the application of an MMP inhibitor significantly improved the preservation of ECM components and mechanical properties of the bioscaffolds, which supported cell viability and function in vitro. The study also confirmed that the MMP inhibition led to the inhibition of MMP2 and MMP9, providing a novel method to enhance ECM preservation during liver decellularization.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Mohammadsadegh Nadimifar, Weiguang Jin, Clara Coll-Satue, Gizem Bor, Paul Joseph Kempen, Ali Akbar Moosavi-Movahedi, Leticia Hosta-Rigau
Summary: This study presents a metal-phenolic self-assembly approach that can prepare nanoparticles fully made of hemoglobin. The nanoparticles exhibit good oxygen binding and releasing capabilities.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jyoti Kumari, Roel Hammink, Jochem Baaij, Frank A. D. T. G. Wagener, Paul H. J. Kouwer
Summary: Fibrosis is the formation of fibrous connective tissue in response to injury, leading to organ dysfunction. A novel hybrid hydrogel combining synthetic polyisocyanide with hyaluronic acid has been developed, showing strong antifibrotic properties.
BIOMATERIALS ADVANCES
(2024)
Letter
Materials Science, Biomaterials
Melissa Machado Rodrigues, Cristian Padilha Fontoura, Charlene Silvestrin Celi Garcia, Sandro Tomaz Martins, Joao Antonio Pegas Henriques, Carlos Alejandro Figueroa, Mariana Roesch Ely, Cesar Aguzzoli
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jessica Polak, David Sachs, Nino Scherrer, Adrian Suess, Huan Liu, Mitchell Levesque, Sabine Werner, Edoardo Mazza, Gaetana Restivo, Mirko Meboldt, Costanza Giampietro
Summary: Human skin equivalents (HSEs) play a crucial role in tissue engineering. This study introduces a 3D-printed culture insert to apply a static radial constraint on HSEs and examines its effects on tissue characteristics. The results show that the diameter of the culture insert significantly influences tissue contraction, fibroblast and matrix organization, keratinocyte differentiation, epidermal stratification, and basement membrane formation. This study provides important insights for the design of skin tissue engineering.
BIOMATERIALS ADVANCES
(2024)
Review
Materials Science, Biomaterials
Shiliang Chen, Tianming Du, Hanbing Zhang, Jing Qi, Yanping Zhang, Yongliang Mu, Aike Qiao
Summary: This paper reviewed the primary methods for improving the overall properties of biodegradable zinc stents. It discussed the mechanical properties, degradation behavior, and biocompatibility of various improvement strategies. Alloying was found to be the most common, simple, and effective method for improving mechanical properties. Deformation processing and surface modification further improved the mechanical properties and biological activity of zinc alloys. Meanwhile, structural design could endow stents with special properties. Manufacturing zinc alloys with excellent properties and exploring their interaction mechanism with the human body are areas for future research.
BIOMATERIALS ADVANCES
(2024)