Journal
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
Volume 31, Issue 7, Pages 1271-1277Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.msec.2011.04.002
Keywords
Cyclodextrin; Ferrocene; Gold nanoparticles; Dopamine; Ascorbic acid
Categories
Funding
- National Natural Science Foundation of China [20773107, 20973151, 20901065]
- Natural Science Key Foundation of Educational Committee of Jiangsu Province of China [07KJA15015]
- Specialized Research Fund for the Doctoral Program of Higher Education (SRFDP) [20093250110001]
- Foundation of Jiangsu Provincial Key Program of Physical Chemistry in Yangzhou University
- Foundation of Key Laboratory of Environmental Materials & Environmental Engineering of Jiangsu Province [K090032]
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A novel dopamine sensor was fabricated by forming the inclusion complex between mono-6-thio-beta-cyclodextrin (CD-SH) and ferrocene (Fe) functionalized gold nanoparticles (GNPs) films on a platinum electrode. The properties of the GNPs/CDSH-Fc nanocomposite were characterized by Fourier transform infrared spectra, UV-visible absorption spectroscopy, transmission electron microscopy and cyclic voltammetry. The electrochemistry of dopamine (DA) was investigated by cyclic voltammetry (CV) and differential pulse voltammograms (DPV). The electrooxidation of dopamine could be catalyzed by Fc/Fc(+) couple as a mediator and had a higher electrochemical response due to the unique performance of GNPs/CDSH-Fc. The anodic peaks of DA and ascorbic acid (AA) in their mixture can be well separated by the prepared electrode. Under optimum conditions linear calibration graphs were obtained over the DA concentration range 2.0 x 10(-6) to 5.0 x 10(-5) M with a correlation coefficient of 0.998 and a detection limit of 9.0 x 10(-8) M (S/N = 3). The modified electrode had been effectively applied for the assay of DA in dopamine hydrochloride injections. This work provides a simple and easy approach to selectively detect DA in the presence of AA. (C) 2011 Elsevier B.V. All rights reserved.
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