Article
Chemistry, Physical
Pedro Akira Bazaglia Kuroda, Carlos Roberto Grandini, Conrado Ramos Moreira Afonso
Summary: The technique of micro-arc oxidation (MAO) has been used to alter the surface properties of titanium alloys for biomedical purposes, enhancing their characteristics as an implant. The MAO process allows the incorporation of bioactive components like calcium, phosphorus, and magnesium, improving the corrosion resistance of the alloys. This study successfully modified the surfaces of two titanium alloys, TTZN1 and TTZN2, through MAO treatment, incorporating Ca, P, and Mg elements.
Article
Materials Science, Coatings & Films
Zi-Yi Zhang, Tian-Yu Huang, Da-Jun Zhai, Hai-Bo Wang, Ke-Qin Feng, Lin Xiang
Summary: In this study, hydroxyapatite coatings with different amounts of Sr doping were prepared on the surface of titanium alloy using micro-arc oxidation. The coatings' characteristics and bioactivity were evaluated, and it was found that the Sr-doped MAO coatings promote the proliferation of preosteoblasts, with higher Sr content leading to higher cell proliferation.
SURFACE & COATINGS TECHNOLOGY
(2022)
Article
Materials Science, Coatings & Films
Kunyu Ju, Zhongwei Zhao
Summary: In this study, the failure of MAO coatings on titanium was observed for the first time under cathodic conditions in a 6% H2O2 solution. The necessary conditions for failure were determined and the mechanism was summarized based on titanium corrosion. This treatment method is effective for MAO coatings containing Ca, Si, P, or Al and provides an alternative for non-conforming coatings and retired workpieces treatment.
SURFACE & COATINGS TECHNOLOGY
(2023)
Article
Materials Science, Coatings & Films
Shengjie Wang, Lu Deng, You Lv, Tong Zhang, Xinxin Zhang, Zehua Dong, Guangyi Cai
Summary: Incorporating copper into the surface layer of metallic titanium substrate is an effective method to enhance its antifouling ability. In this study, a Cu-modified TiO2 coating was produced on metallic Ti through micro-arc oxidation (MAO) process using an aqueous electrolyte containing Na2Cu-EDTA. The concentration of Na2Cu-EDTA affects the microstructure, corrosion resistance, and antifouling capability of the Cu-modified TiO2 coatings.
SURFACE & COATINGS TECHNOLOGY
(2023)
Article
Materials Science, Multidisciplinary
Yong Zhang, Wei Yang, Sen Yu, Liqun Wang, Xiqun Ma, Wei Gao, Nan Lan, Wenting Shao, Jian Chen
Summary: The addition of CuSO4 to (NaPO3)(6) base solution successfully prepared copper-containing micro-arc oxidation coatings on TC4 titanium alloys. The results showed that the addition of copper resulted in an increase in coating thickness and roughness, as well as a decrease in the coefficient of friction. The antibacterial properties of the coatings were improved with the addition of CuSO4 at certain concentrations. However, the corrosion resistance of the copper-doped coatings did not exceed that of the undoped coatings.
Review
Materials Science, Ceramics
Huixia Guo, Ziye Liu, Yongxin Wang, Jinlong Li
Summary: Adding silicate can increase the density of the coating, and phosphate-aluminate ceramic layer exhibits the lowest wear rate in various environments. The friction coefficient and wear rate of MAO coating in seawater are lower than those in ambient air due to the boundary lubrication effect of seawater, with the presence of divalent metal salts making seawater more lubricous than other salt solutions.
CERAMICS INTERNATIONAL
(2021)
Article
Materials Science, Coatings & Films
Zi-Yi Zhang, Tian-Yu Huang, Da-Jun Zhai, Hai-Bo Wang, Ke-Qin Feng, Lin Xiang
Summary: Coatings with different content of Zn element were successfully formed on Ti6Al4V substrates by micro-arc oxidation (MAO) to enhance the bioactivity and antibacterial activity of titanium alloys. The microstructure and composition of the coatings were characterized, and their bioactive and antibacterial activities were evaluated. The results showed that increasing Zn2+ concentration in the electrolyte resulted in changes in the properties and composition of the coatings, including thickness, surface roughness, porosity, and crystalline phases. The Zn-doped coatings improved cell viability and exhibited antibacterial activity.
SURFACE & COATINGS TECHNOLOGY
(2023)
Article
Materials Science, Coatings & Films
Yakup Yurekturk
Summary: In this study, an Al2O3 ceramic coating was formed on a pure titanium surface using duplex coating technology. Diffusion annealing treatment resulted in a denser structure, higher hardness and elastic modulus, and improved friction and wear resistance for the modified MAO coating.
SURFACE & COATINGS TECHNOLOGY
(2022)
Article
Chemistry, Physical
Rongfa Zhang, Sheng Zhong, Lilan Zeng, Hongyu Li, Rongfang Zhao, Shufang Zhang, Xinting Duan, Jingsong Huang, Ying Zhao
Summary: The study found that MAO coatings with proper magnesium contents can improve the cytocompatibility of Ti-6Al-4V alloys, while coatings with excessively high magnesium content have poor cytocompatibility.
Article
Dentistry, Oral Surgery & Medicine
Mingchao Ding, Jin Shi, Weiqi Wang, Dechao Li, Lei Tian
Summary: This study evaluated the bone response to micro-arc oxidation coated titanium alloy implants containing Ag. The results showed that the combination of micro-arc oxidation and Ag coating improved the surface morphology and osseointegration ability of the implants.
Article
Chemistry, Analytical
Aqeel Abbas, Hsuan-Ping Kung, Hsin-Chih Lin
Summary: The micro-arc oxidation process was used to apply a ceramic oxide coating on a pure titanium substrate. The surface morphology, phase composition, wear behavior, and corrosion resistance of the coatings were influenced by the current frequency and duty ratio.
Article
Cell & Tissue Engineering
Yang Qin, Quan-Ming Zhao, Xiao-Hui Ni, Shi Yin, Zhi-Gang Ma, Jin-Ping Ni, Ya-Qing Xia, Shoma Suresh, Sasirekha Krishnan, Chun-Xiang Zou, Murugan Ramalingam
Summary: Titanium is a commonly used material in orthopedic implants, but often lacks in osteogenic response. A study showed that surface modification of titanium with cobalt-containing titanium dioxide coatings improved cellular response, with homogeneous distribution of cobalt observed on the surface resulting in enhanced osteoblast adhesion and proliferation compared to unmodified titanium.
JOURNAL OF BIOMATERIALS AND TISSUE ENGINEERING
(2021)
Article
Materials Science, Multidisciplinary
L. Maj, D. Wojtas, A. Jarzebska, M. Bieda, K. Trembecka-Wojciga, R. Chulist, W. Koziol, A. Goral, A. Trelka, K. Janus, J. Kawalko, M. Kulczyk, F. Muhaffel, H. Cimenoglu, K. Sztwiertnia
Summary: This work studied the microstructure of titania coating fabricated on the surface of hydrostatically extruded titanium grade 4 using the micro-arc oxidation method. The investigation revealed that a well-adherent porous coating is produced on the top surface and side walls of the extruded rod. The presence of a continuous amorphous layer compensates for the effect of anisotropic substrate, resulting in a comparable and homogenous microstructure with a large number of micropores.
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
(2022)
Article
Materials Science, Coatings & Films
Lingyun Guo, Chunna Gao, Fan Wang, Jie Wei, Jun Hu, Yubo Xu
Summary: The study successfully fabricated micro-arc oxidation (MAO) coatings containing silicon nitride (Si3N4), which showed promising potential for orthopedic applications with osteogenic and bactericidal capability.
SURFACE & COATINGS TECHNOLOGY
(2023)
Article
Materials Science, Multidisciplinary
Harumi Tsutsumi, Yusuke Tsutsumi, Masaya Shimabukuro, Tomoyo Manaka, Peng Chen, Maki Ashida, Kunio Ishikawa, Hideki Katayama, Takao Hanawa
Summary: A customized micro-arc oxidation (MAO) treatment technique was developed to achieve desirable antibacterial properties on Ti surfaces. The specimens treated with Ag and Zn showed excellent antibacterial properties against Escherichia coli, which remained effective even after 6 months of immersion in physiological saline to simulate practical usage.
Article
Nutrition & Dietetics
Wenzhen Yin, Ziru Li, Weizhen Zhang
Article
Nutrition & Dietetics
Yun Ji, Yuan Gao, Hong Chen, Yue Yin, Weizhen Zhang
Article
Biochemistry & Molecular Biology
Yun Ji, Wenzhen Yin, Yuan Liang, Lijun Sun, Yue Yin, Weizhen Zhang
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Review
Biochemistry & Molecular Biology
Yun Ji, Yue Yin, Lijun Sun, Weizhen Zhang
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Review
Biochemistry & Molecular Biology
Yuan Liang, Wenzhen Yin, Yue Yin, Weizhen Zhang
Summary: Ghrelin-GHSR signaling plays a critical role in energy homeostasis, and therapeutic strategies targeting this system for metabolic disorders involve various approaches such as neutralization of ghrelin, antagonism of ghrelin receptor, and inhibition of ghrelin O-acyltransferase. Compounds targeting this system have shown promising efficacy in animals and in vitro studies, but further clinical trials are needed to validate their efficacy in humans.
CURRENT MEDICINAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Yun Ji, Yue Yin, Weizhen Zhang
INTERNATIONAL JOURNAL OF GENOMICS
(2020)
Article
Endocrinology & Metabolism
Zhuo Mao, Mingji Feng, Zhuoran Li, Minsi Zhou, Langning Xu, Ke Pan, Shaoxiang Wang, Wen Su, Weizhen Zhang
Summary: ETV5, identified as a novel transcription factor, plays a crucial role in regulating hepatic fatty acid metabolism by enhancing PPAR signaling and fatty acid degradation pathways. Depletion of ETV5 leads to increased lipid accumulation in the liver, suggesting ETV5 may serve as a therapeutic target for hepatic steatosis.
Article
Cell Biology
Yue Yin, Qin Wang, Meiyuzhen Qi, Chen Zhang, Ziru Li, Weizhen Zhang
Summary: The study revealed that ghrelin blocks the progression of NASH induced by LPS by attenuating Kupffer cells M1 polarization. Ghrelin may serve as a marker and therapeutic target for NASH.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Cell Biology
Xiaodan Chen, Lingling Chen, Jiali Tan, Liping Zhang, Juan Xia, Bin Cheng, Weizhen Zhang
Summary: This study investigated the role and mechanisms of the R-spondin 1 (Rspo1)-leucine-rich repeat-containing G protein-coupled receptor 4 (LGR4) axis in the initiation of self-defense of bone mesenchymal stem cells (BMSCs) and the maintenance of bone homeostasis under radiation stress. Results showed that targeting the Rspo1-LGR4 axis may provide a novel strategy for the intervention of radiation-induced bone damage.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Genetics & Heredity
Wenzhen Yin, Yuan Liang, Lijun Sun, Yue Yin, Weizhen Zhang
Summary: Maternal intermittent fasting (IF) affects offspring metabolism, resulting in lower birth weight and impaired glucose metabolism. The hepatic DNA methylation of adult offspring is significantly altered, with increased differentially methylated DNA regions.
Letter
Pharmacology & Pharmacy
Hong Chen, Lijun Sun, Lu Feng, Michael Mulholland, Weizhen Zhang, Yue Yin
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Nutrition & Dietetics
Xue Han, Miaomiao Li, Lijun Sun, Xinjuan Liu, Yue Yin, Jianyu Hao, Weizhen Zhang
Summary: The study reveals that p-hydroxybenzoic acid (HA), derived from dietary polyphenols, has a therapeutic effect on inflammatory bowel disease (IBD) by improving the mucosal barrier in a gut microbiota-dependent manner. This provides new dietary choices for the prevention and treatment of IBD.
Article
Biology
Yuan Liang, Wenzhen Yin, Chao Luo, Lijun Sun, Tiange Feng, Yunhua Zhang, Yue Yin, Weizhen Zhang
Summary: Long-term intermittent fasting before pregnancy disrupts intestinal homeostasis of offspring, leading to disorders in glucose and lipid metabolism.
COMMUNICATIONS BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Wenzhen Yin, Lijun Sun, Yuan Liang, Chao Luo, Tiange Feng, Yunhua Zhang, Weizhen Zhang, Yue Yin
Summary: The study found that long-term pre-pregnancy intermittent fasting can lead to health problems in offspring during pregnancy, including low body weight, increased adipose tissue, and impaired glucose metabolism. This effect may be achieved through DNA methylation-dependent suppression of hepatic mTORC1 signaling activity.
Article
Nutrition & Dietetics
Yunhua Zhang, Ziming Zhu, Lijun Sun, Wenzhen Yin, Yuan Liang, Hong Chen, Yanghui Bi, Wenbo Zhai, Yue Yin, Weizhen Zhang
Summary: This study found that single-nucleotide polymorphisms in G protein-coupled receptor 180 (GPR180) are associated with hypertriglyceridemia. Knocking down hepatic GPR180 resulted in decreased triglyceride and cholesterol contents, improved hepatic lipid deposition, and reduced adiposity. It also downregulated transcription factors and their target genes related to lipid metabolism. Therefore, GPR180 may be a potential drug target for the intervention of obesity and liver steatosis.
Article
Materials Science, Biomaterials
Mohammadreza Kasravi, Alireza Yaghoobi, Tahereh Tayebi, Mahsa Hojabri, Abdolkarim Talebi Taheri, Fatemeh Shirzad, Bahram Jambar Nooshin, Radman Mazloomnejad, Armin Ahmadi, Fatemeh A. Tehrani, Ghasem Yazdanpanah, Mohammad Hadi Farjoo, Hassan Niknejad
Summary: As a promising approach in translational medicine, the decellularization of discarded livers to produce bioscaffolds that support recellularization has potential in overcoming the limitations of conventional liver transplantation. In this study, the researchers investigated the use of matrix metalloproteinase (MMP) inhibition to preserve the extracellular matrix (ECM) during liver decellularization. The results demonstrated that the application of an MMP inhibitor significantly improved the preservation of ECM components and mechanical properties of the bioscaffolds, which supported cell viability and function in vitro. The study also confirmed that the MMP inhibition led to the inhibition of MMP2 and MMP9, providing a novel method to enhance ECM preservation during liver decellularization.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Mohammadsadegh Nadimifar, Weiguang Jin, Clara Coll-Satue, Gizem Bor, Paul Joseph Kempen, Ali Akbar Moosavi-Movahedi, Leticia Hosta-Rigau
Summary: This study presents a metal-phenolic self-assembly approach that can prepare nanoparticles fully made of hemoglobin. The nanoparticles exhibit good oxygen binding and releasing capabilities.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jyoti Kumari, Roel Hammink, Jochem Baaij, Frank A. D. T. G. Wagener, Paul H. J. Kouwer
Summary: Fibrosis is the formation of fibrous connective tissue in response to injury, leading to organ dysfunction. A novel hybrid hydrogel combining synthetic polyisocyanide with hyaluronic acid has been developed, showing strong antifibrotic properties.
BIOMATERIALS ADVANCES
(2024)
Letter
Materials Science, Biomaterials
Melissa Machado Rodrigues, Cristian Padilha Fontoura, Charlene Silvestrin Celi Garcia, Sandro Tomaz Martins, Joao Antonio Pegas Henriques, Carlos Alejandro Figueroa, Mariana Roesch Ely, Cesar Aguzzoli
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jessica Polak, David Sachs, Nino Scherrer, Adrian Suess, Huan Liu, Mitchell Levesque, Sabine Werner, Edoardo Mazza, Gaetana Restivo, Mirko Meboldt, Costanza Giampietro
Summary: Human skin equivalents (HSEs) play a crucial role in tissue engineering. This study introduces a 3D-printed culture insert to apply a static radial constraint on HSEs and examines its effects on tissue characteristics. The results show that the diameter of the culture insert significantly influences tissue contraction, fibroblast and matrix organization, keratinocyte differentiation, epidermal stratification, and basement membrane formation. This study provides important insights for the design of skin tissue engineering.
BIOMATERIALS ADVANCES
(2024)
Review
Materials Science, Biomaterials
Shiliang Chen, Tianming Du, Hanbing Zhang, Jing Qi, Yanping Zhang, Yongliang Mu, Aike Qiao
Summary: This paper reviewed the primary methods for improving the overall properties of biodegradable zinc stents. It discussed the mechanical properties, degradation behavior, and biocompatibility of various improvement strategies. Alloying was found to be the most common, simple, and effective method for improving mechanical properties. Deformation processing and surface modification further improved the mechanical properties and biological activity of zinc alloys. Meanwhile, structural design could endow stents with special properties. Manufacturing zinc alloys with excellent properties and exploring their interaction mechanism with the human body are areas for future research.
BIOMATERIALS ADVANCES
(2024)
