Article
Plant Sciences
Sofia Encarnacao, Cristina de Mello-Sampayo, Belmira Carrapico, Berta Sao Braz, Ana Patricia Jordao, Conceicao Peleteiro, Luis Catarino, Isabel B. Moreira da Silva, Luis F. Gouveia, Beatriz Silva Lima, Olga Silva
Summary: Anacardium occidentale L. is a traditional herbal preparation used to treat type 2 diabetes, and its hypoglycemic activity has been tested and validated in vivo using db/db mice. The study found that AoBTHP significantly reduces fasting and non-fasting glycemia, and the presence of alpha- and beta-glucosidase inhibitors, such as gallic acid, may contribute to its hypoglycemic effect.
Article
Chemistry, Multidisciplinary
Kahynna C. Loureiro, Alessandro Jager, Ewa Pavlova, Isabel B. Lima-Verde, Petr Stepanek, Leandro S. Sangenito, Andre L. S. Santos, Marco Chaud, Hernane S. Barud, Monica F. La R. Soares, Ricardo L. C. De Albuquerque-Junior, Juliana C. Cardoso, Eliana B. Souto, Marcelo da Costa Mendonca, Patricia Severino
Summary: Brazil produces over thirty thousand tons of cashew gum annually, with potential for innovative applications in drug delivery systems. Extracted cashew gum can be purified and used for pharmaceutical product development. Nanoparticles of cashew gum exhibit low polydispersity and average size dependent on oil content, showing potential for drug delivery systems.
APPLIED SCIENCES-BASEL
(2021)
Article
Polymer Science
Bhagvan P. Kamaliya, Lakha Chopda, Pragnesh N. Dave
Summary: Conductive biopolymer hydrogels have been developed by adding CoFe2O4 nanoparticles to the hydrogel matrix, resulting in improved electrical properties. Higher loading of nanoparticles can affect the electrical conductivity of the hydrogel composite.
IRANIAN POLYMER JOURNAL
(2022)
Article
Plant Sciences
Glenda Q. Ramos, Italo C. da Costa, Marcelo E. H. Maia da Costa, Erveton P. Pinto, Robert S. Matos, Henrique D. da Fonseca Filho
Summary: AFM, profilometry and SEM measurements on both sides of the Anacardium occidentale L. leaf reveal some singularities in ultrastructure due to their different morphologies and roughness. The study shows that adaxial and abaxial sides have similar microtextures but different spatial frequencies. This research provides insights into the surface morphology of leaves at different scales, with quantitative parameters confirming the spatial patterns displayed.
Article
Food Science & Technology
Antonio Augusto Araujo Lima Filho, Paulo Henrique Machado de Sousa, Icaro Gusmao Pinto Vieira, Victor Borges Fernandes, Fernando Eugenio Teixeira Cunha, Francisco Ernani Alves Magalhaes, Larissa Morais Ribeiro da Silva
Summary: Plant-based beverages often lack nutrients, but fermentation can help address this issue. This study investigated the fermentation process and symbiotic potential of kefir and kombucha in cashew nut beverages. Different inocula, including 100% kefir, 50/50% kefir-kombucha mix, and 100% kombucha, were used in the fermentation process. The results showed that the mixed cultures were more efficient in consuming oligosaccharides, and there was no acute toxicity observed in zebrafish. However, the locomotor activity was lower in the mixed and 100% kombucha samples, indicating potential probiotic activity. The sugar content decreased over time in the 50/50% sample. Fermented cashew nut-based beverages offer a healthy alternative with new flavors and textures that can be utilized in cooking and recipe creation.
INTERNATIONAL JOURNAL OF GASTRONOMY AND FOOD SCIENCE
(2023)
Article
Food Science & Technology
Adrielle Rodrigues Costa, Jailson Renato de Lima Silva, Pedro Silvino Pereira, Jose Weverton Almeida-Bezerra, Maria Aurea Soares de Oliveira, Paulo Riceli Vasconcelos Ribeiro, Edy Sousa de Brito, Marcos Antonio Drumond, Joae Tavares Calixto Junior, Jean Paul Kamdem, Antonia Eliene Duarte, Luiz Marivando Barros, Henrique Douglas Melo Coutinho
Summary: This study investigated the influence of environmental factors on the metabolic diversity of phytochemical compounds from extracts of leaves and bark of Anacardium occidentale. The results showed differences in physicochemical properties of the soils in the two collection areas and identified various phytochemical compounds in the extracts.
Article
Polymer Science
Mikihiro Hayashi, Keisuke Shibata, Shogo Nobukawa
Summary: This report discusses the enhancement of toughness in amorphous glassy polymers by incorporating a flexible polyester main chain into poly(methyl methacrylate) (PMMA) resins. The graft-type PMMA exhibited higher elongation without compromising modulus compared to PMMA homopolymer and blend PMMA containing a plasticizer. Analysis of the ductile nature of the graft-type PMMA was done through X-ray scattering, scanning electron microscopy observation, and rheological measurement, with investigation into the effects of main chain and graft chain length on tensile properties.
Article
Food Science & Technology
Tan Phat Dao, Duc Ngoc Vu, Duong Vu Nguyen, Van Thinh Pham, Thi Yen Nhi Tran
Summary: By optimizing the processing stages of blanching, osmotic, and drying, a dried jelly cashew apple product was successfully produced with enhanced retention of major nutrients and good organoleptic acceptability. The study showed that suitable conditions in each processing stage contributed to higher levels of ascorbic acid content, total phenolic content, and tannin compounds retention, with a product recovery efficiency of 21.45%. The formation of jelly drying cashew apples (JDC) aims to utilize by-products and add value to the cashew industry.
FOOD SCIENCE & NUTRITION
(2022)
Article
Materials Science, Multidisciplinary
Subhadeep Chakraborty, Biswarup Dutta, Nayan Ghosh, Suman Halder, Rahul Chatterjee, Srijoni Sengupta, Sagar Pal, Abhijit Bandyopadhyay
Summary: Poly (2-methacryloyloxyethyl trimethyl ammonium chloride) (PMETAC) and polyacrylamide (PAM) were simultaneously grafted on xanthan gum (XG) to develop a highly branched polyelectrolyte for flocculating kaolin suspension at a lower concentration. The strategically grafted copolymer showed high efficiency in flocculating kaolin suspension at a neutral pH. The settling time and turbidity of the suspension were greatly reduced by the binary grafted copolymer as compared to neat XG and mono-grafted XG.
MATERIALS TODAY COMMUNICATIONS
(2023)
Article
Engineering, Chemical
Adham Salimovich Rafikov, Saodat Adilbekovna Khodjaeva, Sardorbek Khodjibaevich Karimov, Abdusattar Turgunivich Ibragimov
Summary: Graft copolymers of chloroprene rubber with acrylic acid were synthesized in a mixture of dimethylformamide and benzene, using potassium persulfate as an initiator. The degree of grafting and efficiency of grafting increased with the concentration of monomer, initiator, temperature, and process time. Mechanism studies confirmed the formation of radical active centers during the graft copolymerization process. The synthesized copolymers exhibited excellent adhesion properties.
POLYMER ENGINEERING AND SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Sandra-Yaneth Gaitan-Jimenez, Luz-Patricia Restrepo-Sanchez, Fabian Parada-Alfonso, Carlos-Eduardo Narvaez-Cuenca
Summary: Cashew nut-shell liquid (CNSL) and its components have the potential to act as natural antioxidants, with cardols and cardanols being effective antioxidants for soybean oil.
Article
Polymer Science
Khursheed Ahmad Shiekh, Mooksupang Liangpanth, Siriporn Luesuwan, Rinlanee Kraisitthisirintr, Kittaporn Ngiwngam, Saroat Rawdkuen, Pornchai Rachtanapun, Thomas Karbowiak, Wirongrong Tongdeesoontorn
Summary: Chitosan films loaded with cashew leaf extract showed potential as bioactive and eco-friendly packaging materials, with the ethanol-extracted mature cashew leaf extract displaying higher free radical scavenging activity. The film containing 5% mature cashew leaf extract exhibited superior mechanical properties compared to other samples.
Article
Plant Sciences
Sofia Encarnacao, Rita Serrano, Cristina Almeida, Olga Silva
Summary: The aim of this study was to obtain the necessary data, including macroscopic, micromorphological, chemical, and purity information, to safely use the red and white types of Anacardium occidentale L. stem barks (AoB) as medicinal plants. The red AoB had a brown inner surface, while the white AoB had a dark-brown inner surface. Microscopic analysis revealed that sclereid cells were larger in red AoB compared to white AoB, while calcium oxalate druses and starch grain areas were larger in white AoB. Chromatographic profiling showed the presence of gallic and protocatechuic acids and other phenolic derivatives in both types of AoBs. The condensed tannins were the major secondary metabolites class in the AoBs. The obtained data are crucial for ensuring the quality of AoB as raw material for the pharmaceutical market.
Article
Materials Science, Multidisciplinary
Rawiporn Promsung, Yeampon Nakaramontri, Claudia Kummerloewe, Jobish Johns, Norbert Vennemann, Nitinart Saetung, Ekwipoo Kalkornsurapranee
Summary: In this study, natural rubber was grafted with various acrylic monomers to enhance its mechanical and thermal properties, with improved mechanical properties and crosslinking observed in the grafted rubber vulcanizates. The newly developed curing technique allows for easier processing at low temperatures.
MATERIALS TODAY COMMUNICATIONS
(2021)
Article
Nanoscience & Nanotechnology
Rishabha Malviya, Shakshi Raj, Shivkanya Fuloria, Vetriselvan Subramaniyan, Kathiresan Sathasivam, Usha Kumari, Dhanalekshmi Unnikrishnan Meenakshi, Omji Porwal, Darnal Hari Kumar, Amit Singh, Srikumar Chakravarthi, Neeraj Kumar Fuloria
Summary: The study successfully fabricated chitosan-TGP polyelectrolyte complex stabilized cubic nanoparticles of simvastatin, showing high entrapment efficiency and small size. These nanoparticles exhibited better control on human breast cancer cell lines and the unusual anticancer effect of simvastatin nanoparticles is supported by various research studies.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Luis Eduardo C. Costa, Tarcisio Vieira Brito, Renan O. Silva Damasceno, Willer M. Sousa, Francisco Clark N. Barros, Venicios G. Sombra, Jose Simiao C. Junior, Diva A. Magalhaes, Marcellus H. L. P. Souza, Jand-Venes R. Medeiros, Regina Celia M. de Paula, Andre Luiz Reis Barbosa, Ana Lucia P. Freitas
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2020)
Article
Chemistry, Applied
Antonia Carla de Jesus Oliveira, Luise Lopes Chaves, Fabio de Oliveira Silva Ribeiro, Lais Ramos Monteiro de Lima, Thaisa Cardoso Oliveira, Fatima Garcia-Villen, Cesar Viseras, Regina C. M. de Paula, Pedro Jose Rolim-Neto, Fernando Hallwass, Edson C. Silva-Filho, Durcilene Alves da Silva, Jose Lamartine Soares-Sobrinho, Monica Felts de la Roca Soares
Summary: Chemical modification of polysaccharides using microwave irradiation for the synthesis of phthalated cashew gum was investigated in this study, showing promising properties for improving the treatment of Chagas disease. The modified biopolymers were characterized for their structural and physicochemical properties, and the nanoparticles used for drug delivery systems exhibited specific characteristics such as size, zeta potential, and in vitro release behavior.
CARBOHYDRATE POLYMERS
(2021)
Article
Biochemistry & Molecular Biology
Lais Ramos Monteiro Lima, Everton Lucas de Lima Ramos, Maria Francilene Souza Silva, Fabio de Oliveira Silva Ribeiro, Jeanlex S. Sousa, Claudia Pessoa, Durcilene Alves Silva, Judith P. A. Feitosa, Haroldo C. B. Paula, Regina Celia Monteiro de Paula
Summary: In this study, aminated poly(N-isopropylacrylamide) was successfully grafted onto oxidized galactomannan polysaccharide from Delonix regia via Schiff base reaction. The self-organizing ability of the obtained nanoparticle copolymers was investigated, showing promising potential for drug delivery with good cell viability and transition temperature close to human body temperature. The use of free aldehyde groups in the oxidized polysaccharide for pro-drug formation with substances possessing NH2 groups was also highlighted.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Irisvan S. Ribeiro, Francisco J. G. Pontes, Maria J. M. Carneiro, Nayara A. Sousa, Vicente P. T. Pinto, Fabio O. S. Ribeiro, Durcilene A. Silva, Gisele S. Araujo, Jose D. B. Marinho Filho, Ana J. Araujo, Haroldo C. B. Paula, Judith P. A. Feitosa, Regina C. M. de Paula
Summary: Polymer-based nanoparticles prepared in this study showed excellent drug encapsulation, controlled release performance, and biocompatibility, making them promising for drug delivery applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Applied
Lindauro C. Pereira Junior, Fernando G. Nascimento, Samara R. B. D. Oliveira, Glauber C. Lima, Francisco Diego S. Chagas, Venicios G. Sombra, Judith P. A. Feitosa, Eliane M. Soriano, Marcellus H. L. P. Souza, Guilherme J. Zocolo, Lorena M. A. Silva, Regina C. M. de Paula, Renan O. S. Damasceno, Ana Lucia P. Freitas
Summary: The study isolated and characterized a polysaccharide from the marine alga Acanthophora spicifera, which exhibited protective potential against chemically-induced gastric mucosa injury. The sulfated polysaccharide showed promising gastroprotective effects by preventing lipid peroxidation and enhancing the defense mechanisms of the gastric mucosa.
CARBOHYDRATE POLYMERS
(2021)
Article
Biochemistry & Molecular Biology
Maria J. M. Carneiro, Claudio B. A. Paula, Irisvan S. Ribeiro, Lais R. M. de Lima, Fabio O. S. Ribeiro, Durcilene A. Silva, Gisele S. Araujo, Jose D. B. Marinho Filho, Ana J. Araujo, Rosemayre S. Freire, Judith P. A. Feitosa, Regina C. M. de Paula
Summary: Stimulus-responsive nanoparticles with dextran-graft-poly (N-isopropylacrylamide) copolymers synthesized via Schiff base formation show thermal and pH dual responsiveness. Conjugation of doxorubicin to the copolymers results in nanoparticles that exhibit selective release of the drug in tumor cells, demonstrating high cytotoxicity against cancer cells and low toxicity towards non-tumor cells.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Thaisa Cardoso de Oliveira, Antonia Carla de Jesus Oliveira, Yuri Basilio Gomes Patriota, Luise Lopes Chaves, Fabio de Oliveira Silva Ribeiro, Regina C. M. de Paula, Edson Cavalcanti Silva-Filho, Durcilene Alves da Silva, Monica Felts de La Roca Soares, Jose Lamartine Soares-Sobrinho
Summary: A new hydrophobic polymer based on angico gum (AG) was developed, and new nanoparticles were produced to expand the applications of natural polysaccharides in nanomedicine. By utilizing Plackett-Burman's experimental design, nanoparticles with different characteristics were successfully produced. NVP-loaded PAG nanoparticles showed significant promotion of drug release.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Chemistry, Physical
Maria K. S. O. Abreu, Maria A. S. Silva, Dieric S. Abreu, Ana R. Richter, Regina C. M. de Paula, Vera R. L. Constantino, Igor F. Vasconcelos, Francisco G. S. de Oliveira, Acacio S. de Melo, Marcio A. Correa, Izaura C. N. Diogenes
Summary: This study improves the colloidal stability of CoFe2O4 in water media by encapsulating it in CMCG. The results show that after encapsulation, CoFe2O4 forms a polymer-caged MNPs aggregate with a negatively charged layer. Despite the dilution effect of CMCG, the material maintains magnetization.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2023)
Article
Biochemistry & Molecular Biology
Fabio de Oliveira Silva Ribeiro, Fatima de Cassia Evangelista de Oliveira, Claudia Pessoa, Jhones do Nascimento Dias, Patricia Albuquerque, Edymilais da Silva Sousa, Sidney Goncalo de Lima, Lais Ramos Monteiro de Lima, Venicios G. Sombra, Regina Celia Monteiro de Paula, Even Herlany Pereira Alves, Daniel Fernando Pereira Vasconcelos, Darllan Damasceno Fontenele, Bruno Iles, Jand Venes Rolim Medeiros, Alyne Rodrigues de Araujo, Durcilene Alves da Silva, Jose Roberto de Souza de Almeida Leite
Summary: Lemon gum (LG) was isolated and characterized from Citrus x latifolia in Brazil. The biocompatibility of LG was evaluated in vitro and in vivo, and it showed antiproliferative activity against human prostate adenocarcinoma cancer cells. The results indicate the potential of LG for biomedical and biotechnological applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Oncology
Raimundo Fernandes de Araujo Junior, George A. Lira, Timo Schomann, Romulo S. Cavalcante, Natalia Feitosa Vilar, Regina Celia Monteiro de Paula, Raelle Ferreira Gomes, Chih Kit Chung, Carla Jorquera-Cordero, Olena Vepris, Alan B. Chan, Luis J. Cruz
Summary: This study investigates the down-regulation of interaction between tumour-associated macrophages (TAMs) and colorectal cancer cells by nanoparticles (NPs) loaded with retinoic acid (RA) and coated with cholesterol (CHO), in combination with an anti-PD-L1 immune checkpoint inhibitor. The IL-10R/IL-10 axis is shown to overstimulate the STAT3 pathway and downregulate the NF-kappa B signalling pathway, leading to immunosuppression and epithelial-mesenchymal-transition of colorectal cancer. The use of RA-loaded NPs coated with CHO and anti-PD-L1 is found to be more effective in blocking this signalling pathway.
TRANSLATIONAL ONCOLOGY
(2023)
Article
Polymer Science
Francisco das C. M. Brito, Wilton C. Lopes, Fabio O. S. Ribeiro, Raiza Raianne Luz Rodrigues, Klinger Antonio da Franca Rodrigues, Fabricio dos Santos Machado, Ana Jersia Araujo, Jose Delano Barreto Marinho Filho, Antonia Carla J. Oliveira, Edson C. S. Filho, Irisvan S. Ribeiro, Regina C. M. de Paula, Fernando Hallwass, Vicente Galber F. Viana, Durcilene A. Silva
Summary: This study modified the cashew gum through an amine reaction, which changed its molecular weight and surface charge. The amine group binding to the gum was confirmed, and cytotoxicity tests showed that the modified gum had increased thermal stability and no cytotoxic potential at concentrations below 50.0 mg/L.
Article
Chemistry, Multidisciplinary
Aline T. dos Santos, Emerson L. da Silva, Raquel C. Montenegro, Jeanlex S. de Sousa, Regina C. M. de Paula, Judith P. A. Feitosa
Summary: Copolymers of N-isopropylacrylamide (NIPAm) grafted with Dextran sulfate (DS) hold great potential for drug release, especially in targeted delivery to inflamed regions. Two different ratios of the copolymers were synthesized and confirmed using spectroscopic techniques. These copolymers demonstrated self-organization behavior in aqueous medium at temperatures above 34°C, with sizes smaller than 300 nm and spherical shapes. DS-g-3PNIPAm showed specificity to leukemic cells without affecting normal cell proliferation. Encapsulating and delivering the poorly water-soluble drug MTX using DS-g-3PNIPAm can overcome its severe side effects and improve bioactivity and stability. Among the thermo-responsive copolymers and targeted MTX nanocarriers, the DS-g-PNIPam exhibited the best performance.
JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY
(2023)
Article
Chemistry, Physical
Ana R. Richter, Jose G. Veras-Neto, Jeanlex S. Sousa, Josilayne F. S. Mendes, Raquel O. S. Fontenelle, Stephanie A. N. M. Silva, Jose D. B. Marinho-Filho, Ana J. Araujo, Judith P. A. Feitosa, Haroldo C. B. Paula, Francisco M. Goycoolea, Regina C. M. de Paula
Summary: This study reports the effect of acyl chain length on hydrophobized cashew gum derivatives. By using different anhydrides, the properties of nanoparticles and drug delivery were investigated, resulting in nanoparticles with desirable properties.
COLLOIDS AND INTERFACES
(2022)
Article
Chemistry, Applied
Lais R. M. Lima, Clara M. W. S. A. Cavalcante, Maria J. M. Carneiro, Josilayne F. S. Mendes, Nayara A. Sousa, Rosimeyre S. Freire, Vicente P. T. Pinto, Raquel O. S. Fontenelle, Judith P. A. Feitosa, Regina C. M. de Paula
Summary: Thermo-responsive copolymers were synthesized for loading galactomannan and antifungal drug amphotericin-B, showing good hemocompatibility and controlled release profile. The copolymer nanoparticles demonstrated effective antifungal activity with improved hemocompatibility compared to commercial amphotericin-B.
CARBOHYDRATE POLYMER TECHNOLOGIES AND APPLICATIONS
(2021)
Article
Polymer Science
Carlos Pinheiro Chagas de Lima, Andreia Hansen Oster, Fabio Rossi Cavalcanti, Regina Celia Monteiro de Paula, Judith Pessoa Andrade Feitosa
Summary: The study showed that sulfated chicha gum (SCHG) can act as an effective elicitor, enhancing the activity of guaiacol peroxidase and polyphenol oxidases while increasing the lignin content in apple fruits. Plant exudate may serve as an abundant, renewable, and safe source of elicitors.
POLIMEROS-CIENCIA E TECNOLOGIA
(2021)
Article
Materials Science, Biomaterials
Mohammadreza Kasravi, Alireza Yaghoobi, Tahereh Tayebi, Mahsa Hojabri, Abdolkarim Talebi Taheri, Fatemeh Shirzad, Bahram Jambar Nooshin, Radman Mazloomnejad, Armin Ahmadi, Fatemeh A. Tehrani, Ghasem Yazdanpanah, Mohammad Hadi Farjoo, Hassan Niknejad
Summary: As a promising approach in translational medicine, the decellularization of discarded livers to produce bioscaffolds that support recellularization has potential in overcoming the limitations of conventional liver transplantation. In this study, the researchers investigated the use of matrix metalloproteinase (MMP) inhibition to preserve the extracellular matrix (ECM) during liver decellularization. The results demonstrated that the application of an MMP inhibitor significantly improved the preservation of ECM components and mechanical properties of the bioscaffolds, which supported cell viability and function in vitro. The study also confirmed that the MMP inhibition led to the inhibition of MMP2 and MMP9, providing a novel method to enhance ECM preservation during liver decellularization.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Mohammadsadegh Nadimifar, Weiguang Jin, Clara Coll-Satue, Gizem Bor, Paul Joseph Kempen, Ali Akbar Moosavi-Movahedi, Leticia Hosta-Rigau
Summary: This study presents a metal-phenolic self-assembly approach that can prepare nanoparticles fully made of hemoglobin. The nanoparticles exhibit good oxygen binding and releasing capabilities.
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jyoti Kumari, Roel Hammink, Jochem Baaij, Frank A. D. T. G. Wagener, Paul H. J. Kouwer
Summary: Fibrosis is the formation of fibrous connective tissue in response to injury, leading to organ dysfunction. A novel hybrid hydrogel combining synthetic polyisocyanide with hyaluronic acid has been developed, showing strong antifibrotic properties.
BIOMATERIALS ADVANCES
(2024)
Letter
Materials Science, Biomaterials
Melissa Machado Rodrigues, Cristian Padilha Fontoura, Charlene Silvestrin Celi Garcia, Sandro Tomaz Martins, Joao Antonio Pegas Henriques, Carlos Alejandro Figueroa, Mariana Roesch Ely, Cesar Aguzzoli
BIOMATERIALS ADVANCES
(2024)
Article
Materials Science, Biomaterials
Jessica Polak, David Sachs, Nino Scherrer, Adrian Suess, Huan Liu, Mitchell Levesque, Sabine Werner, Edoardo Mazza, Gaetana Restivo, Mirko Meboldt, Costanza Giampietro
Summary: Human skin equivalents (HSEs) play a crucial role in tissue engineering. This study introduces a 3D-printed culture insert to apply a static radial constraint on HSEs and examines its effects on tissue characteristics. The results show that the diameter of the culture insert significantly influences tissue contraction, fibroblast and matrix organization, keratinocyte differentiation, epidermal stratification, and basement membrane formation. This study provides important insights for the design of skin tissue engineering.
BIOMATERIALS ADVANCES
(2024)
Review
Materials Science, Biomaterials
Shiliang Chen, Tianming Du, Hanbing Zhang, Jing Qi, Yanping Zhang, Yongliang Mu, Aike Qiao
Summary: This paper reviewed the primary methods for improving the overall properties of biodegradable zinc stents. It discussed the mechanical properties, degradation behavior, and biocompatibility of various improvement strategies. Alloying was found to be the most common, simple, and effective method for improving mechanical properties. Deformation processing and surface modification further improved the mechanical properties and biological activity of zinc alloys. Meanwhile, structural design could endow stents with special properties. Manufacturing zinc alloys with excellent properties and exploring their interaction mechanism with the human body are areas for future research.
BIOMATERIALS ADVANCES
(2024)
